Abstract：
:Sex differences in estrogen-induced progestin receptors have been described in specific regions of the rat brain. To determine if alpha 1-neurotransmission plays a role in the expression of the sex differences in progestin receptor induction, the effects of the alpha 1-antagonist, prazosin, on progestin binding in microdissected regions of the rat brain was determined. Adrenalectomized/gonadectomized male or female rats were administered various doses of estradiol benzoate (EB) in combination with prazosin. With all treatment paradigms, and in both sexes, no significant effect of prazosin treatment on progestin receptor levels was observed. These results are consistent with the idea that sex differences in the estrogen-induction of progestin receptors in the rat hypothalamus are not due to sex differences in the alpha 1-adrenergic regulation of progestin receptor synthesis.
journal_name
Brain Resjournal_title
Brain researchauthors
Brown TJ,Naftolin F,MacLusky NJdoi
10.1016/0006-8993(90)90631-Ksubject
Has Abstractpub_date
1990-04-02 00:00:00pages
238-42issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(90)90631-Kjournal_volume
512pub_type
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