Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice.


:We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was detected. These results indicate that KD has neuroprotective effects throughout diminishing nuclear clusterin accumulation that is involved in caspase-3 independent cell death mechanism.


Brain Res


Brain research


Noh HS,Kim DW,Kang SS,Cho GJ,Choi WS




Has Abstract


2005-04-25 00:00:00














  • Morphologic and autoradiographic evidence for a laminated pretectal olivary nucleus in the squirrel monkey.

    abstract::The pretectal olivary nucleus of the squirrel monkey was examined in both normal and autoradiographic material. In the Nissl- and fiber-stained tissue the nucleus appears as a laminated structure. The distribution of retinal terminals within the nucleus was examined by the autoradiographic tracing method. These data r...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Weber JT,Young R,Hutchins B

    更新日期:1981-11-09 00:00:00

  • Effects of chronic ethanol administration on acetylcholinesterase activity in the somatosensory cortex and basal forebrain of the rat.

    abstract::A chronic diet of ethanol has detrimental effects on the cholinergic system in adult humans and rats. This study examined the effects of chronic exposure to dietary ethanol on the anatomical organization of true acetylcholinesterase (AChE) active elements in rat cerebral cortex. We focused on the somatosensory cortex ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Miller MW,Rieck RW

    更新日期:1993-11-05 00:00:00

  • Injection of anti-neuropeptide Y gamma-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats.

    abstract::The effect of immunoneutralization of hypothalamic neuropeptide Y (NPY) on food intake was examined to clarify the involvement of NPY in the control mechanism of feeding behavior. Injection of anti-NPY gamma-globulin into the bilateral hypothalamic paraventricular nuclei of 24-h food-deprived rats significantly inhibi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shibasaki T,Oda T,Imaki T,Ling N,Demura H

    更新日期:1993-01-22 00:00:00

  • No evidence of brain cell degeneration after long-term sleep deprivation in rats.

    abstract::Sleep deprivation leads to cognitive impairments in humans and, if sustained for 2-3 weeks in rats, it is invariably fatal. It has been suggested that neural activity associated with waking, if it is not interrupted by periods of sleep, may damage brain cells through excitotoxic or oxidative mechanisms and eventually ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cirelli C,Shaw PJ,Rechtschaffen A,Tononi G

    更新日期:1999-09-04 00:00:00

  • Cysteamine-induced depletion of central somatostatin-like immunoactivity: effects on behavior, learning, memory and brain neurochemistry.

    abstract::The effects of a wide range of doses of systemically administered cysteamine were studied on locomotor behavior, passive avoidance memory, cortical and cerebrospinal fluid somatostatin-like immunoactivity and cortical levels of dopamine and norepinephrine. High doses of cysteamine (200 and 250 mg/kg s.c.) led to susta...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Haroutunian V,Mantin R,Campbell GA,Tsuboyama GK,Davis KL

    更新日期:1987-02-17 00:00:00

  • Factors affecting paired-pulse facilitation in hippocampal CA1 neurons in vitro.

    abstract::Factors underlying paired-pulse facilitation (PPF) were studied by intracellular and field recordings of CA1 neurons in the hippocampal slice in vitro, following stimulation of the Schaffer collaterals apical dendritic afferents. Similar magnitudes of PPF were found using the slopes or peaks of the excitatory postsyna...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Leung LS,Fu XW

    更新日期:1994-07-04 00:00:00

  • Organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis and upper cervical spinal cord associated with orofacial neuropathic pain.

    abstract::The aim of this study was to evaluate spatial organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord (C1), and to clarify the involvement in mechanisms underlying orofacial secondary hyperalgesia following infraorbital nerve injury. We found that the h...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shibuta K,Suzuki I,Shinoda M,Tsuboi Y,Honda K,Shimizu N,Sessle BJ,Iwata K

    更新日期:2012-04-27 00:00:00

  • Heterosynaptic stimulation modulates the duration of post-tetanic potentiation at an Aplysia synapse without affecting other aspects of synaptic transmission.

