Abstract：
:Chemical (C) kindling by means of repeated spaced injections into the amygdala (AM) of a subconvulsive dose of L-glutamate and L-aspartate combined in a molar ratio of 1:3. (Glu/Asp) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled Stage 5 seizure in rats. These C-kindled AM sites responded readily to electrical stimulation with very rapid development of kindled seizure. When a separate group of rats electrically kindled at the AM were subjected to identical C-kindling at the kindled AM site, a similar positive transfer effect was observed. In addition, 30 days following the last injection, kindled Stage 5 seizure was triggered with a single injection of Glu/Asp, one-half of the dose used for C-kindling. These results suggest that the glutamate and/or aspartate systems participate in the development and persistence of increased seizure susceptibility induced by AM kindling.
journal_name
Brain Resjournal_title
Brain researchauthors
Mori N,Wada JAdoi
10.1016/0006-8993(87)90481-1subject
Has Abstractpub_date
1987-11-03 00:00:00pages
45-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(87)90481-1journal_volume
425pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Perinatal asphyxia to the developing brain remains a major cause of morbidity. Hypothermia is currently the only established neuroprotective treatment available for term born infants with hypoxic-ischemic encephalopathy, saving one in seven to eight infants from developing severe neurological deficits. Therefore, addi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.05.040
更新日期：2016-09-01 00:00:00
abstract：:By utilizing the microinjection of low nanoliter volumes of convulsant drug and recording from the injection site, we have been able to electrophysiologically identify a layer of cat striate cortex that is most sensitive to the epileptogenic effects of penicillin. This band encompasses cortical depths of approximately...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91084-8
更新日期：1982-06-10 00:00:00
abstract：:Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects of their conditio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.05.021
更新日期：2011-07-11 00:00:00
abstract：:Effects of ketamine on glutamate-induced swelling of astrocytes in primary cell culture were studied. Following the exposure to 1 mM glutamate (Glu) for 4 h the intracellular water space (as measured by 3-O-methyl-[14C]glucose uptake) of astrocytes was increased by two-fold concomitant with cell swelling and disappear...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90845-7
更新日期：1989-05-22 00:00:00
abstract：:Suppression of geniculate ponto-geniculo-occipital (PGO) waves was achieved in kittens by performing bilateral mesencephalic lesions of the PGO pathways. Sleep-wake parameters and the spontaneous unit activity in the lateral geniculate nucleus (LGN) were then chronically recorded during one month after the lesions. Wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90735-9
更新日期：1987-04-14 00:00:00
abstract：:Little is known about the movement of 5-aminolevulinic acid (delta-aminolevulinic acid; ALA) between blood and brain. This is despite the fact that increases in brain ALA may be involved in generating the neuropsychiatric symptoms in porphyrias and that systemic administration of ALA is currently being used to delinea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03749-6
更新日期：2003-01-10 00:00:00
abstract：:Chick neural cultures were used to study effects of insulin, thyrotropin releasing hormone, growth hormone and glucagon on myelin lipid synthesis in vitro. The incorporation of [3H]galactose into myelin associated lipids such as cerebroside and sulfatide was used as an index for various hormonal effects on myelination...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90831-0
更新日期：1986-04-16 00:00:00
abstract：:The ability of crude cerebrum supernatant to stabilize, at a low temperature, cold-labile microtubules purified from beef brain was studied during development in the rat. The cold-stabilizing activity of the supernatant was low during the first postnatal week, rose significantly during the second postnatal week, and t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90238-6
更新日期：1988-08-01 00:00:00
abstract：:Adult Long-Evans female rats sustained electrolytic fimbria-fornix lesions and, two weeks later, received intrahippocampal suspension grafts of fetal septal tissue. Sham-operated and lesion-only rats served as controls. Between 6.5 and 8 months after grafting, both the [3H]choline accumulation and the electrically evo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01092-0
更新日期：1995-12-18 00:00:00
abstract：:Oxygen therapy (OT) with hyperbaric oxygen (HBO) or normobaric hyperoxia (NBO) improves the oxygenation of penumbral tissue in experimental ischemic stroke. However, whether this results in the improvement of energy metabolism is unclear. We investigated the effect of both OTs on tissue acidosis and on ATP production....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.064
更新日期：2011-09-30 00:00:00
abstract：:Neurofilament expression in peripheral olfactory neurons of adult rats was investigated by immunoblotting and immunohistochemistry using monoclonal antibodies specific for each of the 3 neurofilament proteins. Immunoblotting analysis of olfactory epithelium extracts demonstrated the presence of only the 200 kDa (NFH) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90416-s
更新日期：1991-05-31 00:00:00
abstract：:Three types of hyperpolarization in response to applied acetylcholine (ACh) were observed in 4 identified neurones (RP1, RP2, RP3 and RP4) in the right parietal ganglion of the African giant snail, Achatina fulica Férussac. In order to clarify the ionic mechanisms of these responses, the neurones were voltage-clamped ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90416-6
更新日期：1986-05-28 00:00:00
abstract：:The neurobiology of social bonding, despite its relevance to human mental health, has been studied primarily in rodents. In this study we used position emission tomography (PET), registered with structural magnetic resonance imaging (MRI) to investigate central glucose uptake in 17 males of a monogamous primate specie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.09.087
更新日期：2007-12-12 00:00:00
abstract：:The postnatal development of acetylcholinesterase (AChE, EC 3.1.1.7) and NADH-diaphorase was examined in the caudate-putamen nucleus and substantia nigra of rats ranging from 3 to 90 days in age. From 3 to 15 days post partum islands of AChE and NADH-diaphorase activity were observed in the caudate-putamen nucleus. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)91022-2
