Abstract：
:Motoneuron phenotype in the spinal cord is regulated by an intrinsic genetic program, extrinsic environmental signals and target-derived molecules. Axonal lesions trigger a phenotype switch to foster repair phenomena and axonal re-growth. We have investigated the influence of the long-term treatment with thyroid hormone and all trans retinol palmitate (RA) on motoneuron phenotype and spinal cord reaction to axotomy in adult male rats. Neurochemical markers, investigated by in situ hybridization and immunocytochemistry, included choline acetyltransferase (ChAT), calcitonin gene-related peptide (CGRP) and neurotrophin low affinity receptor p75. Treatment was administered for 56 days and then mid-thigh sciatic axotomy was performed on a number of animals from each experimental groups; the rats were examined 9 days after surgery. The results indicate that: (1) Number and size of ChAT-immunoreactive neurons in the lumbar tract of the spinal cord was reduced in hypothyroid compared to control rats, whereas steady-state level of ChAT mRNA in labelled motoneurons failed to be modified by hypo and hyperthyroidism, but was increased by RA administration; (2) none of the administered treatments did alter CGRP mRNA level, whereas all of them influenced the axotomy-induced changes of motoneuron phenotype; (3) in hyperthyroid rats ChAT mRNA level of lumbar motoneurons not reduced homolateral to lesion while the number of ChAT-IR profiles was pronouncedly reduced; (4) up-regulation of p75 induced by peripheral nerve lesion was reduced in RA-treated rats. These data indicate that the motoneuron phenotype is regulated by transcription factors, which also play a role in phenotype switch regulation after axotomy.
journal_name
Brain Resjournal_title
Brain researchauthors
Giardino L,Giuliani A,Bettelli C,Calzà Ldoi
10.1016/s0006-8993(01)03266-8subject
Has Abstractpub_date
2002-01-25 00:00:00pages
122-32issue
2eissn
0006-8993issn
1872-6240pii
S0006899301032668journal_volume
925pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Neurotensin (NT), a tridecapeptide, is a neurotransmitter that elicits potent effects including hypothermia and antinociception in mice and rats. To date, there are two types of the neurotensin receptor (NTR) that have been molecularly cloned from the rat. However, several lines of evidence suggest the presence of add...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00150-4
更新日期：1998-05-11 00:00:00
abstract：:The locus coeruleus of the adult albino rat is a clearly delimited nucleus in Nissl-stained preparations. It is surrounded by an extensive, relatively neuron-free neuropil which is not stained in reduced silver and Luxol fast blue preparations. Most if not all locus coeruleus neurons contain the enzyme dopamine-beta-h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90207-9
更新日期：1976-06-25 00:00:00
abstract：:The effects of caffeine ingestion and exposure to bright light, both separately and in combination, on salivary melatonin and tympanic temperature were assessed in humans. Four treatments during a 45.5 h sleep deprivation period were compared: Dim Light-Placebo, Dim Light-Caffeine, Bright Light-Placebo and Bright-Ligh...
