Cerebral protein synthesis alterations in response to acute and chronic immobilization stress in the rat.

Abstract:

:The quantitative autoradiographic method with L-(35S)methionine was used to determine the effects of 1-acute (4h) and 2-chronic (14 days) immobilization stress followed by one week of recovery. Acute stress induced a significant decrease in methionine incorporation into proteins in 17 of the 35 brain structures examined (mean effect: -22%), and a significant increase in the prepositus hypoglossal nucleus (+23%). Chronic stress induced a significant decrease in methionine incorporation into proteins in 8 of the 35 structures analyzed. Only 4 structures were similarly affected in both these conditions. Our results indicate that stress-induced specific molecular changes in brain are also associated with changes in more general molecular components of cellular metabolism.

journal_name

Brain Res

journal_title

Brain research

authors

Giaume M,Grange E,Baubet V,Gay N,Sermet E,Sarda N,Bobillier P

doi

10.1016/0006-8993(95)00046-s

subject

Has Abstract

pub_date

1995-03-27 00:00:00

pages

121-6

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(95)00046-S

journal_volume

675

pub_type

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