Abstract：
:To elucidate the intracellular mechanism of the bursting activity which is characteristic of seizure discharge, the behavior of the intracellular cyclic nucleotide and the intracellular calcium during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. Cyclic AMP was increased about 3-fold by the incubation of ganglia with PTZ. The effect of PTZ on phosphodiesterase activity measured using either cyclic AMP or cyclic GMP as substrate showed a slight increase in cyclic AMP phosphodiesterase activity. The release of calcium from the lysosome fraction was increased by the incubation of ganglia with dibutyryl cyclic AMP. Protein kinase activity was stimulated by the incubation of ganglia with PTZ. Adenylate cyclase activity was stimulated by the incubation of ganglia with PTZ. These findings suggest that PTZ-induced bursting activity in snail neurons is initiated by an intracellular increase of cyclic AMP, which promotes calcium release from lysosomes and induces protein kinase activation.
journal_name
Brain Resjournal_title
Brain researchauthors
Onozuka M,Kishii K,Furuichi H,Sugaya Edoi
10.1016/0006-8993(83)90137-3subject
Has Abstractpub_date
1983-06-20 00:00:00pages
277-86issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(83)90137-3journal_volume
269pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Amyloid beta protein (A beta), has been reported to be toxic to neurons in vitro. However, the molecular mechanism leading to neuronal death remains unknown. Here we report protective effects of phenothiazines, a class of neuroleptic agent, against A beta toxicity in primary cultures of rat cortical neurons and PC12 c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01300-5
更新日期：1997-02-14 00:00:00
abstract：:(1) Input conductances of giant interneurons in the isolated spinal cord of lampreys were measured with two separate intracellular electrodes. Bath applications of 0.4--3 mM beta-alanine and taurine produced large, reversible conductance increases which were Cl-dependent. (2) Strychnine at 1--2.5 microM might be a com...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90628-0
更新日期：1979-09-14 00:00:00
abstract：:The anterograde neuronal tracing properties of Fluoro-Gold (FG) were characterized in this study by its ability to label the retinohypothalamic tract (RHT) upon pressure injection of the substance into the vitrous body of the eye in the Djungarian hamster, Phodopus sungorus. Tracing was compared to the anterograde neu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01151-1
更新日期：1997-01-16 00:00:00
abstract：:Previous neuroimaging studies provided evidence that visual mental imagery relies, in part, on the primary visual cortex. We hypothesized that, analogous to the finding that motor imagery increases the excitability of motor cortex, visual imagery should increase visual cortex excitability, as indexed by a decrease in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02478-2
更新日期：2002-05-31 00:00:00
abstract：:Some kinds of nociception appear to be partially mediated by the release of substance P (SP) in the spinal cord dorsal horn from terminals of primary afferent nociceptors. Only some nociceptors contain and release SP however. Specifically, SP appears to be released by unmyelinated (C) nociceptive afferents when activa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01466-7
更新日期：1997-03-28 00:00:00
abstract：:We investigated whether somatostain modulates the generation of long-term potentiation (LTP) in rat perforant path-dentate gyrus synapse in vivo. When somatostatin was injected intracerebroventricularly (i.c.v.) 20 min prior to the tetanus, the intensity of LTP increased dose dependently. Synaptic potential evoked by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00233-8
更新日期：1996-06-03 00:00:00
abstract：:Stress early in life puts the individual at a greater risk for developing mental disorders in adulthood. The animal model of maternal separation involves daily removal of pups from their mother over the early postnatal period and leads to several behavioral deficits in adults. Since this period corresponds to a time o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.136
更新日期：2006-07-12 00:00:00
abstract：:To investigate the possible mechanisms by which neurons in the caudate-putamen (CPu) and globus pallidus (GP) participate in pain and nociception, the present study characterized the response properties of CPu and GP neurons to non-noxious and noxious thermal stimuli in anesthetized rats. Nociceptive CPu and GP neuron...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00971-8
