Role of neuron soma firing in the restoration of neurotensin store in sympathetic preganglionic neuron terminals after stimulus-evoked depletion.


:We have previously shown that prolonged preganglionic stimulation (e.g. 40 Hz 20 min) depletes the neurotensin (NT) store of preganglionic axon terminals in the stellate ganglion (SG) of the cat and that replenishment of the store requires several days. The present study investigates the mechanisms which control turnover of the NT store in sympathetic preganglionic axon terminals. NT content of the SG and of the preganglionic axons which innervate it was determined by radioimmunoassay in the anesthetized cat. This study shows that, during the 24 h after 40-Hz 20-min stimulation of the preganglionic input to the SG, the rate of NT accumulation proximal to a ligature on the stimulated input is three times that observed in the control. The poststimulus increase in NT accumulation rate is prevented by treatment with protein-synthesis inhibitors. When the centripetal propagation of action potentials from the stimulus site on the preganglionic axons is prevented by a tetrodotoxin block applied locally during the stimulation period, the poststimulus increase in NT accumulation rate and the replenishment of the store are both prevented. These data suggest that the level of activity of the neuron regulates NT supply to the axon terminals, presumably by regulating NT synthesis. Thus, in the sympathetic preganglionic neuron, the action potential provides a mechanism for matching peptide synthesis to release.


Brain Res


Brain research


Maher E,Bachoo B,Polosa C




Has Abstract


1994-03-21 00:00:00














  • Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation.

    abstract::In many persons with temporal lobe epilepsy, dentate granule cells form an interconnected synaptic network. This recurrent mossy fiber circuit mediates reverberating excitation that may facilitate seizure propagation by synchronizing granule cell discharge. The involvement of specific glutamate receptors in granule ce...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Okazaki MM,Nadler JV

    更新日期:2001-10-05 00:00:00

  • Chronic exposure to alcohol during development alters the membrane properties of cerebellar Purkinje neurons in culture.

    abstract::The active and passive membrane properties of developing Purkinje neurons in control cultures and cultures chronically treated with 20 or 40 mM ethanol for 1 or 2 weeks were examined using whole-cell current-clamp techniques. The membrane properties were characterized by the features of the voltage responses evoked by...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gruol DL

    更新日期:1991-08-30 00:00:00

  • Chemical stimulation of the lateral hypothalamus induces antiallodynic and anti-thermal hyperalgesic effects in animal model of neuropathic pain: Involvement of orexin receptors in the spinal cord.

    abstract::To date several circuities in supraspinal site of the central nervous system have been known to engage in pain modulation. Lateral hypothalamus (LH) is known as part of the circuit of pain modulation among supraspinal sites. Its role in several animal pain models has been well defined. In this study, we examined the r...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Salehi S,Kashfi K,Manaheji H,Haghparast A

    更新日期:2020-04-01 00:00:00

  • Cardiovascular responses to gustatory and mechanical stimulation of the nasopharynx in rats.

    abstract::The effects of natural (mechanical and gustatory) stimulation of the nasopharynx or electrical stimulation of the pharyngeal branch of the glossopharyngeal (PH-IXth) nerve on the changes in heart rate (HR) and arterial blood pressure (BP) were investigated in paralyzed and anesthetized rats. Afferent responses in the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hanamori T,Ishiko N

    更新日期:1993-08-13 00:00:00

  • Cytosol androgen receptors in guinea pig brain and pituitary.

    abstract::Cytosol androgen receptors were assayed in guinea pig brain and pituitary tissues, using [3H]R1881 as ligand. These receptors had an apparent Kd of 0.04 nM and were androgen-specific (R1881 greater than dihydrotestosterone greater than testosterone = estradiol greater than progesterone). Concentrations of cytosol andr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bonneau M,Ahdieh HB,Thornton JE,Feder HH

    更新日期:1987-06-09 00:00:00

  • Localization of cholecystokinin receptors on neuronal elements in rat caudate nucleus.

