Abstract：
:The present study investigated the effect of dextromethorphan and 6,7-dinitroquinoxaline-2,3-dione (DNQX) pre-treatment on the development of cocaine- and lidocaine-induced seizures. The dopaminergic action of cocaine was also studied. The NMDA antagonist dextromethorphan and the non-NMDA (AMPA/kainate) antagonist DNQX both significantly decreased the intensity of the seizure response to intravenous convulsant doses of cocaine and lidocaine individually (20 mg/kg) and in combination (5 mg/kg each). The incidence of seizures in rats receiving cocaine or lidocaine individually was significantly reduced by pre-treatment with dextromethorphan but not DNQX. Haloperidol did not have an effect on the incidence or intensity of seizures induced by cocaine or lidocaine, alone or in combination. The results suggest that local anesthetic-induced convulsive seizures are mediated by excitatory glutamate transmission through both NMDA and non-NMDA receptor systems.
journal_name
Brain Resjournal_title
Brain researchauthors
Barat SA,Abdel-Rahman MSdoi
10.1016/s0006-8993(97)00147-9subject
Has Abstractpub_date
1997-05-09 00:00:00pages
179-83issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00147-9journal_volume
756pub_type
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