Temporary inactivation of the nucleus accumbens disrupts acquisition and expression of fear-potentiated startle in rats.

Abstract:

:Recent research suggests that in addition to its prominent role in appetitive learning, the nucleus accumbens (NAC) may also be involved in fear conditioning. In the present study, we investigated whether temporary inactivation of the NAC, by injection of tetrodotoxin (TTX), affects acquisition and expression of conditioned fear, as measured by fear-potentiated startle (FPS). TTX injection into the NAC totally blocked acquisition and markedly decreased expression of conditioned fear to a discrete visual conditioned stimulus (CS). Interestingly, temporary inactivation of the NAC did not affect shock sensitization of startle, indicating that both the perception of the shock and short-term contextual conditioning was not affected by intra-accumbal TTX injection. Taken together, these results show that the NAC is crucial for acquisition and expression of long-term conditioned fear, as measured by fear-potentiated startle, to discrete CSs, but not short-term conditioned fear to a context.

journal_name

Brain Res

journal_title

Brain research

authors

Schwienbacher I,Fendt M,Richardson R,Schnitzler HU

doi

10.1016/j.brainres.2004.08.037

subject

Has Abstract

pub_date

2004-11-19 00:00:00

pages

87-93

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(04)01361-7

journal_volume

1027

pub_type

杂志文章
  • Ultrastructural organization of receptor cell axons in frog olfactory nerve.

    abstract::Repeated odorant or electrical stimulation of the frog olfactory nerve leads to long-lasting reduction of excitability of the receptor neurons. In the turtle olfactory nerve electrical stimulation causes an increase in extracellular potassium concentration due to the efflux of potassium from active axons. Elevated pot...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90340-h

    authors: Daston MM,Adamek GD,Gesteland RC

    更新日期:1990-12-24 00:00:00

  • Astroglial expression of ATL-derived factor, a human thioredoxin homologue, in the gerbil brain after transient global ischemia.

    abstract::Distribution of adult T cell leukemia derived factor (ADF/TRX), a human thioredoxin homologue, was studied by immunohistochemistry in gerbil brain during reperfusion after transient cerebral ischemia. In control brains, immunoreactivity was observed widely in the central nervous system, including the ependyma, tanycyt...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90130-f

    authors: Tomimoto H,Akiguchi I,Wakita H,Kimura J,Hori K,Yodoi J

    更新日期:1993-10-15 00:00:00

  • Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein.

    abstract::Neurofibrillary tangles (NFTs) are a pathological hallmark of many neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP17). However, the cellular origin and the consequence of the NFT formation are poorly un...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.05.106

    authors: Wen Y,Yang S,Liu R,Simpkins JW

    更新日期:2004-10-01 00:00:00

  • Non-linear kinetics of glutamyl-tRNA synthesis catalyzed by high molecular weight complexes from rat brain neuronal cells but not from glial cells.

    abstract::High molecular weight complexes of aminoacyl-tRNA synthetases isolated from rat brain catalyze the formation of glutamyl-tRNA with an initial lag time of the order of 1 min, as previously reported for the formation of glutamyl-tRNA and glutaminyl-tRNA catalyzed by similar complexes from bovine brain (Vadeboncoeur and ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0169-328x(86)90016-1

    authors: Lacoste L,Hertz L,Lapointe J

    更新日期:1986-07-01 00:00:00

  • Regulation of cholecystokinin receptors in the ventromedial nucleus of the hypothalamus: sex steroid hormone effects.

    abstract::Quantitative autoradiography was used to analyze cholecystokinin receptor (CCK-R) binding in the ventromedial hypothalamic nucleus (VMH) of gonadectomized rats treated with estrogen or testosterone. In the rostral VMH, sex steroids did not affect binding levels. In the caudal VMH, in both gonadectomized male and femal...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01561-2

    authors: Popper P,Priest CA,Micevych PE

    更新日期:1996-03-18 00:00:00

  • Behavioral effects of lipopolysaccharide in rats: involvement of endogenous opioids.

    abstract::Activation of the immune system in response to either infection or lipopolysaccharide (LPS) produces neurophysiological, neuroendocrine and behavioral changes. Some of the physiological consequences of LPS are mediated by endogenous opioid peptides. The following studies were designed to characterize the effects of LP...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91908-9

    authors: Yirmiya R,Rosen H,Donchin O,Ovadia H

    更新日期:1994-06-13 00:00:00

  • Immunohistochemical detection of Bax and Bcl-2 proteins in gerbil hippocampus following transient forebrain ischemia.

