Abstract:
:Nocistatin, a product of the same precursor as nociceptin/orphanin FQ (N/OFQ), has been shown to antagonize effects of N/OFQ. N/OFQ stimulates feeding, most probably by inhibiting activation of neurons containing oxytocin (OT) and vasopressin (VP), peptides considered as satiety factors, and implicated in the development of conditioned taste aversion (CTA). The present study was designed to investigate whether intracerebroventricularly (ICV) injected nocistatin (a) affects deprivation- and N/OFQ-induced feeding, (b) causes CTA, and (c) induces activation of hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei, as well as OT and VP neurons present in these regions. C-Fos immunohistochemistry was used as a marker of cellular activation. Nocistatin (1-3 nmol) significantly reduced food intake in deprived rats during the first and second hour post-injection. Doses of 1-3 nmol suppressed N/OFQ-induced feeding. Nocistatin at the highest (3 nmol) dose did not cause CTA. It also did not affect activation of the PVN or SON. In nocistatin-treated animals, the percentage of Fos-positive OT and VP neurons was similar to controls. We conclude that nocistatin antagonizes the influence of N/OFQ on feeding and suppresses deprivation-induced food consumption through mechanisms other than aversion. Nocistatin does not, however, activate the PVN or SON. It does not exert its effects via VP or OT neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Olszewski PK,Shaw TJ,Grace MK,Billington CJ,Levine ASdoi
10.1016/s0006-8993(00)02535-xsubject
Has Abstractpub_date
2000-07-28 00:00:00pages
181-7issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02535-Xjournal_volume
872pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Nitric oxide (NO) has been proposed as an intercellular messenger mediating postsynaptic to presynaptic information transfer in the induction of long-term potentiation. A number of studies support the possible involvement of NO in synaptic plasticity. NO may have a role in synaptogenesis and synaptic plasticity in dev...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01161-5
更新日期:1999-01-23 00:00:00
abstract::During retinal development, common precursors give rise to various types of cells in a time course specific to each cell type. Previously, we demonstrated that the bHLH gene Hes1 inhibits neuronal differentiation whereas, in Hes1-null retina, precursors prematurely differentiate into neurons and form abnormal rosette-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.01.045
更新日期:2004-04-09 00:00:00
abstract::Alterations in local cerebral glucose utilization (LCGU) induced by electrical stimulation of the sensory relay nucleus (VPL) or parafascicular nucleus (Pf) of the thalamus in conscious rats were measured by the [14C]2-deoxyglucose method, the objective being to assess the mechanism of analgesia induced by electrical ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90357-x
更新日期:1987-04-07 00:00:00
abstract::When female golden hamsters are maintained on a photoperiod of less than 12.5 h of light per day, they go into a pineal gland-induced anestrus in 6-10 weeks. This acyclicity is similar in certain respects to the testicular regression which occurs in male golden hamsters maintained on a short photoperiod. A recent stud...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91428-9
更新日期:1986-08-13 00:00:00
abstract::This paper describes an electrochemical method for the detection of dopamine and serotonin in vitro. Dopamine and serotonin can be distinguished from each other without interference from metabolites. 3-4-dihydroxyphenylacetic acid and 5-hydroxyindoleacetic acid. The method also provides selective differentiation of do...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91224-9
更新日期:1989-08-21 00:00:00
abstract::In the present experiment we tested the hypothesis that early interference with noradrenaline transmission can have permanent consequences for brain function in adulthood. Neonatal depletion of noradrenaline by daily subcutaneous injections of clonidine results in supersensitivity to noradrenaline in adult hippocampal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91824-z
更新日期:1990-12-03 00:00:00
abstract::Individual variability in the behavioral responsiveness to psychostimulant drugs is due, in part, to genetic factors. The present study investigated the effects of acute and repeated administrations of cocaine (0, 5, 10 or 20 mg/kg, i.p.) on locomotor activity in male and female rats from genetically distinct strains ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01742-4
更新日期:1999-09-18 00:00:00
