Astrocyte proliferation precedes a decrease in basket cells in the dentate fascia following chronic ethanol treatment in mice.

Abstract:

:The effect of chronic ethanol administration on the density of basket cells in the dentate gyrus of mice selectively bred for their sensitivity to acute ethanol exposure (long-sleep, LS and short-sleep, SS) was assessed in two experiments. In addition, the effect of chronic ethanol on the density of dentate granule cells and astrocytes was examined. In the first experiment, mice received 3 weeks of a liquid ethanol diet with 35% of their calories derived from ethanol (EDC). In this experiment, LS mice did not demonstrate a change in the density of granule cells or in the density of basket cells. There was, however, a significant increase in the density of astrocytes as a result of this treatment for the LS mice. The SS mice were unaffected on all measures. In the second experiment, portions of which have been reported previously, mice received a diet with 23% EDC for 3 months. As a result of this exposure, LS mice showed a significant decrease in the density of basket cells, but there was no change in the density of granule cells or astrocytes. There was no difference between controls and experimental mice from the SS group on any of these parameters. These results suggest that at least in the dentate gyrus, chronic ethanol treatment selectively reduces the density of basket cells but only in mice that are more sensitive to the hypnotic effects of acute ethanol exposure. Furthermore, this effect seems to be preceded by an apparent increase in the density of astrocytes.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Brain Res

journal_title

Brain research

authors

Scheetz AJ,Markham JA,Fifková E

doi

10.1016/0006-8993(88)90369-1

subject

Has Abstract

pub_date

1988-09-20 00:00:00

pages

246-52

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(88)90369-1

journal_volume

460

pub_type

杂志文章
  • Temperature and amiloride alter taste nerve responses to Na+, K+, and NH+4 salts in rats.

    abstract::The effects of adaptation/stimulus temperature (25 degrees C vs. 35 degrees C) on taste nerve responses to salt stimulation and amiloride suppression were assessed in rats. We measured the integrated responses of the chorda tympani nerve to 500 mM concentrations of NaCl, Na2SO4, sodium acetate (NaAc), KCl, K2SO4, pota...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/S0006-8993(96)01118-3

    authors: Lundy RF Jr,Contreras RJ

    更新日期:1997-01-09 00:00:00

  • Met-enkephalin-like immunoreactivity in microdialysates from nucleus tractus solitarii in piglets during normoxia and hypoxia.

    abstract::Met-enkephalin-like immunoreactivity in microdialysates from the respiratory-related nucleus tractus solitarii was determined simultaneously with ventilatory responses in seven, spontaneously breathing, developing swine under conditions of normoxia, hypoxia and recovery from hypoxia for 30 min each. Assayed levels of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00541-w

    authors: Yan S,Zhang C,Laferrière,Moss IR

    更新日期:1995-07-31 00:00:00

  • Neuroprotective effects of the N-terminal tripeptide of IGF-1, glycine-proline-glutamate, in the immature rat brain after hypoxic-ischemic injury.

    abstract::Insulin growth factor 1 (IGF-1) has an important role in brain development and is strongly expressed during recovery after a hypoxic-ischemic injury. Some of its central actions could be mediated through the N-terminal tripeptide fragment of IGF-1: Gly-Pro-Glu (GPE). The neuroprotective properties of GPE given after a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)03148-1

    authors: Sizonenko SV,Sirimanne ES,Williams CE,Gluckman PD

    更新日期:2001-12-13 00:00:00

  • Dysregulated iron metabolism in the choroid plexus in fragile X-associated tremor/ataxia syndrome.

    abstract::Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder associated with premutation alleles of the FMR1 gene that is characterized by progressive action tremor, gait ataxia, and cognitive decline. Recent studies of mitochondrial dysfunction in FXTAS have suggested that iron dysre...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2014.11.058

    authors: Ariza J,Steward C,Rueckert F,Widdison M,Coffman R,Afjei A,Noctor SC,Hagerman R,Hagerman P,Martínez-Cerdeño V

    更新日期:2015-02-19 00:00:00

  • Auditory-motor coupling affects phonetic encoding.

    abstract::Recent studies have shown that moving in synchrony with auditory stimuli boosts attention allocation and verbal learning. Furthermore rhythmic tones are processed more efficiently than temporally random tones ('timing effect'), and this effect is increased when participants actively synchronize their motor performance...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2017.11.022

    authors: Schmidt-Kassow M,Thöne K,Kaiser J

    更新日期:2019-08-01 00:00:00

  • Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity.

