Abstract:
:Ethanol and nerve growth factor (NGF) affect the survival of cholinergic neurons in the rat medial septum. To investigate whether calcium (Ca2+) homeostasis in these neurons is affected by ethanol or NGF treatment, changes in intracellular free Ca2+ concentration ([Ca2+]i) were studied in embryonic (E21) cultured medial septal neurons before stimulation (basal) and during stimulation with high potassium (K+). Changes in [Ca2+]i across time were measured in cultures of neurons treated without ethanol or with 100, 200, 400, or 800 mg% ethanol with NGF (+NGF) or without NGF (-NGF). Changes in [Ca2+]i were analyzed from fluorescence images, using indo-1. The effect of ethanol or NGF treatment was to reduce the rise in basal [Ca2+]i. The combination of ethanol and NGF treatment in +NGF neurons led to increases in basal [Ca2+]i with the greatest increase in basal [Ca2+]i occurring with 200 mg% ethanol. The effect of ethanol or NGF was to increase [Ca2+]i during stimulation with high K+. The greatest increases in [Ca2+]i occurred with 100 and 800 mg% ethanol. Together, ethanol and NGF treatment in +NGF-treated neurons led to significantly greater increases or decreases in K+ stimulated changes in [Ca2+]i compared to similarly treated -NGF neurons. We conclude that in medial septal neurons (before and during depolarization) changes in Ca2+ homeostasis occur in the presence of ethanol or NGF. The changes in [Ca2+]i following ethanol treatment are greater when NGF is present.
journal_name
Brain Resjournal_title
Brain researchauthors
Webb B,Suarez SS,Heaton MB,Walker DWdoi
10.1016/0006-8993(95)00955-3subject
Has Abstractpub_date
1995-12-01 00:00:00pages
61-74issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)00955-3journal_volume
701pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Group-housed Sprague-Dawley (SD) rats exposed for 1 h to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT, a component of fox feces) did not display changes in hippocampal serotonin (5-HT) metabolism and [3H]5-HT reuptake, compared to water or butyric acid. Such an observation extended to isolated SD and Fischer 344 rats. W...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03944-6
更新日期:2003-01-24 00:00:00
abstract::The amygdala plays an important role in the regulation of motivational states, especially those associated with addiction. The amygdala also expresses high levels of brain-derived neurotrophic factor (BDNF), an activity-dependent neurotrophin that can influence the reinforcing and locomotor activating properties of ps...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03160-8
更新日期:2002-09-13 00:00:00
abstract::The actions of convulsant and sedative barbiturates on responses to gamma-aminobutyric acid (GABA) application and on inhibitory postsynaptic currents were compared using voltage-clamp techniques in cultured rat hippocampal neurons. The convulsant barbiturates, 5-ethyl-5-(3-methylbut-2-enyl) barbituric acid (3M2B), an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90910-4
更新日期:1990-05-14 00:00:00
abstract::A role for glutamatergic signaling in the nucleus accumbens (NA) in both the expression and extinction of cocaine seeking has been suggested. The effects of extinction following cocaine self-administration on the expression and synaptosomal distribution of GluR1 and NMDAR1 glutamate receptor subunits in the NA shell a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.01.047
更新日期:2009-04-24 00:00:00
abstract::Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity and the central terminal fields of branches of the mandibular and chorda tympani nerves were visualized histochemically at the same time using transganglionic transport of wheat germ agglutinin conjugated with horseradish peroxidase. The blue NA...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01210-9
更新日期:1998-01-19 00:00:00
abstract::Microinjection of mRNA from adult rat brains into Xenopus oocytes induced an electrophysiological response to acetylcholine in the cells. The cells responded to acetylcholine through muscarinic receptors which appeared on the cell surface after microinjection of the mRNA and showed the depolarization, mainly due to an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90166-0
更新日期:1985-07-15 00:00:00
abstract::Anticipation of an unavoidable painful stimulation, i.e. anticipation stress, induces analgesia. This analgesia may result from activation of the endogenous opioid peptide system as it is blocked by naloxone. The present paper characterizes the anticipation stress further by following the kinetics of the analgesia ris...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91674-0
更新日期:1989-12-04 00:00:00