journal_title：Brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0006-8993(96)01268-1
更新日期：1997-01-30 00:00:00
abstract：:Spatial neglect may involve neglect dyslexia resulting in a failure to identify words or parts of words in the contralesional hemispace. The present study explored a well-documented dissociation in neglect dyslexics' word processing, i.e. impaired reading aloud in the presence of good lexical decision performance for ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.069
更新日期：2008-01-16 00:00:00
abstract：:The protective activity of trimetazidine (TMZ) against cochlear neurotoxicity induced by intraperitoneal and intracochlear administration of kainic acid (KA) has been analyzed. The amplitude of the CAP N1 wave was significantly higher in KA rats pretreated with TMZ, independently of the administration route, than in t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01258-5
更新日期：1999-04-24 00:00:00
abstract：:An in vitro preparation of the medulla oblongata of the rat was used to examine the responses to reducing pH, at constant CO2, of neurons in several identified nuclei. Neurons in an area close to the ventral surface, which is thought to be the location of pH-sensitive central respiratory chemoreceptors, did not respon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90300-1
更新日期：1983-07-25 00:00:00
abstract：:The N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor is linked to an ion channel that is blocked by the phencyclidine analog N-(1-[thienyl]cyclohexyl)piperidine (TCP). Previous studies have shown that NMDA and glycine act together to increase the access of [3H]TCP to its binding site, presumably b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90918-2
更新日期：1990-05-21 00:00:00
abstract：:Multiple sclerosis patients typically experience increased pain that is relatively insensitive to opiate treatment. The mechanistic basis for this increased nociception is currently poorly understood. In the present study, we utilized the Theiler's murine encephalomyelitis virus (TMEV) model of MS to examine possible ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.034
更新日期：2008-01-29 00:00:00
abstract：:The objective of this study was to determine if a prefrontal somatosensory mismatch response (sMMR) could be recorded in response to deviations in duration of somatosensory stimuli. Intracranial somatosensory event-related potentials were recorded from temporal, parietal, and frontal lobe sites in 12 pediatric patient...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.072
更新日期：2010-01-15 00:00:00
abstract：:Melatonin is a hormone that mostly produced from the pineal gland, and it performs as a strong neuroprotectant to both neuron and glial cells against methamphetamine (METH)-induced neurotoxicity. Recently, it has been found that METH also damages the blood brain barrier (BBB) structure and function. However, the prote...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.08.045
更新日期：2016-11-01 00:00:00
abstract：:Two experiments were undertaken to investigate dopaminergic involvement in the local rate of responding on a fixed ratio 5 (FR5) instrumental lever pressing schedule. Rats were trained to press a lever for food reinforcement on a FR5 schedule, and a computer program was used to record the interresponse time (IRT) for ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90958-p
更新日期：1993-11-19 00:00:00
abstract：:Immunohistochemical and retrograde tracing techniques were combined to demonstrate the occurrence of displaced ganglion cells (DGCs) exhibiting substance P-like immunoreactivity (SP-LI) in the pigeon retina. Following injections of rhodamine-labeled latex microspheres into the nucleus of the basal optic root (accessor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91159-x
更新日期：1991-04-12 00:00:00
abstract：:Homer1a is implicated in depression in humans and depression-like behavior in mice. To further understand the role of Homer1a in stress-induced emotional changes, we applied very mild stress to Homer1a knockout (H1a KO) mice. The wild-type (WT) and H1a KO mice were restrained for 2h daily for 7 consecutive days at the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.008
更新日期：2015-04-24 00:00:00
abstract：:We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was de...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.097
更新日期：2005-04-25 00:00:00
abstract：:Secondary hemorrhage after thrombolysis in ischemic stroke is an important complication, which has been difficult to study in preclinical disease models. We have established and characterized a model of thromboembolic middle cerebral artery occlusion in rats. Advantages of this model include a very low rate of spontan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.10.067
更新日期：2011-01-12 00:00:00
abstract：:This study investigates the reanalysis processes as a consequence of conflict between incompatible sentential representations in sentence comprehension. Using the event-related potential (ERP) technique, we examined the situation in which the sentential representation built upon world knowledge (i.e., the plausibility...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.090
更新日期：2008-04-08 00:00:00
abstract：:The blockade of central histaminergic H(2) receptors has been reported to aggravate ischemic neuronal damage. Since excess release of excitatory neurotransmitters is closely related to ischemic neuronal damage, the effects of ranitidine on ischemic release of dopamine were investigated in gerbil striatum. Changes in t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03107-9
