Abstract：
:1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) was used to lesion the substantia nigra of rodents to look for changes in various animal models of epilepsy and seizures. MPTP, acutely administered to C57BL/6J mice, could cause seizures at high doses and enhanced maximal electroshock seizures at lower doses. Older mice were more sensitive to MPTP toxicity. MPTP given over 1 week to produce a 75% drop of striatal dopamine had no effect on seizure thresholds to pentylenetetrazol or picrotoxin and did not change the maximal electroshock seizure. Epileptic gerbils given maximally tolerated doses of MPTP had only a slight striatal dopamine reduction (32%) while seizures remained unaltered. The data are consistent with the hypothesis that chronic dysfunction of dopamine containing substantia nigra neurons have no significant influence on seizures in these animal models.
journal_name
Brain Resjournal_title
Brain researchauthors
Van Ness PC,Olsen RW,Verity MAdoi
10.1016/0006-8993(89)91370-xsubject
Has Abstractpub_date
1989-12-18 00:00:00pages
289-92issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(89)91370-Xjournal_volume
504pub_type
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