Abstract：
:Three types of hyperpolarization in response to applied acetylcholine (ACh) were observed in 4 identified neurones (RP1, RP2, RP3 and RP4) in the right parietal ganglion of the African giant snail, Achatina fulica Férussac. In order to clarify the ionic mechanisms of these responses, the neurones were voltage-clamped using two microelectrodes and the reversal potential of the ACh-induced currents was measured under several external ionic environments. Experiments revealed the existence of two different ACh-induced currents (Cl- and K+). It was concluded that the 3 types of hyperpolarizing responses were due to the relative sizes of the two currents in a neurone. Effects of some cholinergic antagonists on these currents were studied. Benzoquinonium blocked both currents at nearly the same concentration. D-Tubocurarine, decamethonium and atropine blocked Cl- current but not K+ current. These drugs did not show any clear voltage-dependency on their blocking actions. Tetraethylammonium blocked the ACh-induced K+ current at a lower concentration than that needed to block the other K+ channels in molluscan neurones, but it had little effect on Cl- current. These results suggest that two currents may be mediated by different ACh receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Furukawa Y,Kobayashi Mdoi
10.1016/0006-8993(86)90416-6subject
Has Abstractpub_date
1986-05-28 00:00:00pages
227-35issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)90416-6journal_volume
374pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young adults (18-30 years old) and 43 seniors (60-75 years old) were included. A general executive score was derived from...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.04.045
更新日期：2016-07-01 00:00:00
abstract：:Electrolytic lesions were placed in the medial cerebellar nucleus in tree shrews (Tupaia glis) or in fibers issuing from this nucleus. Brains and spinal cords were processed according to Fink-Heimer procedure following survival times of 2-7 days. In control animals lesions were placed in the cerebellar cortex and, in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)91044-8
更新日期：1979-08-10 00:00:00
abstract：:The inhibitory effect of different concentrations of lithium (0.15-10 x 10(-3) M) on cAMP production induced by isoprenaline (1 x 10(-4) M) after the blockade of alpha(2)-adrenoceptors in the rat cerebral cortex was investigated. Low lithium concentrations (0.3-0.6 x 10(-3) M) exerted a significant inhibitory effect a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.019
更新日期：2003-12-19 00:00:00
abstract：:The relationship between fiber tract formation and transverse and longitudinal borders of the diencephalon was investigated in Alligator embryos beginning when this structure was a single unit and continuing until internal subgroups were present within individual segments. At all stages of development, distinct bundle...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.081
更新日期：2010-02-08 00:00:00
abstract：:A histo-enzymatic technique for visualizing and quantifying endogenous NAD(H) in brain tissue was developed, based on coupled enzymatic cycling reactions that reduce nitrotetrazolium blue chloride to produce formazan. Conditions were used where the endogenous level of nicotinamide adenine dinucleotides (NAD(H)) was th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.042
更新日期：2010-02-26 00:00:00
abstract：:Our recent results showed that angiotensin II or III (AII, AIII) microinjected into the zona incerta (ZI) significantly increased water intake. The most effective doses of AII and AIII were also defined. The two neuropeptides had their effects differently on drinking via different receptors. AII bound to AT(1) that wa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.002
更新日期：2004-03-26 00:00:00
abstract：:Our previous studies have demonstrated that a mixture of bovine brain gangliosides ( BBG ) applied to Neuro-2a neuroblastoma cells markedly increased the degree and rate of neurite formation. In the present study, the cytoskeletal basis for BBG -mediated neurite outgrowth was investigated by comparing cells grown in t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90075-0
更新日期：1984-03-01 00:00:00
abstract：:Dorsal root ganglia (DRG) are key elements in sensory signaling under physiological and pathological conditions. Little is known about electrical coupling among cells in these ganglia. In this study, we injected the fluorescent dye Lucifer yellow (LY) into single cells to examine dye coupling in DRG. We found no dye c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.12.021
更新日期：2005-03-02 00:00:00
abstract：:The kindling process represents a progressively augmenting electrical and behavioral response to brain stimulation, that has been proposed as a model for the development of epileptogenesis. The first experiment examined the effects of hypophysectomy on the kindling process. The effects of hypophysectomy were found to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)91032-1
更新日期：1979-06-22 00:00:00
abstract：:Conflicting results concerning the issue of whether or not chronic morphine exposure induces an increase in CCK biosynthesis have been found in many CNS sites, including the spinal cord, where CCK activity may contribute to the facilitation of the development of opiate tolerance. The present study was undertaken in or...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01068-9
更新日期：1999-03-06 00:00:00
abstract：:The morphological basis of how visceral information from the nucleus of the solitary tract (NTS) is relayed from the parabrachial nucleus (PBN) to the central nucleus of the amygdala (Ce) was studied at the light and electron microscopic levels using the anterograde tracer, Phaseolus vulgaris leucoagglutinin (PHA-L), ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91262-9
更新日期：1994-11-14 00:00:00
abstract：:The extensive outgrowth from explanted goldfish retina in vitro stimulated by the axotomy of the optic nerve several days prior to the explantation, enables a more direct examination of the events which accompany optic nerve regeneration. Thus far neuritic outgrowth has been obtained in serum-containing medium. In the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90073-6
更新日期：1982-01-01 00:00:00
abstract：:The homozygous Brattleboro rat (di/di), displaying a hypothalamic form of diabetes insipidus, synthesizes a vasopressin (VP) precursor with an abnormal C-terminus. The phenotypic expression of coexisting peptides in mutant magnocellular VP cells shows a differential pattern. 7B2 is one of the peptides which is not det...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91218-4
更新日期：1992-07-10 00:00:00
