Abstract：
:The right wingbuds of stage 23-25 chick embryos were amputated at the future elbow region and a segment of 2-day neural tube was implanted longitudinally into the limb stump of experimental embryos to induce limb regeneration. Control embryos had no implant in the amputated limb stump. To analyze effects of the neural tube implant (NTI) upon the host nervous system, quantitative determinations were made of the peripheral limb field (PLF), dorsal root ganglia (DRG) and spinal cord lateral motor column (LMC) of the amputated side for comparison with similar determinations of the unamputated side in all embryos. The PLF was estimated by determining the area of the skeletal elements of the amputated and unamputated limb of each embryo. The size of the DRG was estimated by determining the sectional-profile area of a pair of ganglia; the LMC was determined by counting the neurons on both sides of a single spinal cord segment. The PLF was less on the amputated than on the unamputated side but was significantly greater in amputated limbs that received a NTI. The size of the DRG was positively correlated with the size of the PLF in all groups, indicating the DRG was not directly affected by the NTI but did respond to target structures. The number of neurons in the LMC was not positively correlated with the PLF and was not reduced by limb amputation in embryos with a NTI. The data suggest that the NTI may have protected host spinal cord cells from the induced-cell death expected to follow limb amputation; perhaps the implant produces a neuronal survival factor.
journal_name
Brain Resjournal_title
Brain researchauthors
Sisken BF,Fowler I,Matson G,Thudium P,Barr Edoi
10.1016/0165-3806(85)90196-8subject
Has Abstractpub_date
1985-04-01 00:00:00pages
245-52issue
2eissn
0006-8993issn
1872-6240journal_volume
351pub_type
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