Abstract：
:High (2.5-5 micrograms) doses of ventral tegmental morphine, which normally facilitate brain stimulation reward, were found to cause a complete cessation of bar pressing for brainstem stimulation in animals pretreated with systemic pimozide (0.175-0.35 mg/kg). It was hypothesized that the behavioral failure was due to depolarization inactivation of the dopamine system. Electrophysiological evidence indicates that sufficient doses of morphine or neuroleptics can each cause inactivation by themselves. The behavior was reinstated by ventral tegmental muscimol, which normally suppresses both the behavior and dopamine cell firing but which reinstates dopamine cell firing in depolarization-inactivated cells. This behavioral reinstatement appears to confirm the hypothesis that depolarization inactivation of the dopamine system caused the behavioral failure, and appears to establish depolarization inactivation as a phenomenon of behavioral, and thus potential clinical, importance.
journal_name
Brain Resjournal_title
Brain researchauthors
Rompré PP,Wise RAdoi
10.1016/0006-8993(89)91402-9subject
Has Abstractpub_date
1989-01-16 00:00:00pages
152-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(89)91402-9journal_volume
477pub_type
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