Abstract：
:We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.
journal_name
Brain Resjournal_title
Brain researchauthors
Boraud T,Bezard E,Guehl D,Bioulac B,Gross Cdoi
10.1016/s0006-8993(97)01563-1subject
Has Abstractpub_date
1998-03-16 00:00:00pages
157-60issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(97)01563-1journal_volume
787pub_type
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