    abstract::Excitotoxic neuronal death underlies many neurodegenerative disorders. Because cannabinoid receptor agonists act presynaptically to inhibit glutamate release, we examined the effects of Win 55212-2, a full agonist at CB(1) receptors, and Delta(9)-tetrahydrocannabinol (THC), a partial agonist, on the survival of neuron...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.03.011

    authors: Gilbert GL,Kim HJ,Waataja JJ,Thayer SA

    更新日期:2007-01-12 00:00:00

  • Presynaptic localization of omega-conotoxin-sensitive calcium channels at the frog neuromuscular junction.

    abstract::By the use of anti-omega-CTx antibodies in indirect immunofluorescence we demonstrated the presence of omega-CTx binding sites in the presynaptic compartment of frog nerve-muscle preparations. The images we obtained indicate that omega-CTx-sensitive channels are clustered at discrete sites corresponding in distributio...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90981-z

    authors: Torri Tarelli F,Passafaro M,Clementi F,Sher E

    更新日期:1991-05-03 00:00:00

  • Sumatriptan modifies cortical free radical release during cortical spreading depression. A novel antimigraine action for sumatriptan?

    abstract::Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02400-8

    authors: Read SJ,Parsons AA

    更新日期:2000-07-07 00:00:00

  • Termination of a separate (proprioceptive?) cuneothalamic tract from external cuneate nucleus in monkey.

    abstract::The termination of a pathway recently discovered in monkey, from the external cuneate nucleus (ECN) to the thalamus, has been investigated with the degeneration method. A previous HRP study showed that the projection is crossed. The ECN fibers terminate a wedge-shaped zone located dorsally in the rostral half of the c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90856-8

    authors: Boivie J,Boman K

    更新日期:1981-11-16 00:00:00

  • Rotational movement (circling) in normal humans: sex difference and relationship to hand, foot and eye preference.

    abstract::An endogenous asymmetry in striatal dopaminergic function has been identified in rats, and related to spontaneous and drug-induced circling (rotation, turning). We have developed an electronic device for measuring in humans the same kinds of rotational movements observed in rats. Our data indicate that, without being ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91074-2

    authors: Bracha HS,Seitz DJ,Otemaa J,Glick SD

    更新日期:1987-05-19 00:00:00

  • Paeoniflorin attenuates Aβ1-42-induced inflammation and chemotaxis of microglia in vitro and inhibits NF-κB- and VEGF/Flt-1 signaling pathways.

    abstract::Alzheimer׳s disease (AD) is a neurodegenerative disease with elusive pathogenesis, which accounts for most cases of dementia in the aged population. It has been reported that persistent inflammatory responses and excessive chemotaxis of microglia stimulated by beta-amyloid (Aβ) oligomers in the brain may accelerate th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.05.035

    authors: Liu H,Wang J,Wang J,Wang P,Xue Y

    更新日期:2015-08-27 00:00:00

  • Astrocytes cultured from specific brain regions differ in their expression of adrenergic binding sites.

    abstract::We sought to characterize regional heterogeneity of astrocytes using adrenergic receptor sites as cellular markers. Primary cultures made from 6 regions of neonatal rat brain consisted almost exclusively of astrocytes. Membranes from astrocytes cultured 1-3 weeks were prepared for radioligand binding assays of beta- a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91027-e

    authors: Ernsberger P,Iacovitti L,Reis DJ

    更新日期:1990-05-28 00:00:00

  • Vasoactive intestinal polypeptide (VIP) and cerebrospinal fluid (CSF) of sleep-deprived cats restores REM sleep in insomniac recipients.

    abstract::In the past few years a steadily increasing number of substances have been suggested to qualify as sleep-inducing factors. Most 'sleep factors' appear to exert their effects on slow-wave sleep. Recently, however, it has been shown that the cerebrospinal fluid (CSF) of sleep-deprived cats may contain a rapid eye moveme...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91561-1

    authors: Prospéro-Garcia O,Morales M,Arankowsky-Sandoval G,Drucker-Colin R

    更新日期:1986-10-15 00:00:00

  • Differential ultrastructural distribution of synapsin and synaptophysin proximal to a ligation in bovine splenic nerve.

