Abstract：
:Ferulic acid (FA) has an important effect on scavenging free radicals, which is related to the alleviation of various neurodegenerative diseases. However, there are few studies about its effects on vascular dementia. In this study, we demonstrated the effect of FA on oxidative damage of brain microvascular endothelial cells (BMECs) which underwent oxygen-glucose deprivation (OGD) for 2h. Our data showed that FA significantly reversed the oxidative stress state of OGD-treated BMECs and reduced mitochondrial dysfunction. In further study, we found that FA upregulated the expression of LC3-II, a marker of autophagy. Besides, mitophagy was observed by transmission electron microscopy. The mechanism of FA inducing autophagy was found to be related to mitochondrial fission, according to the effects of siRNA and inhibitor of dynamin-related protein 1, which was responsible for fission. All above suggested that FA mitigated OGD-induced mitochondrial oxidative damage by punctate-mitochondria-dependent autophagy.
journal_name
Brain Resjournal_title
Brain researchauthors
Chen JL,Duan WJ,Luo S,Li S,Ma XH,Hou BN,Cheng SY,Fang SH,Wang Q,Huang SQ,Chen YBdoi
10.1016/j.brainres.2017.04.006subject
Has Abstractpub_date
2017-07-01 00:00:00pages
17-26eissn
0006-8993issn
1872-6240pii
S0006-8993(17)30169-5journal_volume
1666pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90244-7
更新日期：1987-09-08 00:00:00
abstract：:Effects of phenytoin (PHT) on the intracellular calcium and intracellular protein changes during pentylenetetrazole (PTZ)-induced bursting activity in the neurons of the Japanese land snail Euhadra peliomphala were examined. In the examination with a computer controlled electron probe X-ray microanalyzer, PHT clearly ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91510-0
更新日期：1985-02-18 00:00:00
abstract：:A disintegrin and metalloproteinase (ADAM) 12 represents a member of a large family of similarly structured multi-domain proteins. In the central nervous system (CNS), ADAM12 has been suggested to play a role in brain development, glioblastoma cell proliferation, and in experimental autoimmune encephalomyelitis. Furth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.02.049
更新日期：2010-04-22 00:00:00
abstract：:Synapses onto dendritic spines in the lateral amygdala formed by afferents from the auditory thalamus represent a site of plasticity in Pavlovian fear conditioning. Previous work has demonstrated that thalamic afferents synapse onto LA spines expressing glutamate receptor (GluR) subunits, but the GluR subunit distribu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.045
更新日期：2007-02-23 00:00:00
abstract：:Brain levels of tyrosine, dopamine (DA), noradrenaline (NA), tryptophan, 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) were measured after 30, 60 and 120 min of sustained seizure activity, induced in paralyzed, artificially ventilated and anaesthetized (70% N2O) rats by administration of bicucull...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90031-8
更新日期：1978-11-24 00:00:00
abstract：:A major mesolimbic projection towards the hippocampal formation (HF) has been extensively described, but no clear evidence of its dopaminergic content has been demonstrated. In order to evaluate the percentage of dopaminergic (DA) cells of ventral tegmental area (VTA-A10) and adjacent substantia nigra (SN-A9) projecti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90512-6
更新日期：1994-12-30 00:00:00
abstract：:Previously, we have shown that intracisternal (i.c.) administration of beta-endorphin suppresses brain and liver DNA synthesis in rat pups. This finding is consistent with the view that endogenous CNS beta-endorphin plays an important role in controlling postnatal growth. Recent evidence suggests that brain CCK8, the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91175-4
更新日期：1994-10-24 00:00:00
abstract：:The location of edema and territory of extravasation of serum protein were examined in the white matter of cats with different forms of intracranial pathology following an impact-acceleration injury to the head. Edema was tested with an organic density gradient and Evans blue dye was used as a marker for breakdown of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91611-7
更新日期：1985-06-24 00:00:00
abstract：:To examine the structural interactions between synaptically connected neurons in Aplysia, we have developed a method for simultaneously labeling two identified cell with different and compatible intraneuronal marking agents (horseradish peroxidase and [3H]N-acetyl-D-galactosamine) visible in both the light and electro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90621-8
更新日期：1979-09-14 00:00:00
abstract：:Iontophoretic injection of cAMP elicits a slow, transient inward current in identified buccal feeding motoneurons and in the giant cerebral interneuron of the snail, Lymnaea stagnalis. The current is voltage independent, and is abolished in the absence of extracellular Na+. Application of the phosphodiesterase inhibit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91330-3
更新日期：1988-01-12 00:00:00
abstract：:Glial cell line derived neurotrophic factor (GDNF) is a potent survival factor for several types of neurons. GDNF binds with high affinity to GDNF-family receptor alpha-1 (GFR alpha-1). This receptor is expressed in different areas of the brain, including the hippocampus and dentate gyrus. By using in situ hybridizati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02682-2
更新日期：2000-09-22 00:00:00
abstract：:The characteristics of synaptic transmission in whole embryonic avian sympathetic ganglia have been examined by intracellular recording. Neurons in lumbar paravertebral ganglia of chick embryos exhibit both fast nicotinic excitatory postsynaptic potentials (EPSPs) and non-cholinergic slow EPSPs. Fast nicotinic transmi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90073-2
更新日期：1985-09-01 00:00:00
abstract：:The localization of calcitonin gene-related peptide (CGRP)-like immunoreactive (CGRPI) structures in the cochlea was examined in the rat using immunocytochemistry. Numerous CGRPI fibers entered the organ of Corti in the intraganglionic spiral bundle and formed a dense fiber patch at the base of the inner hair cells. M...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90992-8
更新日期：1985-12-09 00:00:00
abstract：:Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) containing fibers and neurons within the hippocampal formation and entorhinal cortex of the new world monkey were determined using a direct histochemical procedure. Occasional intensely stained bipolar NADPH-d positive neurons were seen in the polymorphi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90924-z
