Abstract:
:Locations of cells responsive to microiontophoretically applied angiotensin II (AII) were compared to distributions of AII receptor binding sites identified by autoradiography in the lumbar enlargement region of the rat spinal cord. Angiotensin II receptor binding sites were densely concentrated in the superficial layers of the dorsal horn. Considerably lower densities of binding sites were present in the remaining gray matter. Effects of microiontophoretically applied AII on lumbar spinal cord cells did not vary with location within the gray matter. AII facilitated firing of most cells in the lumbar cord whether the cells were in superficial or deeper laminae of the dorsal horn or in the ventral horn. The distribution of AII binding sites and the distribution of cells that were responsive to AII suggest that AII may play a role in modulating both sensory and motor functions of the spinal cord.
journal_name
Brain Resjournal_title
Brain researchauthors
White SR,Penner JD,Speth RC,Chan JYdoi
10.1016/0006-8993(88)91398-4subject
Has Abstractpub_date
1988-02-16 00:00:00pages
195-201issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(88)91398-4journal_volume
441pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Brevetoxins (PbTx) are potent allosteric enhancers of voltage-gated sodium channel (VGSC) function and are associated with periodic "red tide" blooms. These neurotoxins produce neuronal injury and death in cerebellar granule cells (CGC) following acute exposure. In murine neocortical neurons, brevetoxin induces Ca(2+)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.10.018
更新日期:2005-01-07 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by upper and lower motor neuron death with ascending paralysis leading to death. In a transgenic mouse model of ALS (SOD1-G93A) weakness appears at 3 months of age, and because of progressive paralysis leads to death by 5 months. Cyclospo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02012-1
更新日期:2001-03-16 00:00:00
abstract::Recent evidence suggests that the primary visual cortex (V1) of rodents expresses surprisingly high levels of plasticity into adulthood. For example, long-term potentiation (LTP) is readily induced in the mature V1 of adult rodents in vivo. Here, adult, urethane-anesthetized rats were used for a detailed characterizat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.10.006
更新日期:2012-12-07 00:00:00
abstract::Neuropeptide Y (NPY) has been detected immunocytochemically in cerebral cortex and subcortical white matter of the primate frontal, parietal, temporal, and occipital lobes. Because little is known about NPY in the primate insular lobe and because peptides play an important role in normal neuronal functioning and alter...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91245-n
更新日期:1993-02-19 00:00:00
abstract::The distribution of NK(1) receptor immunoreactivity in the amygdaloid complex, induction of NK(1) receptor endocytosis in the amygdala following immobilisation stress, and the ability of pretreatment with the substance P antagonist L-760,735 or imipramine to block this response were examined in gerbils, a species with...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01976-9
更新日期:1999-11-27 00:00:00
abstract::While moderate calorie restriction (CR) in the absence of malnutrition has been consistently shown to have a systemic, beneficial effect against aging in several animals models, its effect on the brain microstructure in a non-human primate model remains to be studied using post-mortem histopathologic techniques. In th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.02.046
更新日期:2013-05-01 00:00:00
abstract::Dendrites were transected 100 microns from nerve cell somata. The probability of cell survival increased as a function of the extent of proximal segment retraction. The retraction effect is probably the result of increased resistance to calcium and sodium currents at the lesion. It is speculated that limitation of ner...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90526-9
更新日期:1987-11-10 00:00:00
abstract::The substantia nigra pars reticulata (SNr) receives both inhibitory GABAergic and excitatory glutamatergic afferents from diverse origins. Ischemic injury to the striatum and/or the globus pallidus causes delayed transneuronal death of the SNr neurons, in the course of which neuronal disinhibition induced by loss of G...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01052-9
更新日期:1996-12-16 00:00:00
abstract::The injured spinal cord does not heal properly. In contrast, tissue repair and functional recovery occur after skin or muscle injuries. The reason for this dichotomy in wound repair is unclear but inflammation, and specifically macrophage activation, likely plays a key role. Macrophages have the ability to promote the...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.12.045
更新日期:2015-09-04 00:00:00
abstract::The action of gamma-aminobutyric acid (GABA) in the supraoptic nucleus was investigated using guinea pig brain slices. GABA produced a membrane depolarization accompanied by a decrease in the input resistance. The action of GABA was concentration-dependent throughout a wide range of concentrations (10(-7)-10(-3) M). I...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90059-x
更新日期:1987-02-17 00:00:00
abstract::In six decerebrated and in eight alpha-chloralose anesthetized, paralyzed and mechanically ventilated beagle dogs, we have studied involvement of glutamate and glutamate receptors in transmission of excitatory inputs from the airway sensory receptors to the nucleus tractus solitarius and from this site to airway-relat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02890-0
更新日期:2000-11-10 00:00:00
abstract::Water deprivation caused daily urinary Na output to more than double in normal sheep, but caused no increase in Na excretion in sheep (A3VL-sheep) in which the anterior third ventricle wall had been ablated. Dehydrated A3VL-sheep exhibited a much greater degree of hypernatremia than dehydrated normal sheep, although w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90326-8
更新日期:1983-03-21 00:00:00
abstract::Mice were treated with dopamine (DA) receptor agonist and antagonist drugs: Agonists: (+/-)-SKF 38393 ((+/-)-1-phenyl-2,3,4, 5-tetrahydro-(1H)-3-benzazepine-7,8-diol) [DA D1-like]; bromocriptine, [DA D2 selective]; quinpirole, [DA D2/D3 preferring]; (+/-)-7-hydroxy-dipropylamino-tetralin (7-OH-DPAT), [DA D3/D2 preferr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01395-5
更新日期:1999-06-05 00:00:00
abstract::The effect of single administrations of MK-801 (5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine) or PCP (phencyclidine) on the induction of audiogenic seizure susceptibility by noise in immature rats was examined. Treatments with these non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists resul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91237-u
