Apoptotic cascade of neurons in the subcortical sensory relay nuclei following the neonatal infraorbital nerve transection.

abstract：:The effects of norepinephrine (NE) on inhibitory synaptic potentials were studied on CA1 pyramidal neurons in the hippocampal slice in vitro. Norepinephrine caused the appearance of multiple population spikes in the CA1 region of the hippocampal slice, reminiscent of the actions of gamma-aminobutyric acid (GABA) antag...

journal_title：Brain research

authors： Madison DV,Nicoll RA

更新日期：1988-02-23 00:00:00

abstract：:Water deprivation caused daily urinary Na output to more than double in normal sheep, but caused no increase in Na excretion in sheep (A3VL-sheep) in which the anterior third ventricle wall had been ablated. Dehydrated A3VL-sheep exhibited a much greater degree of hypernatremia than dehydrated normal sheep, although w...

journal_title：Brain research

authors： McKinley MJ,Denton DA,Park RG,Weisinger RS

更新日期：1983-03-21 00:00:00

abstract：:Cerebral accumulation of amyloid beta protein (Abeta) is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Insulin degrading enzyme (IDE) is involved in Abeta degradation, therefore the gene encoding for insulin degrading enzyme is one of the candidate genes risky for AD. In Chinese Han ...

journal_title：Brain research

authors： Zuo X,Jia J

更新日期：2009-01-16 00:00:00

abstract：:The development of hypertension in spontaneously hypertensive rats (SHR) and hyperactive voiding in rats with urethral obstruction are characterized by abnormal smooth muscle growth, increased tissue levels of nerve growth factor (NGF) and altered patterns of innervation. The present study was undertaken to determine ...

journal_title：Brain research

authors： Spitsbergen JM,Clemow DB,McCarty R,Steers WD,Tuttle JB

更新日期：1998-04-20 00:00:00

abstract：:Male rats were dehydrated for 22 h and then given 4 h intracerebroventricular (i.c.v.) infusions which commenced 2 h prior to the beginning of a 2-h fluid access period. I.c.v. infusion of iso-osmotic 0.27 M mannitol-CSF more than halved the amount of water normally drunk by dehydrated rats during the fluid access per...

journal_title：Brain research

authors： Osborne PG,Denton DA,Weisinger RS

更新日期：1987-05-26 00:00:00

abstract：:Rat pinealocytes use L-glutamate as a modulator for melatonin synthesis. Upon binding of L-glutamate to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity and melatonin output. Although L-gluta...

journal_title：Brain research

authors： Ishio S,Yamada H,Craft CM,Moriyama Y

更新日期：1999-12-11 00:00:00

abstract：:Horseradish peroxidase (HRP, 30% solution, 0.1-0.3 mul, 72 h) was injected unilaterally into the basal striatum (STR) and the dorsal ventricular ridge (DVR) of adult turtles (Chrysemys picta) in order to demonstrate the cells of origin of some afferents to these telencephalic structures. After selective STR injection,...

journal_title：Brain research

authors： Parent A

更新日期：1976-05-21 00:00:00

abstract：:To provide evidence to support the calcium hypothesis of cerebral ischemia, we examined the effects of extracellular calcium and calcium antagonists (verapamil, flunarizine, nicardipine) on in vitro 'ischemia' using guinea pig hippocampal slices. As a model of in vivo ischemia we used a state of both glucose and oxyge...

journal_title：Brain research

authors： Amagasa M,Ogawa A,Yoshimoto T

更新日期：1990-08-27 00:00:00

abstract：:The hypothesis that inhibition of nitric oxide (NO) synthase with subsequent decrease in the production of NO might attenuate the development of kappa-opiate tolerance was examined. Concurrent treatment of NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA) (2-8 mg/kg, i.p.) along with U-50,488H (25 mg/kg, i.p.) ...

journal_title：Brain research

authors： Thorat SN,Reddy PL,Bhargava HN

更新日期：1993-09-03 00:00:00

abstract：:Hamsters exhibited a circadian variation in metabolic activity determined by [14C]2-deoxyglucose uptake in the suprachiasmatic nuclei, as has been previously reported for rats. The 13-line ground squirrel, a diurnal rodent, did not show a circadian variation in metabolic activity. The data are consistent with the hypo...

