Plectin immunopositivity appears in the astrocytes in the white matter but not in the gray matter after stab wounds.

abstract：:The cerebellum and inferior olive of adult homozygous leaner mutant mice (tgIa/tgIa) were examined using anti-vitamin D-dependent calcium binding protein immunohistochemistry, and Nissl staining. The immunohistochemical staining revealed that cerebellar Purkinje cell loss in leaner is restricted to alternating saggita...

journal_title：Brain research

authors： Heckroth JA,Abbott LC

更新日期：1994-09-26 00:00:00

abstract：:We have elucidated the spatial and temporal localization of Cdk5 and p35nck5a in the developing rat postnatal cerebellum. Both proteins were highly expressed in cell bodies of post mitotic and immature neurons. The localization of Cdk5 in cellular compartment was changed from cell body to the axon in development. On t...

journal_title：Brain research

authors： Matsushita M,Tomizawa K,Lu YF,Moriwaki A,Tokuda M,Itano T,Wang JH,Hatase O,Matsui H

更新日期：1996-09-23 00:00:00

abstract：:Using a double-labeling method that combines retrograde tracing and immunocytochemistry, we demonstrated the presence of a hippocampofugal gamma-aminobutyric acid (GABA)-like immunoreactive (GABA-LI) neuron system in the rat. As a preliminary experiment, knife-cut of the dorsal fornix was made and it resulted in a rem...

journal_title：Brain research

authors： Shinoda K,Tohyama M,Shiotani Y

更新日期：1987-04-14 00:00:00

abstract：:Antibodies binding to the 150 kDa neurofilament protein NF150 have been purified from a serum raised by immunizing a rabbit with alpha-MSH. The NF150-binding antibodies were purified by affinity chromatography on a column of cytoskeletal proteins coupled to CNBr-activated Sepharose-4B. Immunocytochemical application o...

journal_title：Brain research

authors： Verhaagen J,Edwards PM,Jennekens FG,Schotman P,Gispen WH

更新日期：1987-02-24 00:00:00

abstract：:In the present study we evaluated the role of NMDA receptors on the pressor and bradycardic responses to L-glutamate (L-Glu) microinjected into the nucleus tractus solitarius (NTS) of unanesthetized rats. L-Glu (1 nmol/100 nl) was microinjected into the NTS before and 10 min after microinjection of phosponovaleric aci...

journal_title：Brain research

authors： Colombari E,Bonagamba LG,Machado BH

更新日期：1997-02-28 00:00:00

abstract：:The distribution of S-100-immunoreactive material was examined in the central nervous system of the gastropod snail. Helix pomatia, and electrophysiological properties of S-100-positive neurons were characterized. Immunocytochemical studies revealed S-100-like protein to be present in neurons localized in the cerebral...

journal_title：Brain research

authors： Kubista H,Kerschbaum HH,Hermann A

更新日期：1996-04-15 00:00:00

abstract：:Electrode-implanted rats pressed a lever to self-stimulate a reward mechanism in their lateral hypothalamus (LH) each time with a brief train of pulses. Interdigitation of a medial hypothalamus (MH) train into the ipsilateral LH train inhibited the reward as indicated by a reduced lever pressing rate. Such interdigita...

journal_title：Brain research

authors： Porrino LJ,Coons EE,MacGregor B

更新日期：1983-10-31 00:00:00

abstract：:The effects of stimulating the reticular formation were studied during fictive locomotion in lampreys (Ichthyomyzon unicuspis). The in vitro isolated preparation of the brainstem and spinal cord was used and fictive locomotion was induced by bath application of N-methyl-D-aspartate (NMDA; 50-100 microM). During differ...

journal_title：Brain research

authors： Guertin P,Dubuc R

更新日期：1997-04-11 00:00:00

abstract：:Accumulating evidence indicates that extensive microglia activation-mediated local inflammation contributes to neuronal injury in cerebral ischemia. We have previously shown that 4-(2-butyl-6, 7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), a potent volume-regulated anion channel (VRAC) inhibitor, s...

journal_title：Brain research

authors： Han Q,Liu S,Li Z,Hu F,Zhang Q,Zhou M,Chen J,Lei T,Zhang H

更新日期：2014-01-13 00:00:00

abstract：:The central amygdaloid nucleus (CeA) receives projection from the parabrachial nucleus (PBN) gustatory neurons and descendingly projects to the PBN, and taste responses in the PBN are significantly affected by stimulation or lesion of the CeA. To examine whether the GABA receptors within the CeA are involved in this m...

