Abstract:
:The influence of dopamine D1 receptor agonist, SKF 38393 has been studied in vitro in the model of low calcium spontaneous epileptiform discharges. Application of SKF 38393 (3 microM) to the perfusing medium evoked a decrease in neuronal firing rate of hippocampal CA1 neurons. The effect of SKF 38393 was blocked by pretreatment with SCH 23390. It is concluded that simulation of hippocampal D1 dopamine receptors by SKF 38393 inhibits epilepsy-like events induced by low calcium concentration in the perfusing fluid.
journal_name
Brain Resjournal_title
Brain researchauthors
Smiałowski Adoi
10.1016/0006-8993(90)90208-ssubject
Has Abstractpub_date
1990-09-24 00:00:00pages
148-50issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)90208-Sjournal_volume
528pub_type
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