Tetrodotoxin blocks NPY-induced but not muscimol-induced phase advances of wheel-running activity in Syrian hamsters.

abstract：:Dynamic microvascular remodeling maintains an optimal continuous supply of oxygen and nutrients to the brain to account for prolonged environmental variations. The objective of this study was to determine the relative time course of capillary regression during re-oxygenation after exposure to prolonged moderate hypoxi...

journal_title：Brain research

authors： Benderro GF,LaManna JC

更新日期：2014-06-20 00:00:00

abstract：:Single unit discharges in the superior secondary gustatory nucleus of the carp, Cyprinus carpio L., were studied electrophysiologically in response to chemical stimulation of the external chemoreceptors of the facial skin surface. Of 36 gustatory neurons recorded, 80.6% were facilitated by taste stimuli and 19.4% were...

journal_title：Brain research

authors： Marui T

更新日期：1981-07-27 00:00:00

abstract：:Thermoregulatory (brown adipose tissue temperature) experiments were conducted in age-matched anesthetized, male Sprague-Dawley and Long Evans rats kept at 37 degrees C given unilateral electrical stimulation of the ventromedial hypothalamic nucleus or the lateral preoptic area or after intravenous infusion of norepin...

journal_title：Brain research

authors： Hugie T,Halvorson I,Thornhill J

更新日期：1992-03-13 00:00:00

abstract：:Evidence is presented which suggests that central neural changes occur during the brief early phase after subcutaneous formalin injection that are essential for the expression of pain during the long-lasting (tonic) later phase. First, tonic pain responses to subcutaneous formalin injections are abolished only if the ...

journal_title：Brain research

authors： Coderre TJ,Vaccarino AL,Melzack R

更新日期：1990-12-03 00:00:00

abstract：:Chronic pain tends to be intractable, regardless of whether the etiology has improved or is persistent. This intractability may be due, in part, to conditioning factors, but studies of the underlying mechanism are limited. We predicted that the body might learn pain sensation during sustained pain. In the present stud...

journal_title：Brain research

authors： Nakama-Kitamura M,Kitamura Y

更新日期：2011-08-11 00:00:00

abstract：:Astrocytes produce and bind endothelins (ETs), suggesting that these cells have ET autoregulatory and eliminatory functions. To further investigate these functions in primary rat astrocytes, ET-1 levels in the cell culture media (RIA/HPLC) and intracellular content of ET-1 mRNA (RT PCR) were measured under basal and s...

journal_title：Brain research

authors： Hasselblatt M,Kamrowski-Kruck H,Jensen N,Schilling L,Kratzin H,Sirén AL,Ehrenreich H

更新日期：1998-03-02 00:00:00

abstract：:Acute hyperammonemia is associated with motor disturbances that are thought to involve striatal dopaminergic dysfunction. Discharge of striatal dopaminergic neurons is controlled by N-methyl-D-aspartate (NMDA) receptors, the excessive activation of which contributes to ammonia neurotoxicity. Here we show that ammonium...

journal_title：Brain research

authors： Anderzhanova E,Oja SS,Saransaari P,Albrecht J

更新日期：2003-07-11 00:00:00

abstract：:An immunoneutralization technique with specific antibodies was used to explore the role of endogenous neuropeptide Y (NPY) in the adrenocorticotropic hormone (ACTH) release after hypoglycemic stress in the dog. Dogs received injections of rabbit antihuman NPY gamma-globulin (anti-NPY) or normal gamma-globulin (NGG) in...

journal_title：Brain research

authors： Inui A,Inoue T,Nakajima M,Okita M,Sakatani N,Okimura Y,Chihara K,Baba S

更新日期：1990-03-05 00:00:00

abstract：:Specific silver impregnation techniques for extracellular amyloid and intraneuronal neurofibrillary changes were used to examine the presubiculum in Alzheimer victims. Extended amyloid clouds in the absence of neurofibrillary changes were noted in the parvopyramidal layer of the presubiculum proper. The corresponding ...

journal_title：Brain research

authors： Kalus P,Braak H,Braak E,Bohl J

更新日期：1989-08-07 00:00:00

abstract：:The effect of hypoxia on the structure and function of the synaptosomal membranes and myelin fraction (glial cells, neuronal cells bodies and axonal membranes) was investigated by measuring Na+,K(+)-ATPase activity and levels of lipid peroxidation products in cerebral cortical synaptosomal membranes and myelin fractio...