更新日期：2002-02-01 00:00:00
abstract：:Several reports during the last three decades have indicated that biosynthesis of N-acetylaspartate (NAA) occurs primarily in the mitochondria. But a recent report by Lu et al. in this journal [2004; 122: 71-78] and subsequent two reports that cited those data suggested a predominant microsomal localization of the NAA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.06.040
更新日期：2008-08-28 00:00:00
abstract：:Met5-enkephalin- (Met-ENK), Leu5-enkephalin-, Met5-enkephalin-Arg6-Phe7-, metorphamide- and BAM 22P-like peptides could be detected in the lumbar spinal cord of the chicken by immunocytochemistry and/or high performance liquid chromatography. However, a peptide identical to Met5-enkephalin-Arg6-Gly7-Leu8 could not be ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91187-x
更新日期：1986-07-02 00:00:00
abstract：:125I-alpha-Scorpion toxin (alpha-ScTx) binds to a component of the voltage-sensitive Na+ channel. We have previously shown that receptor capacity on dissociated mouse brain cells increases between days 12 and 19 of fetal life as does the expression of neurotoxin-sensitive 22Na+ influx. In the present study we have inv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90136-2
更新日期：1987-03-01 00:00:00
abstract：:The present study utilized the [14C]2-deoxyglucose (2-DG) cell labeling procedure to characterize a functional pathway from the prefrontal cortex (Pfc) and mediodorsal thalamic nucleus (MD) to the hypothalamus. Rats were injected with 2-DG prior to a 45 min experimental paradigm consisting of alternating 30 s on-off p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90151-3
更新日期：1984-09-24 00:00:00
abstract：:Traumatic brain injury (TBI) is one of the largest health problems in the United States and affects both cognitive and motor function. Although weakness is common in TBI patients, few studies have demonstrated a reduction in strength in models of brain injury. We have developed a behavioral method to measure volitiona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.07.039
更新日期：2014-09-25 00:00:00
abstract：:As measured by extracellular single-cell recording, the responses to adenosine triphosphate (ATP) by ATP-sensitive chemoreceptors (ATP cells) on the olfactory organ of the spiny lobster are markedly suppressed by adenosine diphosphate (ADP), adenosine monophosphate (AMP) and to a lesser extent, adenosine, when each is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90964-5
更新日期：1989-09-11 00:00:00
abstract：:Retinal lesions in pigeons produced a marked depletion of somata and neuropil staining for both calbindin-D28k and parvalbumin immunoreactivities in the contralateral optic tectum. Calbindin-like immunoreactivity reappeared in some tectal layers by 6 weeks postlesion, whereas paravalbumin-like immunoreactivity recover...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91206-8
更新日期：1994-10-24 00:00:00
abstract：:Intrathecally-administered clonidine inhibited the spontaneous firing of single neurons in the pontine nucleus locus coeruleus of rats. Such inhibition of neuron firing was not observed when the non-lipophilic alpha 2 adrenoceptor agonist (oxymetazoline) was administered intrathecally. It is concluded that lipophilic ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90752-7
更新日期：1983-10-16 00:00:00
abstract：:The neuronal mechanisms of sneezing were examined in precollicular-postmammillary decerebrate cats. Mechanical stimulation (frequency 20 Hz, peak-to-peak displacement 0.5 mm) of the nasal membrane evoked a series of sneezes. In the same preparation, electrical stimulation (duration 0.2 ms, frequency 10 Hz, 5-50 microA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90171-7
更新日期：1990-03-19 00:00:00
abstract：:It is well established that extracellular choline is transported into central cholinergic nerve terminals by 'high' and 'low' affinity processes to form the neurotransmitter acetylcholine (ACh). The intent of the present investigation was to ascertain whether extracellular acetate might also be transported into centra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01485-0
更新日期：1997-04-04 00:00:00
abstract：:This study evaluated the effects of intrathecal administration of a low-analgesic dose of the selective mu-agonist DAMGO co-administered with sequentially increasing doses of either the selective delta-agonist DPDPE or the selective kappa-agonist, U50,488H on mechanical nociceptive thresholds in the rat. Potent analge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91297-t
更新日期：1990-10-22 00:00:00
abstract：:The cholinergic presynaptic terminals of Torpedo electric organ have been examined morphometrically following stimulation by KCI and sucrose. The objective was to confirm correlations predicted by the vesicle hypothesis between miniature end-plate potentials (MEPPs) and morphometric changes in terminal ultrastructure....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00109-1
更新日期：1997-04-25 00:00:00
abstract：:A substantial projection from the retina to the dorsal raphe nucleus (DRN) has been demonstrated in the Chilean degus, a diurnal/crepuscular hystricomorph rodent. Following intraocular injection of cholera toxin subunit B (CTB), immunocytochemically labeled CTB-positive axons and terminals were observed in all major r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02061-3
更新日期：2001-03-23 00:00:00
