Hippocampofugal gamma-aminobutyric acid (GABA)-containing neuron system in the rat: a study using a double-labeling method that combines retrograde tracing and immunocytochemistry.

Abstract:

:Using a double-labeling method that combines retrograde tracing and immunocytochemistry, we demonstrated the presence of a hippocampofugal gamma-aminobutyric acid (GABA)-like immunoreactive (GABA-LI) neuron system in the rat. As a preliminary experiment, knife-cut of the dorsal fornix was made and it resulted in a remarkable accumulation of GABA-LI fibers caudal to the section. This suggested the presence of a hippocampofugal GABAergic projection. The hypothesis was confirmed by the double-labeling method: injection of the biotinylated wheat germ agglutinin (B-WGA) into the septum resulted in labeling numerous neurons in the hippocampus and some of them also showed GABA-like immunoreactivity by the simultaneous immunostaining with the antiserum against GABA.

journal_name

Brain Res

journal_title

Brain research

authors

Shinoda K,Tohyama M,Shiotani Y

doi

10.1016/0006-8993(87)90757-8

subject

Has Abstract

pub_date

1987-04-14 00:00:00

pages

181-6

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(87)90757-8

journal_volume

409

pub_type

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