Abstract：
:The brain contains neurons which alter their firing rates when ambient glucose concentrations change. An ATP-sensitive K+ (Katp) channel on these neurons closes and increases cell firing when ATP is produced by intracellular glucose metabolism. Binding of the antidiabetic sulfonylurea drugs to a site linked to this channel has a similar effect. Here rats with a propensity to develop diet-induced obesity (DIO) or to be diet-resistant (DR) when fed a diet moderately high in fat, energy and sucrose (HE diet) had low and high affinity sulfonylurea binding assessed autoradiographically with [3H]glyburide in the presence or absence of Gpp(NH)p. Before HE diet exposure, chow-fed DIO- and DR-prone rats were separated by their high vs. low 24 h urine NE levels. In DR-prone rats, low affinity [3H]glyburide binding sites comprised up to 45% of total binding with highest concentrations in the hypothalamus and amygdala. But DIO-prone rats had few or no low affinity binding sites throughout the forebrain. High affinity [3H]glyburide binding was similar between phenotypes. When rats developed DIO after 3 months on HE diet, their low affinity binding increased slightly. DR rats fed the HE diet gained the same amount of weight as chow-fed controls but their low affinity binding sites were reduced to DIO levels and both were significantly lower than chow-fed controls. By contrast, high affinity [3H]glyburide binding was increased in DR rats throughout the forebrain so that it significantly exceeded that in both DIO and chow-fed control rats. These studies demonstrate a significant population of low affinity sulfonylurea binding sites throughout the forebrain which, along with high affinity sites, are regulated as a function of both weight gain phenotype and diet composition.
journal_name
Brain Resjournal_title
Brain researchauthors
Levin BE,Brown KL,Dunn-Meynell AAdoi
10.1016/s0006-8993(96)00835-9subject
Has Abstractpub_date
1996-11-11 00:00:00pages
293-300issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(96)00835-9journal_volume
739pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Both direct pituitary and indirect CNS mechanisms have been postulated for the influence of opiate agonists on prolactin secretion. By examining the interactions between terminals of neurons containing opioid peptides and hypothalamic TH-positive cell bodies, this paper addressed the anatomical basis for the latter me...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90338-a
更新日期：1992-05-22 00:00:00
abstract：:The present experiments were aimed to determine the extent to which differentiated neuroblastoma cells may serve as a donor source for neural transplantation studies. Rodent-derived C1300 and human-derived LA-N-2 cells stained positively for choline acetyltransferase in vitro whether left untreated or rendered amitoti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90182-x
更新日期：1987-08-04 00:00:00
abstract：:Male and female hooded rats were raised from weaning in either a complex or an isolated environment in two separate replications. After one month, the brains were Golgi-Cox stained and dendritic fields of dentate gyrus granule cells were quantified. There was a sex difference in response to the environment. Females ra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90125-8
更新日期：1985-04-29 00:00:00
abstract：:Heme oxygenase-carbon monoxide-cGMP (HO-CO-cGMP) pathway has been reported to be involved in peripheral and spinal modulation of inflammatory pain. However, the involvement of this pathway in the modulation of acute painful stimulus in the absence of inflammation remains unknown. Thus, we evaluated the involvement of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.044
更新日期：2011-04-18 00:00:00
abstract：:The distribution and density of noradrenergic (NA) and serotonergic (5-HT) varicosities in the superior olive (SO) and periolivary region (PO) and their relationship to olivocochlear neurons was studied. Antibodies against 5-HT and the NA precursor enzyme dopamine beta-hydroxylase were utilized to examine the density ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01541-3
更新日期：1999-07-31 00:00:00
abstract：:The immunohistochemical studies on a peroxisomal enzyme, catalase, were done on brains from human fetuses to adults. The catalase-positive neurons appeared in the basal ganglia, thalamus and cerebellum at 27-28 weeks of gestation, and in the frontal cortex at 35 weeks. They then increased in number with gestational ag...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90314-l
更新日期：1991-08-16 00:00:00
