Abstract：
:Elevation of [K+]o for 30 s from 4 to 120 mM produced a fast and reversible depolarization and transient increase in [Ca2+]i in fura-2 loaded Retzius cells of the leech. The protein phosphatase inhibitor, okadaic acid, significantly slowed the return of [Ca2+]i toward baseline without affecting the amplitude of depolarization or rate of repolarization. Furthermore, okadaic acid and another phosphatase inhibitor, calyculin A, prolonged Ba(2+)-dependent action potentials. These results suggest that the kinetics of Ca2+ influx may be regulated by the activity of phosphatases PP-1 and/or PP-2A.
journal_name
Brain Resjournal_title
Brain researchauthors
Kleinhaus AL,Zeman RJdoi
10.1016/0006-8993(94)91800-7subject
Has Abstractpub_date
1994-07-11 00:00:00pages
326-30issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91800-7journal_volume
650pub_type
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