Abstract:
:The climbing fiber input to the cerebellar cortex was destroyed using both electrolytic and chemical (3-acetylpyridine) lesions. The long-term effects of climbing fiber deafferentation on the ansiform lobule of weanling and adult rats were examined at both the light and electron microscopic levels. Image analysis of Golgi-impregnated Purkinje cells indicated a significantly lower number of smooth branches and spiny branchlets following climbing fiber deafferentation of both adult and weanling rats. The results suggest that the lower number of smooth branches and spiny branchlets following climbing fiber deafferentation of the weanling rat is the result of a loss of postnatal growth rather than transneuronal degeneration. Ultrastructural evidence is provided in confirmation of these quantitative findings. Formation of ectopic dendritic spines was found following climbing fiber deafferentation of the weanling rat, but not the adult. It is shown that ectopic spines and the denervated dendritic thorns of these animals were synaptically innervated by the parallel fiber system and basket axons. The formation of ectopic spines on climbing fiber deafferentated Purkinje cells may represent a form of dendritic plasticity. Ultrastructurally, the dendritic arborizations of weanling deafferentated Purkinje cells showed no signs of transneuronal degeneration. However, the primary response to climbing fiber deafferentation in the adult rat was marked transneuronal degeneration of the Purkinje cell dendrites. It is suggested that the inability of the adult Purkinje cell to form ectopic spines and to replace the excitatory postsynaptic potential of the climbing fiber varicosity is directly related to the Purkinje cell's subsequent transneuronal degeneration.
journal_name
Brain Resjournal_title
Brain researchauthors
Anderson WA,Flumerfelt BAdoi
10.1016/0006-8993(86)90022-3subject
Has Abstractpub_date
1986-09-24 00:00:00pages
228-44issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(86)90022-3journal_volume
383pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Cerebral ischemia initiates an inflammatory response in the brain that is associated with the induction of a variety of cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1alpha/beta (IL-1alpha/beta) that contributes to stroke injury. Transient middle cerebral artery occlusion (tMCAO) in spon...
journal_title:Brain research
pub_type: 杂志文章,收录出版
doi:10.1016/j.brainres.2006.11.080
更新日期:2007-02-23 00:00:00
abstract::We have previously demonstrated that ibotenate (IBO)-stimulated polyphosphoinositide (PPI) hydrolysis is increased for a long period in the amygdala/pyriform cortex (AM/PC) of amygdala (AM)- and hippocampal (HIPP)-kindled rats. This finding indicates that enhanced function of the PPI-coupled excitatory amino acid (EAA...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90370-o
更新日期:1992-01-08 00:00:00
abstract::Extracellular recordings of action potentials were made from neurones antidromically identified as neurosecretory cells in the paraventricular and supraoptic nuclei of urethane-anesthetized female rats. Eighty-six neurones were examined for their responsiveness to 10 ng of angiotensin II (AII) injected into the third ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90048-7
更新日期:1980-04-28 00:00:00
abstract::Physical activity has been proposed as a behavior intervention that promotes mental health and some of the benefits induced by exercise have been related to the glutamatergic system. Indeed, glutamate is the most abundant excitatory neurotransmitter in brain. Thus, we evaluated if voluntary exercise in mice could modu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.038
更新日期:2005-12-14 00:00:00
abstract::The effects of an intensive short-term glucocorticoid (e.g. triamcinolone) regimen in cats have been studied on the actions of the dopamine (DA) receptor agonist apomorphine (APO) on spinal lumbar primary afferent excitability (dorsal root reflex or DRR) and monosynaptic reflex (MSR) transmission. Glucocorticoid dosin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90894-6
更新日期:1983-05-16 00:00:00
abstract::Positron emission tomography, using the dopa analogue [18F]6-fluoro-L-dopa, has been used to depict the neostriatum in living monkeys. The amount of 18F that accumulated preferentially in the striatum could be augmented by a peripheral decarboxylase inhibitor. Striatal 18F could also be discharged with reserpine. This...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91187-3
更新日期:1983-11-28 00:00:00
abstract::Parkinson's disease (PD) is characterized by progressive degeneration of nigrostriatal dopaminergic neurons. Several factors such as inhibition of the mitochondrial respiration, generation of hydroxyl radicals and reduced free radical defense mechanisms causing oxidative stress, have been postulated to contribute to t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02994-2
