Late development of Zif268 ocular dominance columns in primary visual cortex of primates.

abstract：:Cerebral autoregulation was tested here in 3- and 18-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) was measured in each rat using radioactive micropheres under unanesthetized control conditions and after hypotension induced by ganglionic blockade. Under cont...

journal_title：Brain research

authors： Hoffman WE,Albrecht RF,Miletich DJ

更新日期：1981-06-09 00:00:00

abstract：:Recently mutations in ubiquilin-2 were identified in patients with amyotrophic lateral sclerosis (ALS) and ALS/dementia providing direct evidence for the importance of this protein in neurodegenerative diseases. Histological studies have suggested that ubiquilin-1/-2 are associated with various pathological inclusions...

journal_title：Brain research

authors： Rutherford NJ,Lewis J,Clippinger AK,Thomas MA,Adamson J,Cruz PE,Cannon A,Xu G,Golde TE,Shaw G,Borchelt DR,Giasson BI

更新日期：2013-08-02 00:00:00

abstract：OBJECTIVE:Previously, we found that the inhaled anesthetic isoflurane up-regulated the transcriptional factor hypoxia inducible factor (HIF)-1α protein levels during induction of neurodegeneration in the brain of neonatal rats. Here, we investigated the role of HIF-1α and the underlying signaling pathway in the neurode...

journal_title：Brain research

authors： Chai D,Jiang H,Li Q

更新日期：2016-12-15 00:00:00

abstract：:Retinal afferents to the dorsal raphe nucleus (DRN) have been described in a number of species, including Mongolian gerbils, but functional correlates of this optic pathway are unknown at present. To determine whether temporally modulated photostimulation can affect c-Fos expression in the gerbil DRN, quantitative ana...

journal_title：Brain research

authors： Fite KV,Wu PS,Bellemer A

更新日期：2005-01-21 00:00:00

abstract：:Prenatal cocaine exposure causes alterations in auditory brainstem response in children and experimental animals and has adverse effects on auditory information processing and language skills in children. These effects may result from lesions in the cochlea since this organ is particularly sensitive to chemical insult...

journal_title：Brain research

authors： Trigueiros-Cunha N,Leão P,Renard N,Tavares MA,Eybalin M

更新日期：2006-05-01 00:00:00

abstract：:A major function of the dopamine in the striatum is to control the activity of its efferent systems which contain primarily GABAergic neurons. Direct intracerebral injections of haloperidol into the corpus striatum impaired the performance of rats trained to depress a lever in a sensitive reaction time task. Rats were...

journal_title：Brain research

authors： Amalric M,Koob GF

更新日期：1989-04-03 00:00:00

abstract：:Ethylcholine aziridinium ion (AF64A) diluted in artificial perilymph, or artificial perilymph alone was infused into the cochlea of chinchillas. After a survival time of 7 days, the cochleas were fixed with aldehydes, post-fixed in osmium and embedded in epoxy resin for light and electron microscopy. The ultrastructur...

journal_title：Brain research

authors： Morley BJ,Spangler KM,Schneider BL,Javel E

更新日期：1991-03-22 00:00:00

abstract：:The effects of the sulfated octapeptide of cholecystokinin (CCK8-S), the non-sulfated homolog (CCK8-NS) as well as the C-terminal di-, tri- and tetrapeptidic fragments (respectively CCK2, CCK3 and CCK4) were studied in vitro in rat hippocampal slices by extracellular recording of the spontaneous action potential disch...

journal_title：Brain research

authors： Böhme GA,Stutzmann JM,Blanchard JC

更新日期：1988-06-07 00:00:00

abstract：:Prolonged exposure of opioid receptors to agonists leads to their regulation by the classical process of clathrin-dependent internalization, followed by their intracellular degradation (down regulation). We have previously shown that the opioid agonist etorphine induced an additional process of down regulation of mu-o...

journal_title：Brain research

authors： Kaplan E,Binyaminy B,Gafni M,Keren O,Sarne Y

更新日期：2011-04-22 00:00:00

abstract：:To examine the hypothesis that the increased adrenocortical activity during lactation induced the loss of the prolactin (PRL) -releasing effect of morphine, we studied the effect of morphine in adrenalectomized (ADX) and sham-operated primiparous lactating Wistar rats. Animals were adrenalectomized 4 days after delive...