journal_title：Brain research

authors： Kang Y,Yan J,Huang T

更新日期：2004-11-26 00:00:00

abstract：:Regulation of the intracellular calcium concentration ([Ca(2+)](i)) is of critical importance for synaptic function. Therefore, neurons buffer [Ca(2+)](i) using intracellular Ca(2+)-binding proteins (CaBPs). Previous evidence suggests that Calbindin-D(28K) (CB), an abundantly expressed endogenous fast CaBP, plays an i...

journal_title：Brain research

authors： Westerink RH,Beekwilder JP,Wadman WJ

更新日期：2012-04-23 00:00:00

abstract：:Excitatory amino acid neurotoxicity and the inflammatory response are suspected as mediators of some of the pathological sequelae occurring as a result of spinal cord injury. Here we report temporal and regional increases of the NMDA receptor agonist, quinolinic acid (QUIN), in an experimental model of spinal contusio...

journal_title：Brain research

authors： Popovich PG,Reinhard JF Jr,Flanagan EM,Stokes BT

更新日期：1994-01-07 00:00:00

abstract：:To understand the role of hypothalamic dopamine in thermoregulation, single unit activity was recorded in vitro, from constantly perfused tissue slices of rat preoptic area and anterior hypothalamus, PO/AH. The firing rate and thermosensitivity of individual PO/AH neurons were determined before, during and after tissu...

journal_title：Brain research

authors： Scott IM,Boulant JA

更新日期：1984-07-23 00:00:00

abstract：:In vitro assays offer a means of screening potential therapeutics and accelerating the drug development process. Here, we utilized neuronal cultures on planar microelectrode arrays (MEA) as a functional assay to assess the neurotoxicity of amyloid-β 1-42 (Aβ42), a biomolecule implicated in the Alzheimer׳s disease (AD)...

journal_title：Brain research

authors： Charkhkar H,Meyyappan S,Matveeva E,Moll JR,McHail DG,Peixoto N,Cliff RO,Pancrazio JJ

更新日期：2015-12-10 00:00:00

abstract：:Brain iron overload has a detrimental role in brain injury after intracerebral hemorrhage (ICH). Lipocalin 2 (LCN2), a siderophore-binding protein, is involved in cellular iron transport. The present study investigated changes in LCN2 expression after ICH and the role of iron in those changes. Male Sprague-Dawley rats...

journal_title：Brain research

authors： Dong M,Xi G,Keep RF,Hua Y

更新日期：2013-04-10 00:00:00

abstract：:The anatomical distribution of L-[3H]glutamate binding sites was determined in the presence of various glutamate analogues using quantitative autoradiography. The binding of L-[3H]glutamate is accounted for by the presence of 3 distinct binding sites when measured in the absence of Ca2+, Cl- and Na+ ions. The anatomic...

journal_title：Brain research

authors： Monaghan DT,Yao D,Cotman CW

更新日期：1985-08-12 00:00:00

abstract：:The time course of autoradiographic binding of major second messengers in the rat brain was studied at 2, 7, and 24 h after withdrawal from butorphanol infusion. [3H]Forskolin and [3H]phorbol 12,13-dibutyrate (PDBu) were used to label adenylate cyclase and protein kinase C (PKC), respectively. Rats were rendered depen...

journal_title：Brain research

authors： Jang CG,Rockhold RW,Ho IK

更新日期：1999-03-13 00:00:00

abstract：:The reactivity of dopaminergic (DA) terminals in the nucleus accumbens was investigated in male rats submitted to tail-pinch or various social interactions. The DA activity was assessed by measurement of the presynaptic metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) by using differential pulse voltammetry in free m...

journal_title：Brain research

authors： Louilot A,Le Moal M,Simon H

更新日期：1986-11-12 00:00:00

abstract：:In a whole mount preparation of the hooded rat retina, stained with methylene blue, the ganglion cell density was counted over the retina. The density ranged from 6200-6500/sq.mm to 1000-1500/sq.mm. The area with a density higher than 6000/sq.mm was called the central area and was centered at about 1 mm (20 degrees) a...

journal_title：Brain research

authors： Fukuda Y

更新日期：1977-01-07 00:00:00

abstract：:Cerebrovascular diseases are currently a major global health problem. Considering the limitations of current therapy, the search for new alternatives for the treatment of these diseases is necessary and, in this context, curcumin, a molecule that has neuroprotective properties already described in the literature. A li...