    abstract::Synaptophysin and synapsin, closely correlated on synaptic vesicles in terminals, may show a differential distribution at synapse formation and maturation. In order to disclose the fine structural details of these differences, synapsin and synaptophysin distribution was studied by immunocytochemistry on ligated bovine...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00617-9

    authors: Quatacker J,Partoens P,De Potter W

    更新日期:1998-08-17 00:00:00

  • Light-induced stimulation of retinal dopamine: a dose-response relationship.

    abstract::Light stimulates dopamine (DA) release in the retina. The purpose of this study was to determine the threshold and dose-response relationship between ocular light exposure and retinal DA synthesis in vivo. Groups of dark-adapted rats were exposed to 0, 1, 3, 5, 10, 25, 50, 100 or 1000 microwatts per square centimeter ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91211-x

    authors: Brainard GC,Morgan WW

    更新日期:1987-10-20 00:00:00

  • Assessment of CMV, RSV and SYN1 promoters and the woodchuck post-transcriptional regulatory element in adenovirus vectors for transgene expression in cortical neuronal cultures.

    abstract::In order to investigate protein function in rat primary cortical neuronal cultures, we modified an adenoviral vector expression system and assessed the strength and specificity of the cytomegalovirus (CMV), rous sarcoma virus (RSV), and rat and human synapsin 1 (SYN1) promoters to drive DsRed-X expression. We also inc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.04.089

    authors: Boulos S,Meloni BP,Arthur PG,Bojarski C,Knuckey NW

    更新日期:2006-08-02 00:00:00

  • Morphological and electrophysiological properties of neurons in an area of the chick brain involved in learning.

    abstract::The intermediate, medial part of the hyperstriatum ventrale (IMHV) is an area of the avian forebrain which is essential for two forms of early learning in the domestic chick. We have developed an in vitro slice preparation which contains part of the IMHV and have found that the electrophysiological properties of the a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00361-7

    authors: Bradley PM,Burns BD,King TM,Webb AC

    更新日期:1996-07-15 00:00:00

  • Local anesthetics inhibit veratridine-induced secretion of calcitonin gene-related peptide (CGRP) from cultured rat trigeminal ganglion cells.

    abstract::Secretion of calcitonin gene-related peptide (CGRP) was studied with the model system of dispersed adult rat trigeminal ganglion cells. Veratridine stimulated secretion of CGRP immunoreactivity. Tetrodotoxin and local anesthetics inhibited veratridine-stimulated peptide secretion. These observations implicate sodium c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91441-1

    authors: Peterfreund RA,Vale WW

    更新日期:1986-08-13 00:00:00

  • Adaptive plasticity in the primate spinal stretch reflex: reversal and re-development.

    abstract::Monkeys can gradually increase or decrease the amplitude of the segmentally mediated spinal stretch reflex (SSR) without change in initial muscle length or background EMG activity. Both increase (under the SSR increases mode) and decrease (under the SSR decreases mode) occur slowly, progressing steadily over weeks. Th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90259-7

    authors: Wolpaw JR

    更新日期:1983-11-14 00:00:00

  • AIF-mediated mitochondrial pathway is critical for the protective effect of diazoxide against SH-SY5Y cell apoptosis.

    abstract::It has been well established that the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) opener, diazoxide, has protective effects on the heart and brain following ischemia/reperfusion injury. However, the mechanism of the neuroprotective effects of diazoxide remains unclear. This study highlights the anti-apo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.11.019

    authors: Zhang H,Wang ZQ,Zhao DY,Zheng DM,Feng J,Song LC,Luo Y

    更新日期:2011-01-25 00:00:00

  • The pharmacological and anatomical substrates of the amphetamine response in the rat.

    abstract::Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d-amphetamine in adult rats. The lesions resulted in a depletion of over 99 per cent of striatal tyrosine hydroxylase activity (indicating a near total lesion of the nigro-striatal dopamine ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(75)90834-3

    authors: Creese I,Iversen SD

    更新日期:1975-01-17 00:00:00

  • Opiate effects on rabbit vagus nerve: electrophysiology and radioligand binding.

    abstract::Intracellular recordings were made from rabbit nodose ganglion cells in vitro. Morphine (up to 100 micro M), normorphine (up to 10 micro M) and D-Ala2, Leu5-enkephalin (DADLE) (up to 5 micro M) each had no detectable effect on the electrical properties of the cell membrane, except for local anesthetic-like actions at ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)91066-0

    authors: Shefner SA,North RA,Zukin RS

    更新日期:1981-09-21 00:00:00

  • Axonal transport of adenylate cyclase activity in normal and axotomized frog sciatic nerve.