abstract::The medial nucleus of the amygdala, bed nucleus of the stria terminalis, and medial preoptic area appear to mediate steroidal regulation of mating behavior in male rodents. The mechanism of action has not been determined. One way testosterone could enhance neuronal function is by increasing neurotransmitter levels, th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91077-r
更新日期:1992-09-11 00:00:00
abstract::Epileptiform activity induced by 4-AP in hippocampal area CA1 is characterised by short recurrent discharges. These are occasionally superimposed by slow field potential (fp) shifts. Simultaneous recordings of fps and [K(+)](o) in area CA1 and temporal cortex showed a slow fp shift in both regions, but associated rise...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03541-2
更新日期:2002-11-22 00:00:00
abstract::This study tested the hypothesis that the short-latency excitation of the phrenic motor output elicited by superior laryngeal nerve (SLN) stimulation requires non-NMDA receptor-mediated neurotransmission in the region of the dorsal respiratory group (DRG) of the adult cat. Injection of the non-NMDA receptor antagonist...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00355-t
更新日期:1995-06-05 00:00:00
abstract::Autoradiographic techniques were used to test if positive modulators of AMPA-type glutamate receptors have regionally differentiated effects on ligand binding. Cyclothiazide, a drug with ten fold greater effects on 'flip' than 'flop' splice variants of the receptors, had unequal effects across the subdivisions of hipp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01315-2
更新日期:1998-02-02 00:00:00
abstract::It has been well established that the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) opener, diazoxide, has protective effects on the heart and brain following ischemia/reperfusion injury. However, the mechanism of the neuroprotective effects of diazoxide remains unclear. This study highlights the anti-apo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.11.019
更新日期:2011-01-25 00:00:00
abstract::One monoclonal antibody 115A10 (MAb 5A10) specifically stained a subpopulation of retinal bipolar cells in various vertebrates. In the bullfrog retina, MAb 5A10 stained the large bipolar cells, but not the small bipolar cells. Labeling of the living bipolar cells was observed in isolated cell preparation of the frog r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90919-x
更新日期:1987-07-28 00:00:00
abstract::The aim of this study was to identify the medullary vagal nuclei involved in the different phases of swallowing activated physiologically in a species with an esophagus similar to human. In decerebrate cats, the pharyngeal (0.5-1.0 ml water in pharynx (N=6)) or esophageal (1-3 ml air in esophagus (N=5)) phases of swal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.03.061
更新日期:2004-07-16 00:00:00
abstract::A study was undertaken of the possible relationship of the binding affinity of a series of anticholinergic psychotomimetic drugs to their psychopharmacological and anticholinergic effects. Binding was measured to brain homogenates and nerve endings using [3H]quinuclidinyl benzilate (QB), a highly potent psychotomimeti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90889-7
更新日期:1977-03-25 00:00:00
abstract::The effects of the dopamine transporter (DAT) inhibitors cocaine and GBR12909 on DAT and dopamine D(2) receptors were evaluated in the brains under awake and isoflurane-anesthetized monkeys using high-resolution positron emission tomography (PET) in combination with microdialysis. The striatal DAT availability and dop...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02018-1
更新日期:1999-12-04 00:00:00
abstract::Nodes of Ranvier in the central nervous system in mammals are characterized by the presence of perinodal astrocytic processes. This study examines the association between processes of radial glia and the axolemma at nodes of Ranvier in the spinal cord of the mature axolotl, an animal in which radial glia represent a l...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90595-m
更新日期:1991-05-17 00:00:00
abstract::The Leu-enkephalin dalargin does not normally penetrate the blood brain barrier when given intravenously. Drug targeting to the brain was investigated by using poly(butylcyanoacrylate) nanoparticles which were coated with polysorbate 80. When injected intravenously in mice, dalargin-loaded nanoparticles coated with th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01375-x
更新日期:1996-02-26 00:00:00
abstract::Schaffer collaterals of rat and mouse hippocampal slices were stimulated with bursts of pulses (300 Hz for 50 ms, 2-s intervals) for 30-s which caused a stable increase in the size of the population spike known as long-term potentiation. The release of adenosine triphosphate (ATP) was measured with a luciferase-lucife...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90567-2
