Abstract：
:Histaminergic neurons of the tuberomammillary nucleus (TMN) are hypothesized to promote wakefulness, but little is known about the activity of these cells during spontaneous behavior. We measured histaminergic neuron activity in the dorsomedial, ventrolateral, and caudal TMN at four different times using Fos and adenosine deaminase immunohistochemistry and recordings of sleep/wake behavior. Because circadian factors could influence neuronal activity, we then assessed TMN neuron activity in predominantly sleeping or awake animals, all killed at the same time of day. In both experiments, Fos expression in histaminergic neurons of all three TMN subnuclei was higher during periods of wakefulness. These results demonstrate that histaminergic neurons throughout the TMN are wake-active, and this activity is largely independent of the time of day.
journal_name
Brain Resjournal_title
Brain researchauthors
Ko EM,Estabrooke IV,McCarthy M,Scammell TEdoi
10.1016/j.brainres.2003.08.044subject
Has Abstractpub_date
2003-12-05 00:00:00pages
220-6issue
2eissn
0006-8993issn
1872-6240pii
S0006899303036382journal_volume
992pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:We immunocytochemically examined the effect of chronic salt loading on the content of calretinin, a calcium-binding protein, in both the supraoptic nucleus and the magnocellular parts of the hypothalamic paraventricular nucleus. In control rats that were given water for drinking, the supraoptic nucleus contained a clu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00003-9
更新日期：1995-03-06 00:00:00
abstract：:Central administration of CRH results in endocrinological, cardiovascular, and behavioral effects that suggest stress or anxiety. Among these is a marked pressor response. Parenteral administration of CRH, however, results in hypotension. We used parenteral administration of antalarmin, a novel, small molecule CRH1 re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02742-6
更新日期：2000-10-27 00:00:00
abstract：:A systematic clinical neuroscience protocol is described for the use to examine the trigemino-cardiac reflex (TCR) response in humans. Target neurosurgical conditions are operations that require manipulations around the peripheral and central part of the trigeminal nerve and its branches, e.g. the cerebellopontine ang...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.08.060
更新日期：2007-05-29 00:00:00
abstract：:High (2.5-5 micrograms) doses of ventral tegmental morphine, which normally facilitate brain stimulation reward, were found to cause a complete cessation of bar pressing for brainstem stimulation in animals pretreated with systemic pimozide (0.175-0.35 mg/kg). It was hypothesized that the behavioral failure was due to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91402-9
更新日期：1989-01-16 00:00:00
abstract：:To evaluate roles of the sympathetic nervous system in enhancing glucose uptake in skeletal muscles in response to electrical stimulation of the ventromedial hypothalamic nucleus (VMH), the effects of guanethidine treatment and adrenal demedullation on the response were examined in rats anesthetized and injected with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91085-5
更新日期：1994-06-27 00:00:00
abstract：:The normal patterns of the occurrence of tryptophan, 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and monoamine oxidase (MAO) activity in chick brain during development were investigated. Tryptophan level in the brain on the 7th day of embryonic development was rather high and decreased gradually un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90183-3
更新日期：1975-08-15 00:00:00
abstract：:To investigate whether a task rule carried over from the preceding trial modifies an early portion of the stimulus-locked lateralized readiness potential (sLRP), participants were asked to perform two different flanker tasks that were switched. One task required a left-hand response for a central letter "H" in a five-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.050
更新日期：2010-07-30 00:00:00
abstract：:Bilirubin, a product of haemoglobin metabolism, has been suggested to damage neurons by increasing activation of N-methyl-D-aspartate (NMDA) receptors when it reaches high levels in the blood [15,19], as occurs in neonatal jaundice [7]. Bilirubin is also generated in the brain following synthesis of the messenger carb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02676-7
更新日期：2000-10-06 00:00:00
abstract：:The distribution of cortical neurons which project to the spinal cord was investigated in the developing and adult rat using the retrograde transport of horseradish peroxidase (HRP). Following injections of HRP into the cervical spinal cord of a postnatal day 4 rat, retrogradely labeled neurons are located in layer Vb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90161-5
更新日期：1984-04-01 00:00:00
abstract：:We report here that following partial spinal transections in adult lampreys, the fibers of the spinal cords can regenerate and restore some intersegmental coordination to the central pattern generator for locomotion, as tested in the isolated cord preparation. However, the regeneration by this test is not successful i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91090-1
更新日期：1989-09-04 00:00:00
abstract：BACKGROUND:Toll-like receptor 4 (TLR4) is an important mediator of the innate immune response. It significantly contributes to neuroinflammation and may be involved in ischemic tolerance. It is unknown how cerebral ischemia in the cortex and postconditioning might affect inflammatory reactions in the hippocampus or whe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.005
更新日期：2011-04-12 00:00:00
abstract：:Recent findings have shown that systemic morphine increases extracellular dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), ascorbic acid (AA) and uric acid concentrations in the striatum of freely moving rats. The morphine-induced increase in DA oxidative metabolism is highly correlated with...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00371-0
更新日期：1998-06-22 00:00:00
abstract：:[125I]CGP 42112, first developed to identify angiotensin II receptor subtype 2 (AT2), was recently shown to bind to a novel non-angiotensin binding site in injured rat brain tissue. We addressed the question whether non-angiotensin [125I]CGP 42112 binding appears after kainic acid induced hippocampal neurodegeneration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01035-3
更新日期：1995-12-08 00:00:00
abstract：:Experimental studies and clinical observations show that spinal cord lesions are greatly enlarged by a process called secondary cell death. A detailed understanding of the molecular and cellular processes underlying these events is still lacking. In clinical studies using methylprednisolone in spinal cord injured pati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01410-j