journal_title：Brain research

authors： Flood DG,Gibbs FP

更新日期：1982-01-28 00:00:00

abstract：:Scratching elicited by the intrathecal (i.t.) administration of substance P (SP) into the lumbosacral spinal cord of rats was not reduced by spinalization or i.t. pretreatment with the analgesic morphine. Spinalization also did not affect scratching elicited by i.t. kainic acid and potentiated scratching elicited by i...

journal_title：Brain research

authors： Bossut D,Frenk H,Mayer DJ

更新日期：1988-07-12 00:00:00

abstract：:We examined how adjective ordering is used in language comprehension by crossing order preference and concreteness in phrases consisting of two adjectives and a noun. We used both more typical phrases in which the preferred order has a concrete second adjective ("exhaustive hardback encyclopedia") and those with a con...

journal_title：Brain research

authors： Huang HW,Federmeier KD

更新日期：2012-09-26 00:00:00

abstract：:EEG recordings of hippocampal theta activity and neocortical activity were correlated with direct observations and photographic recordings of the behaviour of unrestrained cats. The behaviour studied included (1) both spontaneous and induced changes in level of arousal (sleep-wakefulness), (2) different types of orien...

journal_title：Brain research

authors： Kemp IR,Kaada BR

更新日期：1975-09-23 00:00:00

abstract：:The brainstem nucleus, locus coeruleus (LC), is the major, if not the sole, source of noradrenergic (NE) innervation of the telencephalon. It is generally held that LC neurons project diffusely to the entire neuroaxis and this had been the basis for theories that postulate 'general' functions (sleep, attention, learni...

journal_title：Brain research

authors： Shipley MT,Halloran FJ,de la Torre J

更新日期：1985-03-11 00:00:00

abstract：:Attempts were made to determine the cells of origin of the spinal projections to the PAG using retrograde axoplasmic transport techniques of HRP and fluorescent markers. Following injections limited to the lateroventral subnucleus of the PAG, labels were transported to the contralateral laminae I, III, V, VII and X pr...

journal_title：Brain research

authors： Liu RP

更新日期：1983-03-28 00:00:00

abstract：:Recently, much attention has focused on the role of the melanocortin system in the regulation of energy homeostasis, especially the satiety effects of the pro-opiomelanocortin (POMC)-derived peptide alpha-melanocyte stimulating hormone (alpha-MSH). We have found that POMC mRNA levels are similar in fat and thin sheep ...

journal_title：Brain research

authors： Henry BA,Rao A,Ikenasio BA,Mountjoy KG,Tilbrook AJ,Clarke IJ

更新日期：2001-11-09 00:00:00

abstract：:An electrophysiological approach has been used to trace the central course of individual C fibres from a cutaneous (sural) and muscle (gastrocnemius) nerve in anaesthetized rats. Single C fibres were recorded from the central part of cut peripheral nerves and a glass micropipette used to map the spinal cord with low t...

journal_title：Brain research

authors： McMahon SB,Wall PD

更新日期：1985-12-16 00:00:00

abstract：:Surgical tissue samples of the human dentate gyrus were immunostained for glutamate decarboxylase (GAD), the gamma-aminobutyric acid (GABA)-synthesizing enzyme, and studied by both light and electron microscopy. Immunoreactive neurons and terminals displayed similar morphological characteristics as known from studies ...

journal_title：Brain research

authors： Schlander M,Thomalske G,Frotscher M

更新日期：1987-01-13 00:00:00

abstract：:Quantal analysis of transmitter release is useful in examining presynaptic mechanisms involved in synaptic transmission. However, in central neurons, the presence of multiple synapses makes it difficult to use the traditional quantal analysis, developed for the neuromuscular transmission. We developed a method to mini...

journal_title：Brain research

authors： Singh G,Xu JY,Sastry BR

更新日期：2008-05-01 00:00:00

abstract：:Brain oscillations provide a rich source of potentially useful endophenotypes (intermediate phenotypes) for psychiatric genetics, as they represent important correlates of human information processing and are associated with fundamental processes from perception to cognition. These oscillations are highly heritable, a...