    abstract::Repetitive stimulation of an axon in the right visceropleural connective to the abdominal ganglion of Aplysia californica produces post-tetanic potentiation (PTP) of a unitary monosynaptic EPSP recorded from cell R15. PTP decays within one half hour following cessation of repatitive stimulation. Stimulation of the lef...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Newlin SA,Schlapfer WT,Barondes SH

    更新日期:1980-01-06 00:00:00

  • Noradrenergic innervation of hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in rats.

    abstract::Hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons, the central regulators of the hypothalamic-pituitary-thyroid axis, are located in the paraventricular nucleus of the hypothalamus (PVN). These neurons are well-known to be stimulated by cold exposure through activation of ascending brainstem pa...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Füzesi T,Wittmann G,Lechan RM,Liposits Z,Fekete C

    更新日期:2009-10-19 00:00:00

  • Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein.

    abstract::Missense mutations of presenilin 1 (PS-1) and presenilin 2 (PS-2) genes cause the majority of early-onset familial forms of Alzheimer's disease (AD). We previously characterized the distribution of the PS-1 protein in the mouse brain by immunohistochemistry using an antibody directed against an epitope located in the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Blanchard V,Czech C,Bonici B,Clavel N,Gohin M,Dalet K,Revah F,Pradier L,Imperato A,Moussaoui S

    更新日期:1997-05-30 00:00:00

  • Evaluation of opioid receptor subtype antagonist effects in the ventral tegmental area upon food intake under deprivation, glucoprivic and palatable conditions.

    abstract::Opioid receptor subtype antagonists differentially alter food intake under deprivation (24 h), glucoprivic (2-deoxy-D-glucose, 500 mg/kg, i.p.) or palatable (10% sucrose) conditions with mu (beta-funaltrexamine) and kappa (nor-binaltorphamine), but not delta1 ([D-Ala2,Leu5,Cys6]enkephalin) opioid antagonists reducing ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ragnauth A,Ruegg H,Bodnar RJ

    更新日期:1997-08-29 00:00:00

  • Origin of ascending auditory projections to the nucleus mesencephalicus lateralis pars dorsalis in the chicken.

    abstract::Ascending auditory projections to the nucleus mesencephalicus lateralis pars dorsalis (MLd) were studied in white Leghorn chickens by means of unilateral injections of horseradish peroxidase into the MLd and by injections of tritiated leucine into nucleus angularis or the combined nucleus magnocellularis and nucleus l...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Conlee JW,Parks TN

    更新日期:1986-03-05 00:00:00

  • Motor space structures perceptual space: evidence from human saccadic adaptation.

    abstract::Saccadic adaptation is the progressive correction of systematic saccade targeting errors. When a saccade to a particular target is adapted, saccades within a spatial window around the target, the adaptation field, are affected as a function of their distance from the adapted target. Furthermore, previous studies sugge...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Collins T,Doré-Mazars K,Lappe M

    更新日期:2007-10-03 00:00:00

  • Behavioral evidence for midbrain dopamine depolarization inactivation.

    abstract::High (2.5-5 micrograms) doses of ventral tegmental morphine, which normally facilitate brain stimulation reward, were found to cause a complete cessation of bar pressing for brainstem stimulation in animals pretreated with systemic pimozide (0.175-0.35 mg/kg). It was hypothesized that the behavioral failure was due to...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rompré PP,Wise RA

    更新日期:1989-01-16 00:00:00

  • Exploring and targeting saccades dissociated by saccadic adaptation.

    abstract::Saccadic adaptation maintains saccade accuracy and has been studied with targeting saccades, i.e. saccades that bring the gaze to a target, with the classical intra-saccadic step procedure in which the target systematically jumps to a new position during saccade execution. Post-saccadic visual feedback about the error...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lavergne L,Vergilino-Perez D,Lemoine C,Collins T,Doré-Mazars K

    更新日期:2011-09-30 00:00:00

  • The release of noradrenaline in the locus coeruleus and prefrontal cortex studied with dual-probe microdialysis.