journal_title：Brain research

authors： Razdan B,Marro PJ,Tammela O,Goel R,Mishra OP,Delivoria-Papadopoulos M

更新日期：1993-01-15 00:00:00

abstract：:The distribution of [3H]kainic acid (KA) binding sites in the rat CNS was determined by in vitro autoradiography. KA sites are distributed throughout the CNS gray matter in an anatomically specific pattern with telencephalic structures and the cerebellum accounting for the majority of the binding. These results, toget...

journal_title：Brain research

authors： Monaghan DT,Cotman CW

更新日期：1982-12-02 00:00:00

abstract：:The aetiology of the sporadic form of amyotrophic lateral sclerosis (ALS) is poorly understood although abnormalities in glutamate and glycine transport have been implicated which both could contribute to a neurodegenerative process mediated through the N-methyl-D-aspartate (NMDA) receptor. In this study we have used ...

journal_title：Brain research

authors： Virgo L,de Belleroche J

更新日期：1995-04-03 00:00:00

abstract：:Astrocytic gap junctions have been implicated in a variety of signaling pathways essential to normal brain function. However, no information exists on the prevalence of gap junction channels and their function in the aging brain. Here we have compared the expression of the two most abundant astrocytic gap junction pro...

journal_title：Brain research

authors： Cotrina ML,Gao Q,Lin JH,Nedergaard M

更新日期：2001-05-18 00:00:00

abstract：:Rat hippocampal slices were incubated with [3H]uridine in vitro to analyze the metabolism of nuclear RNA and the RNA precursor fractions. Labeling of total nuclear RNA was linear for 4 h of incubation and proportional to the concentration of labeled uridine in the incubation medium. Addition of 3.5 X 10(-8) M corticos...

journal_title：Brain research

authors： Dokas LA,Liauw A

更新日期：1984-07-23 00:00:00

abstract：:Peripheral axotomy in neonatal rats induces neuronal death. We studied the anti-apoptotic protein Bcl-2 and cell death promoter Bax in spinal cord of neonatal rats after sciatic transection and treatment with melatonin, a neuroprotective substance. Pups were unilaterally axotomized at P2 and received melatonin (1 mg/k...

journal_title：Brain research

authors： Rogério F,Jordão H Jr,Vieira AS,Maria CC,Santos de Rezende AC,Pereira GA,Langone F

更新日期：2006-09-27 00:00:00

abstract：OBJECTIVE:There is an increasing interest concerning the contribution of astrocytes to the intrinsic bioremediation of ischemic brain injury. The aim of this work was to disclose the effects and mechanism of dexmedetomidine (DEX) on the apoptosis of astrocytes under oxygen glucose deprivation (OGD) condition. METHODS:...

journal_title：Brain research

authors： Feng P,Zhang A,Su M,Cai H,Wang X,Zhang Y

更新日期：2021-01-01 00:00:00

abstract：:Two distinct serotonin receptors in mammalian brain are labeled respectively with [3H]serotonin (5-HT1) and [3H]spiperone (5-HT2). In general agonists display highest affinities for 5-HT1 while antagonists prefer 5-HT2 sites. To conduct regional studies of 5-HT receptors, we estimated 5-HT2 sites with [3H]spiperone, u...

journal_title：Brain research

authors： Peroutka SJ,Snyder SH

更新日期：1981-03-16 00:00:00

abstract：:Three weeks of hypoxic exposure results in a spectrum of systemic physiological and local brain tissue adaptations. Cytochrome oxidase histochemistry was used as an indicator of changes in energy demand in response to hypoxia. We found overall cytochrome oxidase activity decreased in hypoxic adapted rats as compared t...

journal_title：Brain research

authors： LaManna JC,Kutina-Nelson KL,Hritz MA,Huang Z,Wong-Riley MT

更新日期：1996-05-13 00:00:00

abstract：:The particular vulnerability of hippocampal CA3/CA4 neurons to intracerebroventricularly administered kainate did not occur in rats until postnatal day 16. Glutamate applied in the same way failed to show comparable neurodegenerative signs, even when administered in large doses to adult animals. Alternatively, both ka...

journal_title：Brain research

authors： Wolf G,Keilhoff G

更新日期：1984-05-01 00:00:00

abstract：:Amphetamine releases dopamine through a transporter-mediated mechanism. The purpose of this report was to further our understanding of the intracellular pool from which amphetamine releases dopamine: the cytoplasmic pool, the vesicular pool, or both. Rats were treated with D-amphetamine (AMPH) (1.0 or 10.0 mg/kg) or a...

