Sustained elevation in hippocampal NGF-like biological activity following medial septal lesions in the rat.


:Several laboratories have documented an increase in hippocampal nerve growth factor (NGF) levels, measured with biological or immunological assays, within 1-2 weeks following septal lesions or fimbria/fornix transections. In the present study we have determined the increase in NGF-like biological activity in medium conditioned by hippocampal slices at more prolonged times following medial septal lesion. In contrast to reports based on immunological assays, which demonstrate a transient increase in hippocampal NGF, elevated NGF-like biological activity was present in hippocampal slice-conditioned medium up to one year after a medial septal lesion.


Brain Res


Brain research


Collins F,Crutcher KA




Has Abstract


1989-06-26 00:00:00














  • Catecholamine effects on dissociated tiger salamander Muller (glial) cells.

    abstract::Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell res...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Henshel DS,Miller RF

    更新日期:1992-03-20 00:00:00

  • Opioid supraspinal analgesic synergy between the amygdala and periaqueductal gray in rats.

    abstract::Analgesia can be elicited following microinjections of morphine, mu-selective agonists and beta-endorphin into the amygdala. These analgesic responses are mediated by opioid synapses in the periaqueductal gray (PAG) since general (naltrexone), mu (beta-funaltrexamine) and delta2 (naltrindole isothiocyanate) opioid ant...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pavlovic ZW,Bodnar RJ

    更新日期:1998-01-01 00:00:00

  • Neural responses to monetary incentives in younger and older adults.

    abstract::Reward anticipation is associated with activity in the dopaminergic midbrain as well as the ventral striatum, amygdala, and medial prefrontal cortex. Dopaminergic neuromodulation declines with age, suggesting that incentive processing should also undergo age-related change. However, the literature is mixed, perhaps re...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Spaniol J,Bowen HJ,Wegier P,Grady C

    更新日期:2015-07-01 00:00:00

  • Dispreferred adjective orders elicit brain responses associated with lexico-semantic rather than syntactic processing.

    abstract::We examined how adjective ordering is used in language comprehension by crossing order preference and concreteness in phrases consisting of two adjectives and a noun. We used both more typical phrases in which the preferred order has a concrete second adjective ("exhaustive hardback encyclopedia") and those with a con...

    journal_title:Brain research

    pub_type: 杂志文章,随机对照试验


    authors: Huang HW,Federmeier KD

    更新日期:2012-09-26 00:00:00

  • Comparison of the immunocytochemical distribution of the phosphoprotein B-50 in the cerebellum and hippocampus of immature and adult rat brain.

    abstract::In this study we compare the distribution of the phosphoprotein B-50 in two regions of immature and adult rat brain using affinity-purified antibodies to B-50. In the cerebellum of the 8-day-old rat we observed distinct patterns of distribution of B-50 immunoreactivity (BIR) in the premigratory zone and the developing...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Oestreicher AB,Gispen WH

    更新日期:1986-06-11 00:00:00

  • The auditory cortical projections onto the medial geniculate body in the cat. An experimental anatomical study with silver and autoradiographic methods.

    abstract::The auditory cortical projections to the medial geniculate body (MGB) were studied in the cat. Lesions carefully restricted to each one of the subdivisions of the auditory and peri-auditory cortex were made and degenerating fibres were mapped in the MGB. In other experiments L-[4-5-3-H]leucine was injected into the co...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pontes C,Reis FF,Sousa-Pinto A

    更新日期:1975-06-20 00:00:00

  • Conformational changes of opioid receptor induced by the electric footshock.

    abstract::The present electric shock (ES) schedule followed in these experiments produced different functional changes in endogenous putative opioid agonist- and antagonist-type receptors, depending on the type of receptor: the amount of antagonist binding was increased by ES application, while the amount of agonist binding was...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nabeshima T,Matsuno K,Kameyama T

    更新日期:1985-09-16 00:00:00

  • Vascular permeability alterations to horseradish peroxidase in experimental brain injury.

