Co-localization of estrogen and angiotensin receptors within subfornical organ neurons.

Abstract:

:A double-staining immunocytochemical study was done in ovariectomized (OVX) female rats that were either treated with 17beta-estradiol (E(2)) (OVX+E(2)) to produce an approximate circulating level of 30 pg/ml plasma, or not-treated with E(2) (OVX), to investigate the distribution of subfornical organ (SFO) neurons that contained estrogen receptors (ER), and to determine whether these neurons also contained the angiotensin II AT(1)-receptor (AT(1)R). Neurons that contained either ER-like immunoreactivity only, AT(1)R-like immunoreactivity only, or both ER and AT(1)R immunoreactivity were found throughout the extent of the SFO in both the OVX+E(2) and OVX rats. However, some regional differences were apparent in both groups of female rats. Neurons containing the ER were predominantly found in the peripheral regions of the SFO, near large blood vessels and the ependymal layer of the third ventricle. A number of lightly stained ER containing neurons was also observed scattered throughout the central core region of the SFO. OVX only animals were found to have a larger number of ER containing neurons in the SFO compared to the E(2) treated animals. Neurons containing AT(1)R were also found throughout the SFO, but without a distinct distribution pattern in either group of rats, although there were more neurons that exhibited AT(1)R immunoreactivity in the OVX animals. Finally, a distinct group of SFO neurons was found that exhibited both ER and AT(1)R immunoreactivity in both groups of animals, although a larger number of these double labelled neurons was found in the OVX animal. Most of these neurons were also found along the peripheral border of the SFO in close proximity to blood vessels and the ventricular lining. These data have demonstrated the co-existence of ER and AT(1)R in SFO neurons of the female rat, and suggest that circulating level of E(2) alter the expression of both the ER and AT(1)R in these neurons. In addition, these data suggest that E(2) may alter the physiological responses of SFO neurons to angiotensin II by down regulating the number of AT(1)R.

journal_name

Brain Res

journal_title

Brain research

authors

Rosas-Arellano MP,Solano-Flores LP,Ciriello J

doi

10.1016/s0006-8993(99)01672-8

subject

Has Abstract

pub_date

1999-08-07 00:00:00

pages

254-62

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(99)01672-8

journal_volume

837

pub_type

杂志文章
  • Preferential occupation of mineralocorticoid receptors by corticosterone enhances glutamate-induced burst firing in rat midbrain dopaminergic neurons.

    abstract::Sensitisation to the behavioural effects of amphetamine, a phenomenon which appears to involve the potentiation of excitatory amino acid (EAA)-mediated transmission at the level of dopaminergic (DA) neurons in the ventral tegmental area (the A10 cell group), is known to be affected by corticosteroid manipulations. Sin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00722-6

    authors: Overton PG,Tong ZY,Brain PF,Clark D

    更新日期:1996-10-21 00:00:00

  • Relationship between grey matter integrity and executive abilities in aging.

    abstract::This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young adults (18-30 years old) and 43 seniors (60-75 years old) were included. A general executive score was derived from...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.04.045

    authors: Manard M,Bahri MA,Salmon E,Collette F

    更新日期:2016-07-01 00:00:00

  • Voltage-gated potassium currents within the dorsal vagal nucleus: inhibition by BDS toxin.

    abstract::Voltage-gated potassium (Kv) channels are essential components of neuronal excitability. The Kv3.4 channel protein is widely distributed throughout the central nervous system (CNS), where it can form heteromeric or homomeric Kv3 channels. Electrophysiological studies reported here highlight a functional role for this ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.10.090

    authors: Dallas ML,Morris NP,Lewis DI,Deuchars SA,Deuchars J

    更新日期:2008-01-16 00:00:00

  • Biostimulation and nursing modify mating-induced c-FOS immunoreactivity in the female rabbit forebrain.

    abstract:UNLABELLED:Mating in rabbits lasts only 3-5s but profoundly changes the female׳s physiology and behavior (e.g., inhibition of scent-marking and ambulation, changes in EEG, and release of GnRH). The behavioral responsiveness to copulation is reduced in lactating rabbits, relative to estrous does, but is enhanced after s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.02.033

    authors: González-Mariscal G,García Dalmán C,Jiménez A

    更新日期:2015-05-22 00:00:00

  • The transition from controlled to compulsive drug use is associated with a loss of sensitization.

