Abstract:
:Noradrenaline effects on oxidative metabolism (tricarboxylic acid cycle activity) were examined by measuring the formation of 14CO2 from labeled aspartate in primary cultures of cerebral astrocytes and neurons and of cerebellar granule cells. At all time periods studied, CO2 formation in astrocytes was significantly increased in the presence of noradrenaline. The EC50 value was calculated to be 5 x 10(-7) M. No corresponding stimulation of CO2 production in cerebellar or cortical neurons was observed, suggesting that the stimulation of energy metabolism by noradrenaline in vivo may be confined to astrocytes.
journal_name
Brain Resjournal_title
Brain researchauthors
Subbarao KV,Hertz Ldoi
10.1016/0006-8993(90)91157-csubject
Has Abstractpub_date
1990-09-17 00:00:00pages
346-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(90)91157-Cjournal_volume
527pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Neurophysiological responses were recorded in individual fibers of the lingual and chorda tympani nerves and in single cortical neurons in the rat in response to a battery of tactile, thermal and chemical stimuli applied to the oral cavity. Two categories of thermally sensitive units were identified. Chorda tympani fi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90458-n
更新日期:1990-04-16 00:00:00
abstract::The ventral tegmental area has been suggested as a possible site of action for the rewarding effect of opiates on the basis of the fact that local morphine injections in this but not other regions are rewarding. That this is a necessary and not just a sufficient site of opiate rewarding action was suggested by the fac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91232-5
更新日期:1983-01-03 00:00:00
abstract::We investigated the responses of putative aortic baroreceptor neurons to mechanical stimulation of their processes. Putative aortic baroreceptor neurons were identified by applying the carbocyanine dye DiI to the adventitia of the aortic arch of anesthetized rats. After at least 1 week, the nodose ganglia were removed...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00153-4
更新日期:1997-05-16 00:00:00
abstract::The expression of adenylyl cyclase (AC) isoforms in the adult rat vestibular periphery was investigated using reverse transcription polymerase chain reaction (RT-PCR). AC II, IV and V mRNAs were expressed in both Scarpa's ganglion and vestibular end organs. In addition, in the vestibular end organs, an AC mRNA not pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02007-2
更新日期:2000-03-24 00:00:00
abstract::(1) Input conductances of giant interneurons in the isolated spinal cord of lampreys were measured with two separate intracellular electrodes. Bath applications of 0.4--3 mM beta-alanine and taurine produced large, reversible conductance increases which were Cl-dependent. (2) Strychnine at 1--2.5 microM might be a com...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90628-0
更新日期:1979-09-14 00:00:00
abstract::The morphological features and distribution of luteinizing hormone-releasing hormone (LHRH)-immunoreactive cell bodies and fibers of the hypothalamic and the neighboring mesencephalic regions were studied in the normal newborn infant by immunohistochemistry. Within the hypothalamus, numerous LHRH-immunoreactive like (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90929-6
更新日期:1990-05-21 00:00:00
abstract::Central catecholaminergic nerves have been shown to participate in the integration of cardio-cardiac reflexes induced by coronary artery ligation in the rat. In this study we measured the turnover of dopamine, norepinephrine and epinephrine in microdissected brain regions to identify some of the specific neural loci i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)91010-1
更新日期:1982-03-11 00:00:00
abstract::Retinal afferents to the dorsal raphe nucleus (DRN) have been described in a number of species, including Mongolian gerbils, but functional correlates of this optic pathway are unknown at present. To determine whether temporally modulated photostimulation can affect c-Fos expression in the gerbil DRN, quantitative ana...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.10.054
更新日期:2005-01-21 00:00:00
abstract::The omega-3 fatty acids are essential dietary nutrients and one of their important roles is providing the fatty acid with 22 carbons and 6 double bonds known as docosahexaenoic acid (DHA) for nervous tissue growth and function. Inadequate intakes of omega-3 fatty acids decrease DHA and increase omega-6 fatty acids in ...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2008.08.078
更新日期:2008-10-27 00:00:00
abstract::Visually identified and electrophysiologically characterized sympathetic preganglionic neurons (SPNs) were recorded using the whole-cell voltage clamp technique in slices of neonatal rat spinal cord. Monosynaptic excitatory postsynaptic currents (EPSCs) were evoked by electrical stimulation of the nucleus intercalatus...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01549-7
更新日期:1998-04-20 00:00:00
abstract::The effects of selective dopamine (DA) depleting lesions with 6-hydroxydopamine microinjection into the SN, CPu, and NAS, as well as radiofrequency lesions of the CPu on the performance characteristics of rats trained on a single-valued 20-s peak-interval (PI) timing procedure or a double-valued 10-s and 60-s PI proce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.06.031
更新日期:2006-09-13 00:00:00
abstract::The effects of duloxetine were examined on cloned Kv4.3 channels stably expressed in CHO cells using the whole-cell patch-clamp technique. Duloxetine decreased the peak amplitude of Kv4.3 currents with an acceleration of the decay rate of current inactivation in a concentration-dependent manner. The IC(50) values requ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.05.028
更新日期:2012-07-23 00:00:00
abstract::Chromatography of partially purified choline acetyltransferase (CAT) over carboxymethyl cellulose may result in the loss of up to 95% of the enzyme activity. This loss of activity can be prevented by running the chromatographs at low protein concentration with a large gradient volume suggesting that interactions betwe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90552-8
更新日期:1983-10-03 00:00:00
abstract::The acute stroke phase is a critical time frame used to evaluate stroke severity, therapeutic options, and prognosis while also serving as a major tool for the development of diagnostics. To further understand stroke pathophysiology and to enhance the development of treatments, our group developed a translational pig ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146778