abstract::The activity of single dopaminergic (DA) neurons (total n = 77) in the midbrain of awake, unrestrained rats was examined. The firing rates and patterns of ventral tegmental area (A10) cells (n = 39) were similar to those of identified DA neurons in anesthetized and paralyzed rats. Unit activity was briefly stimulated ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90988-7
更新日期:1987-03-03 00:00:00
abstract::Neurofilament expression in peripheral olfactory neurons of adult rats was investigated by immunoblotting and immunohistochemistry using monoclonal antibodies specific for each of the 3 neurofilament proteins. Immunoblotting analysis of olfactory epithelium extracts demonstrated the presence of only the 200 kDa (NFH) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90416-s
更新日期:1991-05-31 00:00:00
abstract::Endogenous opioid systems (i.e. opioids and opioid receptors) play a role in regulating neural development. Using the cerebellar cortex of 6-day-old rats, the most potent opioid peptides involved with cell proliferation were assessed. In both the external germinal (granule) layer (EGL), a germinative matrix giving ris...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91585-o
更新日期:1991-03-01 00:00:00
abstract::Diabetes mellitus (DM) may lead to gastrointestinal motility disorders. Rodent models of DM indicate the presence of morpho-functional abnormalities of the enteric nervous system. Here, we evaluated whether experimental DM can cause changes in the excitatory cholinergic fibers, neuronal density, and voltage-gated sodi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.11.041
更新日期:2019-04-01 00:00:00
abstract::Hypoxia-inducible transcription factors (HIFs) are crucially involved in brain development and cellular adaptation to hypoxia and ischemia. Degradation of HIF is regulated under normoxia by oxygen-dependent hydroxylation of specific prolyl residues on the labile alpha-subunit by HIF prolyl hydroxylases (PHD). Prolyl-4...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.05.023
更新日期:2009-07-14 00:00:00
abstract::Considerable disagreement exists concerning the degree to which sparing and/or recovery of function occurs following CNS damage at birth rather than in adulthood. To study this question, the spinal cord was hemisected in neonatal and adult cats and the motor behavior of the two groups was compared when the neonatal op...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90046-9
更新日期:1983-08-01 00:00:00
abstract::Depending on experimental conditions, chronic cocaine exposure can induce an increase in binding to the dopamine transporter (DAT). One possible mechanism for the cocaine-induced-upregulation in DAT binding sites is through stimulation of presynaptic D2 receptors by excess synaptic dopamine. To test this hypothesis, t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01033-5
更新日期:1996-12-02 00:00:00
abstract::A quantitative freeze-fracture study of perivascular astrocytic processes in rat cerebral cortex disclosed rapid disintegration of orthogonal arrays of the intramembrane particles in acute global ischemia. The process apparently preceded the development of astrocytic swelling. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91348-9
更新日期:1984-05-21 00:00:00
abstract::In continuation of earlier computer simulation studies 15 of the feedback inhibition exercised by the Golgi cells of the cerebellum, an attempt is made at modeling the behavior of Purkinje and basket cells under somewhat more complex functional circumstances. The simulation study is based on a realistic network model ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(74)90531-9
更新日期:1974-03-15 00:00:00
abstract::Glycine is thought to be a major inhibitory neurotransmitter in the mammalian CNS. Two types of physiologically identified interneurons, Renshaw cells and Ia inhibitory interneurons, were intracellularly stained with horseradish peroxidase, and their axon terminals were studied at the electron microscopic level. Post-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90590-r
更新日期:1991-04-26 00:00:00
abstract::Alpha-lipoic acid (ALA) is an endogenous short-chain fatty acid that has beneficial protective effects against various vascular diseases. In this study, we sought to determine whether ALA could induce pre- or post-treatment protective effects against simulated ischemia and reperfusion-induced cerebral endothelial cell...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.09.009
更新日期:2012-10-30 00:00:00
abstract::Reverse transcription-polymerase chain reaction demonstrated the expression of heme oxygenase-1 and heme oxygenase-2 (HO-2) mRNA in the cochlea, but the former was considered to be much lower than the latter. The HO-2-like immunoreactivity was observed mainly in supporting cells in the organ of Corti and in the spiral...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04209-9
