Abstract：
:The neurotrophic effect of bFGF on dopamine (DA) neurons in vitro depends upon its mitogenic activity on glial cells. We examined whether glial secretion of the dopaminergic growth factor GDNF is responsible for the trophic activity of bFGF on mesencephalic DA neurons. When added with lower concentrations of bFGF, GDNF had an additive trophic effect, which disappeared at optimal bFGF concentrations. However, addition of GDNF-neutralizing antibodies could not modify the bFGF-induced survival and growth of DA neurons. These results indicate that although GDNF could be secreted by bFGF stimulated glia, its secretion alone does not account for the trophic effect of bFGF on mesencephalic DA neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Hou JG,Mytilineou Cdoi
10.1016/0006-8993(96)00311-3subject
Has Abstractpub_date
1996-06-10 00:00:00pages
145-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(96)00311-3journal_volume
724pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01488-8
更新日期：1996-03-25 00:00:00
abstract：:Opioid receptor subtype antagonists differentially alter food intake under deprivation (24 h), glucoprivic (2-deoxy-D-glucose, 500 mg/kg, i.p.) or palatable (10% sucrose) conditions with mu (beta-funaltrexamine) and kappa (nor-binaltorphamine), but not delta1 ([D-Ala2,Leu5,Cys6]enkephalin) opioid antagonists reducing ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00539-8
更新日期：1997-08-29 00:00:00
abstract：:Baclofen-sensitive GABAB receptor binding to various brain regions was compared in age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rat. The specific [3H]baclofen binding was significantly higher in SHR cerebellum, hippocampus and nucleus tractus solitarii (NTS), but lower in medulla, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90941-2
更新日期：1985-12-09 00:00:00
abstract：:The effect of immunoneutralization of hypothalamic neuropeptide Y (NPY) on food intake was examined to clarify the involvement of NPY in the control mechanism of feeding behavior. Injection of anti-NPY gamma-globulin into the bilateral hypothalamic paraventricular nuclei of 24-h food-deprived rats significantly inhibi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91727-a
更新日期：1993-01-22 00:00:00
abstract：:The behaviour and cognitive abilities of marmosets with bilateral ablations of either the archicortex on the mediodorsal surface or the paleocortex on the ventrolateral surface of the frontal lobes were assessed in terms of the types of information being handled, the mode of action (inhibitory versus productive mechan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90937-i
更新日期：1993-11-19 00:00:00
abstract：:GEC1 protein shares high identity with GABARAP (GABA(A) Receptor-Associated Protein), interacts with tubulin and GABA(A) receptors and is potentially involved in intracellular transport processes. Recently, using quantitative real time PCR, we have reported the gec1 mRNA expression in different rat brain areas. In the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.077
更新日期：2008-05-19 00:00:00
abstract：:Golgi examination of neurons of self-stimulation areas of the lateral hypothalamus and substantia nigra-ventral tegmental areas of adult Wistar rats that had experienced self-stimulation for 10 days revealed a significantly higher number of dendritic branching points in the two self-stimulation areas, and also in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91079-v
更新日期：1990-09-10 00:00:00
abstract：:Epidemiological studies have shown that steroidal as well as non-steroidal anti-inflammatory drugs lower the risk of developing Alzheimer's Disease (AD). A suppressive effect of these anti-inflammatory drugs on local inflammatory events in AD brains has been suggested, however the mechanisms responsible are still unkn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01204-3
更新日期：1997-11-28 00:00:00
abstract：:Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived inna...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.033
更新日期：2009-10-06 00:00:00
abstract：:Previous studies have demonstrated that postnatal (days 2-29 of life) administration of lead (200 mg/kg/day by gavage) to Long-Evans rats caused permanent increases in lithium-induced polydipsia (LIP). These lead-induced increases in LIP were apparently not of renal origin, did not occur in animals treated with lead a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90570-5
更新日期：1984-04-16 00:00:00
abstract：:Despite the significant advances that have been made in understanding the pathophysiology of cerebral ischemia on the cellular and molecular level, only one drug, the thrombolytic tissue plasminogen activator (rt-PA), is approved by the FDA for use in patients with acute ischemic stroke. Therefore, there is a critical...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.061
更新日期：2007-10-10 00:00:00
abstract：:The thalamic paraventricular nucleus (PVT) receives afferents from numerous brain areas, including the hypothalamic suprachiasmatic nucleus (SCN), considered to be the major circadian pacemaker. The PVT also sends projections to the SCN, limbic system centers and some nuclei involved in the control of the Sleep-Wake c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.09.017
更新日期：2008-11-19 00:00:00
abstract：:The role of the lateral parabrachial area (lPB) in the acquisition of a delayed taste aversion learning task (TAL) was examined by delivering the peripherally acting aversive compound, methylscopolamine (MSP), through two different routes, intraperitoneal and intraventricular. Consistent with previous anatomical, beha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02453-7
更新日期：2000-07-14 00:00:00
abstract：:Group-housed Sprague-Dawley (SD) rats exposed for 1 h to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT, a component of fox feces) did not display changes in hippocampal serotonin (5-HT) metabolism and [3H]5-HT reuptake, compared to water or butyric acid. Such an observation extended to isolated SD and Fischer 344 rats. W...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03944-6
更新日期：2003-01-24 00:00:00