更新日期:1989-04-24 00:00:00
abstract::The neurotoxic effects of exogenous glutamate were studied in the rat cochlea. Glutamate-treated rats (4 g/kg/day i.p., postnatal days 2-9) exhibited electrophysiologically-measured elevations in high frequency thresholds usually associated with hair cell loss in the basal region of the cochlea. While surface preparat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90090-i
更新日期:1991-06-28 00:00:00
abstract::We investigated the influence of muramyl dipeptide (MDP), a cell wall component of Gram-positive bacteria, on cytokine-induced nitric oxide (NO) production in rat primary astrocytes. MDP alone did not induce NO release in astrocyte cultures. However, MDP increased astrocyte NO production and subsequent nitrite accumul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02920-6
更新日期:2000-11-10 00:00:00
abstract::The present study was designed to determine the types of acetylcholine receptors involved in the initiation of epileptic seizures from the zona incerta and surrounding structures by cholinergic stimulation in rats. Unilateral intracerebral microinjection of the mixed muscarinic and nicotinic agonist carbachol (3 micro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90017-5
更新日期:1994-04-18 00:00:00
abstract::Neonatal destruction of nigrostriatal dopamine neurons by cerebroventricular injection of 6-hydroxydopamine (6-OHDA) results in a serotonin (5-HT) hyperinnervation of the rostral neostriatum in adult rat. Quantitative ligand-binding autoradiography was used to compare the density of various 5-HT receptor subtypes in t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90995-y
更新日期:1993-03-26 00:00:00
abstract::While much has been elucidated about the hypothalamic controls of energy balance, the epidemic of obesity continues to escalate. Recent work has suggested that extra-hypothalamic central nervous system structures may play a previously un-appreciated role in the control of ingestive behavior and body weight regulation....
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2010.06.009
更新日期:2010-09-02 00:00:00
abstract::The horizontal and vertical vestibulo ocular reflex (VOR) of head tilted (het) mutant mice was compared to C57BL/6 controls. Eye movements were recorded in darkness using a temporarily attached search coil. Contributions of semicircular canal versus otolith organ signals were investigated by providing a canal only (ve...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02505-8
更新日期:2003-05-16 00:00:00
abstract::Systemic administration of kainic acid in the rat results in the development of a characteristic excitotoxic syndrome, consisting of automatisms (wet dog shakes, WDS), sustained limbic seizures and brain damage. Since kainate increases the release of excitatory amino acid neurotransmitters such as glutamate, this synd...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90227-5
更新日期:1994-08-01 00:00:00
abstract::This paper describes an electrochemical method for the detection of dopamine and serotonin in vitro. Dopamine and serotonin can be distinguished from each other without interference from metabolites. 3-4-dihydroxyphenylacetic acid and 5-hydroxyindoleacetic acid. The method also provides selective differentiation of do...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91224-9
更新日期:1989-08-21 00:00:00
abstract::This review provides a snapshot of the current ethical issues related to research with human brain organoids. The issues fall into the following main themes: research oversight; human biomaterials procurement and donor consent; translational delivery; animal research; and organoid consciousness and moral status. Each ...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2020.146653
更新日期:2020-04-01 00:00:00
abstract::GABA levels, high affinity GABA uptake and glutamic acid decarboxylase levels are reduced in rat ventroanterolateral thalamic nucleus after destruction of the entopeduncular nucleus with kainic acid. This is strong evidence that GABA is an entopedunculothalamic neurotransmitter. The striatoentopeduncular pathway is al...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90693-4
更新日期:1981-02-23 00:00:00
abstract::Hybridization histochemical and immunohistochemical methods were used to characterize the distribution of corticotropin-releasing factor (CRF) messenger RNA (mRNA) and peptide, respectively, in the central auditory system of the rat. Cell bodies expressing CRF mRNA and/or immunoreactivity (IR) were detected at each le...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90571-c
更新日期:1991-04-26 00:00:00