Striatal dopamine metabolism in living monkeys examined by positron emission tomography.

abstract：:The effects of selective axotomy of serotoninergic neurons produced by an intracerebroventricular injection of 5,7-dihydroxytryptamine (200 micrograms free base) on 5-HT1B binding sites labeled with S-CM-G-[125I]TNH2 were investigated by quantitative autoradiography in the rat brain. Results show, 21 days after surger...

journal_title：Brain research

authors： Manrique C,Segu L,Héry F,Héry M,Faudon M,François-Bellan AM

更新日期：1993-10-01 00:00:00

abstract：:There are marked increases in noradrenaline (NA) release during emergence from general anesthesia induced with volatile anesthestics. These changes in NA in the posterior hypothalamus of the rat were assessed by intracranial microdialysis. Sevoflurane and halothane in equipotent concentrations were used to obtain the ...

journal_title：Brain research

authors： Chave S,Kushikata T,Ohkawa H,Ishiara H,Grimaud D,Matsuki A

更新日期：1996-01-15 00:00:00

abstract：:In this study, we investigated the modulatory effect of 5alpha-pregnan-3alpha-ol-20-one, a neurosteroid, on the binding characteristics of [3H]flunitrazepam (2 nM), [3H]muscimol (5 nM), and 4 nM [35S]t-butylbicyclophosphorothionate (TBPS) in cerebral cortex, cerebellum, and hippocampus of control, ethanol-dependent, a...

journal_title：Brain research

authors： Mehta AK,Ticku MK

更新日期：1998-09-14 00:00:00

abstract：:Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 microgram/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of th...

journal_title：Brain research

authors： Rock JP,Oldfield EH,Schulte HM,Gold PW,Kornblith PL,Loriaux L,Chrousos GP

更新日期：1984-12-10 00:00:00

abstract：:The effects of two kinds of antibiotics, minocycline (MNC) and ampicillin (AB-PC), on human sleep were investigated on 19 healthy male students to test for a relationship between human sleep and protein synthesis. These drugs and placebos were capsulated identically in appearance and were given to the subjects using t...

journal_title：Brain research

authors： Nonaka K,Nakazawa Y,Kotorii T

更新日期：1983-12-12 00:00:00

abstract：:The effects of systemically administered interleukin-1beta (1.0 microg) on in vivo variations of monoamines was assessed in several brain regions. Administration of the cytokine provoked a modest increase of extracellular 5-HIAA and HVA from the nucleus accumbens, and 5-HIAA from the hippocampus. Following mild neurog...

journal_title：Brain research

authors： Merali Z,Lacosta S,Anisman H

更新日期：1997-07-04 00:00:00

abstract：:The synchronization of circadian rhythms in sleep, endocrine and metabolic functions with the environmental light cycle is essential for health, and dysfunction of this synchrony is thought to play a part in the development of many neurological disorders. There is a demonstrable need to develop new therapeutics for th...

journal_title：Brain research

authors： Gannon RL

更新日期：2014-10-17 00:00:00

abstract：:Intoxication with organophosphorus (0P) anticholinesterase agents such as soman triggers irreversible lesions in some cerebral areas. Administration of soman at the LD 50 leads to an increased activity of NADPH-diaphorase (= NO-synthase) in the cerebral endothelial cells from the 6th hour after poisoning. This activit...

journal_title：Brain research

authors： Bouchaud C,Chollat-Namy A,Duserre S,Delamanche IS

更新日期：1994-10-17 00:00:00

abstract：:Sera from patients with multiple sclerosis (MS) frequently produce demyelination of central nervous system tissue cultures. The nature of the factors responsible for demyelination is not as yet clearly established. However, several authors previously reported, in in vivo and in vitro models, demyelinating activity in ...

journal_title：Brain research

authors： Grundke-Iqbal I,Bornstein MB

更新日期：1979-01-19 00:00:00

abstract：:Previous studies showed the role of basolateral amygdala (BLA) in cannabinoid-induced antinociception. Furthermore, the nucleus accumbens (NAc) plays an important role in mediating the suppression of pain in animal models. The present study extended the role of dopamine receptors within the NAc in antinociceptive effe...

journal_title：Brain research

authors： Haghparast A,Ghalandari-Shamami M,Hassanpour-Ezatti M

更新日期：2012-08-30 00:00:00

abstract：:A comparison was made of the effects of left and right cerebral decortication on cytotoxic activity of natural killer and natural cytotoxic lymphocytes in the mouse. Natural killer cytotoxic activity was significantly reduced after right decortication, whereas left decortication led to a less pronounced, though still ...

