Abstract：
:The A-ring reduced metabolite of deoxycorticosterone, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) was recently shown to act at the gamma-aminobutyric acid receptor-chloride ion channel complex in rat brain. The behavioral profile of THDOC was investigated using two animal models of anxiety, the two-chambered mouse exploration test and the lick suppression conflict test. THDOC showed anxiolytic activity in both animal models, with an anxiolytic dose range, 5-15 mg/kg i.p., separable from the sedative dose range, above 20-30 mg/kg i.p.
journal_name
Brain Resjournal_title
Brain researchauthors
Crawley JN,Glowa JR,Majewska MD,Paul SMdoi
10.1016/0006-8993(86)91500-3subject
Has Abstractpub_date
1986-11-29 00:00:00pages
382-5issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)91500-3journal_volume
398pub_type
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