The expression and localization of heme oxygenase in the adult guinea pig cochlea.

Abstract:

:Reverse transcription-polymerase chain reaction demonstrated the expression of heme oxygenase-1 and heme oxygenase-2 (HO-2) mRNA in the cochlea, but the former was considered to be much lower than the latter. The HO-2-like immunoreactivity was observed mainly in supporting cells in the organ of Corti and in the spiral ganglion cells. However, in the vascular walls of the cochlea little immunoreactivity was detected. These results suggest that HO-2 is involved in the auditory neurotransmission and micromechanics of the organ of Corti.

journal_name

Brain Res

journal_title

Brain research

authors

Watanabe K,Oshima T,Kobayashi T,Ikeda K

doi

10.1016/s0006-8993(02)04209-9

subject

Has Abstract

pub_date

2003-03-14 00:00:00

pages

162-6

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006899302042099

journal_volume

966

pub_type

杂志文章
  • Regulation of the blood-brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitro.

    abstract::The blood-brain barrier consists of the cerebral microvascular endothelium, pericytes, astrocytes, and neurons. In this study, we analyzed the influence of primary porcine brain capillary pericytes on the barrier integrity of primary porcine brain capillary endothelial cells in a species-consistent in vitro coculture ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.05.096

    authors: Thanabalasundaram G,Pieper C,Lischper M,Galla HJ

    更新日期:2010-08-06 00:00:00

  • Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease.

    abstract::Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease with unknown etiology that is characterized by the development of abnormal vascular networks at the base of the brain. Recent genome-wide studies identified RNF213 as an important MMD susceptibility gene. However, the exact mechanism by which the RN...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2014.11.014

    authors: Ito A,Fujimura M,Niizuma K,Kanoke A,Sakata H,Morita-Fujimura Y,Kikuchi A,Kure S,Tominaga T

    更新日期:2015-01-12 00:00:00

  • Decarboxylation of L-dopa by cultured mouse astrocytes.

    abstract::Cultured astrocytes contain immunologically specific aromatic L-amino acid decarboxylase (AADC) protein and express the AADC gene. Following incubation with L-Dopa, glial cultures synthesize and metabolize dopamine. The addition of pyridoxal 5-phosphate did not change the rate of dopamine synthesis. The formation of d...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90592-b

    authors: Juorio AV,Li XM,Walz W,Paterson IA

    更新日期:1993-10-29 00:00:00

  • Early developmental exposure to benzodiazepine ligands alters brain 31P-NMR spectra in young adult rats.

    abstract::Alterations in brain high energy phosphate compounds, using 31P-NMR (nuclear magnetic resonance) spectroscopy, were measured in vivo in young adult (3-4 months) rats following prenatal exposure to ligands acting specifically at benzodiazepine (BDZ) binding sites. The exposure induced a decrease in intracellular pH tha...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91202-r

    authors: Miranda R,Ceckler T,Guillet R,Kellogg C

    更新日期:1990-01-01 00:00:00

  • The effect of perceptual load on tactile spatial attention: Evidence from event-related potentials.

    abstract::To investigate whether tactile spatial attention is modulated by perceptual load, behavioural and electrophysiological measures were recorded during two spatial cuing tasks in which the difficulty of the target/non-target discrimination was varied (High and Low load tasks). Moreover, to study whether attentional modul...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2017.08.007

    authors: Gherri E,Berreby F

    更新日期:2017-10-15 00:00:00

  • Freeze-fracture of developing neuronal plasma membrane in postnatal cerebellum.

    abstract::The structure of the plasma membrane of two neuronal cell types was quantitatively assessed in freeze-fracture replicas of rat cerebellar cortex from 2 to 73 postnatal days. The measurement of the number and size of intramembrane particles (IMP) in different regions of the Purkinje cells and of the granule cell showed...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90618-1

    authors: Garcia-Segura LM,Perrelet A

    更新日期:1981-03-09 00:00:00

  • Differential increases in P2X receptor levels in rat vagal efferent neurones following a vagal nerve section.