更新日期:2020-06-01 00:00:00
abstract::Synapses from Mauthner to giant fibers in the hatchetfish are chemically transmitting excitatory axo-axonic synapses located in the medulla. The synapses are 4--10 mum in diameter and easily identified for electron microscopy. Presynaptic vesicles are clustered near the contact regions and are round, clear and 40-60 n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90002-5
更新日期:1975-11-14 00:00:00
abstract::In this study we used two lines of transgenic mice overexpressing tumor necrosis factor alpha (TNF-alpha) in the central nervous system (CNS), one characterized by reactive gliosis, inflammatory demyelination and neurological deficits (Tg6074) the other showing no neurological or phenotypical alterations (TgK3) to inv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01748-5
更新日期:1999-09-04 00:00:00
abstract::The central nervous system (CNS) in adult mammals loses the ability to regenerate after injury. Although electrical stimulation (ES) has been shown to promote neural regeneration, the underlying mechanisms by which ES enhances CNS regeneration remain elusive. The aim of the present study was to investigate the effect ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.08.041
更新日期:2012-10-22 00:00:00
abstract::Previously, we have shown that intracisternal (i.c.) administration of beta-endorphin suppresses brain and liver DNA synthesis in rat pups. This finding is consistent with the view that endogenous CNS beta-endorphin plays an important role in controlling postnatal growth. Recent evidence suggests that brain CCK8, the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91175-4
更新日期:1994-10-24 00:00:00
abstract::In the present study, we investigated the possibility that MK-801 (dizocilpine), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, owes its potent neuroprotective properties to calcium channel blocking ability rather than to its NMDA receptor antagonism. Rat hippocampal slices were exposed to a long hy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00466-4
更新日期:1995-07-03 00:00:00
abstract::The brain cholinergic system may undergo structural and functional alterations both in human epilepsy and in respective animal models, but the causal relationships between these alterations and epilepsy remain to be established. In this study, we attempted to examine how the inhibition of epilepsy-related cholinergic ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.04.027
更新日期:2019-08-15 00:00:00
abstract::Carbonic anhydrase (CA) and cholinesterase (CE) histochemical staining of rabbit spinal nerve roots and dorsal root ganglia demonstrated that among the reactive myelinated axons, with minor exceptions, sensory axons were CA positive and CE negative whereas motor axons were CA negative and CE positive. The high specifi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90145-x
更新日期:1988-06-21 00:00:00
abstract::The [14C]2-deoxyglucose (2-DG) technique has been widely utilized for quantitative measurement of local cerebral metabolic for glucose (1CMRG) in animals. The technique as presently used is limited by the energy of 14C beta-particles, which can travel relatively great distances in tissue. This results in limited audio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90806-4
更新日期:1981-10-26 00:00:00
abstract::In several rodent species social play appears to be necessary for proper deployment of species-specific patterns of aggressive and reproductive behavior. Specifically, in male Syrian hamsters (Mesocricetus auratus), play has been linked to the development of adult aggression. We quantified several types of social play...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.02.012
更新日期:2019-06-01 00:00:00
abstract::The activity of neurons identified as or similar to spinothalamic tract cells was compared in anesthetized, intact monkeys and in unanesthetized, decerebrate or spinalized animals. Background activity and responses to A- and C-fiber volleys were smaller in decerebrate than in the other preparations, suggesting the pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90454-2
更新日期:1984-07-30 00:00:00
abstract::The effects of alpha-bungarotoxin from Bungarus multicinctus and Bungarus caeruleus were studied on three types of cholinergic response in Aplysia central neurones. These responses are the result of three distinct changes in ionic permeability: selective increases in permeabiliyt to Na, Cl and K, respectively. It was ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90142-6
更新日期:1976-05-14 00:00:00
abstract::In previous studies on Alzheimer's patients it was shown that, in frontal and parietal locations, delta and theta responses of AD patients were greatly reduced. The present study analyzed coherence functions in these highly affected frontal and parietal areas. Visual sensory and event related coherences of patients wi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.08.054
更新日期:2010-10-21 00:00:00
abstract::Dynorphin and other kappa opioid agonists are thought to elicit aversive actions and changes in motor activity through direct or indirect modulation of dopamine neurons in ventral tegmental area (VTA) and substantia nigra (SN), respectively. We comparatively examined the immunoperoxidase localization of anti-dynorphin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90693-h
更新日期:1993-02-05 00:00:00
abstract::Application of the cholinergic agonist, carbachol, produced theta-like rhythmical waveforms, recorded in the stratum moleculare of the dentate gyrus in the cat hippocampal formation slices. This effect of carbachol was antagonized by atropine but not D-tubocurarine. These results provide first direct evidence that the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90223-v
更新日期:1992-04-24 00:00:00
abstract::It was previously proposed that norepinephrine (NE)-containing nerve terminals in visual cortex are important for the maintenance of cortical plasticity. Observations at that time indicated that local microperfusion of exogenous NE for 1 week directly into kitten visual cortex, with no alteration of the visual environ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91288-5
更新日期:1984-06-04 00:00:00
abstract::Ingestion of 3, 4-methylenedioxymethamphetamine (MDMA) leads to heightened response to sensory stimulation; thus, MDMA is referred to as "ecstasy" because it produces pleasurable enhancement of such sensation. There have been no electrophysiological studies that report the consequences of MDMA on sensory input. The pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.09.048
更新日期:2009-12-11 00:00:00