    abstract::The present study was undertaken to investigate and compare the properties of noradrenaline release in the locus coeruleus (LC) and prefrontal cortex (PFC). For that aim the dual-probe microdialysis technique was applied for simultaneous detection of noradrenaline levels in the LC and PFC in conscious rats. Calcium om...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pudovkina OL,Kawahara Y,de Vries J,Westerink BH

    更新日期:2001-07-06 00:00:00

  • Effect of 5-HTTLPR on current source density, connectivity, and topological properties of resting state EEG networks.

    abstract::The S allele of serotonin transporter gene (5-HTTLPR) has been found to increase the risk of depression and other mental health problems, but some evidence suggests that S-allele carriers outperform subjects carrying the long allele in an array of cognitive tasks. Evidence linking this polymorphism with individual var...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Proshina EA,Savostyanov AN,Bocharov AV,Knyazev GG

    更新日期:2018-10-15 00:00:00

  • Inositol 1,4,5-trisphosphate 3-kinase distribution in the rat brain. High levels in the hippocampal CA1 pyramidal and cerebellar Purkinje cells suggest its involvement in some memory processes.

    abstract::The distribution of inositol 1,4,5-trisphosphate (InsP3) 3-kinase was studied in the adult rat brain, using polyclonal antibodies raised against the purified 50,000-Da rat brain enzyme by immunohistochemistry and Western blot, in addition to enzymatic assay. Immunohistochemically, the enzyme was detected in neurons, w...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mailleux P,Takazawa K,Erneux C,Vanderhaeghen JJ

    更新日期:1991-01-25 00:00:00

  • Discharge of neurons in the parabrachial pons related to the cardiac cycle: changes during different sleep-waking states.

    abstract::Neuronal activity in the nucleus parabrachialis medialis (NPBM) was examined in unanesthetized, unrestrained cats during each sleep-waking state. Discharge related to the cardiac cycle was assessed by calculating cross-correlation functions between neuronal and cardiac events (using the peak of the EKG 'R' wave as a r...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sieck GC,Harper RM

    更新日期:1980-10-20 00:00:00

  • An intracellular study of synaptic transmission and dendritic morphology in sympathetic neurons of the chick embryo.

    abstract::The characteristics of synaptic transmission in whole embryonic avian sympathetic ganglia have been examined by intracellular recording. Neurons in lumbar paravertebral ganglia of chick embryos exhibit both fast nicotinic excitatory postsynaptic potentials (EPSPs) and non-cholinergic slow EPSPs. Fast nicotinic transmi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dryer SE,Chiappinelli VA

    更新日期:1985-09-01 00:00:00

  • LPS-induced Fos expression in oxytocin and vasopressin neurons of the rat hypothalamus.

    abstract::The aim of this study was to examine the involvement of the hypothalamic oxytocin (OXT) and vasopressin (AVP) neurons in acute phase reaction using quantitative dual-labeled immunostaining with Fos and either OXT and AVP in several hypothalamic regions. Administration of low dose (5 microg/kg) and high dose (125 micro...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Matsunaga W,Miyata S,Takamata A,Bun H,Nakashima T,Kiyohara T

    更新日期:2000-03-06 00:00:00

  • Evidence for a differential modulation of the alpha-2 adrenoceptors by angiotensin II in the nucleus tractus solitarii of the spontaneously hypertensive and the Wistar-Kyoto normotensive rats.

    abstract::An interaction between angiotensin II (Ang II) receptors and alpha 2-adrenoceptors was evaluated in the nucleus tractus solitarii (NTS) of the normotensive Wistar-Kyoto rat (WKY) and of the spontaneously hypertensive rat (SHR) using quantitative receptor autoradiography and cardiovascular analysis. In the WKY rat, Ang...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fior DR,Yang SN,Ganten U,Ganten D,Fuxe K

    更新日期:1995-05-08 00:00:00

  • Homer1a disruption increases vulnerability to predictable subtle stress normally sub-threshold for behavioral changes.

