Abstract：
:Previous results indicate that the dopaminergic system in the anterior medial zona incerta (ZI) exerts a stimulatory effect on LH release. In this report changes in dopamine (DA) turnover in the ZI, preoptic area (POA) and arcuate/median eminence area (ARC/ME) (as assessed by the rate of decline in DA concentration after alpha-methyl-p-tyrosine) have been noted each afternoon (16.00-18.00 h) of the 4 days of the oestrous cycle and also on the morning (9.00-11.00 h) of proestrus (P) and second day of dioestrus (D2). Over the time of the preovulatory LH surge on P, a significant rise in DA turnover was observed in the ZI. As this area contains components of the dopaminergic incerto-hypothalamic (I-H) tract, this study provides evidence to implicate the I-H tract in the physiological stimulation of the preovulatory surge of LH on proestrus. Selective destruction of DA nerve terminals (with 6-hydroxydopamine plus desmethylimipramine) and the various cell bodies (with ibotenic acid) in the ZI both induced a period of dioestrus (9-11 days). The similarity of effect of these two types of lesion indicate that the DA nerve terminals in the ZI stimulate a stimulatory pathway ultimately to induce LH release.
journal_name
Brain Resjournal_title
Brain researchauthors
MacKenzie FJ,James MD,Wilson CAdoi
10.1016/0006-8993(88)90915-8subject
Has Abstractpub_date
1988-03-15 00:00:00pages
75-83issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)90915-8journal_volume
444pub_type
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