Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice.

Abstract:

:We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was detected. These results indicate that KD has neuroprotective effects throughout diminishing nuclear clusterin accumulation that is involved in caspase-3 independent cell death mechanism.

journal_name

Brain Res

journal_title

Brain research

authors

Noh HS,Kim DW,Kang SS,Cho GJ,Choi WS

doi

10.1016/j.brainres.2005.01.097

subject

Has Abstract

pub_date

2005-04-25 00:00:00

pages

114-8

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(05)00161-7

journal_volume

1042

pub_type

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