journal_title：Brain research

authors： Rangaswamy M,Porjesz B

更新日期：2008-10-15 00:00:00

abstract：:Opiates modulate pain perception at a number of different levels within the central nervous system and the importance of synergistic spinal and supraspinal influences have been well documented. In the present study we demonstrate synergistic interactions between the periaqueductal gray and locus coeruleus. Administere...

journal_title：Brain research

authors： Bodnar R,Paul D,Pasternak GW

更新日期：1991-09-06 00:00:00

abstract：:In the framework of a series of investigations concerning the neural substrate of aversion, electrophysiological methods were used in order to specify, within the rat's periaqueductal gray (PAG), functional properties, viz. conduction velocity and refractory period, of PAG neurons already assessed in previous studies ...

journal_title：Brain research

authors： Sandner G,Schmitt P,Karli P

更新日期：1986-10-29 00:00:00

abstract：:Noradrenaline effects on oxidative metabolism (tricarboxylic acid cycle activity) were examined by measuring the formation of 14CO2 from labeled aspartate in primary cultures of cerebral astrocytes and neurons and of cerebellar granule cells. At all time periods studied, CO2 formation in astrocytes was significantly i...

journal_title：Brain research

authors： Subbarao KV,Hertz L

更新日期：1990-09-17 00:00:00

abstract：:The highly rigid and conformationally extended 2-amino-4-phosphonobutanoic acid (AP4) analogue (RS)-1-amino-3-(phosphonomethylene)-cyclobutane-1-carboxylic acid (cyclobutylene AP5) was synthesized and found to inhibit evoked responses in the rat lateral perforant path (LPP) with an IC50 of 41 (+/- 1.5 S.E.M.) microM a...

journal_title：Brain research

authors： Peterson NL,Kroona HB,Johnson RL,Koerner JF

更新日期：1992-01-31 00:00:00

abstract：:Previous reports from this laboratory have indicated that fetal rat striatal grafts have the major types of neuronal and glial components known to be involved in Huntington's chorea. In this study a number of major afferent and efferent innervations seen in normal striatum were examined in the striatal grafts and were...

journal_title：Brain research

authors： Zhou FC,Buchwald N

更新日期：1989-12-11 00:00:00

abstract：:Recently it was reported that there is an increase in monoamine oxidase B (MAO-B) activity in post-mortem brains of patients with Alzheimer's disease. It was postulated that this increase in MAO-B activity was due to gliosis associated with neuronal degeneration. The aim of the present investigation was to evaluate th...

journal_title：Brain research

authors： Jossan SS,Hiraga Y,Oreland L

更新日期：1989-01-09 00:00:00

abstract：:Previous reports of the distribution of calbindin, a 28 kDa vitamin D-induced calcium-binding protein, in the mammalian peripheral vestibular system postulated that this protein was involved in the calcium-dependent mechanisms occurring in the hair cells and ganglion cells. In this study, we examined the possibility o...

journal_title：Brain research

authors： Dechesne CJ,Thomasset M

更新日期：1988-05-16 00:00:00

abstract：:The existence of multiple brain melanocortin receptor types has been postulated, based on the complex pharmacology of intracerebrally administered melanocortin (melanocyte-stimulating hormone-related) peptides. In this study, this hypothesis was tested by determining whether different brain melanocortin receptor popul...

journal_title：Brain research

authors： Tatro JB,Entwistle ML

更新日期：1994-01-28 00:00:00

abstract：:α-Synuclein (α-syn) and oxidative stress play pivotal roles in the pathogenesis of Parkinson's disease (PD). However, the mechanisms underlying the interaction between α-syn and oxidative stress remain poorly understood. The present study provides evidence to suggest that the nuclear translocation of α-syn increases d...

journal_title：Brain research

authors： Zhou M,Xu S,Mi J,Uéda K,Chan P

更新日期：2013-03-15 00:00:00

abstract：:While adult mice receiving picrotoxin (PTX) alone responded with clonic and tonic-clonic seizures, this response was greatly suppressed for mice simultaneously injected with 2,3-butanedione monoxime (BDM). For example, 60% and 10% of the mice convulsed when injected (i.p.) with 3.0 mg/kg PTX alone or PTX plus 205 mg/k...

journal_title：Brain research

authors： Brightman T,Ye JH,Ortiz-Jimenez E,Flynn EJ,Wu WH,McArdle JJ

更新日期：1995-04-24 00:00:00