    abstract::Rats provided limited daily access to cocaine (1 h) maintain stable levels of drug self-administration over time while those switched to longer access (6 h or more) exhibit escalating patterns of drug intake. These results are reminiscent of human recreational and compulsive drug-taking behavior, respectively. We foun...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2003.09.053

    authors: Ben-Shahar O,Ahmed SH,Koob GF,Ettenberg A

    更新日期:2004-01-02 00:00:00

  • Regional effects of hypothyroidism on 5'-nucleotidase and cyclic nucleotide phosphohydrolase activities in developing rat brain.

    abstract::The activities of 5'-nucleotidase (EC 3.1.3.5) and of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) (EC 3.1.4.37) were measured in crude membrane preparations from 6 brain regions of hypothyroid rats 31 days and 42 days after conception (8-9 days and 19-20 days after birth respectively) and from normal rats 31, 36...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(83)90185-2

    authors: King RA,Smith RM,Dreosti IE

    更新日期:1983-04-01 00:00:00

  • Involvement of the mammillary bodies in spatial working memory revealed by cytochrome oxidase activity.

    abstract::In view of the inconclusive findings relating the nuclei of the mammillary bodies (MB) with spatial memory, we evaluated the oxidative metabolic activity of the medial and lateral nuclei of the mammillary bodies (MB) after training young rats (30 days) of both sexes in the Morris water maze. Different groups were trai...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.03.025

    authors: Conejo NM,González-Pardo H,Vallejo G,Arias JL

    更新日期:2004-06-11 00:00:00

  • Disrupted migration and proliferation of neuroblasts after postnatal administration of angiogenesis inhibitor.

    abstract::In adult rodents, neuroblasts originating from the subventricular zone migrate tangentially through the rostral migratory stream (RMS) toward the olfactory bulb where they differentiate into interneurons. Neuroblasts in the RMS migrate in chains for a long distance along specifically arranged blood vessels which promo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2018.08.010

    authors: Angelidis A,Račeková E,Arnoul P,Závodská M,Raček A,Martončíková M

    更新日期:2018-11-01 00:00:00

  • Central dopamine agonist activity on the 8-alpha-amino-ergoline CU 32-085.

    abstract::The effects of the 8-alpha-amino-ergoline CU 32-085 on central dopamine neuronal systems was investigated. Two h after administration of CU 32-085 a slight increase of dopamine levels was observed in the nucleus caudatus-putamen. Radioligand binding studies in vitro have shown that CU 32-085 has a low affinity for str...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91044-3

    authors: Fuxe K,Agnati L,Mascagni F,Kuga S,Helmer-Matyjek E,Goldstein M

    更新日期:1985-03-04 00:00:00

  • Spinal and trigeminal lamina I input to the locus coeruleus anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) in the cat and the monkey.

    abstract::Terminal fibers anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) were observed in the locus coeruleus in the brainstem of the cat and the cynomolgus monkey following injections in lamina I of the spinal or medullary dorsal horn. Thus, thermoreceptive- or nociceptive-specific lamina I cells that pr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90915-v

    authors: Craig AD

    更新日期:1992-07-03 00:00:00

  • Two types of high voltage-activated calcium channels in SH-SY5Y human neuroblastoma cells.

    abstract::Voltage-activated calcium channel currents were recorded from differentiated human neuroblastoma cells. SK-N-SH-SY5Y (SH-SY5Y) line, using patch-clamp techniques. Experimental solutions were designed to suppress sodium and potassium channel currents, and barium ions were used as the charge carrier. Two distinct types ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91300-h

    authors: Reuveny E,Narahashi T

    更新日期:1993-02-12 00:00:00

  • Non-dopaminergic mechanisms in the turning behavior evoked by intranigral opiates.

    abstract::The turning effects of the unilateral intranigral injection of morphine and of different analogs of dynorphin and enkephalin were studied. All injections were made in awake rats through cronically implanted guide cannulae. Dynorphin1-13 at a dose of 10 micrograms (0.6 nmol) and dynorphin1-17 at a dose of 2 micrograms ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91074-1

    authors: Morelli M,Di Chiara G

    更新日期:1985-08-26 00:00:00

  • Environmental enrichment restores cognitive deficits induced by prenatal maternal seizure.

    abstract::Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.06.034

    authors: Xie T,Wang WP,Jia LJ,Mao ZF,Qu ZZ,Luan SQ,Kan MC

    更新日期:2012-08-27 00:00:00

  • Long-term effects of early social isolation in Macaca mulatta: changes in dopamine receptor function following apomorphine challenge.