更新日期：1995-02-20 00:00:00
abstract：:The ketogenic diet (KD) is a non-pharmacological treatment for specific types of epilepsy. In addition, it has been shown to be effective in mitigating other neurologic disorders. The KD is also effective in reducing body mass, leading to an increase in use by the general population for weight loss. As the popularity ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146697
更新日期：2020-05-01 00:00:00
abstract：:The dopamine-releasing and depleting substance amphetamine (AMPH) can make cortical neurons susceptible to damage, and the prevention of hyperthermia, seizures and stroke is thought to block these effects. Here we report a 2-day AMPH treatment paradigm which affected only interneurons in three cortical regions with av...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03439-x
更新日期：2002-12-20 00:00:00
abstract：:Nitric oxide (NO) is a putative neuronal messenger in the olfactory epithelium. We analysed the electrical responses of rat olfactory receptor neurones to NO stimulation in the whole-cell patch clamp mode and found that NO activates the cyclic nucleotide-gated conductance, independent from cyclic GMP. As NO may also o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02990-1
更新日期：2003-08-01 00:00:00
abstract：:We have previously shown that prolonged preganglionic stimulation (e.g. 40 Hz 20 min) depletes the neurotensin (NT) store of preganglionic axon terminals in the stellate ganglion (SG) of the cat and that replenishment of the store requires several days. The present study investigates the mechanisms which control turno...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91865-1
更新日期：1994-03-21 00:00:00
abstract：:Iontophoresis of baclofen produced hyperpolarization and a decrease in input resistance in 32 neurons and no effect in 24 neurons of the ventral respiratory group in cats. Iontophoresed phaclofen antagonized the effect of baclofen, but had negligible effects on periodic fluctuations in membrane potential and spike act...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90832-8
更新日期：1993-09-17 00:00:00
abstract：:Binge-like ethanol treatment of septal neurons blunts GABAAR-mediated miniature postsynaptic currents (mPSCs), suggesting it arrests synaptic development. Ethanol may disrupt postsynaptic maturation by blunting feedback signaling through immature GABAARs. Here, the impact of ethanol on the sensitivity of mPSCs to zolp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.023
更新日期：2006-05-17 00:00:00
abstract：:Williams Syndrome (WS) is a neurodevelopment disorder associated with a hemizygous deletion on chromosome 7. WS is characterized with mental retardation, severe visual-spatial deficits, relative language preservation, and excellent facial recognition. Distinctive auditory features include musical ability, heightened s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.11.038
更新日期：2005-03-10 00:00:00
abstract：:Visual search is characterized as efficient (RT independent of distractor number) or inefficient (RT increasing with distractor number). Our goal was to determine if any brain regions are differentially activated by the attentional demands of these two search modes. We used fMRI to examine activation patterns during s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.07.004
更新日期：2012-09-26 00:00:00
abstract：:Spinal cord patterns of metabolic activity in a model of neuropathic pain were assessed in unanesthetized rats by the [14C]-2-deoxyglucose (2-DG) technique. Rats used in this procedure had demonstrable thermal hyperalgesia ipsilateral to sciatic nerve ligation and ipsilateral hindpaws that were lifted in a guarded pos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91468-g
更新日期：1991-11-15 00:00:00
abstract：:A positive association between cardiorespiratory fitness (CRF) and white matter integrity has been consistently reported in older adults. However, it is unknown whether this association exists in adults over 80 with a range of chronic disease conditions and low physical activity participation, which can influence both...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.003
更新日期：2014-11-07 00:00:00
abstract：:We quantified by microdensitometry the immunoreactivity (IR) to monoclonal antibodies (SP6, SP12, SP15 and SP18) against various synaptic proteins in the molecular layers of the dentate gyrus, CA4, CA3, CA1, subiculum and entorhinal cortex in Alzheimer's disease (AD), Lewy body variant of AD (LBV) and diffuse Lewy bod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91709-4
更新日期：1994-12-19 00:00:00
abstract：:Monoclonal antibody N210 (mabN210) recognizes the 210 kdalton neurofilament protein in mammals and gives characteristic immunocytochemical staining of neurofilament-rich processes. For example, in the cerebellum it recognizes myelinated axons and the calyx formed by basket cell axon collaterals. The distribution of ma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90937-6
更新日期：1986-07-23 00:00:00
abstract：:Kallikrein hydrolyzes various biologically active peptides, other than kininogens, such as vasoactive intestinal polypeptide (VIP), in vitro. Since kallikrein and VIP have been immunohistochemically shown to be present in the perivascular areas of the pineal gland, this study was designed to determine their topographi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00174-7
更新日期：1998-06-29 00:00:00
abstract：:In a previous study, we have demonstrated that an ovalbumin-like antigen is present within approximately one-half of all neurons of chicken spinal ganglia. The current study demonstrates this antigen co-localizes absolutely with neural intermediate filament protein (Peripherin) in small to medium-sized neurons of spin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90342-k
更新日期：1993-11-12 00:00:00
abstract：:When rat striatal membranes, photolabeled with [3H]dopamine under assay conditions similar to those used for dopamine-sensitive adenylate cyclase, were subjected to sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis, several radioactively labeled bands appeared. Labeling of these bands was reduced in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90426-1
更新日期：1981-12-28 00:00:00
abstract：:Hemicholinium-3 (HCh-3) is a potent and specific inhibitor of the high-affinity choline transport process (HAChT) localized on cholinergic neurons. In this study, the specific binding of [3H]HCh-3 (120 Ci/mmol) was characterized in crude synaptic membranes prepared from rat brain. The binding of [3H]HCh-3 to forebrain...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90451-2
更新日期：1985-12-02 00:00:00
