Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease.


:Cerebral accumulation of amyloid beta protein (Abeta) is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Insulin degrading enzyme (IDE) is involved in Abeta degradation, therefore the gene encoding for insulin degrading enzyme is one of the candidate genes risky for AD. In Chinese Han populations we found three polymorphisms in IDE promoter: -1002T/G (rs3758505), -179T/C (rs4646953) and -51C/T (rs4646954). The -1002T and -51C alleles were over-represented in 357 sporadic AD (SAD) patients when compared to those in 331 healthy individuals. Furthermore, -1002T/G and -51C/T were in strong linkage disequilibrium and they constructed a relatively risky -1002T/-51C and a relatively protective -1002G/-51T. Luciferase reporter assay indicated -1002T/-51C had lower transcriptional activity than -1002G/-51T. A more marked increase in -1002T/-51C transcriptional activity was seen when under Abeta(25-35) and serum deprivation treatment. The present study provides evidence that IDE promoter polymorphisms that significantly decrease IDE expression levels are associated with development of SAD.


Brain Res


Brain research


Zuo X,Jia J




Has Abstract


2009-01-16 00:00:00












  • Dopamine and salsolinol levels in rat hypothalami and striatum after schedule-induced self-injection (SISI) of ethanol and acetaldehyde.

    abstract::Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS)--selected ion monitoring technique using deuterated internal standards in rats allowed to self-inject either acetaldehyde, ethanol or saline control solution over 20 days for 1 h/day. Significant increases in m...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Myers WD,Ng KT,Singer G,Smythe GA,Duncan MW

    更新日期:1985-12-09 00:00:00

  • The effect of chronic treatment with a novel aryl-piperazine antipsychotic on monoamine receptors in rat brain.

    abstract::The effects of chronic treatment of rats with RWJ 37796, a novel aryl-piperazine containing antipsychotic drug, on brain monoamine receptors were studied. Rats were treated daily with RWJ 37796 (1.3 mg/kg), the typical antipsychotic haloperidol (1 mg/kg) or vehicle (control) for 21 days, and were sacrificed 3 days aft...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shapiro LA,Offord SJ,Ordway GA

    更新日期:1995-04-24 00:00:00

  • Neuroprotection and immunomodulation in the gut of parkinsonian mice with a plasmalogen precursor.

    abstract::Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It is typically associated with motor symptoms originating from the degeneration of nigrostriatal dopamine (DA) neurons. Early stages of PD have been associated with an alteration in DA production in intestinal DAergic neurons alon...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nadeau J,Smith T,Lamontagne-Proulx J,Bourque M,Al Sweidi S,Jayasinghe D,Ritchie S,Di Paolo T,Soulet D

    更新日期:2019-12-15 00:00:00

  • Cortical auditory neuron interactions during presentation of 3-tone sequences: effective connectivity.

    abstract::The role of cat's primary auditory cortex (AI) in both pattern discrimination and sound localization has been demonstrated by observing that ablations of it disrupt these functions. This research studied effective connectivity variations as a function of modifications in the temporal pattern of acoustic stimulation. R...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Espinosa IE,Gerstein GL

    更新日期:1988-05-31 00:00:00

  • Molarless-induced changes of spines in hippocampal region of SAMP8 mice.

    abstract::We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced lea...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kubo KY,Iwaku F,Watanabe K,Fujita M,Onozuka M

    更新日期:2005-09-28 00:00:00

  • Induction of microtubule-associated protein 1B expression in Schwann cells during nerve regeneration.

    abstract::Microtubule-associated protein 1B (MAP1B) is expressed at high levels during development of the nervous system and is localized primarily in neurons while specific phosphorylated isoforms of MAP1B are localized exclusively in growing axons. The levels of MAP1B are down regulated in most regions of the adult CNS, but r...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ma D,Chow S,Obrocka M,Connors T,Fischer I

    更新日期:1999-03-27 00:00:00

  • Developmental changes in taste responses from glossopharyngeal nerve in sheep and comparisons with chorda tympani responses.

