Abstract:
:To examine the structural interactions between synaptically connected neurons in Aplysia, we have developed a method for simultaneously labeling two identified cell with different and compatible intraneuronal marking agents (horseradish peroxidase and [3H]N-acetyl-D-galactosamine) visible in both the light and electron microscopes. Combining these two agents within a single cell yields a third label.
journal_name
Brain Resjournal_title
Brain researchauthors
Thompson EB,Bailey CHdoi
10.1016/0006-8993(79)90621-8subject
Has Abstractpub_date
1979-09-14 00:00:00pages
201-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(79)90621-8journal_volume
173pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Cortical Spreading Depression (CSD) is a well-studied model of preconditioning that provides a high degree of tolerance to a subsequent ischemic event in the brain. The present study was undertaken in order to determine whether the release of ATP during CSD could contribute to the induction of ischemic tolerance. Dire...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.070
更新日期:2007-09-07 00:00:00
abstract::The goal of the present study was to identify the projection from the subdivisions of the amygdaloid nuclear complex to specified subregions of the dorsal raphe (DR) nucleus and to attempt to compare the density of amygdaloid input to the DR with that of inputs from other limbic structures. Use of a retrograde tracer,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.081
更新日期:2007-04-27 00:00:00
abstract::The development of symptomatic epilepsy is a model of long-term plasticity changes in the central nervous system. The rat pilocarpine model of epilepsy was utilized to study persistent alterations in calcium/calmodulin-dependent kinase II (CaM kinase II) activity associated with epileptogenesis. CaM kinase II-dependen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02623-8
更新日期:2000-09-01 00:00:00
abstract::The effect of aging on delta opioid receptors was examined in the brains of guinea pigs aged 1, 6, 24 and 36 months. Quantitative autoradiography was used to monitor the concentrations of delta receptors in various anatomical regions at five rostro-caudal levels. delta opioid receptor populations were found to be rema...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91021-j
更新日期:1993-06-18 00:00:00
abstract::The depolarizing photoreceptor potential in the molluscan extraocular photoreceptor, A-P-1, results from the light-induced suppression of specific K+ currents. An application of cGMP or IBMX (inhibitor of phosphodiesterase) to A-P-1-evoked light-suppressed currents, similar to the above specific K+ currents. Thus, the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90682-3
更新日期:1989-04-17 00:00:00
abstract::The effect of chronic administration of morphine to rats on the N-methyl-D-aspartate (NMDA) receptors labeled with [3H]MK-801, a non-competitive antagonist, was determined in brain regions and spinal cord. Male Sprague-Dawley rats were rendered tolerant to and physically dependent on morphine by subcutaneous implantat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91740-x
更新日期:1994-03-14 00:00:00
abstract::Dendrites were transected 100 microns from nerve cell somata. The probability of cell survival increased as a function of the extent of proximal segment retraction. The retraction effect is probably the result of increased resistance to calcium and sodium currents at the lesion. It is speculated that limitation of ner...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90526-9
更新日期:1987-11-10 00:00:00
abstract::Membrane properties of rat magnocellular neuroendocrine cells (MNCs) were examined during intracellular recordings in vivo. Current-clamp experiments revealed sustained outward rectification positive to -55 mV and transient outward rectification of depolarizing responses elicited from negative holding potentials. Trai...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90535-4
更新日期:1991-02-01 00:00:00
abstract::The myosin S-1 subfragment was used to label actin filaments in the developing rat brain. The results show actin filaments present throughout the dendritic region with highest concentrations within growth cones and regions of spine development. Between 6 and 25 days postnatal, spines became more complex and actin fila...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90253-1
更新日期:1986-06-01 00:00:00
abstract::The organization of the wing component of the dorsal column-medial lemniscal pathway, and somatosensory projections from the thalamus to the Wulst, are described for an oscine member of the major group of birds, the Passeriformes. Wing primary afferents terminate throughout the cervical spinal cord, but between the br...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00253-9
更新日期:1997-06-06 00:00:00
abstract::The influence of dopamine D1 receptor agonist, SKF 38393 has been studied in vitro in the model of low calcium spontaneous epileptiform discharges. Application of SKF 38393 (3 microM) to the perfusing medium evoked a decrease in neuronal firing rate of hippocampal CA1 neurons. The effect of SKF 38393 was blocked by pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90208-s
更新日期:1990-09-24 00:00:00
abstract::The changes in the excitability of lumbosacral spinothalamic neurons produced by activating afferents in the trigeminal nerve using electrical or mechanical stimuli was investigated in cats anesthetized with alpha-chloralose. In most spinothalamic neurons, weak electrical stimuli or step indentations of the skin of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90776-5
更新日期:1979-11-16 00:00:00
abstract::Postsynaptic effects of dimethylsulfoxide (DMSO) were studied at the frog cutaneous pectoris neuromuscular junction using electrophysiological techniques and computer assisted analysis. It was found that the average amplitude of extracellularly recorded miniature end-plate potentials (meppse) as well as the time const...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91719-h
更新日期:1991-12-06 00:00:00
abstract::The number of viable neurones calculated as soon as adult mollusc ganglia tissue was digested and over different periods of cultivation, show that elevated K+ prevents degradation of intercellular contacts, preserves neurones against lysis, prolongs the time course of neurone survival in culture and inhibits neurite f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90044-0
更新日期:1982-03-18 00:00:00