    abstract::Time-course expression of Bax and Bcl-2 proteins, identified as apoptosis-regulating molecules, was assessed in gerbil hippocampus following transient forebrain ischemia. Brain sections from animals sacrificed at 48, 72, 96 h and 7 days following 5 min ischemia were immunohistochemically evaluated using polyclonal ant...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01436-5

    authors: Hara A,Iwai T,Niwa M,Uematsu T,Yoshimi N,Tanaka T,Mori H

    更新日期:1996-03-04 00:00:00

  • Postsynaptic control of lumbar motoneuron excitability during active sleep in the chronic cat.

    abstract::A correlated intracellular and extracellular study of lumbar motoneuron excitability during sleep and wakefulness was performed in the chronic, unanesthetized, undrugged, normally respiring cat. Experiments were designed to reveal the extent to which hypotonia during active sleep in mammals is dependent on postsynapti...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90836-2

    authors: Morales F,Chase MH

    更新日期:1981-11-30 00:00:00

  • Long-term administration of estrogen or tamoxifen to ovariectomized rats affords neuroprotection to hippocampal neurons by modulating the expression of Bcl-2 and Bax.

    abstract::Recently we reported that chronic treatment with 17beta-estradiol (E2) or tamoxifen (TAM) regulates the ovariectomy-induced downregulation of the key molecules linked to hippocampal synaptic plasticity and signal transduction pathway. We now report modulation of the antiapoptotic (Bcl-2) and proapoptotic (Bax) protein...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.01.080

    authors: Sharma K,Mehra RD

    更新日期:2008-04-14 00:00:00

  • Contrasting features of ERK1/2 activity and synapsin I phosphorylation at the ERK1/2-dependent site in the rat brain in status epilepticus induced by kainic acid in vivo.

    abstract::Extracellular signal-regulated kinase 1/2 (ERK1/2) plays diverse roles in the central nervous system. Activation of ERK1/2 has been observed in various types of neuronal excitation, including seizure activity in vivo and in vitro. However, studies examining ERK1/2 activity and its substrate phosphorylation in parallel...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.08.023

    authors: Yamagata Y,Nairn AC

    更新日期:2015-11-02 00:00:00

  • Enkephalin-immunoreactive fastigial neurons in the rat cerebellum project to upper cervical cord segments.

    abstract::By using enkephalin immunohistochemistry combined with retrograde fluorescent labelling, a great majority of neurons in the rat cerebellum sending their axons to the spinal cord were shown to contain enkephalin immunoreactivity. These neurons were numerous and clustered in the fastigial nucleus but far less abundant i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00557-7

    authors: Ikeda M,Houtani T,Nakagawa H,Baba K,Kondoh A,Ueyama T,Yamamoto T,Gemba H,Sugimoto T

    更新日期:1995-09-04 00:00:00

  • Modulation of dopamine uptake by nitric oxide in cultured mesencephalic neurons.

    abstract::Strong evidence obtained from in vivo and ex-vivo studies suggests the existence of interaction between dopaminergic and nitrergic systems. Some of the observations suggest a possible implication of nitric oxide (NO) in dopamine (DA) uptake mechanism. The present work investigated the interaction between both systems ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.12.054

    authors: Salum C,Raisman-Vozari R,Michel PP,Gomes MZ,Mitkovski M,Ferrario JE,Ginestet L,Del Bel EA

    更新日期:2008-03-10 00:00:00

  • Involvement of GABA(A) and GABA(B) receptors in afterdischarge generation in rat hippocampal slices.

    abstract::It has been hypothesized that a disruption of gamma-aminobutyric acid (GABA) receptor-mediated processes may be involved in the pathophysiology of focal epilepsy. This disinhibition hypothesis has been postulated from the results of in vitro experiments of the interictal activity of focal epilepsy. Less is known, howe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02209-5

    authors: Higashima M,Ohno K,Kinoshita H,Koshino Y

    更新日期:2000-05-26 00:00:00

  • Monoamine metabolism during bicuculline-induced epileptic seizures in the rat.

    abstract::Brain levels of tyrosine, dopamine (DA), noradrenaline (NA), tryptophan, 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) were measured after 30, 60 and 120 min of sustained seizure activity, induced in paralyzed, artificially ventilated and anaesthetized (70% N2O) rats by administration of bicucull...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(78)90031-8

    authors: Calderini G,Carlsson A,Nordström CH

    更新日期:1978-11-24 00:00:00

  • Long-term potentiation-induced synaptic changes in hippocampal dentate gyrus of rats with an inborn low or high learning capacity.