    abstract::Protein uptake and transport within the brain stem vasculature of mechanically brain injured cats was studied by means of both light and electron microscopy utilizing intravenously injected horseradish peroxidase as the protein tracer. In animals sustaining low grade head injuries not of sufficient intensity to elicit...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Povlishock JT,Becker DP,Sullivan HG,Miller JD

    更新日期:1978-09-22 00:00:00

  • Excitotoxicity induced by kainic acid provokes glycogen synthase kinase-3 truncation in the hippocampus.

    abstract::In neuronal cultures, glycogen synthase kinase 3(GSK3) is truncated at the N-terminal end by calpain downstream of activated glutamate receptors. However, the in vivo biological significance of that truncation has not been explored. In an attempt to elucidate if GSK3 truncation has a pathophysiological relevance, we h...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jurado-Arjona J,Goñi-Oliver P,Rodríguez-Prada L,Engel T,Henshall DC,Ávila J,Hernández F

    更新日期:2015-06-22 00:00:00

  • Onset and dynamic expression of S100 proteins in the olfactory organ and the lateral line system in zebrafish development.

    abstract::In the zebrafish olfactory epithelium, three morphologically distinct olfactory neurons express different marker proteins. We utilize this feature to access developmental dynamics of one of the neuron types, the crypt cells, to determine whether they are differentiated at a stage similar to other olfactory neurons. Im...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sandulescu CM,Teow RY,Hale ME,Zhang C

    更新日期:2011-04-06 00:00:00

  • Opiate and digitalis receptor assays distinguish between neuroexcitant and inactive organochlorines and between anesthetics and convulsants.

    abstract::Specific binding of [3H]naloxone to rat brain tissue in vitro was inhibited by the excitant organochlorinated insecticides (OCI), by ether (E) and octanol (OCT), and by the convulsant indoklon (IND) and its anesthetic isomer, isoindoklon (ISO). In the presence of 100 mM NaCl the inhibition of naloxone binding by E, OC...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Labella FS

    更新日期:1981-08-24 00:00:00

  • Rotational movement (circling) in normal humans: sex difference and relationship to hand, foot and eye preference.

    abstract::An endogenous asymmetry in striatal dopaminergic function has been identified in rats, and related to spontaneous and drug-induced circling (rotation, turning). We have developed an electronic device for measuring in humans the same kinds of rotational movements observed in rats. Our data indicate that, without being ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bracha HS,Seitz DJ,Otemaa J,Glick SD

    更新日期:1987-05-19 00:00:00

  • Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia.

    abstract::The beneficial effects of angiotensin II type 1 (AT1) receptor blockers (ARB) in cerebrovascular disease have been shown in clinical trials. However, the effects of ARBs vary based on their unique pharmacologic properties. In this study, we focused on telmisartan, a fat-soluble ARB with selective peroxisome proliferat...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kasahara Y,Taguchi A,Uno H,Nakano A,Nakagomi T,Hirose H,Stern DM,Matsuyama T

    更新日期:2010-06-22 00:00:00

  • Beneficial synergistic effects of concurrent treatment with cilostazol and probucol against focal cerebral ischemic injury in rats.

    abstract::In the present study, we assessed the beneficial synergistic effects of concurrent treatment with low doses of cilostazol and probucol against focal cerebral ischemic infarct in rats. The ischemic infarct induced by 2-h occlusion of middle cerebral artery (MCA) and 22-h reperfusion was significantly reduced in rat bra...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Park SY,Lee JH,Kim CD,Rhim BY,Hong KW,Lee WS

    更新日期:2007-07-09 00:00:00

  • Sexually dimorphic expression of the genes encoding ribosomal proteins L17 and L37 in the song control nuclei of juvenile zebra finches.

    abstract::Studies evaluating the role of steroid hormones in sexual differentiation of the zebra finch song system have produced complicated and at times paradoxical results, and indicate that additional factors may be critical. Therefore, in a previous study we initiated a screen for differential gene expression in the telence...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tang YP,Wade J