    abstract::Various chemical and physical lesions were employed to elucidate the cellular localization of cholecystokinin (CCK) receptors in the rat caudate nucleus. A wide knife cut severing all caudal afferents reduced caudate CCK receptors by approximately 25%, indicating that some receptors lie on axons and (or) terminals of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hays SE,Meyer DK,Paul SM

    更新日期:1981-08-24 00:00:00

  • Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats.

    abstract::Two pathways that have been shown to mediate cerebral ischemic damage are the MEK/ERK cascade and the pro-apoptotic deltaPKC pathway. We investigated the relationship between these pathways in a rat model of focal ischemia by observing and modifying the activation state of each pathway. The ERK1/2 inhibitor, U0126, in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Castañeda D,Zhao H,Mochly-Rosen D,Steinberg GK

    更新日期:2009-01-28 00:00:00

  • Effects of injury discharge on the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat.

    abstract::We recently reported that peripheral nerve injury produced by sciatic nerve transection induces a persistent increase in the expression of the immunoreactive Fos protein product of the c-fos proto-oncogene, an indicator of neuronal activity, in the lumbar spinal cord of the rat and that local anesthetic blockade of th...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chi SI,Levine JD,Basbaum AI

    更新日期:1993-07-23 00:00:00

  • Kappa-bungarotoxin blocks an alpha-bungarotoxin-sensitive nicotinic receptor in the insect central nervous system.

    abstract::Snake venom kappa-neurotoxins are selective antagonists of nicotinic acetylcholine responses in avian, murine and bovine neurons, and have been used as probes for functionally defined vertebrate neuronal nicotinic receptors. The actions of kappa-bungarotoxin, a kappa-neurotoxin, have now been examined at a central inv...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pinnock RD,Lummis SC,Chiappinelli VA,Sattelle DB

    更新日期:1988-08-16 00:00:00

  • Increased secretion of somatostatin-28 from hypothalamic neurons of aged rats in vitro.

    abstract::The purpose of this experiment was to determine whether increased secretion of somatostatin or alterations in its molecular form contribute to the age-related decline in growth hormone secretion. Median eminences were removed from male Sprague-Dawley rats (3-4 and 21-24 months of age) and superfused with Krebs-Ringer ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sonntag WE,Gottschall PE,Meites J

    更新日期:1986-08-20 00:00:00

  • Monoamine metabolism during bicuculline-induced epileptic seizures in the rat.

    abstract::Brain levels of tyrosine, dopamine (DA), noradrenaline (NA), tryptophan, 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) were measured after 30, 60 and 120 min of sustained seizure activity, induced in paralyzed, artificially ventilated and anaesthetized (70% N2O) rats by administration of bicucull...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Calderini G,Carlsson A,Nordström CH

    更新日期:1978-11-24 00:00:00

  • Purkinje cell loss from alternating sagittal zones in the cerebellum of leaner mutant mice.

    abstract::The cerebellum and inferior olive of adult homozygous leaner mutant mice (tgIa/tgIa) were examined using anti-vitamin D-dependent calcium binding protein immunohistochemistry, and Nissl staining. The immunohistochemical staining revealed that cerebellar Purkinje cell loss in leaner is restricted to alternating saggita...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Heckroth JA,Abbott LC

    更新日期:1994-09-26 00:00:00

  • Neuroprotection of inositol hexaphosphate and changes of mitochondrion mediated apoptotic pathway and α-synuclein aggregation in 6-OHDA induced parkinson's disease cell model.

    abstract::Animal and cell experiments showed that inositol hexaphosphate (IP6) was protective on neurons in parkinson's disease (PD) model, but the underlying mechanism of this action was not extensively elucidated. To address this question, we established 6-hydroxydopamine (6-OHDA) induced human dopaminergic cell line SH-SY5Y ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhang Z,Hou L,Li X,Ju C,Zhang J,Li X,Wang X,Liu C,Lv Y,Wang Y

    更新日期:2016-02-15 00:00:00

  • Aging and neuropathic pain.