journal_title：Brain research

authors： Kiem DT,Fekete MI,Bartha L,Nagy G,Makara GB

更新日期：1991-11-01 00:00:00

abstract：:The pattern of generation of neurons in the albino rat superior colliculus has been studied in adult and fetal material. Neurons are generated between embryonic days 12 to 17, with rostrolateral colliculus in advance of caudomedial parts. More of the cells contributing to the deeper layers are generated early, while m...

journal_title：Brain research

authors： Mustari MJ,Lund RD,Graubard K

更新日期：1979-03-23 00:00:00

abstract：:We cloned the genes for the mouse homologue of the neuromedin B receptor (NMB-R) and the bombesin receptor subtype 3 (BRS-3). Both receptor genes consist of three exons with well-conserved intron-exon borders. Although the NMB-R gene spans more than 10 kb, the BRS-3 gene spans only about 4 kb. Comparison of the mouse ...

journal_title：Brain research

authors： Ohki-Hamazaki H,Wada E,Matsui K,Wada K

更新日期：1997-07-11 00:00:00

abstract：:Chemical synaptic transmission was studied with microelectrode techniques in isolated frog cerebella maintained in vitro. Purkinje cell (PC) EPSPs, elicited by selective monosynaptic electrical stimulation of both the parallel fiber (PF) and climbing fiber (CF) inputs, could be inverted by depolarizing (outward) curre...

journal_title：Brain research

authors： Hackett JT

更新日期：1976-09-10 00:00:00

abstract：:Injection of inositol 1,4,5-trisphosphate (InsP3) into dark-adapted Limulus ventral photoreceptors produces a series of discrete bursts of membrane depolarization. Prior injection of aequorin, a luminescent calcium indicator, reveals that the bursts of depolarization are accompanied by individual bursts of intracellul...

journal_title：Brain research

authors： Corson DW,Fein A

更新日期：1987-10-13 00:00:00

abstract：:The sites of action of lidocaine on the responses evoked by stimulation of lateral column (LC) and dorsal root (DR) were studied in the isolated, intra-arterially perfused spinal cord of the bullfrog. When the ventral root volley produced by stimulation was abolished by lidocaine, the presynaptic focal potential was a...

journal_title：Brain research

authors： Kuno M,Matsuura S

更新日期：1982-10-07 00:00:00

abstract：:The aim of this study was to evaluate spatial organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord (C1), and to clarify the involvement in mechanisms underlying orofacial secondary hyperalgesia following infraorbital nerve injury. We found that the h...

journal_title：Brain research

authors： Shibuta K,Suzuki I,Shinoda M,Tsuboi Y,Honda K,Shimizu N,Sessle BJ,Iwata K

更新日期：2012-04-27 00:00:00

abstract：:Effects of iontophoretically applied dopamine were investigated in prefrontal neurons of the monkey which showed activity changes during a visual reaction time task. The task consisted of an initial waiting phase (3.0 s), a warning phase (green lamp, 1.5-3.5 s), a lever-release GO phase (red lamp) and a reward phase. ...

journal_title：Brain research

authors： Sawaguchi T,Matsumura M,Kubota K

更新日期：1986-04-23 00:00:00

abstract：:In alert monkeys, some prefrontal neurons located in the superior dorsolateral area were activated to acoustic stimuli delivered in a restricted range of directions with respect to the animal's head. The effective direction was usually contralateral to the animal. The function of the auditory neurons in connection to ...

journal_title：Brain research

authors： Azuma M,Suzuki H

更新日期：1984-04-30 00:00:00

abstract：:The neurophysiological correlates of autoinhibition at the terminals of nigrostriatal dopaminergic neurons were studied by measuring the changes in antidromic excitability of nigrostriatal neurons following local infusions of various catecholamine agonists and antagonists into the neostriatum. Infusions of apomorphine...

journal_title：Brain research

authors： Tepper JM,Nakamura S,Young SJ,Groves PM

更新日期：1984-09-10 00:00:00

abstract：:The location of edema and territory of extravasation of serum protein were examined in the white matter of cats with different forms of intracranial pathology following an impact-acceleration injury to the head. Edema was tested with an organic density gradient and Evans blue dye was used as a marker for breakdown of ...

journal_title：Brain research

authors： Tornheim PA,Yi LF,Wagner KL,McLaurin RL

更新日期：1985-06-24 00:00:00

abstract：:Proliferating astrocytes and proliferating neuroblasts have been observed in the subgranular zone (SGZ) of the dentate gyrus (DG) in the hippocampus of adult rats under normal conditions. However, whether these proliferating cells are stimulated by running has not been determined. Using immunohistochemical techniques,...

