Abstract：
:A qualitative immunohistochemical study was performed on calcineurin A- and calbindin-positive neurons in the spinal cord of transgenic mice, an animal model of amyotrophic lateral sclerosis, carrying the G93A mutation of the Cu/Zn-superoxide dismutase gene. The results show that calcineurin A-immunoreactive motoneurons are affected by the neurodegenerative process; in contrast, calbindin-positive cells are selectively spared. The findings suggest that calcineurin plays a role as an accessory factor responsible for selective vulnerability in the neurodegenerative process of amyotrophic lateral sclerosis.
journal_name
Brain Resjournal_title
Brain researchauthors
Knirsch U,Sturm S,Reuter A,Bachus R,Gosztonyi G,Voelkel H,Ludolph ACdoi
10.1016/s0006-8993(00)03048-1subject
Has Abstractpub_date
2001-01-19 00:00:00pages
234-8issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)03048-1journal_volume
889pub_type
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