    abstract::Although chronic neuropathic pain disorders are more prevalent in the senescent population, little is known about how the aging process alters the thermal hyperalgesic sensitivity to peripheral nerve injury. In this study, neuropathic pain was induced in young, mature and aged FBNF1 hybrid rats via unilateral ligation...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Novak JC,Lovell JA,Stuesse SL,Cruce WL,McBurney DL,Crisp T

    更新日期:1999-07-03 00:00:00

  • Inhibition by taurine of the phosphorylation of specific synaptosomal proteins in the rat cortex: effects of taurine on the stimulation of calcium uptake in mitochondria and inhibition of phosphoinositide turnover.

    abstract::It has been previously observed that taurine inhibits PKC-activated phosphorylation of specific proteins including a approximately 20k Mr protein in rat cortical synaptosomes. In the present study, the mechanism of the above effects of taurine were investigated. In an intrasynaptosomal cytosol fraction obtained by sub...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Li YP,Lombardini JB

    更新日期:1991-07-05 00:00:00

  • Prolactin response to morphine in intact and adrenalectomized lactating rats.

    abstract::To examine the hypothesis that the increased adrenocortical activity during lactation induced the loss of the prolactin (PRL) -releasing effect of morphine, we studied the effect of morphine in adrenalectomized (ADX) and sham-operated primiparous lactating Wistar rats. Animals were adrenalectomized 4 days after delive...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kiem DT,Fekete MI,Bartha L,Nagy G,Makara GB

    更新日期:1991-11-01 00:00:00

  • Characterization of the binding of [3H]CGP54626 to GABAB receptors in the male bullfrog (Rana catesbeiana).

    abstract::Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the vertebrate brain. GABA activates both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors in mammals. Whether non-mammalian vertebrates possess receptors with similar characteristics is not well understood. We used a mammalian GABA(B)-...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Asay MJ,Boyd SK

    更新日期:2006-06-13 00:00:00

  • Effects of REM sleep deprivation on cholinergic receptor sensitivity and passive avoidance behavior in clomipramine model of depression.

    abstract::This study investigated the effects of REM (rapid eye movement) sleep deprivation (RSD) on the activity of central cholinergic receptors and passive avoidance retention in rats treated neonatally with clomipramine. Male rat pups treated with clomipramine (15 mg/kg, s.c.) twice daily from postnatal day 5 to 21 were sub...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Prathiba J,Kumar KB,Karanth KS

    更新日期:2000-06-09 00:00:00

  • Evidence against oppositional and pharmacokinetic mechanisms of tolerance to diazepam's sedative effects.

    abstract::Acute administration of diazepam (2 mg/kg i.p.) to rats decreased the number of head-dips, locomotor activity and the number of rears made in the holeboard apparatus, indicating sedative effects. After daily treatment for 7 days with diazepam (2 mg/kg) tolerance developed to all these behavioural effects, despite seru...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fernandes C,File SE,Berry D

    更新日期:1996-09-23 00:00:00

  • The influence of aging and hypertension on cerebral autoregulation.

    abstract::Cerebral autoregulation was tested here in 3- and 18-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) was measured in each rat using radioactive micropheres under unanesthetized control conditions and after hypotension induced by ganglionic blockade. Under cont...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hoffman WE,Albrecht RF,Miletich DJ

    更新日期:1981-06-09 00:00:00

  • The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression.

    abstract::Double-pulse stimulation of the perforant path input to the dentate gyrus was used in the following experiments to produce paired pulse depression in that site. This effect provided an estimate of GABA-mediated recurrent inhibition. The depression was enhanced by drugs that facilitate or mimic GABA action and attenuat...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tuff LP,Racine RJ,Adamec R

    更新日期:1983-10-24 00:00:00

  • Influence of anaesthetics on rat striatal dopamine metabolism in vivo.

    abstract::The effects of 4 anaesthetics, halothane, alpha-chloralose, chloral hydrate and pentobarbitone, on rat striatal extracellular dihydroxyphenylacetic acid (DOPAC) levels were determined using in vivo voltammetry. Stable baseline levels of DOPAC were maintained under halothane/N2O and alpha-chloralose while the extracell...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ford AP,Marsden CA