journal_title：Brain research

authors： Belluardo N,Mudò G,Cella S,Bindoni M

更新日期：1990-08-06 00:00:00

abstract：:Systemic administration of the protein synthesis inhibitor, cycloheximide, induced both phase advances and phase delays in the circadian rhythm of wheel-running activity in hamsters (Mesocricetus auratus) maintained in constant darkness or constant light. The magnitude and direction of the phase shifts were dependent ...

journal_title：Brain research

authors： Wollnik F,Turek FW,Majewski P,Takahashi JS

更新日期：1989-09-04 00:00:00

abstract：:The neuronal threshold, which can be determined by the level of depolarization immediately prior to spike generation, is different for responses to conditioned and discriminated stimuli after conditioning. However, it is impossible to determine excitability within a response to stimuli that failed to generate a spike....

journal_title：Brain research

authors： Tsitolovsky LE,Babkina NV

更新日期：2002-08-09 00:00:00

abstract：:The expression of the immediate-early gene c-fos was used as a marker of neuronal activity to investigate the cervical spinal interneuron populations involved in the corticomotoneuronal pathway. Adult rats received unilateral kainate injections in the forelimb area of the primary motor cortex. After a survival period ...

journal_title：Brain research

authors： Curfs MH,Gribnau AA,Dederen PJ,Bergervoet-Vernooij IW

更新日期：1996-06-24 00:00:00

abstract：:Dopaminergic psychostimulants produce behavioral responses of greater magnitude with repeated, intermittent administration, than a single, acute dose, a phenomenon known as 'sensitization'. Alterations in regional neuronal activity produced by quinpirole, a D(2)/D(3) agonist, in quinpirole-naive and quinpirole-sensiti...

journal_title：Brain research

authors： Carpenter TL,Pazdernik TL,Levant B

更新日期：2003-02-28 00:00:00

abstract：:In behaving cats, a cholinergic agonist, carbachol, or Ringer's solution were infused into the pontine reticular formation (PRF). Extracellular microelectrode recordings were obtained from single neurons located 1-4 mm from the infusion site. Sleep polygraphic variables were also recorded. Carbachol microinfusions int...

journal_title：Brain research

authors： Shiromani PJ,McGinty DJ

更新日期：1986-10-29 00:00:00

abstract：:The excitatory amino acid L-glutamate injected into the nucleus of the solitary tract (NTS) in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure (MAP) and reduces heart rate. In this study, we investigated the effects of acute (1 day) and chronic (15 days) electrolytic...

journal_title：Brain research

authors： Vieira AA,Colombari E,De Luca LA Jr,de Almeida Colombari DS,Menani JV

更新日期：2004-10-29 00:00:00

abstract：:The origin of neuronal perikarya which project to the external zone of the median eminence (the tuberoinfundibular neuronal system) was determined in the rat after injection or diffusion of wheat germ agglutinin (WGA) into the median eminence. The retrogradely transported lectin was detected in neurons using an immuno...

journal_title：Brain research

authors： Lechan RM,Nestler JL,Jacobson S

更新日期：1982-08-05 00:00:00

abstract：:The demyelination (dmy) rat is a unique mutant exhibiting severe myelin breakdown in the central nervous system (CNS). In this study, we conducted immunohistochemical and morphometrical investigations in the dmy rat. From around 6 weeks of age, the affected rats developed ataxia especially in the hindlimbs. Afterwards...

journal_title：Brain research

authors： Kuwamura M,Kanehara T,Tokuda S,Kumagai D,Yamate J,Kotani T,Nakane Y,Kuramoto T,Serikawa T

更新日期：2004-10-01 00:00:00

abstract：:Whilst the brain-specific benzodiazepine receptor has been assumed to show a late evolutionary appearance, we present evidence for the presence of a central benzodiazepine binding site in sharks, which shows a high affinity for [3H]Ro 15-1788. However, the receptor density and the affinities of several benzodiazepine ...

journal_title：Brain research

authors： Hebebrand J,Friedl W,Reichelt R,Schmitz E,Möller P,Propping P

更新日期：1988-04-19 00:00:00

abstract：:Bilateral microinjections of the neuroleptic, cis-flupenthixol, were made into 56 forebrain targets distributed across various dopamine (DA) terminal fields in the forebrain. Drug effects on medial forebrain bundle (MFB) stimulation-produced reward were assessed with a rate-frequency procedure implemented in a runway ...

