Abstract:
:Dopaminergic psychostimulants produce behavioral responses of greater magnitude with repeated, intermittent administration, than a single, acute dose, a phenomenon known as 'sensitization'. Alterations in regional neuronal activity produced by quinpirole, a D(2)/D(3) agonist, in quinpirole-naive and quinpirole-sensitized rats were assessed on the basis of local cerebral glucose utilization (LCGU) using the [14C]2-deoxyglucose (2-DG) method. Adult, male Long-Evans rats (180-200 g, n=7-9/group) were subjected to ten injections of quinpirole (0.5 mg/kg, s.c.) administered every 3rd day; controls and quinpirole-naive rats received saline. Locomotor activity was quantitated after injections one and ten to confirm sensitization. The 2-DG procedure was initiated 60 min after an 11th injection in freely moving rats. LCGU was determined in 43 brain regions by quantitative autoradiography. In quinpirole-naive rats, quinpirole decreased LCGU in the caudate/putamen (84% of control), lateral habenula (80% of control), and motor cortex (79% of control). In sensitized rats, quinpirole decreased LCGU in the nucleus accumbens core and shell (77 and 83% of control, respectively) and ventral pallidum (82% of control) as well as in the caudate/putamen (86% of control), lateral habenula (77% of control), and motor cortex (79% of control). This suggests that decreased neuronal activity in the nucleus accumbens and ventral pallidum may underlie the augmented behavioral response to quinpirole in sensitized animals.
journal_name
Brain Resjournal_title
Brain researchauthors
Carpenter TL,Pazdernik TL,Levant Bdoi
10.1016/s0006-8993(02)04115-xsubject
Has Abstractpub_date
2003-02-28 00:00:00pages
295-301issue
2eissn
0006-8993issn
1872-6240pii
S000689930204115Xjournal_volume
964pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Three groups of rats, one with amygdala lesions, one with hippocampal lesions and a control group were trained on a brightness discrimination task under one of three different conditions, enhancement of the negative cue, enhancement of the positive cue or a non-enhanced condition. Animals with amygdala lesions showed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90621-7
更新日期:1977-04-15 00:00:00
abstract::Problems in interpretation of autoradiograms generated by ligand binding in brain tissue may be caused by two types of technical limitations: the differential absorption of 3H-generated emissions within the tissue (differential quenching) and the reduced resolution when 125I and 14C are used as isotopes. In the course...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90290-9
更新日期:1988-08-30 00:00:00
abstract::Cell transplantation using ventral mesencephalic tissue is an experimental approach to treat Parkinson's disease. This approach is limited by poor survival of the transplants and the high number of dopaminergic neurons needed for grafting. Increasing the yield of dopaminergic neurons in donor tissue is of great import...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.05.015
更新日期:2017-08-01 00:00:00
abstract::We have previously shown that systemic administration of non-selective dopamine agonists results in a pronounced expression of the proto-oncoprotein Fos within the lateral habenula. In the current study we examined the effects of selective D1 and D2 dopamine receptor agonists on habenular Fos expression. Rats were inj...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01353-4
更新日期:1997-03-07 00:00:00
abstract::We report here that following partial spinal transections in adult lampreys, the fibers of the spinal cords can regenerate and restore some intersegmental coordination to the central pattern generator for locomotion, as tested in the isolated cord preparation. However, the regeneration by this test is not successful i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91090-1
更新日期:1989-09-04 00:00:00
abstract::Because the occurrence of rapid eye movement (REM) sleep is critically dependent upon an animal's thermal balance, acute pharmacological treatments may effect REM sleep through effects on thermoregulation. We describe how manipulating ambient temperature (T(a)) alters the REM sleep-suppressing effects of systemically-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90184-8
更新日期:1994-02-04 00:00:00
abstract::Kinins, a special class of polypeptides, are represented by bradykinin (BK), kallidin (Lys-BK), as well as their metabolites. The biological actions of these polypeptides binding on their receptors (B1 and B2) have been related to inflammation process, cytokines action, glutamate release and prostaglandins production....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.12.050
更新日期:2004-04-23 00:00:00
