Abstract:
:The regulatory role of endothelins in cerebral microvessels was investigated in a recently developed model system which allows the study of small cerebral vessels in their normal microenvironment. Using brain slices of the rat neocortex, it was shown that the isopeptide endothelin-3 (ET-3) had no effect on cerebral microvessels, while the isopeptide endothelin-1 (ET-1) produced a potent, dose-dependent vasoconstriction. When a recently developed antagonist of ETA receptors (cyclo-[D-Asp-L-Pro-D-Val-L-Leu-D-Trp]; ETant) was administered prior to treatment with ET-1, the vasoconstrictor response to ET-1 was inhibited in a dose-dependent manner. When ETant was administered after the establishment of a constriction by ET-1, the constrictor response to ET-1 was partially reversed, and this effect was weaker than that seen in the pre-treatment paradigm. These findings indicate that constrictor responses to ET-1 in cerebral microvessels are mediated by ETA receptors. Inasmuch as endothelins have been implicated in pathological forms of vasoconstriction in the CNS, the present findings also suggest that endothelin antagonists may be useful in the treatment of cerebral ischemia.
journal_name
Brain Resjournal_title
Brain researchauthors
Sagher O,Jin Y,Thai QA,Fergus A,Kassell NF,Lee KSdoi
10.1016/s0006-8993(09)90024-5subject
Has Abstractpub_date
1994-09-26 00:00:00pages
179-84issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(09)90024-5journal_volume
658pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The effects of 3 different non-noxious stressors on body temperature (Tb) were investigated in the rat: (1) loose restraint in cylinders, (2) removal of the rats from cylinders, exposure to a novel environment and replacement in cylinders, a stressor called here 'novelty', and (3) gentle holding of the rats by the nap...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90537-7
更新日期:1984-04-09 00:00:00
abstract::The analysis of the dynamic properties of epileptiform activity in vitro has led to a better understanding of the time course of neural synchronization and seizure states. Nonlinear analysis is thus potentially useful for the prediction of seizure onset. We have used nonlinear analysis methods to investigate the devel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03166-8
更新日期:2001-02-02 00:00:00
abstract::To study the regulation of striatal acetylcholine (ACH) release, adult male rat striata were dissociated and incubated with 3H-choline to synthesize 3H-ACH. Fractional 3H-ACH efflux per min during continuous perifusion was: (1) tightly regulated; (2) dependent on calcium influx; (3) stimulated by 10 mM K+ and 1 mM glu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00996-4
更新日期:1995-10-30 00:00:00
abstract::(1) Visual, auditory and olfactory input were not necessary for the performance of the lordosis reflex by female rats. Since taste is not involved in this behavior, somatosensory input must be sufficient for triggering the lordosis reflex. (2) Surgical cutaneous denervation markedly reduced the frequency and strength ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90987-2
更新日期:1976-01-09 00:00:00
abstract::Endothelin-1 (ET-1) has been implicated in hematoma-induced cerebral vasoconstriction and modification of cerebral microvascular reactivity, particularly attenuation of vasodilation to cAMP-dependent dilators and enhanced vasoconstriction to ET-1. We examined effects of the ET-1 antagonist, BQ-123, on hematoma-induced...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-09-23 00:00:00
abstract::Insulin growth factor 1 (IGF-1) has an important role in brain development and is strongly expressed during recovery after a hypoxic-ischemic injury. Some of its central actions could be mediated through the N-terminal tripeptide fragment of IGF-1: Gly-Pro-Glu (GPE). The neuroprotective properties of GPE given after a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03148-1
更新日期:2001-12-13 00:00:00
abstract::An analysis of cellular kinetics during closure of the cranial neural folds in the C57BL mouse at 8 and 9 days gestations was obtained by means of tritiated thymidine autoradiography. At 8 days the short generation time (7.5 h) and high labeling index (61.4%) are evidence of intensive proliferative activity occurring ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(81)90049-3
更新日期:1981-10-01 00:00:00