abstract::Spinal muscular atrophy is caused by deletions or mutations in the SMN1 gene that result in reduced expression of the SMN protein. The SMN protein is an essential molecular chaperone that is required for the biogenesis of multiple ribonucleoprotein (RNP) complexes including spliceosomal small nuclear RNPs (snRNPs). Re...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2018.02.022
更新日期:2018-08-15 00:00:00
abstract::In rats, True Blue (or Granular Blue) was injected into the hippocampus of one hemisphere and Nuclear Yellow into a homotopic site of the hippocampus of the contralateral hemisphere. Following restricted injections into the septal part of area dentata fluorescent neurons were found in hilus fasciae dentate on both sid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90463-7
更新日期:1981-05-18 00:00:00
abstract::Neovascularization within syngeneic rat fetal neocortical grafts transplanted into a previously prepared cavity in the cerebral cortex was studied 1 to 3 months after transplantation, utilizing scanning electron microscopy of vascular corrosion casts. The grafts were easily identified and the outer surface of the graf...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00304-9
更新日期:1995-05-29 00:00:00
abstract::Smoking is considered the leading cause of preventable death in the United States, but studies in animals suggest that nicotine is only weakly reinforcing. The maintenance of a dangerous habit by a weakly reinforcing agent has been the topic of some dispute. Using a two-lever "choice" self-administration procedure dev...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03215-2
更新日期:2002-01-04 00:00:00
abstract::Continuing from earlier work which demonstrated the peripheral axonal regulation of Schwann cell myelination, this study has investigated the possibility that a peripheral axon can stimulate oligodendrocyte myelination. To test this hypothesis, regenerating PNS axons were allowed to interact with uncommitted oligodend...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90289-0
更新日期:1979-02-23 00:00:00
abstract::Despite a blood-brain barrier for norepinephrine, the concentration of norepinephrine in plasma and cerebrospinal fluid has been observed to be similar. This relationship between plasma and cerebrospinal fluid norepinephrine levels suggest that peripheral sympathetic neurons innervating blood vessels to brain and spin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91600-8
更新日期:1986-03-05 00:00:00
abstract::The phonemic merger is a unique phenomenon which is referred to as acoustically very different phonemes are recognized as the same phoneme. In our previous study, we demonstrated that the merged speakers had lost the ability to discriminate the merged phonemes pre-attentively, as revealed by their failure in mismatch ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146848
更新日期:2020-08-01 00:00:00
abstract::We have investigated the receptor subtype(s) mediating the noradrenergic inhibition of cerebellar Purkinje cell spontaneous firing rate using local application of specific agonists and antagonists, in situ, via pressure microejection. Extracellular action potentials were recorded from Purkinje neurons in anesthetized ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90552-5
更新日期:1988-10-18 00:00:00
abstract::The levels of PLCgamma, a phospholipase C (PLC) isozyme, were higher in the cytosol fraction than in the membrane fraction in several control brain regions. The levels of PLCgamma were significantly elevated in the membrane, but not in the cytosolic fraction of the hippocampus of AD subjects. In the superior and middl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00935-4
更新日期:1998-11-16 00:00:00
abstract::Secretion of calcitonin gene-related peptide (CGRP) was studied with the model system of dispersed adult rat trigeminal ganglion cells. Veratridine stimulated secretion of CGRP immunoreactivity. Tetrodotoxin and local anesthetics inhibited veratridine-stimulated peptide secretion. These observations implicate sodium c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91441-1
更新日期:1986-08-13 00:00:00
abstract::Emerging evidence that autophagy serves as a sweeper for toxic materials in the brain gives us new insight into the pathophysiology of neurodegenerative diseases. Autophagy is important for maintaining cellular homeostasis associated with metabolism. Some neurodegenerative diseases such as Alzheimer׳s and Parkinson׳s ...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2016.02.049
更新日期:2016-10-15 00:00:00
abstract::The sites of action of lidocaine on the responses evoked by stimulation of lateral column (LC) and dorsal root (DR) were studied in the isolated, intra-arterially perfused spinal cord of the bullfrog. When the ventral root volley produced by stimulation was abolished by lidocaine, the presynaptic focal potential was a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90172-x
更新日期:1982-10-07 00:00:00
abstract::The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. The RAGE-ligand interaction has a putative role in a range of chronic disorders and is also known to contribute to both inflammatory/degenerative processes as well as regenerati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04149-5
更新日期:2003-03-21 00:00:00
abstract::Lateral ventricular injection of antibodies to dynorphin A(1-13) was previously shown to elevate lateral hypothalamic stimulation frequency threshold for eliciting feeding behavior. The antibodies utilized in that study cross-react completely with dynorphin A(1-17) and, to a lesser extent, dynorphin A(1-8). In the pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90284-i
更新日期:1990-01-22 00:00:00
abstract::Adult male guinea pigs were castrated and 24 h later injected with [3H]dihydrotestosterone. Their pituitary glands were then processed for autoradiographic and immunocytochemical analyses. Three percent of the parenchymal cells in the pars distalis were radiolabelled. These cells were primarily gonadotrophs; a small p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90456-7
更新日期:1986-01-08 00:00:00
abstract::Cerebellar granule neuronal cultures have been used to study the molecular mechanisms underlying neuronal functions, including neuronal morphogenesis. However, a limitation of this system is the difficulty to analyze isolated neurons because these are required to be maintained at a high density. Therefore, in the pres...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.09.046
更新日期:2013-11-20 00:00:00