更新日期：1998-11-23 00:00:00
abstract：:There is growing behavioural evidence that the phospholipid growth factor lysophosphatidic acid (LPA) modulates nociceptive responses in vivo. The present study investigated further the effects of LPA on peripheral nociceptive processing. Effects of intraplantar injection of LPA on ongoing and peripheral mechanically ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.005
更新日期：2004-10-01 00:00:00
abstract：:Infection of neonatal mice with ts1, the neuropathogenic mutant of the Moloney murine leukemia virus, results in motor neuronal death in the brainstem and the spinal cord, with gliosis and demyelination, but no inflammatory cell infiltration into the CNS. To evaluate the possible mechanism(s) of ts1-induced neuropatho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00929-3
更新日期：1998-01-01 00:00:00
abstract：:Physical exercise can induce brain plasticity and reduce the cognitive decline observed in type 1 diabetes mellitus (T1DM). We investigated the effects of physical exercise to prevent or reverse spatial memory deficits produced by diabetes and some biochemical and immunohistochemical changes in hippocampal astrocytes ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.10.024
更新日期：2017-01-15 00:00:00
abstract：:The effects of sex steroids on immunoreactive beta-endorphin (EP) release from the rat hypothalamus in vitro were examined using a rat hypothalamic perifusion system and an EP RIA. Testosterone (1-100 ng/ml) and estradiol (10-100 pg/ml) stimulated EP release in a dose-dependent manner. Dehydroepiandrosterone (DHEA, 1-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90221-g
更新日期：1991-07-05 00:00:00
abstract：:A progressive model of Parkinson's disease has been recently developed in the rat where a unilateral excitotoxic injection into the globus pallidus leads to a gradual loss of dopaminergic neurons in the ipsilateral substantia nigra over a period of at least 6 weeks. In this model microglial activation is observed in t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.020
更新日期：2008-06-24 00:00:00
abstract：:IL-10 reduces pro-inflammatory responses after ischemic stroke primarily by acting on glia and endothelium, but relatively little is known about the direct effects of IL-10 on cortical neurons, which are often damaged in stroke. We found by PCR and immunohistochemistry that cortical neurons express IL-10 receptor. Tre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.096
更新日期：2011-02-10 00:00:00
abstract：:Variations in cerebral blood flow and partial pressures of oxygen and carbon dioxide (pO2, pCO2) were studied in rabbits during short-duration (1 min) immobilization stress. The techniques used enabled us to determine these variables locally in the caudate nucleus in a continuous, simultaneous and quantitative fashion...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90927-8
更新日期：1985-08-12 00:00:00
abstract：:The colocalisation of neuropeptide Y (NPY)- and 5-hydroxytryptamine (5-HT)-immunoreactivities in intracardiac neurones in dissociated cultures from the atria and interatrial septum of newborn guinea pig heart was demonstrated by the sequential application of specific antisera which were visualised by two different flu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90541-5
更新日期：1987-09-29 00:00:00
abstract：:Chemotherapy-induced pain is the most common treatment-limiting complication encountered by cancer patients receiving taxane-, vinca alkaloid- or platin-based chemotherapy. Several lines of evidence indicate that activation of pro-inflammatory cascades involving the release of cytokines including tumor necrosis factor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.07.001
更新日期：2008-09-10 00:00:00
abstract：:A decrease in the number of neuronal profiles in the isocortex of man may be observed on microscopic sections in aging and in degenerative diseases such as Alzheimer's disease. It can be the consequence of a loss of neurons per unit volume or of a reduction of the neuronal volume (i.e. pseudo-loss). This latter possib...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91602-8
更新日期：1989-12-11 00:00:00
abstract：:The relationship between placental antigen X-P2 (PAX)-immunoreactive glomeruli and intensely acetylcholinesterase-reactive (IAE) patchy regions was evaluated by comparison of neighboring cryostat sections of the rat olfactory bulb. Both groups of distribution show similar necklace patterns. Each IAE region consists of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90440-x
