Abstract：
:Effects of ketamine on glutamate-induced swelling of astrocytes in primary cell culture were studied. Following the exposure to 1 mM glutamate (Glu) for 4 h the intracellular water space (as measured by 3-O-methyl-[14C]glucose uptake) of astrocytes was increased by two-fold concomitant with cell swelling and disappearance of cellular processes observed by phase-contrast microscopy. Ketamine, when co-incubated with Glu, reduced the astrocytic swelling in a dose-dependent manner. These data suggested that ketamine, in addition to its function as a non-competitive N-methyl-D-aspartate receptor antagonist, is also involved in protecting astrocytes from Glu-induced swelling.
journal_name
Brain Resjournal_title
Brain researchauthors
Chan PH,Chu Ldoi
10.1016/0006-8993(89)90845-7subject
Has Abstractpub_date
1989-05-22 00:00:00pages
380-3issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(89)90845-7journal_volume
487pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:To test the hypothesis that functional metabolic deficits observed following surgical brain injury are associated with changes in cognitive performance in rodents, we performed serial imaging studies in parallel with behavioral measures in control animals and in animals with surgical implants. Memory function was asse...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.134
更新日期：2007-05-04 00:00:00
abstract：:Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.041
更新日期：2015-05-22 00:00:00
abstract：:Rabbits reared from birth in stroboscopic illumination have no experience of visual motion. In primary visual cortex of these animals there is a large reduction in the number of cells which are direction selective. This result, contrary to previous reports, shows that the rabbit visual system can be modified by early ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90099-7
更新日期：1981-01-01 00:00:00
abstract：:We examined the radical-scavenging activity of docosahexaenoic acid (DHA) and its effects on the neuronal cell death induced by oxidative or hypoxic stress in cultured retinal ganglion cells (RGC-5, a rat ganglion cell-line transformed using E1A virus). The radical-scavenging activity [hydrogen peroxide (H(2)O(2)), su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.031
更新日期：2009-01-28 00:00:00
abstract：:Pathophysiological responses to peripheral nerve injury include alterations in the activity, intrinsic membrane properties and excitability of spinal neurons. The intrinsic excitability of α-motoneurons is controlled in part by the expression, regulation, and distribution of membrane-bound ion channels. Ion channels, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.12.012
更新日期：2014-02-14 00:00:00
abstract：:1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) was used to lesion the substantia nigra of rodents to look for changes in various animal models of epilepsy and seizures. MPTP, acutely administered to C57BL/6J mice, could cause seizures at high doses and enhanced maximal electroshock seizures at lower doses. Older ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91370-x
更新日期：1989-12-18 00:00:00
abstract：:The turning effects of the unilateral intranigral injection of morphine and of different analogs of dynorphin and enkephalin were studied. All injections were made in awake rats through cronically implanted guide cannulae. Dynorphin1-13 at a dose of 10 micrograms (0.6 nmol) and dynorphin1-17 at a dose of 2 micrograms ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91074-1
更新日期：1985-08-26 00:00:00
abstract：:Preconditioning-induced cellular adaptation is a new therapeutic strategy for ischemic stroke. This research aims to examine the role of peroxisome proliferator activated receptor (PPAR)-γ co-activator 1-α (PGC-1α) and hypoxia induced factor-1α (HIF-1α) in hypoxic preconditioning-induced protection. In this study, rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.01.059
更新日期：2012-04-04 00:00:00
abstract：:We suggested previously that increases in the extracellular [Ca2+] or [Mg2+] lengthen miniature end-plate currents (m.e.p.c.s.) because the divalent cations decrease the negative surface potential on the end-plate, and thereby increase the voltage drop within the membrane. The increased voltage drop would lengthen the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91065-4
更新日期：1982-06-10 00:00:00
abstract：:The binding of the adenosine receptor agonists, [3H]N-ethylcarboxamidoadenosine (NECA) and [3H]cyclohexyladenosine (CHA) to membrane preparations and to cryostat sections of the rat brain was examined. The xanthine derivative, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) was ca. 500-fold more effective at A1 than at A2 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90589-5
更新日期：1986-03-19 00:00:00
abstract：:The conditioned place preference paradigm was used to study the reinforcing properties of D-amphetamine. Rats were injected (i.p.) with D-amphetamine sulphate (0.5, 1.0 or 5.0 mg/kg) and 10 min later confined for 30 min to one side of a shuttle box in which each of the two compartments had distinctive features. On alt...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90685-0
更新日期：1982-12-16 00:00:00
abstract：:The ketogenic diet (KD) is a non-pharmacological treatment for specific types of epilepsy. In addition, it has been shown to be effective in mitigating other neurologic disorders. The KD is also effective in reducing body mass, leading to an increase in use by the general population for weight loss. As the popularity ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146697
更新日期：2020-05-01 00:00:00
abstract：:Changes in absorbance of voltage-sensitive merocyanine-rhodanine dyes were used to monitor electrical responses in the semilunar ganglion of 4-10-day-old developing chick embryos. The electrical responses were simultaneously recorded from many positions in the ganglion. Stimulation of the afferent nerve fibers (the op...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90130-0
更新日期：1985-01-01 00:00:00
abstract：:The distribution of cortical neurons which project to the spinal cord was investigated in the developing and adult rat using the retrograde transport of horseradish peroxidase (HRP). Following injections of HRP into the cervical spinal cord of a postnatal day 4 rat, retrogradely labeled neurons are located in layer Vb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90161-5
更新日期：1984-04-01 00:00:00