abstract：:The effect of high concentrations of L-ascorbic acid on the in vivo and in vitro growth of human neuroblastoma has been investigated. Directly implemented into cell culture it decreased the DNA, RNA and protein synthesis, and mitosis of neuroblastoma cells, without affecting normal neuronal cells. In vivo treatment of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91139-4
更新日期：1985-09-09 00:00:00
abstract：:Previous research has demonstrated that cross-language activation is present even when proficient bilinguals perform a task only in one language. The present study investigated the time-course of cross-language activation during word production in a second language (L2) by using a picture-word interference paradigm wi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.053
更新日期：2011-01-31 00:00:00
abstract：:Prolonged seizures have long been known to be associated with cell injury and cell death in brain. Such seizure-related neuronal injury has been assumed to be mediated by glutamate, the same excitatory amino acid in the central nervous system which propagates the seizure itself. Elevated extracellular concentrations o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00658-0
更新日期：1996-10-21 00:00:00
abstract：:The periaqueductal gray was shown to be an important component of morphine analgesia and tolerance. Two-way analgesic cross tolerance was obtained between systemic and intracerebral morphine administrations when the intracerebral site was the periaqueductal gray. Rats were pretreated with intraperitoneal morphine and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90448-0
更新日期：1976-02-27 00:00:00
abstract：:The endocrine disruptor Bisphenol-A (BPA) has been shown to modulate estrogenic, androgenic, and anti-androgenic effects. The effects of BPA exposure during early organizational periods of development have been well documented. The current study focuses on the effects of short term, low-dose BPA exposure on anxiety, s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.07.018
更新日期：2013-09-05 00:00:00
abstract：:Mutant Cu/Zn superoxide dismutase (SOD1) associated with familial amyotrophic lateral sclerosis (FALS) causes selective motor neuron loss through unknown mechanisms of cell damage. Damaged neurons frequently undergo apoptosis mediated by the p53 cell survival regulator. We therefore studied whether motor neuron diseas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02745-1
更新日期：2000-10-06 00:00:00
abstract：:Plectin is associated with intermediate filaments, such as glial fibrillary acidic protein (GFAP) and vimentin, which have an important role in the glial reactions after lesions. The present study investigates the plectin immunoreactivity following stab wounds in the cortex and the underlying white matter of adult rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02399-9
更新日期：2000-02-28 00:00:00
abstract：:Conditions for the stimulation of taurine release by illumination or increased K+ concentrations were established. The effect of Mg2+, ruthenium red and verapamil on taurine release induced by both procedures was compared. All these agents antagonize Ca2+-dependent release of neurotransmitters. Illumination-induced re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90054-8
更新日期：1976-09-03 00:00:00
abstract：:This paper describes an electrochemical method for the detection of dopamine and serotonin in vitro. Dopamine and serotonin can be distinguished from each other without interference from metabolites. 3-4-dihydroxyphenylacetic acid and 5-hydroxyindoleacetic acid. The method also provides selective differentiation of do...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91224-9
更新日期：1989-08-21 00:00:00
abstract：PURPOSE:To determine whether antisense oligonucleotides (AODNs) targeted against CRX, a photoreceptor-specific trans-acting factor, suppress CRX expression and interphotoreceptor retinoid binding protein (IRBP) promoter activity. METHODS:Cultures of human retinoblastoma cells were transfected with chloramphenicol acet...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02884-0
更新日期：2001-10-19 00:00:00
abstract：:Both glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) can protect nigrostriatal dopaminergic neurons from neurotoxins in rodent and monkey models of Parkinson's disease (PD). These two neurotrophic factors are usually tested individually. This study was designed to compar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.05.072
更新日期：2005-08-09 00:00:00
abstract：:Previously we reported that several microRNAs (miRNA) are upregulated following experimentally induced traumatic brain injury (TBI) using both in vivo and in vitro approaches. Specific miRNAs were found to be sensitive to therapeutic hypothermia and may therefore be important targets for neuroprotective strategies. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.08.011
更新日期：2013-10-02 00:00:00