    abstract::Homer1a is implicated in depression in humans and depression-like behavior in mice. To further understand the role of Homer1a in stress-induced emotional changes, we applied very mild stress to Homer1a knockout (H1a KO) mice. The wild-type (WT) and H1a KO mice were restrained for 2h daily for 7 consecutive days at the...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shui Y,Wang L,Luo X,Uchiumi O,Yamamoto R,Sugai T,Kato N

    更新日期:2015-04-24 00:00:00

  • Potentiating effects of methamphetamine on the hyperactivity of microencephalic rats treated prenatally with methylazoxymethanol: possible implication of hyperdopaminergia.

    abstract::Microencephalic rats induced by methylazoxymethanol (MAM) were observed to have notable hyperactivity compared to control rats, as measured by several behavioral parameters in an automated field apparatus. Acute injection of the stimulant drug, methamphetamine (MAP), produced an increase in the incidence of locomotion...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Watanabe M,Shimizu K,Kodama Y,Takishima K,Mamiya G,Ichinowatari N

    更新日期:1995-01-23 00:00:00

  • The excitatory amino acid glutamate mediates reflexly increased tracheal blood flow and airway submucosal gland secretion.

    abstract::In six decerebrated and in eight alpha-chloralose anesthetized, paralyzed and mechanically ventilated beagle dogs, we have studied involvement of glutamate and glutamate receptors in transmission of excitatory inputs from the airway sensory receptors to the nucleus tractus solitarius and from this site to airway-relat...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Haxhiu MA,Chavez JC,Pichiule P,Erokwu B,Dreshaj IA

    更新日期:2000-11-10 00:00:00

  • The nictitating membrane response: an electrophysiological study of the abducens nerve and nucleus and the accessory abducens nucleus in rabbit.

    abstract::The nictitating membrane response to periocular electrostimulation was investigated in anesthetized and paralyzed rabbits. Recordings from the abducens nerve, which carries the fibers innervating retractor bulbi muscles that are primarily involved in this reflex, showed two distinct volleys to effective stimulation: a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Berthier NE,Moore JW

    更新日期:1983-01-10 00:00:00

  • Quantitative morphological analysis of spinal motoneurons.

    abstract::Horseradish peroxidase was injected intracellularly into motoneurons responding to cutaneous stimulation of the central foot pad of the hind limb in cats. Three motoneurons were selected for detailed analysis: two excited by foot pad stimulation, and one postsynaptically inhibited by such stimulation. The overall leng...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Egger MD,Egger LD

    更新日期:1982-12-16 00:00:00

  • Loss and displacement of ganglion cells after optic nerve regeneration in adult Rana pipiens.

    abstract::After studying pathway selection in the brain of Rana pipiens during unilateral optic nerve regeneration, several frogs were allowed to survive for lengthy periods for use in the present investigation. Retina flat-mounts were prepared from both eyes at 42-50 weeks postoperation. In some cases, HRP was infiltrated into...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Scalia F,Arango V,Singman EL

    更新日期:1985-10-07 00:00:00

  • Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components.

    abstract::Immunofluorescence on primary dissociated rat neuronal cultures (cortical, hippocampal, and cerebellar) and organotypic hippocampal cultures was used to investigate the pattern of distribution of cell-surface amyloid protein (APP). Antibodies directed against the extracellular (N-terminal) portion of APP or against th...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Storey E,Beyreuther K,Masters CL

    更新日期:1996-10-07 00:00:00

  • (+)-6,7-benzomorphan sigma ligands stimulate dopamine synthesis in rat corpus striatum tissue.

    abstract::The benzomorphan sigma ligands, (+)-N-allylnormetazocine (NANM) and (+)-pentazocine, but not (+)-cyclazocine, stereospecifically stimulated dopamine synthesis in minces of rat corpus striatum by 15-23% over basal values at 0.1-1.0 microM. The effect of (+)-NANM and (+)-pentazocine was blocked by the reported sigma ant...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Booth RG,Baldessarini RJ

    更新日期:1991-08-23 00:00:00