journal_title：Brain research

authors： Sabol KE,Seiden LS

更新日期：1998-09-21 00:00:00

abstract：:Past studies in the rat and Syrian hamster show that metabolic and electrical activity of the suprachiasmatic nuclei (SCN) is inhibited by melatonin (MEL) at about circadian time (ct) 8-11 h. The present experiment examined the effect of MEL on the firing frequency of SCN cells in brain slices prepared from long day (...

journal_title：Brain research

authors： Margraf RR,Lynch GR

更新日期：1993-04-23 00:00:00

abstract：:Structural changes induced by high frequency (HF) stimulation on granule cells of the hippocampal dentate gyrus of rats with inborn high (HP) and low (LP) learning capacity was examined in this study. Two types of axodendritic synapses were processed morphometrically; the axonal bouton on dendritic shafts and those ma...

journal_title：Brain research

authors： Gómez RA,Pozzo Miller LD,Aoki A,Ramírez OA

更新日期：1990-12-24 00:00:00

abstract：:In vivo proton magnetic resonance spectroscopy was used to investigate intracerebral phenylalanine (Phe) concentrations in nine patients with classical phenylketonuria (PKU). The study included serial examinations (n = 31; plasma Phe levels: 0.47-2.24 mmol/l) of patients either receiving a Phe-restricted diet (200 mg ...

journal_title：Brain research

authors： Möller HE,Weglage J,Wiedermann D,Vermathen P,Bick U,Ullrich K

更新日期：1997-12-19 00:00:00

abstract：:Hyperacusis, a marked intolerance to normal environmental sound, is a common symptom in patients with tinnitus, Williams syndrome, autism, and other neurologic diseases. It has been suggested that an imbalance of excitation and inhibition in the central auditory system (CAS) may play an important role in hyperacusis. ...

journal_title：Brain research

authors： Sun W,Deng A,Jayaram A,Gibson B

更新日期：2012-11-16 00:00:00

abstract：:Erythropoietin (EPO) provides neuroprotection and neurorestoration after traumatic brain injury (TBI). The EPO doses used for treatment of TBI significantly increase hematocrit, which may affect the efficacy of EPO therapy for TBI. The aim of this study was to investigate whether normalization of hematocrit would affe...

journal_title：Brain research

authors： Zhang Y,Xiong Y,Mahmood A,Meng Y,Qu C,Schallert T,Chopp M

更新日期：2009-10-19 00:00:00

abstract：:The present study examined the antioxidant effect of phytic acid on iron (II)-enhanced hydroxyl radical (*OH) generation induced by 1-methyl-4-phenylpyridinium ion (MPP(+)) in the extracellular fluid of rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused t...

journal_title：Brain research

authors： Obata T

更新日期：2003-07-18 00:00:00

abstract：:The rostral projection of A delta and C primary afferents in Lissauer's tract (LT) was studied by assessing how far, rostrally, axons entering at a given level could be activated by electrical stimulation. Sural A delta primary afferents in LT exhibited a rostral projection at least as far as the L3/L4 border, 4 segme...

journal_title：Brain research

authors： Traub RJ,Sedivec MJ,Mendell LM

更新日期：1986-12-03 00:00:00

abstract：:Choline supplementation of the maternal diet has long-term facilitative effects on spatial and temporal memory processes in the offspring. To further delineate the impact of early nutritional status on brain and behavior, we examined effects of prenatal-choline availability on hippocampal oscillatory frequency bands i...

journal_title：Brain research

authors： Cheng RK,Williams CL,Meck WH

更新日期：2008-10-27 00:00:00

abstract：:Aspartame (L-aspartyl-L-phenylalanine methyl ester), an artificial low-calorie sweetener, was shown to dose-dependently inhibit L-[3H]glutamate binding to its N-methyl-D-aspartate-specific receptors. L-Aspartic acid, a major endogenous metabolite of aspartame, inhibited the binding more stronger than aspartame, while ...

journal_title：Brain research

authors： Pan-Hou H,Suda Y,Ohe Y,Sumi M,Yoshioka M

更新日期：1990-06-18 00:00:00

abstract：:Diffusion patterns of 14C-labeled penicillin, resulting from microinjections into different neocortical laminae, were compared with simultaneous electrophysiologic monitoring of epileptogenesis across these laminae. Injections into layer IV produced response alterations quickly in all recorded layers even with penicil...

journal_title：Brain research

authors： Chatt AB,Ebersole JS

更新日期：1984-01-09 00:00:00