Abstract:
:Aging leads to a decrease in the number of neurons expressing vasopressin (VP) and vasoactive intestinal polypeptide (VIP) in the suprachiasmatic nucleus (SCN) of the rat. Similar results were observed following prolonged alcohol consumption and withdrawal. In the latter circumstances, the administration of nerve growth factor (NGF) restored the synthesis and expression of those neuropeptides despite the absence of TrkA receptors in SCN neurons. Thus, we decided to test whether the administration of NGF would improve the expression of neuropeptides in the SCN of aged rats. For this purpose, NGF was delivered intraventricularly to aged rats over a period of 14 days. The somatic volume and the total number of VP- and VIP-immunostained SCN neurons were estimated by applying stereological methods. No age-related variations were found regarding the volume of the neuronal cell bodies. Yet, a striking reduction in the number of VP- and VIP-immunoreactive neurons was detected in aged animals and found to be completely retrieved by NGF. This finding shows that exogenous NGF administered to aged rats restores the neurochemical phenotype of the SCN. This might occur either through direct signaling of SCN neurons via p75NTR or through enhancement of the cholinergic input to the SCN.
journal_name
Brain Resjournal_title
Brain researchauthors
Pereira PA,Cardoso A,Paula-Barbosa MMdoi
10.1016/j.brainres.2005.04.066subject
Has Abstractpub_date
2005-06-28 00:00:00pages
123-30issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(05)00646-3journal_volume
1048pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Oxidative stress and massive production of nitric oxide (NO) have been implicated in the neuropathogenesis following peripheral nerve injury. This study was aimed to ascertain whether melatonin would exert its neuroprotective effect on the lesioned hypoglossal neurons after peripheral axotomy, since it is known to red...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02489-6
更新日期:2000-08-11 00:00:00
abstract::Schwann cell is a cell type that forms myelin sheath and provides trophic supports for neuronal cells by producing neurotrophic factors such as neurotrophins and neurokines in both normal and traumatic situations. It was recently reported that after lesion of sciatic nerve, mRNA for cholinergic differentiation factor ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01015-9
更新日期:1997-11-21 00:00:00
abstract::The heterogeneous nature of vesicles has been studied by evaluating exocytotic events released from the cell body of a dopamine-containing neuron of Planorbis corneus. Vesicular exocytosis has been elicited by stimulation with in situ application of elevated potassium and has been monitored electrochemically with a ca...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00989-9
更新日期:1995-12-01 00:00:00
abstract::A double-label immunofluorescence technique was used to demonstrate that immunoreactivities for the functionally antagonistic neuropeptides enkephalin and cholecystokinin octapeptide (CCK) are co-localized within individual neurons and processes in discrete areas of rat midbrain and forebrain. Coexistence was most pro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90085-0
更新日期:1987-02-17 00:00:00
abstract::In anesthetized cats, medial gastrocnemius motor units (MUs) were electrically stimulated via their ventral-root axons with independent random patterns. Muscle tension and homonymous alpha-motoneuron (alpha-MN) membrane potential fluctuations in response to these stimuli were recorded simultaneously. Cross-correlating...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90763-2
更新日期:1985-09-23 00:00:00
abstract::Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90481-x
更新日期:1983-02-28 00:00:00
abstract::Afferents from the nucleus reticularis thalami (RT) to the thalamic ventrobasal complex were studied in the rat by looking for degenerating terminals after selective neurotoxic lesion of RT using injections of kainic acid. Several lines of evidence are presented indicating that RT afferents terminate in the VB by F ty...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90607-8
更新日期:1983-07-04 00:00:00
abstract::The main purpose of the present study was to determine whether specific regions of the mouse brain exhibit different age-related changes in oxidative stress, as indicated by glutathione redox state and the level of protein-glutathionyl mixed disulfides. Comparison of 3- and 21-month-old mice indicated an age-related d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.040
更新日期:2007-01-05 00:00:00
abstract::The melanocortins (MC) can affect interscapular brown adipose tissue (IBAT) thermogenesis via its sympathetic nervous system (SNS) innervation. We chose a site of high MC4-receptor (MC4-R) mRNA co-localization with SNS outflow neurons to IBAT, the subzona incerta (subZI) to test whether IBAT thermogenesis could be inc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.07.003
更新日期:2011-09-09 00:00:00
abstract::Neurturin (NTN) is a recently discovered neurotrophic factor related to glial cell line-derived neurotrophic factor (GDNF) and has a wide spectrum of biological roles in different types of neurons in the central and peripheral nervous systems. However, information on its expression in peripheral tissues has been limit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01590-5
更新日期:1999-07-24 00:00:00
abstract::Selected optic fibers were surgically deflected from one tectum onto the opposite host tectum which was denervated by eye enucleation. At 6-8 months, deflected fibers were labeled with horseradish peroxidase and the retinotopically inappropriate part of tectum was examined using electron microscopy. Numerous (labeled)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90058-2
更新日期:1988-02-01 00:00:00
abstract::An increasing number of studies suggest that learning to read changes the way the brain processes spoken language. Yet, there is still a hot debate about the locus of these literacy effects. While most psycholinguists would argue that these effects are late and postlexical, interactive theories of word recognition sug...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.084
更新日期:2008-01-10 00:00:00
abstract::The sexual and associated behaviour of 10 adult male marmosets was recorded during pair tests with ovariectomized females, before and after bilateral thermal lesions of the hypothalamus. Four sham-lesioned males served as controls. Lesions varied in volume from 1.49 to 3.28 mm3 and extended from the ventromedial hypot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90405-2
更新日期:1988-11-01 00:00:00