abstract::Immunofluorescence on primary dissociated rat neuronal cultures (cortical, hippocampal, and cerebellar) and organotypic hippocampal cultures was used to investigate the pattern of distribution of cell-surface amyloid protein (APP). Antibodies directed against the extracellular (N-terminal) portion of APP or against th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00608-7
更新日期:1996-10-07 00:00:00
abstract::The localization of calcitonin gene-related peptide (CGRP)-like immunoreactive (CGRPI) structures in the cochlea was examined in the rat using immunocytochemistry. Numerous CGRPI fibers entered the organ of Corti in the intraganglionic spiral bundle and formed a dense fiber patch at the base of the inner hair cells. M...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90992-8
更新日期:1985-12-09 00:00:00
abstract::Recently, the gene encoding the cerebrovascular and neuritic plaque amyloid, a pathologic stigma of Alzheimer's disease (AD), has been molecularly cloned and mapped to human chromosome 21, band q21. Changes in the brains of individuals with trisomy 21 (Down syndrome, DS) over 35 years of age closely resemble AD neurop...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(87)90028-3
更新日期:1987-09-01 00:00:00
abstract::Brain edema is a serious consequence of hemispheric stroke and traumatic brain injury and contributes significantly to patient mortality. In the present study, we measured water contents in hippocampal slices as an in vitro model of edema formation. Excitotoxic conditions induced by N-methyl-D-aspartate (NMDA, 300 mic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.012
更新日期:2006-11-29 00:00:00
abstract::Coated vesicles within dentate gyrus granule cell dendrites were found free in the cytoplasm and also attached to the smooth endoplasmic reticulum and plasmalemma. Coated vesicles began increasing in number 40-48 h following partial dendritic deafferentation. This increase continued up to 15-30 days postlesion, after ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90076-7
更新日期:1981-04-27 00:00:00
abstract::The levels of N-acetyl-aspartate (NAA) and N-acetyl-aspartyl-glutamate (NAAG) were measured in several regions and in whole brain of rats from 15 days of gestation (DG) to adulthood by means of an isocratic HPLC method. The levels of NAAG in whole brain increased 3-fold between 15 DG and birth, which was 90% of the ad...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90150-0
更新日期:1984-07-01 00:00:00
abstract::Electrophysiological studies have suggested that the excitatory actions of opioids in the hippocampal formation are mediated by inhibition of interneurons containing GABA; however, an anatomical basis for this interaction has never been established. Thus, we sought to determine the relationship between leu-enkephalin ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00236-3
更新日期:1996-06-10 00:00:00
abstract::Non-peptide receptor ligands with differential affinity for the angiotensin II-1 (AII-1) receptor (EXP3312, EXP3880) or the AII-2 receptor (PD123177) and an angiotensin converting enzyme (ACE) inhibitor captopril were evaluated for the ability to protect against a renin-induced performance deficit in a passive avoidan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91599-v
更新日期:1991-10-11 00:00:00
abstract::The present study investigated the effect of locally infused guanfacine, an alpha2A-adrenergic agonist, into the ventral prefrontal cortex (PFv) on visuomotor associative learning. Two monkeys were well trained on a two-problem visuomotor associative task: the monkeys performed movement A if presented with a circle pa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.07.062
更新日期:2004-10-22 00:00:00
abstract::We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. R...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03975-6
更新日期:2003-02-07 00:00:00
abstract::The intracellular injection technique of HRP with simultaneous recordings of intracellular potential was applied to the crab X-organ-sinus gland peptidergic neurosecretory neurons. At least two classes of neurons were discriminated from the usual type of neurosecretory neurons morphologically as well as electrophysiol...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90468-3
更新日期:1986-01-08 00:00:00
abstract::Corticotropin releasing hormone (CRH) plays a major role in central nervous system responses to stressors and has been implicated in stress-induced alterations in sleep. In the absence of stressors, CRH contributes to the regulation of spontaneous waking. We examined the effects of CRH and astressin (AST), a non-speci...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.11.007
更新日期:2008-01-23 00:00:00