    abstract::Extracellular ATP can influence cells via activation of P2X purinoceptors, the distribution of which can be altered in the central and peripheral nervous systems following injury or tissue damage. Here we have investigated the effect of a unilateral section of the cervical vagus nerve on the distribution of P2X(1), P2...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02797-5

    authors: Atkinson L,Shigetomi E,Kato F,Deuchars J

    更新日期:2003-07-04 00:00:00

  • Effect of phencyclidine (PCP) on blood pressure and catecholamine levels in discrete brain nuclei.

    abstract::PCP (10 mg/kg, s.c.) causes hypertension that is associated with decrease or tendency to decrease the levels of epinephrine and norepinephrine in the hypothalamus and the brainstem regions. If this represents a decreased catecholaminergic activity, then this may enhance sympathetic activity and contribute to the PCP-i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90184-7

    authors: Bayorh MA,Zukowska-Grojec Z,Palkovits M,Kopin IJ

    更新日期:1984-11-12 00:00:00

  • Release of excitatory and inhibitory amino acids from the locus coeruleus of conscious rats by cardiovascular stimuli and various forms of acute stress.

    abstract::The release of amino acids in the locus coeruleus (LC) of conscious, freely moving rats was studied in time periods of 3 min by use of push-pull superfusion under basal conditions and during application of various experimental stimuli known to influence the activity of the LC-noradrenergic system. Tail pinch for 3 min...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01102-1

    authors: Singewald N,Zhou GY,Schneider C

    更新日期:1995-12-15 00:00:00

  • Peripheral nerve lesions cause simultaneous alterations of substance P and enkephalin levels in the spinal cord.

    abstract::The substance P and Met-enkephalin content were measured in the rat lumbar spinal cord after monolateral section of the sciatic nerve. The proximal stump of the lesioned nerve was either ligated, limiting the formation of neuroma, or sutured intraperitoneally, allowing the formation of a very large neuroma. Both types...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91147-3

    authors: Di Giulio AM,Mantegazza P,Dona M,Gorio A

    更新日期:1985-09-09 00:00:00

  • Distribution of neurturin mRNA and immunoreactivity in the peripheral tissues of adult rats.

    abstract::Neurturin (NTN) is a recently discovered neurotrophic factor related to glial cell line-derived neurotrophic factor (GDNF) and has a wide spectrum of biological roles in different types of neurons in the central and peripheral nervous systems. However, information on its expression in peripheral tissues has been limit...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01590-5

    authors: Xian CJ,Huang BR,Zhou XF

    更新日期:1999-07-24 00:00:00

  • Injection of bicuculline elicits firing of luteinizing hormone releasing hormone pulse generator in muscimol-treated ovariectomized rats.

    abstract::We have already demonstrated that, although exogenous gamma-aminobutyric acidA (GABAA) receptor agonist is capable of inhibiting the activity of luteinizing hormone releasing hormone (LHRH) pulse generator, the reduction in the endogenous GABAA receptor activity does not have a significant effect in ovariectomized rat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90145-7

    authors: Hiruma H,Sano A,Kimura F

    更新日期:1994-04-04 00:00:00

  • Ependyma: normal and pathological. A review of the literature.

    abstract::A review of the available literature reveals that proliferation of ependyma occurs during embryological and early postnatal periods of development. Turnover, however, declines significantly during postnatal life and only low levels of residual activity persist into adulthood under normal conditions. In some regions of...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/0165-0173(85)90016-5

    authors: Bruni JE,Del Bigio MR,Clattenburg RE

    更新日期:1985-04-01 00:00:00

  • Intracellular plasma proteins in human fetal choroid plexus during development. II. The distribution of prealbumin, albumin, alpha-fetoprotein, transferrin, IgG, IgA, IgM, and alpha 1-antitrypsin.

    abstract::Individual choroid plexuses of human fetal brain at different developmental stages were investigated by an indirect immunoperoxidase technique. The number and distribution of prealbumin-, albumin-, alpha-fetoprotein-, transferrin-, IgG-, IgA-, IgM- and alpha 1-antitrypsin-containing choroid plexus epithelial cells wer...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(82)90025-6

    authors: Jacobsen M,Jacobsen GK,Clausen PP,Saunders NR,Møllgård K

    更新日期:1982-02-01 00:00:00

  • Differential effects of para-chlorophenylalanine on amphetamine-induced locomotion and stereotypy.

