Abstract：
:Sheep with guide tubes implanted over the brain lateral ventricles, in order to facilitate episodic sampling of cerebrospinal fluid (CSF), were used to determine the effects of increasing cranial blood osmolality or electroconvulsive shock (ECS) on the permeability of the blood-brain barrier (BBB) to zinc. Zinc acetate solution (1 mg Zn/ml) was infused intravenously (i.v.) at 1.0 ml/min for 30 min and then continuously at 0.125 ml/min. This infusion increased plasma total zinc concentration (pZn) approximately 10-fold without altering CSF zinc concentration (CSFZn). After 1.5-3.5 h, 4 M NaCl was infused at 5-10 ml/min for 10 min into one carotid artery with the other carotid artery occluded, or the animals were anaesthetized and given an ECS (140 V, 2 s). Paired samples of blood and CSF were collected before and after these treatments. Results were: (i) CSFZn was approximately one tenth of pZn; (ii) zinc administered i.v. was almost completely excluded from the CSF; (iii) increased cranial blood osmolality or ECS increased CSFZn in all experiments, but the time course and extent of the rise were variable. CSFZn reached the concentrations of zinc in normal sheep plasma in some experiments; (iv) CSFZn subsequently fell towards the low values of zinc in normal CSF; (v) the animals suffered no evident ill-effects from either procedure. The procedures may, therefore, be used for reversible opening of the BBB to particles such as zinc in conscious or anaesthetized sheep with no troublesome sequelae.
journal_name
Brain Resjournal_title
Brain researchauthors
Blair-West JR,Denton DA,Gibson AP,McKinley MJdoi
10.1016/0006-8993(90)90513-bsubject
Has Abstractpub_date
1990-01-15 00:00:00pages
6-10issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)90513-Bjournal_volume
507pub_type
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