    abstract::Adenylate cyclase activity accumulated proximal to a constriction placed around the frog sciatic nerve. The rate of accumulation was linear between 8 and 24 h following placement of the constriction; accumulation rate declined substantially after 24 h. Accumulation of activity distal to the constriction in normal nerv...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90284-0

    authors: Carlsen RC

    更新日期:1982-01-28 00:00:00

  • Homer1a disruption increases vulnerability to predictable subtle stress normally sub-threshold for behavioral changes.

    abstract::Homer1a is implicated in depression in humans and depression-like behavior in mice. To further understand the role of Homer1a in stress-induced emotional changes, we applied very mild stress to Homer1a knockout (H1a KO) mice. The wild-type (WT) and H1a KO mice were restrained for 2h daily for 7 consecutive days at the...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.02.008

    authors: Shui Y,Wang L,Luo X,Uchiumi O,Yamamoto R,Sugai T,Kato N

    更新日期:2015-04-24 00:00:00

  • Effects of central gastrin-releasing peptide on glucose metabolism.

    abstract::Gastrin-releasing peptide (GRP) mediated signals in the central nervous system (CNS) influence many functions associated with energy metabolism. The purpose of the present study was to investigate the central effect of GRP on glucose metabolism in the male rat. Intracerebroventricular (icv) administration of GRP cause...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.08.040

    authors: Jha PK,Foppen E,Challet E,Kalsbeek A

    更新日期:2015-11-02 00:00:00

  • Distinguishing the processing of gestures from signs in deaf individuals: an fMRI study.

    abstract::Manual gestures occur on a continuum from co-speech gesticulations to conventionalized emblems to language signs. Our goal in the present study was to understand the neural bases of the processing of gestures along such a continuum. We studied four types of gestures, varying along linguistic and semantic dimensions: l...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.04.034

    authors: Husain FT,Patkin DJ,Thai-Van H,Braun AR,Horwitz B

    更新日期:2009-06-18 00:00:00

  • Neuroprotection and immunomodulation in the gut of parkinsonian mice with a plasmalogen precursor.

    abstract::Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It is typically associated with motor symptoms originating from the degeneration of nigrostriatal dopamine (DA) neurons. Early stages of PD have been associated with an alteration in DA production in intestinal DAergic neurons alon...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.146460

    authors: Nadeau J,Smith T,Lamontagne-Proulx J,Bourque M,Al Sweidi S,Jayasinghe D,Ritchie S,Di Paolo T,Soulet D

    更新日期:2019-12-15 00:00:00

  • VIP-like immunoreactivity in the anterior hypothalamic area of a hibernating bat varies with physiological state.

    abstract::Vasoactive intestinal polypeptide (VIP)-like immunoreactivity in the anterior hypothalamic area (AHA) was studied in 15 bats which are seasonal hibernators, using the unlabeled antibody enzyme method of Sternberger. Our results showed that the density of immunoreactive fibers and terminal plexuses in the AHA was great...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91422-9

    authors: Laemle LK,Cotter JR

    更新日期:1988-02-16 00:00:00

  • Involvement of cyclic GMP-dependent protein kinase in nitrous oxide-induced anxiolytic-like behavior in the mouse light/dark exploration test.

    abstract::The second messenger cyclic GMP (cGMP) plays a role in the anxiolytic-like behavioral response of mice to nitrous oxide (N2O). This study was conducted to determine whether this behavioral effect of N2O is affected by inhibition of cGMP-dependent protein kinase (PKG). N2O-induced behavior in the light/dark exploration...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.01.015

    authors: Li S,Doss JC,Hardee EJ,Quock RM

    更新日期:2005-03-15 00:00:00

  • Descending spinal pathways mediating the responses of adrenal tyrosine hydroxylase and catecholamines to insulin and 2-deoxyglucose.

    abstract::We investigated the bilateral organization of the descending spinal sympathetic projections that subserve adrenomedullary stimulation caused by insulin hypoglycemia or 2-deoxyglucose (2DG) cellular glucopenia in adult rats with right-sided hemisection of the cord at C6-C7 (i.e. above the site of origin of the adrenal ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90315-4

    authors: Gagner JP,Gauthier S,Sourkes TL

    更新日期:1985-01-28 00:00:00