    abstract::Amphetamine-induced locomotion and stereotypy were concurrently evaluated in order to determine if pretreatment with para-chlorophenylalanine (PCPA) (which is reported to facilitate some of the effects of amphetamine) results in a behavioral pattern similar to the augmentation previously reported to occur with repeate...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90904-5

    authors: Segal DS

    更新日期:1976-11-05 00:00:00

  • Interaction between allopregnanolone and pregnenolone sulfate in modulating GABA-mediated synaptic currents in neurons from the rat medial preoptic nucleus.

    abstract::The two neurosteroids 3alpha-hydroxy-5alpha-pregnane-20-one (allopregnanolone; AlloP) and pregnenolone sulfate (PregS) affect neuronal GABA(A) receptors differently. While AlloP mainly potentiates the currents through GABA(A) receptors, PregS reduces such currents. The present study aimed at clarifying the interaction...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.11.020

    authors: Haage D,Bäckström T,Johansson S

    更新日期:2005-02-01 00:00:00

  • Nicotine-induced release of noradrenaline from hypothalamic synaptosomes.

    abstract::In order to elucidate the functional role of nicotinic receptors in the hypothalamus, the drug-induced release of noradrenaline from hypothalamic synaptosomes was studied utilizing [3H]noradrenaline ([3H]NA). The release of [3H]NA from synaptosomes was significantly increased with an increase of the dose of nicotine, ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)91194-4

    authors: Yoshida K,Kato Y,Imura H

    更新日期:1980-01-27 00:00:00

  • Suppression of noradrenergic innervation compensates for behavioral deficits induced by lesion of dopaminergic terminals in the lateral septum.

    abstract::Spontaneous alternation which is disrupted by lesion of septal dopaminergic (DA) afferents was chosen as a behavioral marker for the study of functional interactions between DA and noradrenergic (NA) innervation of the lateral septum. Three groups of rats were studied: a solvent group which received only vehicle injec...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90669-m

    authors: Taghzouti K,Le Moal M,Simon H

    更新日期:1991-06-21 00:00:00

  • Microglial responsiveness as a sensitive marker for trimethyltin (TMT) neurotoxicity.

    abstract::Activation of microglia is a well-documented phenomenon associated with diverse pathological conditions of the central nervous system. In order to investigate the involvement of microglial cells in the neurotoxic action of the heavy metal compound trimethyltin, three-dimensional brain cell cultures were treated during...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00509-o

    authors: Monnet-Tschudi F,Zurich MG,Pithon E,van Melle G,Honegger P

    更新日期:1995-08-28 00:00:00

  • Expression of hyperpolarization-activated cyclic nucleotide-gated cation channels in rat dorsal root ganglion neurons innervating urinary bladder.

    abstract::Afferent pathways innervating the urinary bladder consist of myelinated Adelta- and unmyelinated C-fibers, the neuronal cell bodies of which correspond to medium and small-sized cell populations of dorsal root ganglion (DRG) neurons, respectively. Since hyperpolarization-activated cyclic nucleotide-gated cation (HCN) ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.08.052

    authors: Matsuyoshi H,Masuda N,Chancellor MB,Erickson VL,Hirao Y,de Groat WC,Wanaka A,Yoshimura N

    更新日期:2006-11-13 00:00:00

  • A topographic measurement of brain pH.

    abstract::The ability of neutral red to serve as an internal pH indicator in biological systems was tested in the rat brain after parenteral adminstration of the dye. The injected dye is avidly taken up by the brain cells and is distributed mainly in intracellular organelles. The ratio of optical signals recorded from the froze...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90869-0

    authors: Kogure K,Alonso OF,Martinez E

    更新日期:1980-08-11 00:00:00

  • Fetal brain transplants induce recuperation of taste aversion learning.