    abstract::To learn whether there are developmental changes in salt and acid taste responses from the posterior tongue, we recorded from the glossopharyngeal nerve, which innervates taste buds in circumvallate papillae, in sheep fetuses, lambs and adults. Multifiber responses to NH4Cl, KCl, NaCl, LiCl, citric and hydrochloric ac...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mistretta CM,Bradley RM

    更新日期:1983-12-01 00:00:00

  • Brain blood flow and extracerebral carotid circulation during sleep in rat.

    abstract::Cerebral blood flow (CBF) and blood flow (BF) in extracerebral head structures were measured during the sleep-wake cycle in rats using radioactive microspheres. While no statistically significant changes occurred in the transition from Waking to quiet sleep (also referred to as synchronized or non-REM Sleep), CBF incr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zoccoli G,Bach V,Cianci T,Lenzi P,Franzini C

    更新日期:1994-03-28 00:00:00

  • Alpha 1-adrenergic agonists act on the ventromedial hypothalamus to cause neuronal excitation and lordosis facilitation: electrophysiological and behavioral evidence.

    abstract::To see if activation of central alpha 1-adrenergic receptors can cause facilitation of lordosis in rats, the behavioral effects of centrally administered alpha 1-agonists, methoxamine (MA) and phenylephrine (PhE), and related agents were studied. In ovariectomized rats treated with estrogen, infusion of MA, PhE, or a ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kow LM,Weesner GD,Pfaff DW

    更新日期:1992-08-21 00:00:00

  • Challenging the brain: Exploring the link between effort and cortical activation.

    abstract::To better understand the contributions of effort on cortical activation associated with motor tasks, healthy participants with varying capacities for isolating the control of individual finger movements performed tasks consisting of a single concurrent abduction of all digits (Easy) and paired finger abduction with di...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mochizuki G,Hoque T,Mraz R,Macintosh BJ,Graham SJ,Black SE,Staines WR,McIlroy WE

    更新日期:2009-12-08 00:00:00

  • Visual stimulation reduces EEG activity in man.

    abstract::Data are presented which show that background electric activity of the human brain is reduced by visual stimulation. Occipital EEG amplitude decreases 5-15% for all frequencies analyzed (0.2-40 Hz) upon pattern stimulation. The reduction is stimulus-specific, i.e. is the strongest for stimuli that activate a large num...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vijn PC,van Dijk BW,Spekreijse H

    更新日期:1991-05-31 00:00:00

  • Antibodies to ependymin block the sharpening of the regenerating retinotectal projection in goldfish.

    abstract::The regenerating optic nerve of goldfish first reestablishes a rough retinotopic map on the tectum, then goes through an activity dependent refinement that appears to involve the elimination of inappropriate branches from early regenerated arbors. Retinotopically appropriate branches and synapses may be stabilized bec...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schmidt JT,Shashoua VE

    更新日期:1988-04-19 00:00:00

  • The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: effects of acute and chronic administration of the interleukin-1-receptor antagonist (IL-1ra).

    abstract::Following infection with influenza virus, animals display decreased locomotor activity and feeding behavior and loss of body weight. It has been suggested that these effects may be mediated by cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), induced by the infe...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Swiergiel AH,Smagin GN,Johnson LJ,Dunn AJ

    更新日期:1997-11-21 00:00:00

  • The role of calcium in short-term potentiation in the rat hippocampal slice.

    abstract::Short-term potentiation of extracellular field excitatory postsynaptic potentials (EPSP's) was investigated in the stratum radiatum of CA1 of the rat hippocampal slice in vitro. A presynaptic tetanus consisting of a single train of stimuli at 250 Hz evoked short-term potentiation (STP), but not long-term potentiation ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Anwyl R,Lee WL,Rowan M

    更新日期:1988-08-30 00:00:00

  • Out with the old and in with the new: Synaptic mechanisms of extinction in the amygdala.

