Abstract：
:Murine brain cells differentiated for 19 days in culture before treatment for 5 days with 10 microM diazepam. Radioligand binding to the benzodiazepine receptors on membranes obtained from these cultures was determined by the filtration assay method. Decreased binding was observed in the membranes from treated cultures relative to untreated cells. However, this decrease appears to be due, at least in part, to competition from residual drug in the assay system despite extensive cell and membrane rinses. These data emphasize the difficulty in ascribing the mechanism of benzodiazepine tolerance observed clinically with chronic treatment to receptor down-regulation as determined by binding assays.
journal_name
Brain Resjournal_title
Brain researchauthors
Prezioso PJ,Neale JHdoi
10.1016/0006-8993(83)90117-8subject
Has Abstractpub_date
1983-12-12 00:00:00pages
354-8issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(83)90117-8journal_volume
288pub_type
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