Abstract：
:The regulation of corticotropin-releasing hormone (CRH) mRNA expression following maternal nutrient restriction was examined in the fetal hypothalamus. Pregnant guinea pigs were food restricted for 48 h or fed normally during late gestation. After nutrient restriction, CRH mRNA levels in the hypothalamic paraventricular nucleus of the fetus were determined using in situ hybridization and were found to be significantly decreased (P<0.0001) compared to controls. In conclusion, we have successfully sequenced the coding sequence of the guinea pig CRH gene, and have shown that a short period (48 h) of maternal nutrient restriction inhibits CRH mRNA expression in the fetal hypothalamus.
journal_name
Brain Resjournal_title
Brain researchauthors
Go KS,Lingas R,Wheeler MB,Irwin DM,Matthews SGdoi
10.1016/s0006-8993(01)02089-3subject
Has Abstractpub_date
2001-03-30 00:00:00pages
179-82issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(01)02089-3journal_volume
896pub_type
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