Spinal pain suppression mechanisms may differ for phasic and tonic pain.

Abstract:

:The dorsolateral funiculus (DLF) spinal pathway has previously been identified as a major pathway involved in descending modulation of pain. While bilateral lesions of the DLF attenuated systemic morphine analgesia as measured by the tail-flick test, they failed to attenuate analgesia as measured by the formalin test. These results suggest that phasic and tonic pain, modeled by the tail-flick and formalin tests, respectively, may utilize different pain suppression mechanisms.

journal_name

Brain Res

journal_title

Brain research

authors

Ryan SM,Watkins LR,Mayer DJ,Maier SF

doi

10.1016/0006-8993(85)90582-7

subject

Has Abstract

pub_date

1985-05-13 00:00:00

pages

172-5

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(85)90582-7

journal_volume

334

pub_type

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