    abstract::The hypothesis that early social isolation results in long-term alterations in dopamine receptor sensitivity was tested using older adult rhesus monkeys. Isolated and control monkeys were challenged with apomorphine (0.1 and 0.3 mg/kg), and the drug effects on spontaneous blink rate, stereotyped behavior, and self-inj...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91089-y

    authors: Lewis MH,Gluck JP,Beauchamp AJ,Keresztury MF,Mailman RB

    更新日期:1990-04-09 00:00:00

  • Simultaneous recordings from pairs of cat somatosensory cortical neurons with overlapping peripheral receptive fields.

    abstract::Fifty-three cell pairs in the somatosensory cerebral cortex were examined in pentobarbital-anesthetized cats for evidence of short latency interactions. Many neuronal pairs separated by distances of 150 to 500 micron were observed to have temporal dependencies. In a subset of 19 pairs where the surrounding multiunit a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91479-9

    authors: Metherate R,Dykes RW

    更新日期:1985-08-19 00:00:00

  • Mechanical hyperalgesia in rat models of systemic and local hyperglycemia.

    abstract::Mechanical hyperalgesia is an early symptom of diabetic neuropathy. To evaluate the mechanisms underlying this symptom, it was studied and compared in rat models of systemic and local hyperglycemia. Systemic hyperglycemia was induced by a single injection of streptozotocin (STZ, 50 mg/kg). Local hyperglycemia either i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03828-3

    authors: Dobretsov M,Hastings SL,Romanovsky D,Stimers JR,Zhang JM

    更新日期:2003-01-17 00:00:00

  • Acidic regulation of junction channels between glomus cells in the rat carotid body. Possible role of [Ca(2+)](i).

    abstract::The purpose of this work was to characterize the gap junctions between cultured glomus cells of the rat carotid body and to assess the effects of acidity and accompanying changes in [Ca(2+)](i) on electric coupling. Dual voltage clamping of coupled glomus cells showed a mean macrojunctional conductance (G(j)) of 1.16 ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02862-1

    authors: Abudara V,Jiang RG,Eyzaguirre C

    更新日期:2001-10-19 00:00:00

  • Fine structure of the central myelin sheath in the myelin deficient mutant Shiverer mouse, with special reference to the pattern of myelin formation by oligodendroglia.

    abstract::The central myelin sheaths of the recessive autosomal mutant mouse, Shiverer, were investigated by electron microscopy with special reference to the pattern of myelin formation. The results obtained may be summarized as follows: (1) the major dense line of myelin lamellae generally failed to be formed, but the axons w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90269-9

    authors: Inoue Y,Nakamura R,Mikoshiba K,Tsukada Y

    更新日期:1981-08-24 00:00:00

  • Embryonic retinal grafts have a beneficial effect on the damaged host retina.

    abstract::The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted in a reduction of th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90300-4

    authors: Laedtke TW,Turner JE

    更新日期:1989-10-23 00:00:00

  • Acute estradiol application increases inward and decreases outward whole-cell currents of neurons in rat hypothalamic ventromedial nucleus.

    abstract::Acute estradiol (E2) can potentiate the excitatory responses of hypothalamic ventromedial nucleus (VMN) neurons to neurotransmitters. To investigate the mechanism(s) underlying the potentiation, the whole-cell patch voltage clamp technique was used to study VMN neurons in hypothalamic slices prepared from female juven...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.07.104

    authors: Kow LM,Devidze N,Pataky S,Shibuya I,Pfaff DW

    更新日期:2006-10-20 00:00:00

  • Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor.

    abstract::Stressors produce rapid activation of the hypothalamic-pituitary-adrenal axis, which typically resolves within 60-90 min following termination of the stressor. In addition, some stressors such as inescapable tailshock (IS) also produce elevated basal levels of corticosterone (CORT), and reduced serum levels of cortico...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02050-8

    authors: Deak T,Nguyen KT,Cotter CS,Fleshner M,Watkins LR,Maier SF,Spencer RL

    更新日期:1999-11-20 00:00:00

  • Blood-brain barrier characteristic enzymatic properties in cultured brain capillary endothelial cells.

    abstract::Isolated brain capillary endothelial cells contain high activity levels of the blood-brain barrier (BBB) marker enzymes gamma-glutamyltranspeptidase (gamma-GT) and alkaline phosphatase (ALP). In primary culture the activities of these specific enzymes decrease with increasing cell proliferation to a constant low value...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91425-g

    authors: Meyer J,Mischeck U,Veyhl M,Henzel K,Galla HJ

    更新日期:1990-04-30 00:00:00

  • Prolonged antinociception following carbon dioxide anesthesia in the laboratory rat.