    abstract::Considerable research indicates that long-term synaptic plasticity in the amygdala underlies the acquisition of emotional memories, including those learned during Pavlovian fear conditioning. Much less is known about the synaptic mechanisms involved in other forms of associative learning, including extinction, that up...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Maren S

    更新日期:2015-09-24 00:00:00

  • Calretinin distribution in the octopus brain: an immunohistochemical and in situ hybridization histochemical analysis.

    abstract::The distribution of calretinin containing neurons examined by in situ hybridization mapping was compared with that obtained by immunocytochemistry in the brain of octopus. Results revealed a close correspondence between the two types of investigations. Western blot analysis disclosed a 29 kDa protein immunostained wit...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Altobelli GG,Cimini V

    更新日期:2007-02-09 00:00:00

  • Glial peroxidase activity in the hypothalamic arcuate nucleus: effects of estradiol valerate-induced persistent estrus.

    abstract::To test the hypothesis that stimulation of glial peroxidase activity by estrogens may play a role in the pathogenesis of the previously reported degenerative changes in the hypothalamic arcuate nucleus that occur in female rats treated with a long-acting estrogen preparation, the cellular localization and number of pe...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schipper HM,Lechan RM,Reichlin S

    更新日期:1990-01-22 00:00:00

  • The effects of an alpha-adrenergic agonist or antagonist on sleep during blockade of catecholamine synthesis in the cat.

    abstract::The effects of clonidine (CLO) and phentolamine (PHE) on the sleep-waking cycle in the cat treated with alpha-methyl-p-tyrosine (AMPT) were investigated with continuous 16--24 h polygraphic recordings. For the evaluation of possible cholinergic interactions in the paradoxical sleep (PS) increasing effect of AMPT, an a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Leppävuori A

    更新日期:1980-07-07 00:00:00

  • Attenuation of Fos-like immunoreactivity in the trigeminal nucleus caudalis following trigeminovascular activation in the anaesthetised guinea-pig.

    abstract::The present study has examined the involvement of sensory neurotransmitters in activating neurones in the trigeminal nucleus caudalis following stimulation of the trigeminovascular system in anaesthetised guinea-pigs. Electrical stimulation of the right trigeminal ganglion produced a unilateral expression of Fos-like ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Clayton JS,Gaskin PJ,Beattie DT

    更新日期:1997-11-14 00:00:00

  • Stress rapidly increases alpha 1d adrenergic receptor mRNA in the rat dentate gyrus.

    abstract::The hippocampal formation is a highly plastic brain region that is sensitive to stress. It receives extensive noradrenergic projections, and noradrenaline is released in the hippocampus in response to stressor exposure. The hippocampus expresses particularly high levels of the alpha(1D) adrenergic receptor (ADR) and w...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Campeau S,Nyhuis TJ,Kryskow EM,Masini CV,Babb JA,Sasse SK,Greenwood BN,Fleshner M,Day HE

    更新日期:2010-04-06 00:00:00

  • Potassium chloride depolarization enhances MPP+-induced hydroxyl radical generation in the rat striatum.

    abstract::We determined that extracellular potassium ion concentration, [K+]o-induced depolarization, enhances 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) generation in the rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused through a micro...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Obata T,Aomine M,Yamanaka Y

    更新日期:2000-01-10 00:00:00

  • S-100 protein synthesis in cultured glioma cell is G1-phase of cell cycle dependent.

    abstract::The kinetics of S-100 protein synthesis was studied in synchronized cultured glioma (C6) cells. The peak of the synthesis was detected at G1-phase of the cell cycle and apparently was not population density-dependent, since sparsely cultured G1-phase cells synthesized the same proportion of the protein per cell as tha...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fan K

    更新日期:1982-04-15 00:00:00

  • Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease.

    abstract::The dipeptide N-acetylaspartylglutamate (NAAG) may be involved in the process of glutamatergic signaling by both acting at glutamate receptors and as a glutamate protransmitter. In the present study we determined the cellular localization and distribution of NAAG-like immunoreactivity (NAAG-LI) in normal human brain a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Passani LA,Vonsattel JP,Coyle JT