    abstract::Structural changes induced by high frequency (HF) stimulation on granule cells of the hippocampal dentate gyrus of rats with inborn high (HP) and low (LP) learning capacity was examined in this study. Two types of axodendritic synapses were processed morphometrically; the axonal bouton on dendritic shafts and those ma...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90371-h

    authors: Gómez RA,Pozzo Miller LD,Aoki A,Ramírez OA

    更新日期:1990-12-24 00:00:00

  • Immediate integration of novel meanings: N400 support for an embodied view of language comprehension.

    abstract::A substantial part of language understanding depends on our previous experiences, but part of it consists of the creation of new meanings. Such new meanings cannot be retrieved from memory but still have to be constructed. The goals of this article were: first, to explore the nature of new meaning creation, and second...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.09.014

    authors: Chwilla DJ,Kolk HH,Vissers CT

    更新日期:2007-12-05 00:00:00

  • Polysynaptic neuronal pathways from group I and group II afferents innervating tail muscles to hindlimb motoneurons in the cat.

    abstract::Postsynaptic potentials evoked in motoneurons innervating m. posterior biceps and semitendinosus (PBSt) and m. triceps surae (GS) by low threshold afferents from various tail muscles located at the level of the second-third caudal vertebrae were investigated in the non-anesthetized and spinalized cat. Afferent inputs ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00039-0

    authors: Wada N,Takayama R,Kanda K,Tokuriki M

    更新日期:1998-03-30 00:00:00

  • Ca2+ and pH affect the neurite formation in cultured mollusc isolated neurones.

    abstract::Neurite formation in neurones isolated from adult molluscs in culture has been shown to depend on the total content of Ca in the cells, intracellular Ca2+ concentration, intracellular acid-alkaline balance, extracellular pH, and the capacity and composition of buffers. The neurones with a low total Ca content prior to...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90546-2

    authors: Kostenko MA,Musienko VS,Smolikhina TI

    更新日期:1983-10-03 00:00:00

  • Effect of substantia nigra stimulation on identified neurons in the VL-VA thalamic complex: comparison between intact and chronically decorticated cats.

    abstract::The effects of substantia nigra (SN) stimulation on the activity of the nucleus ventralis lateralis of the thalamus (VL) have been studied. The VL cells were identified as relay or non-relay cells among the cerebellothalamocortical pathway on the basis of orthodromical activation from the cerebellum and antidromical a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(78)90793-x

    authors: Deniau JM,Lackner D,Feger J

    更新日期:1978-04-21 00:00:00

  • Role of noradrenergic projections to the bed nucleus of the stria terminalis in neuroendocrine and behavioral responses to fear-related stimuli in rats.

    abstract::The bed nucleus of the stria terminalis (BNST) receives dense noradrenergic projections from the brainstem and has been claimed to play a role in expression of a variety of stress responses. Fear-related stimuli suppress vasopressin and facilitate oxytocin release from the neurohypophysis and induce behavioral suppres...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00012-2

    authors: Onaka T,Yagi K

    更新日期:1998-03-30 00:00:00

  • Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism.

    abstract::Early brain injury (EBI) plays a pivotal role in the prognosis of patients with subarachnoid haemorrhage (SAH). Dexmedetomidine (DEX), a highly selective α2 receptor agonist, is reported to exert multiple protective effects in many neurological diseases. This study was designed to investigate whether DEX had neuroprot...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2018.05.040

    authors: Yin D,Zhou S,Xu X,Gao W,Li F,Ma Y,Sun D,Wu Y,Guo Q,Liu H,Han L,Wang Z,Wang Y,Zhang J

    更新日期:2018-11-01 00:00:00

  • Cyclic nucleotides in the rat neostriatum: push-pull perfusion studies.

    abstract::A push-pull perfusion technique was employed for in vivo study of adenosine 3',5'-monophosphate (cAMP) and guanosine 3',5'-monophosphate (cGMP) in the rat caudate nucleus. Addition of dopamine to the perfusion fluid elicited dose-dependent increases of both cAMP and cGMP perfusate concentrations. In separate experimen...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90495-5

    authors: Schoener EP,Hager PJ,Felt BT,Schneider DR

    更新日期:1979-12-21 00:00:00

  • Proportion of unmyelinated axons in rat molar and incisor tooth pulps following neonatal capsaicin treatment and/or sympathectomy.

