Abstract:
:Using a double-labeling method that combines retrograde tracing and immunocytochemistry, we demonstrated the presence of a hippocampofugal gamma-aminobutyric acid (GABA)-like immunoreactive (GABA-LI) neuron system in the rat. As a preliminary experiment, knife-cut of the dorsal fornix was made and it resulted in a remarkable accumulation of GABA-LI fibers caudal to the section. This suggested the presence of a hippocampofugal GABAergic projection. The hypothesis was confirmed by the double-labeling method: injection of the biotinylated wheat germ agglutinin (B-WGA) into the septum resulted in labeling numerous neurons in the hippocampus and some of them also showed GABA-like immunoreactivity by the simultaneous immunostaining with the antiserum against GABA.
journal_name
Brain Resjournal_title
Brain researchauthors
Shinoda K,Tohyama M,Shiotani Ydoi
10.1016/0006-8993(87)90757-8subject
Has Abstractpub_date
1987-04-14 00:00:00pages
181-6issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(87)90757-8journal_volume
409pub_type
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