journal_title：Brain research

authors： Marques MS,Cordeiro MF,Marinho MAG,Vian CO,Vaz GR,Alves BS,Jardim RD,Hort MA,Dora CL,Horn AP

更新日期：2020-11-01 00:00:00

abstract：:Saccadic adaptation maintains saccade accuracy and has been studied with targeting saccades, i.e. saccades that bring the gaze to a target, with the classical intra-saccadic step procedure in which the target systematically jumps to a new position during saccade execution. Post-saccadic visual feedback about the error...

journal_title：Brain research

authors： Lavergne L,Vergilino-Perez D,Lemoine C,Collins T,Doré-Mazars K

更新日期：2011-09-30 00:00:00

abstract：:A new compound, 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), has been evaluated as an excitatory amino acid receptor antagonist using electrophysiological assays and radioligand binding. In autoradiographic preparations, CPP reduces L-[3H]glutamate binding in regions of the hippocampus rich in N-m...

journal_title：Brain research

authors： Harris EW,Ganong AH,Monaghan DT,Watkins JC,Cotman CW

更新日期：1986-09-10 00:00:00

abstract：:Metabolic dysfunction in the relay nuclei of the rat vibrissa circuit follows traumatic brain injury (TBI). This study examined the effects of mild (1.4-1.5 atm) parasagittal fluid-percussion injury on the electrophysiology of this circuit. TBI caused significant reductions in slope and increases in latency of vibriss...

journal_title：Brain research

authors： Sanders MJ,Dietrich WD,Green EJ

更新日期：2001-06-15 00:00:00

abstract：:Fetal mouse retinal ganglion cell axons have been shown to ramify within co-cultured basement membrane secreting tumor explants and upon isolated basement membranes. Here we report that laminin, a glycoprotein found in basement membranes and adhesion sites of a variety of cell types, acted as a substrate for retinal e...

journal_title：Brain research

authors： Smalheiser NR,Crain SM,Reid LM

更新日期：1984-01-01 00:00:00

abstract：:The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesenteric ganglia was depressed by bath application of Met- or Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably af...

journal_title：Brain research

authors： Jiang ZG,Simmons MA,Dun NJ

更新日期：1982-03-04 00:00:00

abstract：:Spinal cord patterns of metabolic activity in a model of neuropathic pain were assessed in unanesthetized rats by the [14C]-2-deoxyglucose (2-DG) technique. Rats used in this procedure had demonstrable thermal hyperalgesia ipsilateral to sciatic nerve ligation and ipsilateral hindpaws that were lifted in a guarded pos...

journal_title：Brain research

authors： Price DD,Mao JR,Coghill RC,d'Avella D,Cicciarello R,Fiori MG,Mayer DJ,Hayes RL

更新日期：1991-11-15 00:00:00

abstract：:The ability of hippocampal serotonergic (5-HT) axons to proliferate in response to damage by para-chloroamphetamine (PCA) was examined in this study. Synaptosomal uptake of 5-HT in the hippocampal formation was decreased to 40% of control 3 days after systemic administration of PCA. Six weeks after PCA, uptake values ...

journal_title：Brain research

authors： Haring JH,Meyerson L,Hoffman TL

更新日期：1992-04-17 00:00:00

abstract：:The serotoninergic (5-hydroxytryptamine, 5-HT) innervation of the rat ventral tegmental area (VTA) was examined by light and electron microscopic radioautography following intraventricular infusion of [3H]5-HT. The [3H]5-HT labeled processes were characterized with respect to their regional distribution, ultrastructur...

journal_title：Brain research

authors： Hervé D,Pickel VM,Joh TH,Beaudet A

更新日期：1987-12-01 00:00:00

abstract：:The enduring effects of postweaning subchronic methylphenidate (MP) treatment and/or previous early preweaning methamphetamine (MA) application on dopamine (DA) fiber density were investigated in multiple cortical and subcortical areas of the gerbil brain. The study aimed to explore three questions: (1) is the develop...

journal_title：Brain research

authors： Grund T,Teuchert-Noodt G,Busche A,Neddens J,Brummelte S,Moll GH,Dawirs RR

更新日期：2007-10-24 00:00:00

abstract：:The in vitro model presented provides an approach to study the nature of cell volume control as well as of swelling mechanisms under pathophysiological conditions. Pertinent parameters of cell volume control can be analyzed in isolation due to a virtually infinite extracellular environment precluding secondary effects...

journal_title：Brain research

authors： Kempski O,Chaussy L,Gross U,Zimmer M,Baethmann A

更新日期：1983-11-21 00:00:00