更新日期:1991-09-27 00:00:00
abstract::Adaptation in aging may become impaired from abnormal expression of corticotropin-releasing factor (CRF) and altered CRF receptor function. In this study, we measured CRF mRNA levels in Fischer 344 rats at various ages. The brains of these rats were processed for in situ hybridization. Relative to 3-month-old rats, le...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01365-1
更新日期:1999-03-20 00:00:00
abstract::We have previously shown that the HSV-2 anti-apoptotic protein ICP10PK is delivered by the replication incompetent virus mutant DeltaRR and prevents kainic acid (KA)-induced epileptiform seizures and neuronal cell loss in the mouse and rat models of temporal lobe epilepsy. The present studies used DeltaRR and the ICP1...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.08.078
更新日期:2006-11-13 00:00:00
abstract::We previously reported that reactive oxygen species (ROS) in paraventricular nucleus (PVN) modulated cardiac sympathetic afferent reflex (CSAR) and mediated the effect of angiotensin II (Ang II) in the PVN on the CSAR. In the present study, we investigated whether the NAD(P)H oxidase in the PVN was a key source of ROS...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.113
更新日期:2006-04-12 00:00:00
abstract::Electrophysiological studies have suggested that the excitatory actions of opioids in the hippocampal formation are mediated by inhibition of interneurons containing GABA; however, an anatomical basis for this interaction has never been established. Thus, we sought to determine the relationship between leu-enkephalin ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00236-3
更新日期:1996-06-10 00:00:00
abstract::Nerve growth activities in rat sciatic nerves were assayed by recording the neuritic outgrowth from chick embryonic ganglia cultured in collagen gels beside nerve fragments for two days. Living nerve explants released activity that resembled nerve growth factor (NGF) in its effect on sympathetic ganglia and that was a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90141-x
更新日期:1982-08-19 00:00:00
abstract::In situ hybridization (ISH) is an essential technique for mapping gene expression in the brain. Although many ISH protocols provide for quantitative analysis of individual mRNAs in different brain regions or across experimental conditions, this technique has lacked the necessary standardization for quantitative compar...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.069
更新日期:2004-03-12 00:00:00
abstract::Angiotensin converting enzyme (ACE) is Zn2+ metallopeptidase which plays an important role in blood pressure homeostasis in mammals and other vertebrates. Homologues of ACE involved in the biosynthesis of mammalian peptide hormones have also been identified in the insects, Musca domestica, Drosophila melanogaster and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01398-x
更新日期:1998-03-02 00:00:00
abstract::Axons in the adult mammalian CNS normally do not regenerate following axotomy even though they retain the capacity for growth under certain experimental conditions. Although this implies that the regeneration of adult axons is under regulative control, very little is known about the signaling pathways "responsible" fo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01468-3
更新日期:1996-04-01 00:00:00
abstract::Nerve fibers and terminals immunoreactive for cholecystokinin (CCK) were demonstrated in the nucleus of the solitary tract (NTS) of the rat using light and electron microscopic immunocytochemistry. The following morphological and biochemical evidence suggests that CCK in the NTS seems to be of extrinsic, most probably...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90408-5
更新日期:1982-12-09 00:00:00
abstract::The pre- and postsynaptic elements of the calyx-type synapse in the chick ciliary ganglion were stained with Lucifer yellow in situ, and the structure of this synapse was examined after enzymatic dissociation of the ganglion. Back-staining of the ciliary nerve resulted in darkly stained neuronal cell bodies. Foreward-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91309-6
更新日期:1987-09-22 00:00:00
abstract::The amount of myelin and its protein composition was studied in hypothyroid rats during the first 30 days after birth. Although the brain weight was 92% of that in the controls, the yield of myelin in hypothyroid animals was only 60% of that in controls. The protein and glycoprotein ocmposition of the isolated myelin ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90764-7
更新日期:1975-02-14 00:00:00
abstract::The effect of L-AP4, a group III mGluR agonist, on sensory synaptic transmission in the lamprey spinal cord has been analyzed. Paired recordings were made between cutaneous mechanosensory neurons (dorsal cells) and postsynaptic spinobulbar giant interneurons. L-AP4 reduced the monosynaptic dorsal cell-evoked EPSP, but...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02462-9
更新日期:2002-05-24 00:00:00
abstract::The central type benzodiazepine receptor (BDZr), an allosteric modulatory site of the GABAA receptor-anion channel, has been shown in vitro to respond to drugs with positive efficacy (agonists), zero efficacy (competitive antagonists) and drugs with negative efficacy (inverse agonists). However, this general concept o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90131-e
更新日期:1991-08-23 00:00:00
abstract::Parkinson's disease (PD) is caused by oxidative stress, and erythropoietin (EPO) reduces oxidative stress in the brain. However, EPO cannot be developed as a treatment for PD, because EPO does not cross the blood-brain barrier (BBB). A brain penetrating form of human EPO has been developed wherein EPO is fused to a ch...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.01.061
更新日期:2011-03-25 00:00:00
abstract::The auditory cortical projections to the medial geniculate body (MGB) were studied in the cat. Lesions carefully restricted to each one of the subdivisions of the auditory and peri-auditory cortex were made and degenerating fibres were mapped in the MGB. In other experiments L-[4-5-3-H]leucine was injected into the co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90465-5
更新日期:1975-06-20 00:00:00
abstract::Cultures of mouse spinal cord were used to visualize binding sites for [125I]angiotensin II (AII) by autoradiography. Visualization by light microscopy shows that neurones, but also glial cells possess angiotensin II binding sites which are located both on soma and processes. These findings open a new field of investi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91642-3
更新日期:1988-03-08 00:00:00