abstract：:Neuropeptide- and serotonin-like immunoreactivities were studied in the lumbar spinal cord of the cat after a longitudinal incision in the ventral funiculus. This lesion, which accomplishes a central axotomy of motoneurons, was accompanied by increased level of Met-enkephalin-like immunoreactivity in nerve endings in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90157-7
更新日期：1990-11-26 00:00:00
abstract：:The influence of glutamate and aspartate on the time course of decay of excitatory currents at neuromuscular junctions of locust skeletal muscle was examined. Both aspartate (up to 10 mM) and glutamate (up to 0.3 mM) had little influence on the decay time of the synaptic currents, whether measured intracellularly by v...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91020-3
更新日期：1980-06-16 00:00:00
abstract：:Leukocyte cell-derived chemotaxin 2 (LECT2) was first isolated as a chemotactic factor from phytohemagglutinin-activated human T-cell leukemia SKW-3 cells. LECT2 is expressed in various tissues, including in the brain, stomach and liver, but the functions of LECT2 in the brain remains unclear. To elucidate these funct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.010
更新日期：2010-01-22 00:00:00
abstract：BACKGROUND:Diminished dopaminergic neurotransmission contributes to decreased reward and negative eating behaviors in obesity. Bariatric surgery is the most effective therapy for obesity and rapidly reduces hunger and improves satiety through unknown mechanisms. We hypothesized that dopaminergic neurotransmission would...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.064
更新日期：2010-09-02 00:00:00
abstract：:Lithium and valproic acid are mood-stabilizing agents that are often used to manage the episodes of mania and depression that characterize bipolar disorder. These agents develop clinical efficacy with chronic treatment, but the neurobiological actions that contribute to their therapeutic effects remain unclear. The pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.102
更新日期：2006-06-06 00:00:00
abstract：:Apoptosis has been shown to be induced by some pathological stimuli. MPP+ is a neurotoxin and an inducer of parkinsonism. When SH-SY5Y cells, human neuroblastoma cell line, were treated with MPP+, cell death estimated by lactate dehydrogenase (LDH) leakage assay occurred. The cell death was associated with the DNA fra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01120-x
更新日期：1995-12-18 00:00:00
abstract：:This article has been removed, consistent with Elsevier Policy on Article Withdrawal. Please see (http://www.elsevier.com/locate/withdrawalpolicy). The Publisher apologizes for any inconvenience this may cause. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.003
更新日期：2009-10-14 00:00:00
abstract：:To investigate whether differences in vulnerability to free radicals might underlie differences among striatal neurons in their vulnerability to neurodegenerative processes such as occur in ischemia and Huntington's disease, we have analyzed the localization of superoxide free radical scavengers in different striatal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01320-2
更新日期：1996-02-05 00:00:00
abstract：:Previous studies in this laboratory have demonstrated that cholinergic receptors within the spinal cord play an important role in the expression of naloxone-precipitated withdrawal symptoms in the morphine-dependent rat. Related cardiovascular studies in non-dependent animals have demonstrated that this spinal choline...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00203-3
更新日期：1995-05-15 00:00:00
abstract：:Amitriptyline, a representative tricyclic antidepressant, has been widely used for the treatment of neuropathic pain, such as post-herpetic and trigeminal neuralgia. In the present study, we investigated the effect of amitriptyline on glycinergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) in acute...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.03.030
更新日期：2012-05-21 00:00:00
abstract：:Intracellular assessments of the physiological actions of cannabinoid receptor agonists and antagonists on adult hippocampal CA1 pyramidal cells in the in vitro slice preparation were performed using current clamp and conventional sharp-electrode intracellular recording procedures. Several manipulations were performed...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02110-7
更新日期：2000-04-28 00:00:00
abstract：:Systemic effects of anesthesia on the dynamics of the apnea-induced Blood Oxygen Level Dependent (BOLD) signal is still not clear. In the present study, the dynamics of the fMRI-BOLD signal and blood flow using laser Doppler flowmetry (LDF) was studied in rats in response to apnea. Two anesthetics namely pentobarbital...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.02.076
更新日期：2004-06-18 00:00:00
abstract：:The pathogenic mechanisms of gene-environment interactions determining variability of human neurodevelopmental disorders remain unclear. In the two consecutive papers, we used the neonatal Borna disease virus (BDV) infection rat model of neurodevelopmental damage to evaluate brain pathology, monoamine alterations, beh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02723-3
更新日期：2002-07-19 00:00:00
abstract：:There is a sizeable literature concerning basal ganglia (BG) functioning that is based on data from experiments employing a method of analysis that is traditionally used with other motor areas. A brief review of this literature is presented and the following conclusion is reached: as compared to the success of traditi...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0165-0173(85)90010-4
更新日期：1985-06-01 00:00:00
abstract：:Glioblastoma multiform is the most common malignant primary brain tumor in adults, but there remains no effective therapeutic approach. 2-methoxyestradiol (2-ME), which is a naturally occurring metabolite of 17beta-estradiol, was shown to enhance radiotherapeutic effect in certain tumors; however, whether 2-ME can als...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.092
更新日期：2007-12-14 00:00:00
abstract：:Individual choroid plexuses of human fetal brain at different developmental stages were investigated by an indirect immunoperoxidase technique. The number and distribution of prealbumin-, albumin-, alpha-fetoprotein-, transferrin-, IgG-, IgA-, IgM- and alpha 1-antitrypsin-containing choroid plexus epithelial cells wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90025-6
更新日期：1982-02-01 00:00:00