    更新日期:2006-12-18 00:00:00

  • Location of rabbit auditory cortex and description of single unit activity.

    abstract::The following data were obtained from microelectrode exploration of rabbit auditory cortex (AC). (1) Location of AC--Major portions of the rabbit's right hemisphere were stereotaxically mapped for auditory responsive and non-responsive regions. Auditory responsive regions were found to lie behind the rhinal sulcus, ex...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kraus N,Disterhoft JF

    更新日期:1981-06-15 00:00:00

  • Effects of para-chloroamphetamine upon the serotonergic innervation of the rat hippocampus.

    abstract::The ability of hippocampal serotonergic (5-HT) axons to proliferate in response to damage by para-chloroamphetamine (PCA) was examined in this study. Synaptosomal uptake of 5-HT in the hippocampal formation was decreased to 40% of control 3 days after systemic administration of PCA. Six weeks after PCA, uptake values ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Haring JH,Meyerson L,Hoffman TL

    更新日期:1992-04-17 00:00:00

  • Chronoamperometry in brain slices: quantitative evaluations of in vivo electrochemistry.

    abstract::Practical utilization of in vivo electrochemistry for brain studies has been impeded by difficulties with specificity and quantitative measurements. Studies in brain slices combined with similar data from intact animals have provided important new information on the nature of the electrochemical studies. Using the enz...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schenk JO,Miller E,Rice ME,Adams RN

    更新日期:1983-10-24 00:00:00

  • Implication of substance P neuronal system in the amygdala as a possible mechanism for hypergravity-induced motion sickness.

    abstract::We previously reported that motion sickness was prevented in rats with amygdala lesion and that provocative motion stimuli increased the number of Fos-positive neurons in the amygdala, suggesting that the amygdala is one of the neural substrates involved in the development of motion sickness. NK-1 receptors in the bra...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Horii A,Nakagawa A,Uno A,Kitahara T,Imai T,Nishiike S,Takeda N,Inohara H

    更新日期:2012-01-30 00:00:00

  • Comparative study of immature and mature olfactory receptor cells in adult frogs.

    abstract::We describe a method to produce frog olfactory epithelium with a population of developmentally synchronized receptor cells suitable for electrophysiological studies. The epithelium is ablated with ZnSO4 and allowed to regenerate for 10 days. Generation of new cells is then blocked by continuous treatment with hydroxyu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lidow MS,Gesteland RC,Shipley MT,Kleene SJ

    更新日期:1987-02-01 00:00:00

  • Hippocampofugal gamma-aminobutyric acid (GABA)-containing neuron system in the rat: a study using a double-labeling method that combines retrograde tracing and immunocytochemistry.

    abstract::Using a double-labeling method that combines retrograde tracing and immunocytochemistry, we demonstrated the presence of a hippocampofugal gamma-aminobutyric acid (GABA)-like immunoreactive (GABA-LI) neuron system in the rat. As a preliminary experiment, knife-cut of the dorsal fornix was made and it resulted in a rem...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shinoda K,Tohyama M,Shiotani Y

    更新日期:1987-04-14 00:00:00

  • Cerebral protein synthesis alterations in response to acute and chronic immobilization stress in the rat.

    abstract::The quantitative autoradiographic method with L-(35S)methionine was used to determine the effects of 1-acute (4h) and 2-chronic (14 days) immobilization stress followed by one week of recovery. Acute stress induced a significant decrease in methionine incorporation into proteins in 17 of the 35 brain structures examin...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Giaume M,Grange E,Baubet V,Gay N,Sermet E,Sarda N,Bobillier P

    更新日期:1995-03-27 00:00:00

  • Maturational changes of amino acid concentration in cerebrospinal fluid of the rat.

    abstract::The cisternal spinal fluid (CF), plasma, and brain stem concentrations of 6 amino acids were measured in suckling rats between birth and one months of age. Each of the amino acids studied had its distinctive maturational pattern of CF concentration. Presumably these amino acids have separate mechanisms of transport fr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Korobkin RK,Cutler RW