abstract：:Cerebral autoregulation was tested here in 3- and 18-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) was measured in each rat using radioactive micropheres under unanesthetized control conditions and after hypotension induced by ganglionic blockade. Under cont...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90454-6
更新日期：1981-06-09 00:00:00
abstract：:Veratridine-induced depolarization caused a large increase in Ca uptake in the rat hippocampal slice (30.2 vs. 9.0 nM/mg dry weight). This uptake was reduced to 18.4 nM/mg when veratridine was combined with anoxia. When compared with veratridine exposure alone, the combination of anoxia and veratridine increased intra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91547-4
更新日期：1994-01-07 00:00:00
abstract：:Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO(2)) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO(2) treatment has a therapeutic effect on ICP dynamics and survival following seve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.049
更新日期：2005-06-21 00:00:00
abstract：:Growth of cultured N1E-115 neuroblastoma cells in 1 microM A23187 for 2 days to elevate internal Ca reduced both membrane Na current and the transient, but not steady state, component of outward K current. Na channel mRNA abundance was reduced by an average value of 45% without effect on Kv3.1. Increases in internal C...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01340-7
更新日期：1996-01-15 00:00:00
abstract：:In nondiabetic animals, estrogen has been shown to provide significant neuroprotection in focal and transient forebrain ischemia models. However, that neuroprotection may be diminished or lost in the diabetic. In this study, we compared the level of brain damage in intact, ovariectomized (OVX) and 17beta-estradiol (E(...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03484-4
更新日期：2002-11-22 00:00:00
abstract：:The pattern of generation of neurons in the albino rat superior colliculus has been studied in adult and fetal material. Neurons are generated between embryonic days 12 to 17, with rostrolateral colliculus in advance of caudomedial parts. More of the cells contributing to the deeper layers are generated early, while m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90004-0
更新日期：1979-03-23 00:00:00
abstract：:Investigations of the time course of various stages of lexical processing have indicated either early or late onset of brain activation for phonological code retrieval. The basis of the differential findings is unclear, but factors related to segmental phonology appear to be part of it. The purpose of the present stud...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.01.014
更新日期：2016-03-15 00:00:00
abstract：:We have investigated the effects of nerve growth factor (NGF, 2.5 ng/ml for 1-2 weeks) on enriched adult rat dorsal root ganglion (DRG) neurons maintained in cell culture in defined media. Whole-cell recordings in cells cultured in the absence and presence of NGF revealed no significant difference in resting membrane ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90564-p
更新日期：1992-01-20 00:00:00
abstract：:Lithium and valproic acid are mood-stabilizing agents that are often used to manage the episodes of mania and depression that characterize bipolar disorder. These agents develop clinical efficacy with chronic treatment, but the neurobiological actions that contribute to their therapeutic effects remain unclear. The pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.102
更新日期：2006-06-06 00:00:00
abstract：:Prenatal cocaine exposure causes alterations in auditory brainstem response in children and experimental animals and has adverse effects on auditory information processing and language skills in children. These effects may result from lesions in the cochlea since this organ is particularly sensitive to chemical insult...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.066
更新日期：2006-05-01 00:00:00
abstract：:Chronic vitamin B12 (cobalamin) deficiency in the mammalian central nervous system causes degenerative damage, especially in the spinal cord. Previous studies have shown that cobalamin status alters spinal cord expression of epidermal growth factor (EGF) and its receptor in rats. Employing a mouse model of cobalamin-d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.01.050
更新日期：2013-03-29 00:00:00
abstract：:Aluminum (Al) concentrations of the rat frontal cortex, parietal cortex, and hippocampus were measured by atomic absorption spectroscopy 16 days after a unilateral intracerebroventricular injection of Na gluconate, Al gluconate, or the cholinotoxin AF64A. A fourth group of rats were injected with AF64A 6 days before i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90946-8
更新日期：1988-03-22 00:00:00