更新日期:2003-03-14 00:00:00
abstract::We have examined the effects of isotonic hypovolemia on the expression of the neuronal nitric oxide synthase (nNOS) gene in the paraventricular (PVN) and supraoptic nuclei (SON) of the rat, using in situ hybridization histochemistry with a 35S-labelled oligodeoxynucleotide probe complementary to nNOS mRNA. Intraperito...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01531-x
更新日期:1998-04-20 00:00:00
abstract::Soman is an organophosphorus (OP) compound which irreversibly inhibits acetylcholinesterase (AChE), the primary synaptic inactivator of acetylcholine. Resultant excessive cholinergic activity elicits generalized convulsions and brain lesions. Recent evidence suggests that other neurotransmitter/neuromodulator systems ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01315-7
更新日期:1997-02-07 00:00:00
abstract::Immunohistochemistry was used to examine the co-occurrence of nicotinic acetylcholine receptor subunits with calcium-binding proteins in ganglion cells of the chick retina. The alpha3 subunit was rarely observed in ganglion cells containing calbindin, calretinin, or parvalbumin. On the other hand, the alpha8 subunit w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)81715-5
更新日期:1997-11-07 00:00:00
abstract::The quantitative 2-[14C]deoxyglucose autoradiographic method was used to study the effects of the acute administration of a sedative anticonvulsant dose of diazepam (2 mg/kg) on rat brain energy metabolism. This benzodiazepine was injected to rats chronically treated for two weeks either by caffeine (10 mg/kg/day) or ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90593-2
更新日期:1987-09-01 00:00:00
abstract::Evolutionary selection pressures have been one of the factors proposed to underlie sex differences in inhibitory control. Consequently, inhibitory control may vary as a function of the menstrual cycle and may be modulated by the stimuli being processed if these stimuli are related to reproductive success. We used func...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.061
更新日期:2008-08-11 00:00:00
abstract::The HSD2 (11-beta-hydroxysteroid dehydrogenase-type 2 enzyme) containing neurons of the nucleus tractus solitarius (NTS) become activated during low-sodium and high-aldosterone states such as hypovolemia. This response may be due to hormonal and/or neural signals. Hormonal signals may activate neurons in the area post...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.098
更新日期:2009-12-08 00:00:00
abstract::The purpose of this study was to determine the effects of specific proinflammatory cytokines interleukin-6 (Il-6), interleukin-1beta (Il-1beta), interferon-gamma (IFN), and tumor necrosis factor-alpha (TNFalpha), on content and distribution of alpha-synuclein (alpha-synuclein), tau and ubiquitin in human derived cultu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.03.081
更新日期:2008-06-27 00:00:00
abstract::Alterations occurring in the antioxidant enzymes, copper, zinc-dependent superoxide dismutase (Cu,Zn-SOD) and glutathione peroxidase (GPX) following nigral dopaminergic denervation are unclear. We now report on the distribution and levels of m-RNA for Cu,Zn-SOD and GPX in basal ganglia of normal and 1-methyl-4-phenyl-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02240-6
更新日期:2003-04-11 00:00:00
abstract::A comparison of morphological and biochemical characteristics of the D1-type dopamine receptor has been assessed in two experimental tissues, the superior cervical ganglion (SCG) and caudate nucleus of the rat. Correlation of the distribution of this dopaminergic binding site using in vitro autoradiographic localizati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91294-7
更新日期:1987-09-22 00:00:00
abstract::Qualitative and computer-assisted analyses were performed on Golgi-impregnated neurons which were serially reconstructed in 3 dimensions. Analysis of the temporal pattern of growth indicated that the initial outgrowth, formation of the adult number of dendrites and virtually all dendritic branching occurred in the pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90192-6
更新日期:1986-01-01 00:00:00
abstract::The postnatal development of the distribution of 3 different ionic channel proteins in rat brain was studied using light microscopic autoradiography. [3H]Ethylenediaminetetrodotoxin, [125I]apamin and (-)-[3H]desmethoxyverapamil were used to label one class of voltage-dependent Na+ channel proteins, one class of Ca2+-d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90175-2
更新日期:1987-08-04 00:00:00