abstract::We previously reported a model of acute cochlear energy failure using a mitochondrial toxin, 3-nitropropionic acid (3-NP), to study mechanisms of inner ear disorders such as inner ear ischemia. In this model, the main cause of hearing loss is apoptosis of fibrocytes in the cochlear lateral wall. Here, we analyzed the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.08.062
更新日期:2011-10-24 00:00:00
abstract::The importance of particular genes in neuronal death following global cerebral ischemia can readily be studied in genetically modified mice provided a reliable model of ischemia is available. For that purpose, we developed a mouse model of global cerebral ischemia that induces consistent damage to different regions of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03014-2
更新日期:2003-08-29 00:00:00
abstract::The aetiology of the sporadic form of amyotrophic lateral sclerosis (ALS) is poorly understood although abnormalities in glutamate and glycine transport have been implicated which both could contribute to a neurodegenerative process mediated through the N-methyl-D-aspartate (NMDA) receptor. In this study we have used ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00052-r
更新日期:1995-04-03 00:00:00
abstract::Zif268 transcription factor is expressed throughout Cebus apella visual cortex at high basal levels. Monocular eyelid suture alters the levels of Zif268 on neurons connected to the deprived eye, revealing ocular dominance columns in the striate cortex of Cebus as previously demonstrated in Old World monkeys (Chaudhuri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00590-2
更新日期:1996-09-02 00:00:00
abstract::We have shown previously that progesterone linked with bovine serum albumin at position 3 of the progesterone molecule (P-3-BSA) was effective in modulating (both stimulating and inhibiting) amphetamine (AMPH)-evoked dopamine (DA) release in vitro from superfused corpus striatal (CS) tissue fragments of ovariectomized...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90395-c
更新日期:1991-01-04 00:00:00
abstract::The pars externa (PE) system of the anterior olfactory nucleus (AON) in a primate, Callithrix jacchus, was defined by its architecture and by its connection patterns with the main olfactory bulb (MOB) as revealed by tracing techniques. Focal, unilateral injections of wheat germ agglutinin-conjugated horseradish peroxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90071-6
更新日期:1988-08-02 00:00:00
abstract::Nitric oxide (NO) is a putative neuronal messenger in the olfactory epithelium. We analysed the electrical responses of rat olfactory receptor neurones to NO stimulation in the whole-cell patch clamp mode and found that NO activates the cyclic nucleotide-gated conductance, independent from cyclic GMP. As NO may also o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02990-1
更新日期:2003-08-01 00:00:00
abstract::The density of specific prostaglandin E2 (PGE2) binding sites was quantitatively mapped in the rat brain using in vitro autoradiography. The anterior wall of the third ventricle and the nucleus solitary tract were found to have a very high density of binding sites (greater than 15 fmol/mg tissue). Two thalamic nuclei ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90720-t
更新日期:1992-05-29 00:00:00
abstract::The local cerebral circulatory and metabolic effects of MK-801, a selective non-competitive N-methyl-D-aspartate receptor antagonist have been examined in conscious rats with quantitative autoradiographic techniques using [14C]iodoantipyrine and [14C]2-deoxyglucose as tracers. Local cerebral blood flow (CBF) and local...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90172-8
更新日期:1990-03-19 00:00:00
abstract::The understanding of sarcasm reflects a complex process, which involves recognizing the beliefs of the speaker. There is a clear association between deficits in mentalizing, which is the ability to understand other people's behavior in terms of their mental state, and the understanding of sarcasm in individuals with a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.088
更新日期:2006-12-08 00:00:00
abstract::Our previous single unit and ultrastructural studies of visual cortex of dark-reared rats revealed an impairment of intracortical inhibitory mechanisms [2,3,5]. Neurochemical changes in inhibitory neurotransmitter and/or neuropeptides, such as gamma-aminobutyric acid (GABA) and somatostatin (SS), respectively, may con...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00553-3
更新日期:1995-08-21 00:00:00