更新日期:2001-02-23 00:00:00
abstract::The associative learning functions of the central nervous system of Limax maximus have been established with behavioral experiments on intact animals (Sahley et al., J. comp. Physiol., 144 (1981) 1) and physiological experiments on the isolated CNS (Culligan and Gelperin, Brain Research, 266 (1983) 319). We now report...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90323-8
更新日期:1984-06-25 00:00:00
abstract::Multiple dose administration of methamphetamine (MA) results in long-lasting toxic effects in the nigrostriatal dopaminergic system. These effects are considered to be primarily due to oxidative damage mediated by increased production of hydrogen peroxide or other reactive oxygen species in the dopaminergic system. Th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02122-8
更新日期:1999-12-18 00:00:00
abstract::Administration of vitamin B12 (VB12) has been reported to normalize human sleep-wake rhythm disorders such as non-24-h sleep-wake syndrome (HNS), delayed sleep phase syndrome (DSPS) or insomnia. However, the mechanisms of the action of VB12 on the rhythm disorders are unknown. In the present study, therefore, effects ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00349-6
更新日期:1996-07-15 00:00:00
abstract::In a previous study, we demonstrated that cholera toxin-A subunit, as well as the whole toxin, selectively blocks opioid-induced prolongation of the Ca2+ component of the action potential duration (APD) in dorsal root ganglion (DRG) neurons, indicating mediation of this excitatory effect by Gs-linked opioid receptors....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90751-v
更新日期:1990-10-29 00:00:00
abstract::Amphetamine releases dopamine through a transporter-mediated mechanism. The purpose of this report was to further our understanding of the intracellular pool from which amphetamine releases dopamine: the cytoplasmic pool, the vesicular pool, or both. Rats were treated with D-amphetamine (AMPH) (1.0 or 10.0 mg/kg) or a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00720-3
更新日期:1998-09-21 00:00:00
abstract::Intracerebroventricular (ICV) streptozotocin (STZ) treated rat has been described as a suitable model for sporadic Alzheimer's disease (AD). Central application of STZ has demonstrated behavioral and neurochemical features that resembled those found in human AD. Chronic treatments with antioxidants, acetylcholinestera...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.09.056
更新日期:2011-12-02 00:00:00
abstract::We investigated the effect of losartan, a nonpeptide angiotensin II (Ang II)-type 1 (AT1) receptor antagonist, on the responses evoked by Ang II and L-glutamate (L-Glu) in the rostral ventrolateral medulla (RVLM). Adult spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were anesthetized with halothane ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91344-7
更新日期:1994-12-05 00:00:00
abstract::Methylazoxymethanol acetate (MAM)-induced cortical hypoplasia resulted in a 2-fold increase in the concentration of norepinephrine and its metabolite, 3-methoxyl-4-hydroxyphenylglycol sulfate, and a 26% decrease in the Bmax for the beta-receptor ligand, [3H]dihydroalprenolol (DHA) in the rat cortex. Chronic treatment ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90195-x
更新日期:1982-08-01 00:00:00
abstract::The ventral tegmental area is a site of action by psychostimulants in the production of behavioral sensitization. Recently, G proteins of the ventral tegmental area have been implicated in behavioral sensitization to cocaine. To further investigate the specific role of G proteins, rats were treated with either 15 or 3...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90049-f
更新日期:1992-05-08 00:00:00
abstract::Until recently, the bulk of research on the human reward system was focused on studying the dopaminergic and opioid neurotransmitter systems. However, extending the initial data from animal studies on reward, recent pharmacological brain imaging studies on human participants bring a new line of evidence on the key rol...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.02.003
更新日期:2014-03-27 00:00:00
abstract::We previously reported that reactive oxygen species (ROS) in paraventricular nucleus (PVN) modulated cardiac sympathetic afferent reflex (CSAR) and mediated the effect of angiotensin II (Ang II) in the PVN on the CSAR. In the present study, we investigated whether the NAD(P)H oxidase in the PVN was a key source of ROS...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.113
更新日期:2006-04-12 00:00:00