更新日期：1976-04-23 00:00:00
abstract：:It has been previously observed that taurine inhibits PKC-activated phosphorylation of specific proteins including a approximately 20k Mr protein in rat cortical synaptosomes. In the present study, the mechanism of the above effects of taurine were investigated. In an intrasynaptosomal cytosol fraction obtained by sub...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90234-m
更新日期：1991-07-05 00:00:00
abstract：:This report describes the relationship between monoamines, sleep and seizures before and 1-month after amygdala kindling in young cats (<1 year old; n=8; six female and two male). Concentrations (fmoles of norepinephrine or NE, dopamine or DA and serotonin or 5-HT) were quantified in consecutive, 5-min microdialysis s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03265-0
更新日期：2001-02-16 00:00:00
abstract：:Activity produced by direct microelectrophoretic application of glutamate onto 19 convergent neurones in trigeminal nucleus caudalis, was strongly depressed during and after the application of heterotopic noxious conditioning stimuli: noxious heat (52 degrees C) applied to the tail, noxious pinches applied to the tail...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90695-4
更新日期：1984-10-29 00:00:00
abstract：:In the present study we analyzed the effect of ascorbate (0.8 mM)/Fe2+ (2.5 microM)-induced membrane lipid peroxidation on the levels of intracellular free calcium,[Ca2+]i and on the possible mechanisms involved in the perturbation of intracellular calcium homeostasis during oxidative stress. For this purpose, the inf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01554-x
更新日期：1996-03-25 00:00:00
abstract：:Neuropeptide Y (NPY) presynaptically inhibits excitatory transmission in area CA1 of rat hippocampus. As postsynaptic NPY receptors in certain other tissues have been shown to be coupled to G-proteins, we have tested the hypothesis that the hippocampal NPY effects are also mediated by G-proteins. Pretreatment of rats ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90403-4
更新日期：1989-09-25 00:00:00
abstract：:The blood-brain interface in elasmobranchs was examined using physiological and anatomical techniques. Electrolyte analyses of plasma and cerebrospinal fluid (CSF) in control fish and in fish with elevated plasma cation concentration (Ca, Mg or K) demonstrated homeostasis of CSF calcium and magnesium concentrations in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91083-0
更新日期：1981-12-07 00:00:00
abstract：:The effects of acute and chronic phencyclidine (PCP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in discrete regions of rat brain. Both acute and chronic administration of PCP induced high locomotor activity, stereotypy and ataxia. On PCP administration, NTLI decreased significantly in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91601-4
更新日期：1985-05-06 00:00:00
abstract：:In kindled rats, the administration of cysteamine (CSH, 200 mg/kg, i.p.) 4 h prior to a kindled seizure leads to long-term (up to 10 days) inhibition of kindled seizures. CSH (200 mg/kg, i.p.) also induces myoclonic seizures in kindled rats. We suggest that the long-term inhibition of kindled seizures might be the res...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91453-3
更新日期：1987-05-26 00:00:00
abstract：:Previous studies in piglets show that opioid-induced pial artery dilation was impaired following fluid percussion brain injury (FPI). This study was designed to determine the role of the newly described opioid nociceptin orphanin FQ (NOC/oFQ) in such impaired dilation to other opioids after FPI. CSF NOC/oFQ concentrat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02367-2
更新日期：2000-06-30 00:00:00
abstract：:We investigated the effect of losartan, a nonpeptide angiotensin II (Ang II)-type 1 (AT1) receptor antagonist, on the responses evoked by Ang II and L-glutamate (L-Glu) in the rostral ventrolateral medulla (RVLM). Adult spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were anesthetized with halothane ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91344-7
更新日期：1994-12-05 00:00:00
abstract：:Alteration in the blood-nerve barrier may be of primary importance in the development of experimental lead neuropathy. Using quantitative track autoradiography, we have directly demonstrated that there is a 15-fold increase in the rate of 210Pb accumulation in the endoneurium 70 days after the onset of chronic intoxic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90318-8
更新日期：1981-11-23 00:00:00
abstract：:Following lesions of the pyramidal tract in hamsters, retrograde changes were studied in the sensorimotor cortex and in the pyramidal tract axons proximal to the lesion, at survival times ranging from 2 weeks to 14 months. Severe cell shrinkage occurred in layer 5 pyramidal neurons as early as 2 weeks, but there was n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90130-4
更新日期：1975-05-16 00:00:00
abstract：:A role for glutamatergic signaling in the nucleus accumbens (NA) in both the expression and extinction of cocaine seeking has been suggested. The effects of extinction following cocaine self-administration on the expression and synaptosomal distribution of GluR1 and NMDAR1 glutamate receptor subunits in the NA shell a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.047
更新日期：2009-04-24 00:00:00
abstract：:The involvement of endogenous serotonergic pathways in the mediation of antinociception has been indicated by electrophysiological, pharmacological and behavioral experiments. However, manipulation of the indole pathway, either by lesioning of raphe nuclei or drug intervention, often produces disparate results. In par...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90883-3
更新日期：1987-11-24 00:00:00
abstract：:Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 microgram/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90315-9
更新日期：1984-12-10 00:00:00
abstract：:Neonatal rats were exposed to lead from parturition to weaning via the milk of dams drinking 0.2% lead acetate solution. The alterations of long-term potentiation (LTP) and paired-pulse facilitation (PPF) of hippocampal dentate gyrus in adult rats (90-115 days) following developmental lead exposure were studied in viv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00739-2
更新日期：1998-09-28 00:00:00