journal_title：Brain research

authors： Stellar JR,Corbett D

更新日期：1989-01-16 00:00:00

abstract：:Alpha-lipoic acid (ALA) is an endogenous short-chain fatty acid that has beneficial protective effects against various vascular diseases. In this study, we sought to determine whether ALA could induce pre- or post-treatment protective effects against simulated ischemia and reperfusion-induced cerebral endothelial cell...

journal_title：Brain research

authors： Xie R,Li X,Ling Y,Shen C,Wu X,Xu W,Gao X

更新日期：2012-10-30 00:00:00

abstract：:We examined protein kinase C gamma-like immunoreactivity (PKCgamma-LI) of trigeminothalamic neurons in the rat medullary dorsal horn (MDH) after injecting a retrograde tracer, Fluoro-Gold (FG), into the thalamus. Over 90% of FG-labeled neurons in the marginal layer (lamina I) and a few FG-labeled neurons in the superf...

journal_title：Brain research

authors： Li YQ,Li JL,Li H,Kaneko T,Mizuno N

更新日期：2001-09-21 00:00:00

abstract：:Saccadic eye tracking was studied in a monkey given i.v. injections of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The Parkinson-like symptoms which appeared in the animal's general motor behavior (akinesia, bradykinesia, hypokinesia) were also observed in its eye tracking. Similar oculomotor deficits are see...

journal_title：Brain research

authors： Brooks BA,Fuchs AF,Finocchio D

更新日期：1986-09-24 00:00:00

abstract：:The aim of this study was to assess the effect of Alzheimer's disease has on the functional integrity of several signal transduction proteins. The relative levels of the G-protein alpha subunits Gs alpha-L, Gs alpha-S, Gi alpha-2 and G(o) alpha were measured by western blotting and found to be unchanged in membranes p...

journal_title：Brain research

authors： Ross BM,McLaughlin M,Roberts M,Milligan G,McCulloch J,Knowler JT

更新日期：1993-09-17 00:00:00

abstract：:Following codepletion of endogenous serotonin (5-HT, greater than 90%) and thyrotropin-releasing hormone (TRH, 66%) by neonatal treatment with the serotonergic neurotoxin, 5,7-dihydroxytryptamine (DHT), a 33% (n = 12, P less than 0.01) increase in specific TRH receptor binding was observed in adult rat spinal cord (SC...

journal_title：Brain research

authors： Sharif NA,Towle AC,Burt DR,Mueller RA,Breese GR

更新日期：1989-02-20 00:00:00

abstract：:The concentrations of GABA, glutamate, aspartate, glycine, taurine, glutamine, asparagine and alanine were determined in the CSF of 10 Senegalese baboons (Papio papio) following initial ketamine anaesthesia and subsequent administration (4 h later) of different compounds known to alter either inhibitory or excitatory ...

journal_title：Brain research

authors： Valin A,Voltz C,Naquet R,Lloyd KG

更新日期：1991-01-04 00:00:00

abstract：:The effects of the GABAA agonist, isoguvacine, on NMDA-induced burst firing of substantia nigra dopaminergic neurons were studied with intracellular and whole cell recordings in vitro. NMDA application caused the neurons to fire in rhythmic bursts. Although the NMDA-induced bursty firing pattern was insensitive to hyp...

journal_title：Brain research

authors： Paladini CA,Iribe Y,Tepper JM

更新日期：1999-06-19 00:00:00

abstract：:The extrafusal and intrafusal muscle fibers in the masseter muscle are innervated by motoneurons in the trigeminal motor nucleus (Mo 5). In the present study, we found that the number of trigeminal motor neurons in the male mouse was significantly larger than that in the female. However, we could not detect any signif...

journal_title：Brain research

authors： Maeda N,Sugiyama H,Suemune S,Wakisaka H,Niida S,Ogata K,Miyata K

更新日期：1993-11-05 00:00:00

abstract：:Insulin-like 6 immunoreactivity (irINSL6) was detected in Leydig cells of the mouse testis. In the brain, labeled somata were detected mainly in the caudal hypothalamus and midbrain. Double labeling the brainstem sections revealed that irINSL6 somata were 5-hydroxytryptamine (5-HT) positive. The presence of irINSL6 in...

journal_title：Brain research

authors： Brailoiu GC,Dun SL,Yin D,Yang J,Chang JK,Dun NJ

更新日期：2005-04-08 00:00:00