    abstract::The occurrence of unmyelinated axons was examined ultrastructurally in rat molar and incisor root pulps of normal rats, of neonatally capsaicin-treated rats, of rats subjected to neonatal capsaicin treatment followed by resection of the superior cervical ganglion and of sympathectomized but otherwise normal rats. Foll...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90533-1

    authors: Fried K,Aldskogius H,Hildebrand C

    更新日期:1988-10-25 00:00:00

  • Influence of pyramidotomy on limb flexion movements induced by cortical stimulation and on associated postural adjustment in the cat.

    abstract::Flexion movements induced by cortical stimulation and the associated postural adjustments in bilaterally pyramidotomised cats have been studied by means of an apparatus which measures separately the changes of force under each limb in the upright position of the animal. The results show: (1) The general motor behaviou...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(78)90586-3

    authors: Nieoullon A,Gahéry Y

    更新日期:1978-06-23 00:00:00

  • Methyl-beta-carbolinium analogs of MPP+ cause nigrostriatal toxicity after substantia nigra injections in rats.

    abstract::Eleven beta-carbolinium compounds (beta C+s) and MPP+ were stereotaxically injected (40-200 nmol in 5 microliter of vehicle) unilaterally into the substantia nigra of anesthetized adult male Sprague-Dawley rats. The rats were sacrificed after three weeks. The ipsilateral striatum was analyzed for dopamine and DOPAC le...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00082-2

    authors: Neafsey EJ,Albores R,Gearhart D,Kindel G,Raikoff K,Tamayo F,Collins MA

    更新日期:1995-03-27 00:00:00

  • Affected and unaffected quantitative aspects of grip force control in hemiparetic patients after stroke.

    abstract::Adequate grip force modulation is critical to manual dexterity and often impaired in hemiparetic stroke patients. Previous studies in hemiparetic patients suggest that aspects of grip force control may be differently affected by the lesion. We developed a visuomotor power grip force-tracking task allowing quantificati...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.03.007

    authors: Lindberg PG,Roche N,Robertson J,Roby-Brami A,Bussel B,Maier MA

    更新日期:2012-05-03 00:00:00

  • Effects of fenfluramine and phentermine (fen-phen) on dopamine and serotonin release in rat striatum: in vivo microdialysis study in conscious animals.

    abstract::We measured the effects of acute or chronic administration of fenfluramine and phentermine, alone or in combination, on brain dopamine and serotonin release into striatal dialysates of freely moving rats. Samples collected every 30 min were assayed in a single run by high-pressure liquid chromatography. Acute or chron...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)01003-8

    authors: Balcioglu A,Wurtman RJ

    更新日期:1998-11-30 00:00:00

  • Effects of a mutation in the TM2-TM3 linker region of the glycine receptor alpha1 subunit on gating and allosteric modulation.

    abstract::Alcohols and volatile anesthetics modulate the function of cys-loop ligand-gated ion channels, binding to a putative site between transmembrane domains two and three. The extracellular linker between these two domains is important in the transduction of the gating signal from the glycine binding site to the channel ga...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.03.031

    authors: Dupre ML,Broyles JM,Mihic SJ

    更新日期:2007-06-04 00:00:00

  • E-64-d prevents both calpain upregulation and apoptosis in the lesion and penumbra following spinal cord injury in rats.

    abstract::Calpain, a Ca(2+)-dependent cysteine protease, has been implicated in cytoskeletal protein degradation and neurodegeneration in the lesion and adjacent areas following spinal cord injury (SCI). To attenuate apoptosis or programmed cell death (PCD) in SCI, we treated injured rats with E-64-d, a cell permeable and selec...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02260-5

    authors: Ray SK,Matzelle DC,Wilford GG,Hogan EL,Banik NL

    更新日期:2000-06-09 00:00:00

  • The enhanced processing of visual novel events in females: ERP correlates from two modified three-stimulus oddball tasks.

    abstract::The ability to detect and cope with unpredictable novel events is fundamental for adapting to a rapidly changing environment and ensuring the survival of the organism. Despite knowledge of gender differences in emotional processing, little is currently known about the impact of gender on neural processing of emotion-i...

    journal_title:Brain research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.brainres.2011.12.017

    authors: Yuan J,Xu S,Li C,Yang J,Li H,Yuan Y,Huang Y

    更新日期:2012-02-09 00:00:00