abstract::Mechanisms regulating sexual differentiation of the zebra finch song system appear to include both genetic and hormonal factors. Sorting Nexin 2 (SNX2), which is involved in trafficking proteins between cellular membranes, and androgen receptor (AR) mRNA are both increased in song control nuclei of juvenile males comp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.04.084
更新日期:2010-07-09 00:00:00
abstract::Conditioned place preference and locomotor sensitization are rodent behavioral models commonly used to investigate the actions of drugs of abuse. However, few studies have examined both paradigms in the same group of animals. We were interested in developing a combined protocol which successfully induced both conditio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.03.054
更新日期:2008-06-05 00:00:00
abstract::Amyloid β-protein (Aβ) is the major component of extracellular plaques in the brains of patients with Alzheimer's disease. It has been suggested that the interaction of Aβ with membrane cholesterol is essential for Aβ to exert neurotoxicity; however, the effect of phospholipids, another major membrane lipid component,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.04.035
更新日期:2016-07-01 00:00:00
abstract::The opiate antagonist, naloxone, produces dose-dependent biphasic changes in clinical pain. The mechanism of the analgesia produced by low dose naloxone is unknown. To study the analgesic effect of naloxone, we have used a programmable infusion pump, which eliminates placebo-induced endorphin-mediated analgesia, to ad...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91653-7
更新日期:1986-02-19 00:00:00
abstract::Dorsal temporal pole (dTP) is a cortical region at the rostral end of the superior temporal gyrus that forms part of the ventral auditory object processing pathway. Anatomical connections with frontal and medial temporal areas, as well as a recent single-unit recording study, suggest this area may be an important part...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.12.025
更新日期:2016-06-01 00:00:00
abstract::The present study investigated the role of calcitonin gene-related peptide (CGRP) on nociception in nucleus raphe magnus (NRM) and the interaction between CGRP and opioid peptides in NRM of rats. CGRP-like immunoreactivity was found at a concentration of 6.0+/-0. 77 pmol/g in NRM tissue of ten samples of rats, suggest...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02473-2
更新日期:2000-08-04 00:00:00
abstract::The present study examined the effects of stereotaxic delivery of corticosterone to the amygdala on anxiety-like behavior and corticotropin-releasing factor (CRF) mRNA level in the central nucleus of the amygdala (CeA). Micropellets (30 microg) of crystalline corticosterone or cholesterol (control) were implanted bila...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02019-9
更新日期:2000-04-10 00:00:00
abstract::Mouse embryonic stem (ES) cells were transplanted into the cochlea of adult guinea pigs in order to explore their survival, differentiation, and possible integration with the host tissue. With the purpose of investigating the possible effect of manipulating the local embryonic microenvironment, ES cells were transplan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.06.016
更新日期:2005-07-27 00:00:00
abstract::We have previously reported progressive reactive astrocytes in the cerebellum of taiep rats, one of the most regions affected by demyelination, and activation of cerebellar glial cells in vitro. Based on the hypothesis that activated glial cells produce high levels of reactive nitrogen intermediates, we assessed the p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.08.097
更新日期:2006-11-22 00:00:00
abstract::We examined the distribution of choline acetyltransferase (ChAT) mRNA in the brain of six autopsied individuals by in situ hybridization with 35S-labeled human ChAT riboprobes. Neurons containing hybridization signal for ChAT mRNA were observed in the nucleus of the diagonal band of Broca, the basal nucleus of Meynert...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00677-5
更新日期:1998-09-21 00:00:00
abstract::A modified glyoxylic acid technique was used to examine central and peripheral nervous tissues in Aplysia californica. In addition to confirming the distribution of catecholamines and serotonin in the central nervous system, the method demonstrated the presence of monoamines in the opaline gland and bag cell clusters ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91081-8
更新日期:1983-01-17 00:00:00
abstract::Administration of aminooxyacetic acid, (an inhibitor of gamma-aminobutyric acid (GABA)-transaminase which enhances the hypothalamic GABA content) increased luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in prepubertal rats (16 days of age), and decreased the levels of these pituitary hormones i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91508-x
更新日期:1991-11-01 00:00:00