更新日期：1990-05-21 00:00:00
abstract：:The control of hypoglossal motoneurons during sleep is important from a basic science perspective as well as to understand the bases for pharyngeal occlusion which results in the obstructive sleep apnea syndrome. In the present work, we used intracellular recording techniques to determine changes in membrane propertie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02955-3
更新日期：2000-12-08 00:00:00
abstract：:We examined protein kinase C gamma-like immunoreactivity (PKCgamma-LI) of trigeminothalamic neurons in the rat medullary dorsal horn (MDH) after injecting a retrograde tracer, Fluoro-Gold (FG), into the thalamus. Over 90% of FG-labeled neurons in the marginal layer (lamina I) and a few FG-labeled neurons in the superf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02777-9
更新日期：2001-09-21 00:00:00
abstract：:Nitric oxide (NO) is a putative neuronal messenger in the olfactory epithelium. We analysed the electrical responses of rat olfactory receptor neurones to NO stimulation in the whole-cell patch clamp mode and found that NO activates the cyclic nucleotide-gated conductance, independent from cyclic GMP. As NO may also o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02990-1
更新日期：2003-08-01 00:00:00
abstract：:Slow field potentials (SFP) lasting up to 5 s followed penicillin-induced bursts in CA3 of guinea pig hippocampal slices and accounted for most of the interburst interval. The longest lasting component of the SFP which was maximal in the distal apical dendritic region was usually absent in s. pyramidale. Potassium flu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90138-7
更新日期：1987-02-10 00:00:00
abstract：:Autism is marked by overgrowth of the brain at the earliest ages but not at older ages when decreases in structural volumes and neuron numbers are observed instead. This has led to the theory of age-specific anatomic abnormalities in autism. Here we report age-related changes in brain size in autistic and typical subj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.101
更新日期：2011-03-22 00:00:00
abstract：:Frequency-modulated (FM) sweeps are important components of most natural sounds. To examine the processing of these stimuli we applied a two-tone paradigm. Repeated stimulus presentation usually leads to reduced neuronal responses. However, in a former study repetition enhancements which have been observed when FM ton...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.009
更新日期：2011-09-09 00:00:00
abstract：:The distribution of avian pancreatic polypeptide (APP)-like immunoreactivity (APP-IR) in the chicken retina was investigated by means of immunohistochemistry. The observation from frozen sections showed that APP-IR is localized in the stratified amacrine cells of the first sublayer. Examination of whole-mounts reveale...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90022-2
更新日期：1984-09-17 00:00:00
abstract：:The axonal transport of radiolabeled slow phase proteins and fast phase glycoproteins was studied in rabbit hypoglossal nerve one week after axotomy. The nerves were ligated and cut to prevent axonal regeneration into the distal stump. In this situation of obstructed axonal outgrowth, the axonal transport of these com...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90953-2
更新日期：1982-10-28 00:00:00
abstract：:Following the administration of horseradish peroxidase (HRP) in the middle or lower cervical cord segments of neonatal (1-10 days), developing (15-20 days) and mature (2-4 months) albino rats, labeled pyramidal neurons were found in layer V of the cerebral cortex. They formed one continuous band of labeled neurons in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91327-6
更新日期：1983-04-11 00:00:00
abstract：:In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1β) together with nitric oxide (NO) and superoxide anion (O2(-)). Here we investigated the role of NO and O2(-) in the signaling mechanism by which IL-1β is induced in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.08.030
更新日期：2015-11-02 00:00:00
abstract：:Inducible cyclooxygenase 2 (COX 2) converts arachidonic acid to prostaglandins, which are thought to mediate various peripheral lipopolysaccharide (LPS)-induced central effects, including generation of fever and activation of the hypothalamic-pituitary-adrenal axis. To localize prostaglandin production in the brain fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00402-8
更新日期：1998-08-17 00:00:00
abstract：:There is emerging evidence that increased acetylcholine levels in brain reduce anxiety. More specifically there is evidence that some of these anxiolytic effects of acetylcholine are modulated by the hippocampus. In the present study we examined the roles of the cholinergic systems in the dorsal and ventral hippocampu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02965-7
更新日期：2002-09-13 00:00:00
abstract：:Histaminergic fibers in the mesencephalic nucleus of the trigeminal nerve of Long-Evans rats were examined by light and electron microscopy after peroxidase-antiperoxidase immunocytochemical staining for histidine decarboxylase (HDC) as a marker. By light microscopy, neurons in the mesencephalic nucleus of the trigemi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90109-0
更新日期：1987-08-25 00:00:00
abstract：:Serotonin (5-HT) produces both short- and long-term enhancement of generator potentials in identified type B-photoreceptors of Hermissenda. The actions of 5-HT have been shown to modulate both light- and voltage-dependent conductances. To further examine light-dependent processes we studied spontaneous and light-elici...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90969-t
更新日期：1993-11-19 00:00:00
abstract：:Drug addiction is characterized by persistent relapse vulnerability during abstinence. In abstinent drug users, relapse is often precipitated by re-exposure to environmental contexts that were previously associated with drug use. This clinical scenario is modeled in preclinical studies using the context-induced reinst...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.09.004
更新日期：2015-12-02 00:00:00
abstract：:Histaminergic neurons of the tuberomammillary nucleus (TMN) are hypothesized to promote wakefulness, but little is known about the activity of these cells during spontaneous behavior. We measured histaminergic neuron activity in the dorsomedial, ventrolateral, and caudal TMN at four different times using Fos and adeno...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.044
更新日期：2003-12-05 00:00:00