abstract：:Some kinds of nociception appear to be partially mediated by the release of substance P (SP) in the spinal cord dorsal horn from terminals of primary afferent nociceptors. Only some nociceptors contain and release SP however. Specifically, SP appears to be released by unmyelinated (C) nociceptive afferents when activa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01466-7
更新日期：1997-03-28 00:00:00
abstract：:The regulation of corticotropin-releasing hormone (CRH) mRNA expression following maternal nutrient restriction was examined in the fetal hypothalamus. Pregnant guinea pigs were food restricted for 48 h or fed normally during late gestation. After nutrient restriction, CRH mRNA levels in the hypothalamic paraventricul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02089-3
更新日期：2001-03-30 00:00:00
abstract：:The triggering of ectopic action potentials (APs) at axon terminals in a chronic epileptic cobalt focus was investigated in thalamocortical (TC) neurons of rats under urethane anesthesia. TC cells which were in register with an active epileptic aggregate discharged bursts of 2-11 APs. According to the rules of the col...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90628-m
更新日期：1992-03-27 00:00:00
abstract：:The effects of neonatal dopamine depletion on activity levels and locomotor patterns were tested in rats at 4 months of age. Measurements were taken using an activity pattern monitor. The lesioned group was significantly hypoactive in comparison to the control animals during the initial exposures to the monitor. Exami...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91637-3
更新日期：1994-05-09 00:00:00
abstract：:Global forebrain ischemia of 5-min duration results in delayed neuronal death (DND) of CA1 neurons in the gerbil hippocampus. DND can be prevented by a preconditioning sublethal ischemic stimulus (2. 5 min), a phenomenon, known as ischemic tolerance induction. Striking evidence exists for the involvement of regulatory...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02503-8
更新日期：2000-07-28 00:00:00
abstract：:Wild red foxes, proverbially cunning carnivores, are investigated for adult hippocampal neurogenesis and morphological characteristics of the dentate gyrus. Adult red foxes harbor almost 15-times more young, doublecortin-positive neurons in their dentate gyrus than domesticated dogs. The number of doublecortin-positiv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.02.075
更新日期：2010-04-30 00:00:00
abstract：:Transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-beta 1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-beta 1 on neurite regeneration following a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00253-3
更新日期：1996-06-03 00:00:00
abstract：:Following cholinergic denervation of the hippocampus by medial septal lesions, and unusual neuronal reorganization occurs, in which peripheral sympathetic fibers, originating from the superior cervical ganglia, grow into the hippocampus. Previously, we have found that both hippocampal sympathetic ingrowth (HSI) and ch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00070-7
更新日期：1995-04-10 00:00:00
abstract：:Ferulic acid (FA) has an important effect on scavenging free radicals, which is related to the alleviation of various neurodegenerative diseases. However, there are few studies about its effects on vascular dementia. In this study, we demonstrated the effect of FA on oxidative damage of brain microvascular endothelial...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.04.006
更新日期：2017-07-01 00:00:00
abstract：:Coated vesicles within dentate gyrus granule cell dendrites were found free in the cytoplasm and also attached to the smooth endoplasmic reticulum and plasmalemma. Coated vesicles began increasing in number 40-48 h following partial dendritic deafferentation. This increase continued up to 15-30 days postlesion, after ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90076-7
更新日期：1981-04-27 00:00:00
abstract：:The presence of adrenocorticotropic hormone (ACTH)-immunoreactive cells and melanocortin (MC) receptors (MC4 and to a lesser extent MC3) has been demonstrated in the medullary reticular formation in the general area where rostral ventrolateral medullary pressor area (RVLM) is located. The importance of RVLM in the reg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.002
更新日期：2006-08-02 00:00:00
abstract：:Serotonin (5-HT), dopamine (DA) and noradrenaline (NE) play important roles in brain postnatal maturation. Therefore, deficits in brain availability of biogenic amines during critical developmental phases might underlie neurodevelopmental disturbances associated with cognitive impairment. To test this hypothesis we ev...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.006
更新日期：2008-06-27 00:00:00
abstract：:The dopamine transporter from rat caudate-putamen was photolabeled with [125I]DEEP as previously described. Treatment of photolabeled membranes with neuraminidase and N-glycanase reduced the molecular weight of the [125I]DEEP photolabeled dopamine transporter complex, whereas treatment with alpha-mannosidase had no ef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91627-d
更新日期：1991-01-25 00:00:00
abstract：:In alert cats, extracellular spikes of neurons in the medial pontine tegmentum were recorded simultaneously with whole nerve discharges of the abducens and medial rectus nerves during horizontal vestibular nystagmus. Nystagmus-related neurons were classified by their firing patterns in relation to the abrupt cessation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90941-0
更新日期：1981-10-05 00:00:00
abstract：:The regenerating optic nerve of goldfish first reestablishes a rough retinotopic map on the tectum, then goes through an activity dependent refinement that appears to involve the elimination of inappropriate branches from early regenerated arbors. Retinotopically appropriate branches and synapses may be stabilized bec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90886-4
更新日期：1988-04-19 00:00:00
abstract：:Cortical Spreading Depression (CSD) is a well-studied model of preconditioning that provides a high degree of tolerance to a subsequent ischemic event in the brain. The present study was undertaken in order to determine whether the release of ATP during CSD could contribute to the induction of ischemic tolerance. Dire...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.070
更新日期：2007-09-07 00:00:00