abstract::The mechanism of action of norepinephrine (NE)-induced potentiation of the population spike in the dentate gyrus of hippocampal slices was examined and compared with NE effects in field CA1. NE-induced potentiation was confined to the dentate gyrus, where slices perfused for 30 min with concentrations of NE as low as ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91299-5
更新日期:1985-12-30 00:00:00
abstract::Almost anyone who has ever lost weight can attest that it is harder to sustain weight loss than to lose weight. Maintenance of a 10% or greater reduced body weight is accompanied by decreases in energy expenditure to levels significantly below what is predicted solely on the basis of weight and body composition change...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2010.05.062
更新日期:2010-09-02 00:00:00
abstract::The 2,3-benzodiazepine derivative GYKI 52466 has been well characterized as a negative modulator of AMPA-type glutamate receptors. The present study re-examined the effects of GYKI 52466 on AMPA receptor-mediated currents in patches excised from pyramidal neurons in the hippocampal CA1 field and found that this drug h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03323-0
更新日期:2001-02-23 00:00:00
abstract::Rats received a unilateral lesion of the nucleus basalis magnocellularis (NBM) by infusion of ibotenic acid. Starting 2 weeks after the lesion, the animals were treated with nerve growth factor (NGF) or brain-derived neurotrophic factor (BDNF) by intraparenchymal infusion of 3 micrograms per day for 4 weeks. Lesioned ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91775-2
更新日期:1994-03-07 00:00:00
abstract::Morphological, electrophysiological and behavioral studies were carried out in cats after unilateral kainic acid injection in the substantia nigra. A forced contralateral head turning and compulsive circling was observed after surgery. Fifteen days after, when asymmetry disappeared, apomorphine induced an ipsilateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91002-x
更新日期:1987-03-03 00:00:00
abstract::FRAT1 was originally characterized as a protein frequently rearranged in advanced T cell lymphoma, which inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. FRAT1 has been identified as a proto-oncogene involved in tumorigenesis. Previous studies have shown that ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.01.037
更新日期:2010-03-12 00:00:00
abstract::We investigated the electrophysiological properties of the area postrema neurons in acutely prepared rat brain slices using the whole-cell patch-clamp technique. Two different types of transient outward potassium current (I(to)), fast and slow, were found in the area postrema. Both the decay time constant and rise tim...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02651-3
更新日期:2002-06-28 00:00:00
abstract::Expression of the growth-associated protein GAP-43 is increased in the spinal cord of ALS patients and Wobbler (wr) mice, murine models of the disease. In this work we examined if expression of GAP-43 mRNA in control and wr mice was sensitive to steroid treatment. A group of control and wr mice received s.c. a 50 mg p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01783-7
更新日期:1999-09-11 00:00:00
abstract::The molecular mechanisms regulating the retrograde axonal transport of nerve growth factor (NGF) are currently unknown. This study identifies some of the signalling events involved. The phosphoinositide 3-kinase (PI3-kinase) inhibitor wortmannin (1 nmol/eye) irreversibly inhibits the amount of 125I-betaNGF retrogradel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00396-5
更新日期:1998-07-06 00:00:00
abstract::Picture-word interference is a widely employed paradigm to investigate lexical access in word production: Speakers name pictures while trying to ignore superimposed distractor words. The distractor can be congruent to the picture (pictured cat, word cat), categorically related (pictured cat, word dog), or unrelated (p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.02.050
更新日期:2012-04-23 00:00:00
abstract::1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes a disruption of nigrostriatal dopaminergic function which resembles parkinsonism. On the cellular level, the disruption involves a Ca2+ independent release of dopamine, depletion of nigral and striatal dopamine, and the death of dopaminergic neurons. We have p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91035-y
更新日期:1991-02-15 00:00:00
abstract::Structures of the medial temporal lobes are recognized to play a central role in memory processing and to be the primary sites of deterioration in Alzheimer disease (AD). Mild cognitive impairment (MCI) represents potentially an intermediate state between normal aging and AD. Proton magnetic resonance spectroscopy (MR...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.074