abstract：:In continuation of our quantitative studies on 15-day fetal rat brain development, evidence was obtained of ventricular mitoses whose spindles are perpendicular to the surface of the ventricle. In most locations the proportion (ratio) between cells with perpendicular mitoses and predominant cells with mitoses parallel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90094-0
更新日期：1987-01-01 00:00:00
abstract：:Muscle spindles are induced during embryonic development by contact between sensory axons and undifferentiated myotubes. Neonatal guinea pigs deprived of nerve growth factor in utero can have only 15-20% of the normal number of dorsal root ganglion cells. This study demonstrates that such neonates have normal numbers ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90945-6
更新日期：1988-03-22 00:00:00
abstract：:Individuals are found to have better recall for self-referent information than other types of information. However, attribution research has shown that self-reference is highly correlated with emotional valence. The present study attempted to identify and separate the processing of self-reference and emotional valence...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.049
更新日期：2007-06-04 00:00:00
abstract：:Dentate granule cells can be selectively destroyed by intrahippocampal injections of colchicine. This study evaluates the consequences of granule cell destruction on blood pressure regulation in the normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rat (SHR). Bilateral destruction of dentate granule cells...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91473-7
更新日期：1994-09-12 00:00:00
abstract：:We examined the effects of chronic social stress and social rank on monamine concentrations in the prefrontal cortex (PFC) in adult male cynomolgus macaques (Macaca fascicularis). Seventy-five animals were housed in five-member social groups for 28 months and were exposed to three experimental conditions. A 'no-stress...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01146-3
更新日期：1995-12-24 00:00:00
abstract：:Brain extracellular matrix (ECM) is highly degraded after cerebral ischemia. The perlecan c-terminal fragment LG3 is generated at increased levels by proteolytic processing as long as 3 days after ischemia. It has previously been shown that oxygen-glucose deprivation (OGD), reperfusion and interleukin-1 α (IL-1α) stim...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.12.027
更新日期：2012-02-15 00:00:00
abstract：:The non-toxic neuronal binding domain of tetanus toxin (tetanus toxin fragment C, TTC) has been used as a vector to enhance delivery of potentially therapeutic proteins to motor neurons from the periphery following an intramuscular injection. The unique binding and transport properties of this 50-kDa polypeptide sugge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.007
更新日期：2004-06-11 00:00:00
abstract：:Ferulic acid (FA) has an important effect on scavenging free radicals, which is related to the alleviation of various neurodegenerative diseases. However, there are few studies about its effects on vascular dementia. In this study, we demonstrated the effect of FA on oxidative damage of brain microvascular endothelial...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.04.006
更新日期：2017-07-01 00:00:00
abstract：:The brain 5-HT1A receptor system in male wild house mice selected for high and low offensive aggression was investigated by autoradiographic analysis of in situ hybridization and radioligand binding. In high-aggressive mice, characterized by a short attack latency, the rise in plasma corticosterone concentration durin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00723-8
更新日期：1996-10-14 00:00:00
abstract：:Elevated levels of oxidative stress or decreased antioxidant defense mechanisms may underlie the regionally increased oxidative damage to brain observed in many neurodegenerative disorders. Phase I detoxification pathways for reactive aldehydes generated from lipid peroxidation include aldehyde dehydrogenases, alcohol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02897-9
更新日期：2001-10-19 00:00:00
abstract：:The effects of exo- and endogenous cGMP on the resting activity (RA) of afferent crista fibers were studied in isolated preparations of the statocysts of the cuttlefish Sepia officinalis and the squid Sepioteuthis lessoniana. Bath application of the membrane-permeable cGMP analogs 8-bromo-cGMP (B-cGMP) and N(2),2'-o-d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02777-3
更新日期：2000-10-13 00:00:00
abstract：:The possibility has been mentioned that a change in the structure is responsible for the deviant behavioral activity of gamma-endorphin in extracts of postmortem brain and pituitary gland samples of schizophrenic patients. This paper describes the investigation of this possibility by means of: amino acid composition a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90896-6
更新日期：1986-06-18 00:00:00
abstract：:Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.06.034
更新日期：2012-08-27 00:00:00
abstract：:Increased alcohol consumption and heightened aggression have been linked to social isolation. Furthermore, animals treated with alcohol following social separation showed higher aggression together with lower serotonin transmission. Although reduced serotonin transmission in the brain may be related to alcohol-induced...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.02.007
更新日期：2017-05-01 00:00:00
abstract：:The effects of 17beta-estradiol (17betaE2) on spontaneous and excitatory amino acid (EAA) induced nucleus tractus solitarius (NTS) neuronal activity were investigated by electrophysiological and immunohistochemical experiments in ovariectomized female Sprague-Dawley rats. Out of 62 NTS neurons tested, 42 were inhibite...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02629-5
更新日期：2003-06-20 00:00:00
abstract：:Sites which bind oxytocin and vasopressin with high affinity were detected in the brain and upper spinal cord of 12 human subjects, using in vitro light microscopic autoradiography. Tissue sections were incubated with tritiated vasopressin, tritiated oxytocin or an iodinated oxytocin antagonist. The ligand specificity...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90345-v
更新日期：1991-08-02 00:00:00
abstract：:Following unilateral destruction of the entorhinal cortical region of the adult rat, the denervated granule cells of the dentate gyrus are reinnervated as a result of the proliferation of a pathway from the surviving contralateral entorhinal area. The present study investigates the cells of origin of this lesion-induc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90837-5
更新日期：1978-05-26 00:00:00