    abstract::Rats showing disrupted taste aversion due to gustatory neocortex or amygdala lesions were transplanted into the lesioned area with homologous brain tissue obtained from 17-day-old fetuses. Comparisons of taste aversions scores before and after the graft, revealed that the grafted animals significantly recuperated tast...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91507-1

    authors: Bermúdez-Rattoni F,Fernández J,Sánchez MA,Aguilar-Roblero R,Drucker-Colín R

    更新日期:1987-07-21 00:00:00

  • Stereospecific acute neuronotoxicity of 'uncommon' plant amino acids linked to human motor-system diseases.

    abstract::The L-isomer of beta-N-methylamino-L-alanine (BMAA), present in free form in seed of Cycas circinalis, elicits in spinal cord cultures a pattern of acute postsynaptic neuronal vacuolation comparable to that induced by beta-N-oxalylamino-L-alanine (BOAA), an excitotoxic amino acid of greater potency isolated from seed ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90342-8

    authors: Nunn PB,Seelig M,Zagoren JC,Spencer PS

    更新日期:1987-05-05 00:00:00

  • Neural correlates of evaluating hazards of high risk.

    abstract::In personal and in society related context, people often evaluate the risk of environmental and technological hazards. Previous research addressing neuroscience of risk evaluation assessed particularly the direct personal risk of presented stimuli, which may have comprised for instance aspects of fear. Further, risk e...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.05.023

    authors: Herwig U,Brühl AB,Viebke MC,Scholz RW,Knoch D,Siegrist M

    更新日期:2011-07-11 00:00:00

  • Suppression of the hindlimb flexor reflex by stimulation of the medial hypothalamus and thalamus in the rat.

    abstract::Pentobarbital-anesthetized rats received electrical hindpaw stimulation every 10 s to elicit a maximal hindlimb withdrawal reflex. The integrated EMG response in the ipsilateral tibialis anterior was sampled by a computer which also controlled the timing of electrical stimuli applied to the brain. A suppression of the...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91142-6

    authors: Duysens J,Dom R,Gybels J

    更新日期:1989-10-09 00:00:00

  • Direct projections from the caudal spinal trigeminal nucleus to the striatum in the cat.

    abstract::The results of a WGA-HRP and HRP study in the cat indicated that some neurons in the marginal zone (lamina I) of the caudal spinal trigeminal nucleus sent their axons contralaterally to the striatum; mainly to the dorsal part of the putamen, and additionally to the ventrolateral part of the caudate nucleus, at the ste...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90400-8

    authors: Yasui Y,Itoh K,Mizuno N

    更新日期:1987-04-07 00:00:00

  • Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury.

    abstract::Since several different pathways are involved in cerebral ischemia/reperfusion injury, combination therapy rather than monotherapy may be required for efficient neuroprotection. In this study, we examined the protective effects of an apoptosis inhibitor Gly(14)-humanin (HNG) and a necroptosis inhibitor necrostatin-1 (...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.07.080

    authors: Xu X,Chua KW,Chua CC,Liu CF,Hamdy RC,Chua BH

    更新日期:2010-10-08 00:00:00

  • Musical scale properties are automatically processed in the human auditory cortex.

    abstract::While listening to music, we immediately detect 'wrong' tones that do not match our expectations based on the prior context. This study aimed to determine whether such expectations can occur preattentively, as indexed by event-related potentials (ERPs), and whether these are modulated by attentional processes. To this...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.08.023

    authors: Brattico E,Tervaniemi M,Näätänen R,Peretz I

    更新日期:2006-10-30 00:00:00

  • Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat.

    abstract::In barbiturate-anaesthetized spinal cats, antibody microprobes were used to examine immunoreactive substance P (irSP) release at sites within the spinal cord following cutaneous stimuli. A basal level of irSP release was detected in the region of the substantia gelatinosa of the lumbar spinal cord. No increase in this...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90771-8

    authors: Duggan AW,Hendry IA,Morton CR,Hutchison WD,Zhao ZQ

    更新日期:1988-06-07 00:00:00

  • Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey.

    abstract::We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01563-1

    authors: Boraud T,Bezard E,Guehl D,Bioulac B,Gross C

    更新日期:1998-03-16 00:00:00