abstract::In order to establish the basic connectivity of physiologically identified somatosensory regions of the thalamus and telencephalon in the pigeon, injections of wheatgerm agglutinin-horseradish peroxidase were made under electrophysiological control and the projections were charted following conventional neurohistochem...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/0006-8993(87)91127-9
更新日期:1987-06-02 00:00:00
abstract::The blood-brain barrier (BBB) permeability primarily increases in cerebral venules during acute hypertension. Methyl-β-cyclodextrin (MβCD), a cholesterol-depleting agent, decreases the expression of caveolins disrupting caveolar structures. We aimed to determine the effects of MβCD on the BBB permeability of angiotens...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.03.024
更新日期:2019-07-15 00:00:00
abstract::It is well known that locus coeruleus (LC) of the rat shows intense mu-opioid receptor-like immunoreactivity (MOR-LI). In the course of our study on the distribution of MOR-LI in the brain of the Japanese monkey (Macaca fuscata), however, no MOR-LI was found in the LC although the distribution pattern of MOR-LI in oth...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00191-1
更新日期:1997-05-02 00:00:00
abstract::The effect of cerebellar stimulation on the accommodation of the lens was examined in anesthetized cats. An infrared optometer was used to measure the refractive power of the lens during stimulation of the cerebellum. The area giving responses within latencies shorter than 160 msec and amplitudes larger than 0.15 diop...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90334-7
更新日期:1978-09-29 00:00:00
abstract::The localization of adenosine receptors labelled with [3H]cyclohexyladenosine ([3H]CHA) and adenosine transport sites labelled with [3H]nitrobenzylthioinosine ([3H]NBI) was examined in striatum and superior colliculus (SC) using radioligand binding and lesioning methods. Striatal kainic acid lesions significantly redu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91033-4
更新日期:1986-01-22 00:00:00
abstract::Our previous studies have shown that there is a lower cGMP concentration in the aged brain as well as an alteration in the activity of cGMP-hydrolyzing phosphodiesterases (PDEs) and nitric oxide synthase (NOS). The aim of this study was to investigate the effect of specific inhibitors of selected PDEs on object recogn...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.02.108
更新日期:2008-06-24 00:00:00
abstract::We describe a method to produce frog olfactory epithelium with a population of developmentally synchronized receptor cells suitable for electrophysiological studies. The epithelium is ablated with ZnSO4 and allowed to regenerate for 10 days. Generation of new cells is then blocked by continuous treatment with hydroxyu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90122-2
更新日期:1987-02-01 00:00:00
abstract::Thyroid hormones are critical for the maturation and function of the central nervous system. Insufficiency of thyroid hormones in the adulthood causes a wide range of cognitive dysfunctions, including deficits in learning and memory. The present study investigated whether adult-onset hypothyroidism would alter synapti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.042
更新日期:2006-06-22 00:00:00
abstract::The goal of the present study was to identify the projection from the subdivisions of the amygdaloid nuclear complex to specified subregions of the dorsal raphe (DR) nucleus and to attempt to compare the density of amygdaloid input to the DR with that of inputs from other limbic structures. Use of a retrograde tracer,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.081
更新日期:2007-04-27 00:00:00
abstract::Behavioral studies have shown that the hyperalgesia arising from inflammatory agents, such as prostaglandin E(2) (PGE(2)), can be antagonized by activators of the ATP-sensitive potassium current (K(ATP)). This observation raises questions as to whether this suppression results from a direct action on sensory neurons a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.103
更新日期:2007-05-11 00:00:00
abstract::Natural food sources constitute a promising source of new compounds with neuroprotective properties, once they have the ability to reach the brain. Our aim was to evaluate the brain accessibility of quercetin, epigallocatechin gallate (EGCG) and cyanidin-3-glucoside (C3G) in relation to their neuroprotective capabilit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.09.020
更新日期:2016-11-15 00:00:00
abstract::Using a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD), this study investigated on the neuroprotective effects of acupuncture by examining whether acupuncture contributed to inhibiting microglial activation and inflammatory events. C57BL/6 mice were treated with MPT...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.089
更新日期:2007-02-02 00:00:00
abstract::Spatial neglect may involve neglect dyslexia resulting in a failure to identify words or parts of words in the contralesional hemispace. The present study explored a well-documented dissociation in neglect dyslexics' word processing, i.e. impaired reading aloud in the presence of good lexical decision performance for ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.069
更新日期:2008-01-16 00:00:00
abstract::Previous studies employing systemic administration of the dopamine agonist apomorphine have shown that the dose response curves for apomorphine's effects on penile reflexes and seminal emission differ, suggesting that experimentally separable populations of dopamine receptors regulate these two responses. The present ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90328-4
更新日期:1989-10-23 00:00:00
abstract::Almost anyone who has ever lost weight can attest that it is harder to sustain weight loss than to lose weight. Maintenance of a 10% or greater reduced body weight is accompanied by decreases in energy expenditure to levels significantly below what is predicted solely on the basis of weight and body composition change...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2010.05.062
更新日期:2010-09-02 00:00:00
abstract::Fluorescence resonance energy transfer (FRET) is a widely utilized optical technique for measuring small distances of 1-10 nm in live cells. In recent years, its application has been greatly popularized by the discovery of green fluorescent protein (GFP) and many improved variants which make good donor-acceptor fluoro...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2006.01.119
更新日期:2006-05-26 00:00:00
abstract::There are different kinds of visuomotor learnings. One of the most studied is error-based learning where the information about the sign and magnitude of the error is used to update the motor commands. However, there are other instances where subjects show visuomotor learning even if the use of error sign and magnitude...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.05.022
更新日期:2015-08-27 00:00:00