    更新日期:1986-07-30 00:00:00

  • Age-related changes in the neurosensory epithelium of the mouse vomeronasal organ: extended period of postnatal growth in size and evidence for rapid cell turnover in the adult.

    abstract::The total number of neurosensory cells in the mouse vomeronasal organ was estimated during postnatal development by counting the cell density and measuring the total volume of the neurosensory cell layer. There is a 43% increase in neurosensory cell number between 1 and 4 months of age, followed by a 21% fall in cell ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wilson KC,Raisman G

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  • Differential postnatal development of mu and delta opiate receptors.

    abstract::We found a differential postnatal development of mu and delta opiate receptors. Mu receptors labelled with low concentrations of [3H]naloxone appeared to develop earlier than did delta receptors labelled with [3H]D-Ala2-D-Leu5-enkephalin (0.5 nM). Competition binding studies also revealed a delayed appearance of delta...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wohltmann M,Roth BL,Coscia CJ

    更新日期:1982-04-01 00:00:00

  • Trigeminal influences on entopeduncular units.

    abstract::Because considerable work has implicated the basal ganglia in oral-ingestive behavior, an assessment was made of the effects of trigeminal stimuli upon entopeduncular single units. Units wre recorded extracellularly in awake, paralyzed and locally anesthetized cats. The effects of two types of sensory input were teste...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lidsky TI,Robinson JH,Denaro FJ,Weinhold PM

    更新日期:1978-02-10 00:00:00

  • Locomotor activity in the ischemic gerbil.

    abstract::Previous studies have shown that within 24 h after ischemic insult, gerbils exhibit an increase in locomotor activity. Because activity gradually diminishes to normal levels with repeated testing, it has been argued that this behavior represents a reversible or transient effect of ischemia. The present study challenge...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Babcock AM,Baker DA,Lovec R

    更新日期:1993-10-22 00:00:00

  • Experimental studies on the olfactory marker protein. I. Presence of the olfactory marker protein in tufted and mitral cells.

    abstract::Partial, unilateral olfactory nerve section was performed in mice, and the behavior of the olfactory marker protein (OMP) studied, after this experimental manipulation, with the peroxidase--antiperoxidase method. The protein, which in normal mice is present only in mature olfactory sensory neurons, after unilateral le...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Monti Graziadei GA,Graziadei PP

    更新日期:1981-03-30 00:00:00

  • Spinal neuronal collaterals to the intralaminar thalamic nuclei and periaqueductal gray.

    abstract::The existence of spinal neuron collaterals projecting to the intralaminar thalamic nuclei (ILN) and the periaqueductal gray (PAG) was determined in the rat using double-labeling, fluorescent, retrograde axoplasmic transport techniques. Distinctively double-labeled neurons, although not numerous, were found in the enti...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Liu RP

    更新日期:1986-02-12 00:00:00

  • REM sleep-suppressing effects of atropine in cats vary with environmental temperature.

    abstract::Because the occurrence of rapid eye movement (REM) sleep is critically dependent upon an animal's thermal balance, acute pharmacological treatments may effect REM sleep through effects on thermoregulation. We describe how manipulating ambient temperature (T(a)) alters the REM sleep-suppressing effects of systemically-...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Szymusiak R,Danowski J,McGinty D

    更新日期:1994-02-04 00:00:00

  • The role of nitric oxide in the neuropathology in soman intoxication.

    abstract::Intoxication with organophosphorus (0P) anticholinesterase agents such as soman triggers irreversible lesions in some cerebral areas. Administration of soman at the LD 50 leads to an increased activity of NADPH-diaphorase (= NO-synthase) in the cerebral endothelial cells from the 6th hour after poisoning. This activit...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bouchaud C,Chollat-Namy A,Duserre S,Delamanche IS

    更新日期:1994-10-17 00:00:00