更新日期:2004-04-02 00:00:00
abstract::We have investigated sensitivity to the conditioned fear procedure of mice is influenced by the genetic deletion of alpha2A adrenoceptors (ARs). We observed a heightened freezing response in the discrete cue memory test in alpha2A AR knockout (alpha2A AR KO) mice and in D79N mice, a transgenic mouse strain with functi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03248-7
更新日期:2003-10-03 00:00:00
abstract::The role of mu opioid receptors in the nucleus raphe dorsalis (DR) in the control of apomorphine-induced aggression was studied in rats. Administration in the DR of a selective mu opioid receptor agonist, (D-Ala2,N-Me-Phe4,Gly5-ol)-enkephalin (DAGO), in doses ranging from 0.01 to 1 microgram/0.5 microliter, dose-depen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90706-3
更新日期:1989-05-29 00:00:00
abstract::Immunohistochemistry was used to examine the co-occurrence of nicotinic acetylcholine receptor subunits with calcium-binding proteins in ganglion cells of the chick retina. The alpha3 subunit was rarely observed in ganglion cells containing calbindin, calretinin, or parvalbumin. On the other hand, the alpha8 subunit w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)81715-5
更新日期:1997-11-07 00:00:00
abstract::Colchicine was injected into the region of the organum vasculosum lamina terminalis/anterior region of the third cerebral ventricle (OVLT/AV3V) to produce a temporary disruption of the nervous connections of this area and the rest of the anterior hypothalamus, but to maintain the vascular connections intact. Rats were...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91648-9
更新日期:1987-12-29 00:00:00
abstract::Systemic administration of mesenchymal stem cells (MSCs) following cerebral infarction exerts functional improvements. Previous research has suggested potential therapeutic mechanisms that promote neuroprotection and synaptogenesis. These include secretion of neurotrophic factors, remodeling of neural circuits, restor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.05.033
更新日期:2018-09-15 00:00:00
abstract::Double-pulse stimulation of the perforant path input to the dentate gyrus was used in the following experiments to produce paired pulse depression in that site. This effect provided an estimate of GABA-mediated recurrent inhibition. The depression was enhanced by drugs that facilitate or mimic GABA action and attenuat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90909-5
更新日期:1983-10-24 00:00:00
abstract::SBA and NADPH-d histochemistries allow identification of functionally distinct components of the amphibian primary olfactory system. In Pipa, a secondarily aquatic frog, combination of both methodologies, using alternate sets of histological sections, reveals that, apart from Jacobson's organ, this species has a "wate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00507-6
更新日期:1997-07-11 00:00:00
abstract::The distribution of the regulatory (RII beta) subunits of type II cAMP-dependent protein kinase in cortical and subcortical areas was examined in human control and Alzheimer's disease (AD) brains. Four monoclonal antibodies generated against bovine brain RII, which cross-reacted with human brain RII beta, detected RII...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90230-7
更新日期:1992-04-24 00:00:00
abstract::The purpose of the present study is to examine the effects of mental fatigue and motivation on neural network dynamics activated during task switching. Mental fatigue was induced by 2 h of continuous performance; after which subjects were motivated by using social comparison and monetary reward as motivating factors t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.03.015
更新日期:2009-05-13 00:00:00
abstract::The chronic dietary intake of essential polyunsaturated fatty acids (PUFAs) can modulate learning and memory by being incorporated into neuronal plasma membranes. Representatives of two PUFA families, the n-3 and n-6 types become integrated into membrane phospholipids, where the actual (n-6)/(n-3) ratio can determine ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03300-0
更新日期:2002-11-01 00:00:00
abstract::Treated carbon fiber electrodes were used with differential normal pulse voltammetry (DNPV) for in vivo determination of the relative participation of uric acid (UA) to peak 3 derived between 250-300 mV in the dorsal horn of the spinal cord of anesthetized rats. In vitro, treated carbon fiber electrodes respond linear...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90584-1
更新日期:1987-09-01 00:00:00