    更新日期:1977-01-01 00:00:00

  • Analgesic effects of the neurosteroid 3 alpha-androstanediol.

    abstract::The efficacy of 5 alpha-androstane-3 alpha,17 beta-diol (3 alpha-Androstanediol; 3 alpha-Diol) and 4-pregnen-3,20-dione (progesterone; P) in promoting analgesia was investigated. Ovariectomized rats received daily injections of 3 alpha-Diol (0.6, 3.0, 6.0 and 7.5 mg/kg) or vehicle and twice daily injections of estradi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Frye CA,Van Keuren KR,Rao PN,Erskine MS

    更新日期:1996-02-12 00:00:00

  • ATP modulation of sodium currents in rat dorsal root ganglion neurons.

    abstract::The modulation of tetrodotoxin-sensitive (TTX-S) and slow tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons by ATP was studied using the whole-cell patch-clamp method. The effects of ATP on two types of sodium currents were either stimulatory or inhibitory depending on the kinetic para...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Joo Choi E,Hong MP,Kyoo Shin Y,Soo Lee C,Park M,Song JH

    更新日期:2003-04-04 00:00:00

  • Alcohol differentially affects c-Fos expression in the supraoptic nucleus of long-sleep and short-sleep mice.

    abstract::Ethanol administration in long-sleep (LS) and short-sleep (SS) mice results in a large number of Fos-IR neurons in the supraoptic nucleus (SON) in LS, and almost no Fos-IR neurons in the same nucleus in SS mice. In contrast, isotonic saline, hypertonic saline, with or without ethanol, resulted in a similar pattern of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Eisenman LM,Donovan HS,Johnson TE

    更新日期:2002-05-10 00:00:00

  • Acetylcholine induced modulation of hippocampal pyramidal neurons.

    abstract::Applications of acetylcholine to hippocampal slices maintained in vitro resulted in slow depolarizations and simultaneous increases in membrane resistance (RN)in hippocampal pyramidal neurons. Increases in RN had both voltage dependent and voltage independent components. These effects were associated with increases in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Benardo LS,Prince DA

    更新日期:1981-04-27 00:00:00

  • The pattern of retinoic acid receptor expression and subcellular, anatomic and functional area translocation during the postnatal development of the rat cerebral cortex and white matter.

    abstract::Retinoic acid (RA), which is an important modulator of brain development, neural cell proliferation, neurite outgrowth, and synaptic plasticity, is regulated via changes in RA receptors. The pattern of RA receptor changes in the rat cerebral cortex and white matter during postnatal development has not been extensively...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jiang W,Wen EY,Gong M,Shi Y,Chen L,Bi Y,Zhang Y,Liu YF,Chen J,Qu P,Liu YX,Wei XP,Li TY

    更新日期:2011-03-25 00:00:00

  • Immunocytochemical localization of non-NMDA ionotropic excitatory amino acid receptor subunits in human neocortex.

    abstract::The distribution of immunocytochemically localized subunits that comprise ionotropic non-NMDA excitatory amino acid receptors was examined in human frontal, parietal and temporal association neocortex. AMPA/kainate receptor subunits were identified using a monoclonal antibody (3A11) that recognizes an epitope common t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vickers JC,Huntley GW,Hof PR,Bederson J,DeFelipe J,Morrison JH

    更新日期:1995-02-06 00:00:00

  • Identifying motor and sensory myelinated axons in rabbit peripheral nerves by histochemical staining for carbonic anhydrase and cholinesterase activities.

    abstract::Carbonic anhydrase (CA) and cholinesterase (CE) histochemical staining of rabbit spinal nerve roots and dorsal root ganglia demonstrated that among the reactive myelinated axons, with minor exceptions, sensory axons were CA positive and CE negative whereas motor axons were CA negative and CE positive. The high specifi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Riley DA,Sanger JR,Matloub HS,Yousif NJ,Bain JL,Moore GH

    更新日期:1988-06-21 00:00:00