    更新日期:1997-10-24 00:00:00

  • Effect of MK-801 on endogenous dopamine release in vivo.

    abstract::The effect of MK-801 on striatal dopamine (DA) release was investigated by using an in vivo microdialysis technique in the freely moving rat. Systemic injection of MK-801 (0.25, 0.5, 1, 2 mg/kg, i.p.) reduced the extracellular level of DA significantly and produced no change in the level of 3,4-dihydroxyphenylacetic a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kashihara K,Hamamura T,Okumura K,Otsuki S

    更新日期:1990-09-24 00:00:00

  • Interaction of the alpha-2 adrenergic- and opioid receptor with the cGMP system in the mouse cerebellum.

    abstract::The alpha-2 adrenergic agonist dexmedetomidine (Dex), 3-300 microg/kg, i.p., decreased cerebellar cGMP in a dose-dependent manner. Fentanyl (F), an opioid agonist, increased cerebellar cGMP at 0.3 mg/kg, s.c., and decreased it at doses >/=1 mg/kg. The inhibitory effect was receptor specific, that of Dex being blocked ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vulliemoz Y,Virag L,Whittington RA

    更新日期:1998-11-30 00:00:00

  • Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors.

    abstract::Intracerebroventricular (i.c.v.) administration of corticotropin-releasing factor (CRF) biphasically affects performance in tests of learning and memory. In the present study, we used CRF, urocortin (Ucn), a recently cloned CRF homologue, and CRF receptor antagonists, to determine which CRF receptor subtype(s) mediate...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zorrilla EP,Schulteis G,Ormsby A,Klaassen A,Ling N,McCarthy JR,Koob GF,De Souza EB

    更新日期:2002-10-18 00:00:00

  • DIgLONs inhibit initiation of neurite outgrowth from forebrain neurons via an IgLON-containing receptor complex.

    abstract::IgLONs are a family of four GPI-anchored cell adhesion molecules that regulate neurite outgrowth, synaptogenesis and may act as tumour suppressor genes. IgLONs are thought to function as monomers or homodimers and we have proposed that IgLONs also act as heterodimeric complexes termed Dimeric IgLONs or DIgLONs. Here w...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Akeel M,McNamee CJ,Youssef S,Moss D

    更新日期:2011-02-16 00:00:00

  • Alterations in delta opioid receptor levels in discrete areas of the neocortex and in the globus pallidus of the aging guinea pig: a quantitative autoradiographic study.

    abstract::The effect of aging on delta opioid receptors was examined in the brains of guinea pigs aged 1, 6, 24 and 36 months. Quantitative autoradiography was used to monitor the concentrations of delta receptors in various anatomical regions at five rostro-caudal levels. delta opioid receptor populations were found to be rema...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hiller JM,Fan LQ,Simon EJ

    更新日期:1993-06-18 00:00:00

  • Kainate and glutamate neurotoxicity in dependence on the postnatal development with special reference to hippocampal neurons.

    abstract::The particular vulnerability of hippocampal CA3/CA4 neurons to intracerebroventricularly administered kainate did not occur in rats until postnatal day 16. Glutamate applied in the same way failed to show comparable neurodegenerative signs, even when administered in large doses to adult animals. Alternatively, both ka...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wolf G,Keilhoff G

    更新日期:1984-05-01 00:00:00

  • Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.

    abstract::To analyze mediatory mechanisms underlying attention-deficit hyperactivity disorder (ADHD) and their association with epilepsy, the electroencephalogram (EEG) responses to various centrally applied neurotransmitter agonists were studied in spontaneously hypertensive (SH), kainate-treated (KA), and normotensive (contro...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vorobyov V,Schibaev N,Kaptsov V,Kovalev G,Sengpiel F

    更新日期:2011-04-06 00:00:00