Abstract：
:Acidification of the incubation medium markedly increased lipid peroxidation of cortical brain slices. Lactic acidosis caused a more extensive lipid peroxidation than did phosphoric acidosis (+35% at pH 6 and +81% at pH 5), probably due to the rapid diffusion of the protonated form of lactic acid across cell membranes. These results support the hypothesis that free radical mechanisms may be involved in the cytotoxicity of acidosis.
journal_name
Brain Resjournal_title
Brain researchauthors
Bralet J,Bouvier C,Schreiber L,Boquillon Mdoi
10.1016/0006-8993(91)90703-xsubject
Has Abstractpub_date
1991-01-18 00:00:00pages
175-7issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(91)90703-Xjournal_volume
539pub_type
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