journal_title：Brain research

authors： Uda M,Ishido M,Kami K,Masuhara M

更新日期：2006-08-09 00:00:00

abstract：:Rapid eye movement (REM) sleep is hypothesized to result from the activity of REM sleep-generating and REM sleep-inhibiting neurons. The serotoninergic (5-HT) neurons of the dorsal raphe nucleus (DRN) represents one such population of REM-sleep inhibiting neurons since they are silent during REM sleep. Consistent with...

journal_title：Brain research

authors： Blanco-Centurion CA,Salin-Pascual RJ

更新日期：2001-12-27 00:00:00

abstract：:Diurnal changes in the intranuclear release of vasopressin (VP) and oxytocin (OT) in the suprachiasmatic (SCN), paraventricular (PVN) and supraoptic nuclei (SON) of the rat were studied by means of brain microdialysis. A significant diurnal variation in VP release in the SCN was detected, with the highest levels occur...

journal_title：Brain research

authors： Kalsbeek A,Buijs RM,Engelmann M,Wotjak CT,Landgraf R

更新日期：1995-06-05 00:00:00

abstract：:Our previous study reported that cathepsin L may contribute to the death of dopaminergic neurons in rodent model of Parkinson's disease (PD). In this study we detected the changes in the expression of lysosomal cathepsin L in cellular models of PD. In human neuroblastoma SH-SY5Y cells, treatment with 6-hydroxydopamine...

journal_title：Brain research

authors： Xiang B,Fei X,Zhuang W,Fang Y,Qin Z,Liang Z

更新日期：2011-04-28 00:00:00

abstract：:The results showed that the development of seizures (pentylenetetrazole, PTZ-induced kindling; PTZ was administered to rats at a subconvulsive dose of 35mg/kg three times a week, i.p.) was accompanied by a progressive recruitment of limbic structures and a characteristic pattern of changes in the brain tissue concentr...

journal_title：Brain research

authors： Maciejak P,Szyndler J,Turzyńska D,Sobolewska A,Bidziński A,Kołosowska K,Płaźnik A

更新日期：2010-06-25 00:00:00

abstract：:Long-term potentiation (LTP) can be initiated in CA1, but not in the dentate, region of slices from rats with bilateral subcortical deafferentation at 8 week survival time. At about one week survival time, LTP is present in the CA1 region of all and also in the dentate of about 50% of slices. The results suggest that ...

journal_title：Brain research

authors： Czéh G,Horváth Z,Czopf J

更新日期：1990-06-04 00:00:00

abstract：:Ongoing development of the dopamine system during adolescence may provide a partial mechanism for behavioral and psychiatric vulnerabilities. Despite early evidence for a hyperactive adolescent dopaminergic system, recent data suggest that adolescent dopamine may be functionally hypoactive compared to in adults. While...

journal_title：Brain research

authors： Simon NW,Moghaddam B

更新日期：2017-01-01 00:00:00

abstract：:The optic nerve of anesthetized cats was completely cut and the autologous sciatic nerve was transplanted. Sixty days later some populations of retinal ganglion cells were shown to regenerate the axon with retrograde HRP labeling. We verified that ganglion cells that had projected to the lateral geniculate nucleus (LG...

journal_title：Brain research

authors： Watanabe M,Sawai H,Fukuda Y

更新日期：1991-09-27 00:00:00

abstract：:The distribution of agmatine (decarboxylated arginine) was mapped in the central nervous system (CNS) in the rat. Agmatine-like immunoreactivity was identified by light microscopy, exclusively in the cytoplasm of neuronal perikarya. Immunoreactive neurons were present in the cerebral cortex, predominantly within lamin...

journal_title：Brain research

authors： Otake K,Ruggiero DA,Regunathan S,Wang H,Milner TA,Reis DJ

更新日期：1998-03-16 00:00:00

abstract：:In kittens, but not in adult cats, depriving one eye of pattern vision by suturing the lids shut (monocular deprivation or MD) for one week reduces the proportion of binocular units in the visual cortex. A sensitivity of cortical units in adult cats to MD can be produced by infusing exogenous monoamines into the visua...

journal_title：Brain research

authors： McCall MA,Tieman DG,Hirsch HV

更新日期：1982-11-04 00:00:00