更新日期：1993-07-30 00:00:00
abstract：:Senescent (26-28 months) Fischer 344 rats were shown to have a lower density of D2 sites (-36%) without any change in affinity in membranes prepared from homogenized caudate-putamen (CPU), as compared to young adult (5-6 months) rats. In additional rats prepared for quantitative autoradiography of [3H]spiroperidol bin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90298-2
更新日期：1986-07-16 00:00:00
abstract：:The present experiments describe the effect of NMDA and kainate agonists of the NMDA and non-NMDA subtype of receptors respectively of the excitatory amino acids (EAAs) system in prepubertal (16 days of age) and peripubertal (30-day-old rats) male rats on the in vitro hypothalamic release of GnRH, and on the in vivo L...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01216-8
更新日期：1996-01-29 00:00:00
abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) produces symptoms similar to idiopathic Parkinson's disease in primates. A metabolite of MPTP, MPP+ (1-methyl-4-phenylpyridinium), is actively accumulated by dopaminergic (DA) terminals and selectively destroys nigrostriatal DA neurons. The mechanism of this effect r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90616-6
更新日期：1988-12-20 00:00:00
abstract：:Previous research has suggested the potential involvement of the hypothalamic-pituitary-adrenal (HPA) axis in psychostimulant reinforcement. In particular, we have found significant correlations between electric footshock-induced increases in plasma corticosterone and the acquisition, or lack thereof, of intravenous c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00206-5
更新日期：1996-05-25 00:00:00
abstract：:The laminin-alpha2 chain is a component of brain capillary basement membranes and appears also to be present in neurons of rat, rabbit, pig and non-human primate brain as evidenced by immunohistochemistry. In the present study, we have further characterized this very distinct neuronal laminin-alpha2 chain-like immunor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00420-4
更新日期：1997-08-01 00:00:00
abstract：:The glial cell line-derived neurotrophic factor (GDNF) exerts trophic actions on a number of cell types, including mesencephalic dopaminergic (mDA) neurons. Using rat mesencephalic primary cultures enriched in mDA neurons, we show that protracted GDNF stimulation increases their survival and neurite outgrowth. It modu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.071
更新日期：2007-07-23 00:00:00
abstract：:Electrophysiological recordings were made from afferent nerve fibres supplying slowly adapting type I (SA I) cutaneous mechano-receptors in the cat during application of mechanical stimuli (20 mN constant force, 0.2 s rise time and 2 s plateau phase, every 30 s). Close arterial infusion of neomycin (2.5 mg/min for 5 m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91201-1
更新日期：1986-07-02 00:00:00
abstract：:Single unit discharges in the superior secondary gustatory nucleus of the carp, Cyprinus carpio L., were studied electrophysiologically in response to chemical stimulation of the external chemoreceptors of the facial skin surface. Of 36 gustatory neurons recorded, 80.6% were facilitated by taste stimuli and 19.4% were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90184-0
更新日期：1981-07-27 00:00:00
abstract：:It has been confirmed that gabapentin (GBP) induced a inhibition of the voltage-gated persistent sodium current in chronically compressed dorsal root ganglion (DRG) neurons. The persistent sodium current is found in excitable DRG neurons of painful diabetic neuropathy (PDN) rats where it is mediated by tetrodotoxin (T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.032
更新日期：2013-02-01 00:00:00
abstract：:We have developed a sensitive enzymatic-immunoassay to quantify the level of gamma-enolase (a specific neuronal enzyme) which is released from cultured cells after exposure to various toxins. We show that this method can estimate selectively neuronal cell death without significantly interfering with glial cell death. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91264-f
更新日期：1992-10-09 00:00:00
abstract：:Artificial CSF containing 12mEq/1 of potassium (4 times normal concentration) was perfused over the surface of normal neocortex in 10 locally or barbiturate anesthetized cats. Extracellular potassium concentrations ([K+]OS) were measured as a function of time to 8 h and of depth to 3 mm. Analysis of the [K+]O versus d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90265-1
更新日期：1976-01-16 00:00:00