    abstract::In the laboratory rat, inhalation (30 s) of high (> 70%) CO2 concentrations resulted in short-term (1-3 min) anesthesia, followed by a prolonged (up to 60 min) mild antinociception. Exposure to 100% CO2 resulted in significant thermal (hot-plate, 52 degrees, and tail-flick) and mechanical (tail-pinch, 886 g force) ant...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91888-0

    authors: Mischler SA,Alexander M,Battles AH,Raucci JA Jr,Nalwalk JW,Hough LB

    更新日期:1994-03-21 00:00:00

  • Locomotor activity in the ischemic gerbil.

    abstract::Previous studies have shown that within 24 h after ischemic insult, gerbils exhibit an increase in locomotor activity. Because activity gradually diminishes to normal levels with repeated testing, it has been argued that this behavior represents a reversible or transient effect of ischemia. The present study challenge...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91081-3

    authors: Babcock AM,Baker DA,Lovec R

    更新日期:1993-10-22 00:00:00

  • Sensory modulation of hippocampal transmission. I. Opposite effects on CA1 and dentate gyrus synapsis.

    abstract::Neuronal transmission through hippocampal subfields exhibits a high degree of modulation and appears dependent on the behavioral state and hippocampal EEG. Sensory inputs, which profoundly modify the hippocampal EEG, may be involved in modulating hippocampal excitability. Field responses of the CA1 region, evoked by i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90259-4

    authors: Herreras O,Solís JM,Muñoz MD,Martín del Río R,Lerma J

    更新日期:1988-10-04 00:00:00

  • The conduction velocity and segmental distribution of afferent fibers in the rectal nerves of the female rat.

    abstract::The conduction velocity and segmental distribution of afferent fibers in the rectal nerves of the female rat were determined. These afferent fibers had conduction velocities ranging from 0.5-23.5 m/s (Mode = 0.5 m/s; Median = 1 m/s). Sixty-six percent of the fibers had conduction velocities less than 2.5 m/s and were ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91244-b

    authors: Vera PL,Nadelhaft I

    更新日期:1990-09-03 00:00:00

  • Effects of surgical and pharmacological adrenalectomy on the initiation and maintenance of intravenous cocaine self-administration in rats.

    abstract::Previous research has suggested the potential involvement of the hypothalamic-pituitary-adrenal (HPA) axis in psychostimulant reinforcement. In particular, we have found significant correlations between electric footshock-induced increases in plasma corticosterone and the acquisition, or lack thereof, of intravenous c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00206-5

    authors: Goeders NE,Guerin GF

    更新日期:1996-05-25 00:00:00

  • Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats.

    abstract::The motivational effects of exclusively peripheral or central opiate receptor blockade were studied using place conditioning. Place aversions were observed with intraventricular (i.c.v.) methylnaloxone (MN) in both naive (200-1000 ng) and morphine-dependent rats (50-500 ng). Subcutaneous MN (0.03-10 mg/kg) was ineffec...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90452-0

    authors: Hand TH,Koob GF,Stinus L,Le Moal M

    更新日期:1988-12-06 00:00:00

  • Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP).

    abstract::Sardinian alcohol non-preferring (sNP) rats, selected for their low ethanol preference and consumption, carry a point mutation (R100Q) in the gene coding for GABA(A) receptor alpha(6) subunit, which becomes more sensitive to diazepam-evoked GABA currents. We performed binding studies in the cerebellum of normal (RR) a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)04230-0

    authors: Sanna A,Congeddu E,Porcella A,Saba L,Pistis M,Peis M,Marchese G,Ruiu S,Lobina C,Grayson DR,Gessa GL,Pani L

    更新日期:2003-03-28 00:00:00

  • A comparison of vestibular and auditory phenotypes in inbred mouse strains.

    abstract::The purposes of this research were to quantify gravity receptor function in inbred mouse strains and compare vestibular and auditory function for strain- and age-matched animals. Vestibular evoked potentials (VsEPs) were collected for 19 inbred strains at ages from 35 to 389 days old. On average, C57BL/6J (35 to 190 d...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.01.066

    authors: Jones SM,Jones TA,Johnson KR,Yu H,Erway LC,Zheng QY

    更新日期:2006-05-26 00:00:00