Abstract：
:Neonatal MK-801 treatment from postnatal day 8-19 leads to long-term effects on brain function, suggesting that exposure to this drug leads to the development of a brain with immature network properties. One aspect of this hypothesis, that the NMDA receptors preserve their immature state after the treatment, has been tested by measuring the potency of the competitive antagonist D-AP5 in hippocampal slices. We have previously shown that an increased potency to D-AP5 is a characteristic property of NMDA receptors during early life. In the present study we measured field potentials in the CA1 region of rat hippocampal slices evoked by iontophoretic NMDA application in the Schaffer-commissural synaptic fields. Agonist dose-response curves were constructed, followed by bath applications of increasing concentrations of the antagonist D-AP5. The maximum NMDA evoked field response was the same in slices of mature control (PND70-90; 18.9 +/- 1.2 mV) and MK-801 treated rats (PND70-90; 19.3 +/- 0.9 mV), but significantly larger in immature slices (PND10-16; 24.0 +/- 0.6 mV). The sensitivity to NMDA in hippocampal slices from each group was estimated by quantifying the ionotophoretic ejection current (= dose) which evoked 50% of the maximum field response (EC50). A significantly higher sensitivity to NMDA was found in hippocampal slices obtained from MK-801-treated rats (EC50 = 3.6 +/- 0.2 nA) than in slices from control (EC50 = 6.1 +/- 0.7 nA) or immature (EC50 = 5.9 +/- 0.5 nA) animals.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Gorter JA,Brady RJdoi
10.1016/0006-8993(94)91152-5subject
Has Abstractpub_date
1994-11-28 00:00:00pages
63-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(94)91152-5journal_volume
665pub_type
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